Article
Dentistry, Oral Surgery & Medicine
Xiaotang Wang, Xiaocui Nie, Guoqiang Xu, Jiping Gao, Binhong Wang, Junting Yang, Guohua Song
Summary: miR-450b plays a crucial role in the tumorigenesis of oral squamous cell carcinoma (OSCC) by regulating the migration, invasion, and epithelial-mesenchymal transition (EMT) of OSCC cells through its target gene SERPINB2.
Article
Multidisciplinary Sciences
Wenli Zang, Junchao Liu, Fengxue Geng, Dongjuan Liu, Shuwei Zhang, Yuchao Li, Yaping Pan
Summary: This study found that butyrate can promote the migration and invasion of oral squamous cell carcinoma (OSCC) cells by inducing epithelial-mesenchymal transition (EMT), indicating that butyrate may contribute to the metastasis of OSCC.
Article
Immunology
Ying Lin, Ying Qi, Mingjing Jiang, Wei Huang, Bo Li
Summary: There is metabolic interaction between tumor cells and macrophages in oral squamous cell carcinoma (OSCC), which is associated with tumor cell migration, invasion, and epithelial-mesenchymal transition (EMT). GPNMB and CD44 are involved in this process and may serve as potential targets for treating OSCC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Anatomy & Morphology
Xiao-Qin Liu, Yao Yao, Jing-Wen Mu, Feng-Ying Yang
Summary: This study found that high cytoplasmic expression of Sema4A is related to T classification, clinical stage, and nodal metastasis of OSCC patients. Patients with low cytoplasmic Sema4A expression showed higher microvessel density (MVD) and poorer prognosis in OSCC. Over-expression of Sema4A can inhibit the invasion, migration, and angiogenesis abilities of oral squamous cell carcinoma cells.
Article
Endocrinology & Metabolism
Yuanxin Chen, Zhijie Huang, Jianjiang Zhao, Bo Jia
Summary: This study verified the effect of Fusobacterium nucleatum (F. nucleatum) in oral squamous cell carcinoma (OSCC) and explored the possible molecular mechanism. The abundance of F. nucleatum was found to be higher in OSCC compared to paracancerous tissues. F. nucleatum can regulate cell proliferation, migration, and invasion, and promote the progression of OSCC through CCL20.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Pharmacology & Pharmacy
Danni Wang, Mei Tian, Yong Fu, Yawei Sun, Liang Ding, Xiaoxin Zhang, Yue Jing, Guowen Sun, Yanhong Ni, Yuxian Song
Summary: The study found that Halofuginone can inhibit the migration and invasion of oral squamous cell carcinoma (OSCC) by targeting cancer-associated fibroblasts (CAFs), and is involved in this process through inhibiting MMP2 secretion and the TGF-beta/Smad2/3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuntao Sun, Hongyu Yang, Feng Wang, Shanshan Zhao
Summary: In this study, it was found that LPS- and TNF-alpha-induced inflammation suppressed the migration and invasion of OSCC cells, facilitated by upregulating Oct4 expression.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyu Hu, Xin Shen, Jiangxue Tian
Summary: The research found that periodontitis positive correlated microbiota promotes the development of oral squamous cell carcinoma, while periodontitis negative correlated microbiota inhibits its development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Qiusheng Shan, Kiyofumi Takabatake, Haruka Omori, Hotaka Kawai, May Wathone Oo, Keisuke Nakano, Soichiro Ibaragi, Akira Sasaki, Hitoshi Nagatsuka
Summary: The study demonstrates that both VSCC-SCs and SCC-SCs may promote the progression of OSCC, with SCC-SCs showing a more prominent effect, indicating a potential regulatory mechanism for OSCC progression.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ze-Ying Zhang, Yuan-Yuan Sun, He-Chen Wang, Wei-Neng Fu, Chang-Fu Sun
Summary: The study revealed that DOCK6 is upregulated in oral squamous cell cancer and is associated with poor clinical outcomes. The increased expression of DOCK6 is correlated with enhanced migration and invasion of cancer cells. These findings suggest that DOCK6 may serve as a potential therapeutic target and prognostic indicator for OSCC patients.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Oncology
Adjabhak Wongviriya, Richard M. Shelton, Paul R. Cooper, Michael R. Milward, Gabriel Landini
Summary: This study aimed to determine the involvement of S1PR2 in EGF-induced migration and invasion of OSCC lines, as well as any potential crosstalk between the two pathways. The results demonstrated that S1PR2 inhibition reduced EGF-induced migration, invasion, and Rac1 activity. However, S1PR2 activation did not enhance the effect of EGF on migration, invasion, or Rac1 activity. Additionally, EGF promoted S1P production through the upregulation of Sphk1.
CANCER CELL INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Tiina Koivikko, Priscila Campioni Rodrigues, Mari Vehvilaeinen, Petra Hyvonen, Elias Sundquist, Riikka K. Arffman, Ahmed Al-Samadi, Hanna Valimaa, Tuula Salo, Maija Risteli
Summary: This study investigates the predominance of HSV-1 in oral HSV infections and its effect on oral tongue squamous cell carcinoma (OTSCC). The results show that HSV-1 is the predominant type in oral HSV infections and is also detected in OTSCC samples without clinical significance. Furthermore, low doses of HSV-1 do not affect cell survival or invasion in OTSCC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Xin Li, Weidong Yang
Summary: This study found that CLDN7 expression is low in OSCC tissues and that overexpression of CLDN7 inhibits the proliferation, invasion, and migration of OSCC cells. IRF2 was found to bind to the CLDN7 promoter and regulate its expression, also affecting the functions of OSCC cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Oncology
Jing Deng, Maolin Wu
Summary: COX10-AS1 is downregulated in oral squamous cell carcinoma and can act as a tumor suppressor through the miR-361-5p/SPRY1 axis.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Nyein Nyein Chan, Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abe, Kenta Haga, Masami Kawaharada, Kenji Izumi, Tadaharu Kobayashi, Jun-ichi Tanuma
Summary: Cholesterol plays a significant role in cancer progression, particularly in oral squamous cell carcinoma (OSCC) pathogenesis. This study investigates the effects of cholesterol on OSCC cells by manipulating the expression of CAV1, a cholesterol-binding protein involved in intracellular cholesterol transport. The results suggest that cholesterol promotes OSCC cell migration and that CAV1 expression may serve as a prognostic marker for OSCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anesthesiology
Su-Bo Yuan, Guangchen Ji, Bei Li, Tommy Andersson, Volker Neugebauer, Shao-Jun Tang
Review
Oncology
Chandra Prakash Prasad, Purusottam Mohapatra, Tommy Andersson
Article
Urology & Nephrology
Giacomo Canesin, Susan Evans-Axelsson, Rebecka Hellsten, Olov Sterner, Agnieszka Krzyzanowska, Tommy Andersson, Anders Bjartell
Article
Oncology
Chandra Prakash Prasad, Shivendra Kumar Chaurasiya, William Guilmain, Tommy Andersson
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2016)
Article
Oncology
Lubna M. Mehdawi, Chandra Prakash Prasad, Roy Ehrnstrom, Tommy Andersson, Anita Sjolander
MOLECULAR ONCOLOGY
(2016)
Article
Medical Laboratory Technology
Farnaz Moradi, Pontus Berglund, Rickard Linnskog, Karin Leandersson, Tommy Andersson, Chandra Prakash Prasad
TRANSLATIONAL RESEARCH
(2016)
Article
Oncology
Rickard Linnskog, Purusottam Mohapatra, Farnaz Moradi, Chandra Prakash Prasad, Tommy Andersson
Article
Dentistry, Oral Surgery & Medicine
Zdenka Prgomet, Tommy Andersson, Pia Lindberg
EUROPEAN JOURNAL OF ORAL SCIENCES
(2017)
Article
Oncology
Chandra Prakash Prasad, Katja Sodergren, Tommy Andersson
Article
Biochemistry & Molecular Biology
Elin J. Ekstrom, Caroline Bergenfelz, Verena von Bulow, Filiz Serifler, Eric Carlemalm, Goran Jonsson, Tommy Andersson, Karin Leandersson
Article
Oncology
Chandra Prakash Prasad, Shivendra Kumar Chaurasiya, Lena Axelsson, Tommy Andersson
MOLECULAR ONCOLOGY
(2013)
Article
Multidisciplinary Sciences
Giacomo Canesin, Susan Evans-Axelsson, Rebecka Hellsten, Agnieszka Krzyzanowska, Chandra P. Prasad, Anders Bjartell, Tommy Andersson
Article
Oncology
Njainday Pulo Jobe, Lisa Asberg, Tommy Andersson
Summary: The study reveals that WNT5A signaling regulates the invasive behavior of melanoma cells by affecting Rho GTPase activity and morphology. Different WNT5A effects on Cdc42 in various melanoma cell types result in distinct invasion morphologies.
MOLECULAR ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Z. Prgomet, T. Andersson, P. Lindberg
BIOTECHNIC & HISTOCHEMISTRY
(2017)