Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 20, Pages 7665-7674Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo900945x
Keywords
-
Categories
Funding
- Societe de Chimie Therapeutique/SERVIER
Ask authors/readers for more resources
An efficient and highly convergent synthesis of the monomeric counterpart of the antitumor-antibiotic marine natural product marinomycin A was achieved by using optically active titanium complexes to control the configuration of the stereogenic centers, a highly stereo- and regioselective cross-metathesis to generate the (E)-configured C20-C21 double bond, and a Horner-Wadsworth-Emmons olefination followed by a Pd-catalyzed Stille cross-coupling to construct the tetraene moiety.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available