4.7 Article

Efficient and Diverse Synthesis of Indole Derivatives

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 17, Pages 6895-6898

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo900986z

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Funding

  1. University of Pittsburgh Drug Discovery Institute

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A convergent 2-step procedure toward an array of indole derivatives involving an Ugi reaction and a Pictet-Spengler reaction is described. The reactions are versatile regarding different starting materials. Hexacyclic 24 can be produced with unprecedented complexity.

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