Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 74, Issue 2, Pages 703-709Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo802082t
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Funding
- Ministry of Education, Youth and Sports of the Czech Republic [1M0508, MSM002162089-2]
- Czech Science Foundation [203/07/1302]
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Biologically interesting 2-substituted 4-alkylidene pentenolides were prepared with complete control of regio- and stereoselectivity from 2-iodo allylic alcohols via an array of Pd-catalyzed processes, including alkynylation with methyl propiolate, tributyltin hydride addition, and alpha-functionalization. Some of the compounds possess selective cytostatic activity against ovarian carcinoma HeLa S3 and leukemia CCRF-CEM cell lines.
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