☆ 4.7 Article

Enantioselective Synthesis of Chiral α-Aryl or α-Alkyl Substituted Ethylphosphonates via Rh-Catalyzed Asymmetric Hydrogenation with a P-Stereogenic BoPhoz-Type Ligand

JOURNAL OF ORGANIC CHEMISTRY (2009)

Journal

JOURNAL OF ORGANIC CHEMISTRY

Volume 74, Issue 11, Pages 4408-4410

Publisher

AMER CHEMICAL SOC

DOI: 10.1021/jo900417m

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Categories

Chemistry, Organic

Funding

National Natural Science Foundation of China [20802076, 20873145]
Knowledge Innovation Program of the Chinese Academy of Sciences [DICP-S200802]

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Abstract

An enantioselective synthesis of optically active 1-aryl or 1-alkyl substituted ethylphosphonates, based on the first Rh-catalyzed asymmetric hydrogenation of corresponding alpha,beta-unsaturated precursors with a P-stereogenic BoPhoz-type ligand under the mild condition, was developed, in which a wide range of 1-aryl or 1-alkyl substituted ethylphosphonates were achieved in up to 98% ee.

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