Article
Biochemistry & Molecular Biology
Luis Monteiro, Barbas do Amaral, Leonor Delgado, Fernanda Garces, Filomena Salazar, Jose Julio Pacheco, Carlos Lopes, Saman Warnakulasuriya
Summary: The study found that the expression levels of CD44v6, p53, p73, and podoplanin increase gradually along with the progression of oral leukoplakias. Furthermore, high levels of podoplanin expression were found to be associated with an increased risk of malignant transformation.
Review
Biochemistry & Molecular Biology
Nadia Kaunein, Rishi Sanjay Ramani, Kendrick Koo, Caroline Moore, Antonio Celentano, Michael McCullough, Tami Yap
Summary: Oral cancer is the eighth most common cancer worldwide, and early diagnosis and management of oral potentially malignant disorders are crucial for reducing deaths and improving prognosis. Research indicates that miRNAs play a critical role in the initiation and progression of oral cancer, with significant potential in predicting malignant transformation of potentially malignant disorders.
Review
Oncology
Yan Huang, Qiufang Zhang, Zhenzhen Guo, Guanhong Deng, Ruibin Chen, Yanfen Zheng
Summary: This study systematically searched and analyzed the literature on potential saliva and serum biomarkers for oral leukoplakia (OL) malignant transformation. The results showed that IL-6 and TNF-alpha in saliva, as well as LSA and TSA levels in serum, have statistically significant differences in distinguishing healthy controls, OL patients, and oral cancer patients.
Review
Dentistry, Oral Surgery & Medicine
Luis Monteiro, Fernanda Weber Mello, Saman Warnakulasuriya
Summary: A systematic review evaluated biomarkers related to oral leukoplakia, identifying some biomarkers associated with future cancer risk in OL patients. Heterogeneity and lack of standardized reporting were identified as issues in the studies.
Article
Biotechnology & Applied Microbiology
Fengji Li, Lin Qiu, Qian Gao, Liguang Yu, Han Liu, Zhijun Xue, Anqi Tao
Summary: This study aimed to identify key genes for the malignant transformation of oral leukoplakia (OLK) using the Gene Expression Omnibus (GEO) database and experiments. The GEO database was used to screen OLK malignant transformation-related genes, which were then validated through bioinformatic analyses and experiments. The results identified LAPTM4B, NR3C1, and COX6A1 as potential biomarkers for the diagnosis and treatment of OLK malignant transformation.
Article
Dentistry, Oral Surgery & Medicine
Ilkay Evren, Elisabeth R. Brouns, Jos B. Poell, Leon J. Wils, Ruud H. Brakenhoff, Elisabeth Bloemena, Jan G. A. M. de Visscher
Summary: This study aimed to investigate the associations between patients' demographics and habits and the clinical aspect and histopathological characteristics of oral leukoplakia (OL) at patients' first visit. The results showed that different types of OL were associated with smoking, location, and size. However, clinical characteristics cannot substitute microscopic examination of biopsies.
Review
Pharmacology & Pharmacy
Pratima Kumari, Priyanka Debta, Anshuman Dixit
Summary: Oral cancer is a critical health issue, with the majority of new cases occurring in Asia. Various factors, such as genetics and lifestyle, are closely associated with its occurrence and progression. Early signs of oral cancer include oral lesions, genetic mutations, and viral infections. Lesions with dysplastic features have a high risk of malignancy, and OPMDs have a high prevalence in South Asian countries. Early detection, prevention, and treatment of OPMDs are crucial.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Valentina Dikova, Eloisa Jantus-Lewintre, Jose Bagan
Summary: This study investigated the levels of certain salivary cytokines as potential biomarkers for distinguishing between oral squamous cell carcinoma (OSCC), oral leukoplakia (OL), and healthy individuals. The findings suggest that IL-6, IL-8, TNF-alpha, HCC-1, and PF-4 in saliva may be useful in differentiating between these conditions, with IL-6 and TNF-alpha potentially indicating the progression of OSCC, especially in the presence of neck metastases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Leon J. Wils, Jos B. Poell, Laura A. N. Peferoen, Ilkay Evren, Elisabeth R. Brouns, Jan G. A. M. de Visscher, Erik H. van Der Meij, Ruud H. Brakenhoff, Elisabeth Bloemena
Summary: Oral leukoplakia is a common potentially malignant disorder, and classic epithelial dysplasia and differentiated dysplasia are important predictors of its malignant transformation.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Elisabeth R. Brouns, Ilkay Evren, Leon J. Wils, Jos B. Poell, Ruud H. Brakenhoff, Elisabeth Bloemena, Jan G. A. M. de Visscher
Summary: This study emphasizes the value of the slightly modified OL-system in uniform reporting of OL and predicting malignant transformation.
Article
Dentistry, Oral Surgery & Medicine
Hans Prakash Sathasivam, Deepa Nayar, Philip Sloan, Peter J. Thomson, Edward W. Odell, Max Robinson
Summary: The combination of oral epithelial dysplasia grading and DNA ploidy analysis can effectively assess the risk of oral potentially malignant disorders and develop novel management algorithms, as shown by the study results.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Oncology
Xinjia Cai, Jianyun Zhang, Ying Han, Qian Tang, Heyu Zhang, Tiejun Li
Summary: This study developed a novel nomogram model to assess the risks of malignant transformation of oral potentially malignant disorders. The model showed high predictive value and clinical relevance, although not applicable to all cases.
Review
Dentistry, Oral Surgery & Medicine
Jing-Yao Guan, Yong-Hua Luo, Ye-Yu Lin, Zhou-Yang Wu, Jing-Yi Ye, Si-Ming Xie, Jin Li
Summary: This meta-analysis aimed to assess the rate of malignant transformation (MT) of oral leukoplakia (OL) and to study potential risk factors for the MT of OL into oral squamous cell carcinoma (OSCC). The pooled proportion of OL MT for the total population described in the selected studies was 7.20%. Nonhomogeneous type lesions, higher grades of dysplasia, the location of the lesion (tongue and multifocal), and female sex had significant effects on the MT of OL. Patients with significant MT risk factors should be subjected to regular follow-up and observation.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Alejandro Herreros-Pomares, David Hervas, Leticia Bagan-Debon, Eloisa Jantus-Lewintre, Concepcion Gimeno-Cardona, Jose Bagan
Summary: This study aims to compare and describe the composition and diversity of the oral microbiome in patients with homogeneous leucoplakia, proliferative verrucous leukoplakia, oral squamous cell carcinoma, and OSCC preceded by PVL. The number of bacterial species was lower in cancer patients, with Fusobacteriota being the dominant group. PVL and PVL-OSCC patients had a higher abundance of Campilobacterota and lower Proteobacteria compared to other groups. This is the first study comparing oral microbiome alterations in these groups, and further research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pathology
Kenneth P. H. Pritzker, Mark R. Darling, Jason T-K Hwang, David Mock
Summary: Oral epithelial dysplasia, often associated with prolonged exposure to tobacco and alcohol, can regress in some cases with reduction of carcinogen exposure. Histologic dysplasia grade combined with macroscopic images of dysplastic clinical lesions can be used as an educational tool to motivate patients to reduce their known carcinogen exposure, potentially reducing lesion progression and the disease burden of oral cancer.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Moritz Berger, Eva Grau, Daniel Saure, Oliver Ristow, Oliver Thiele, Christof Hofele, Juergen Hoffmann, Robin Seeberger, Kolja Freier
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2015)
Article
Oncology
Koija Freier, Karl Knoepfle, Christa Flechtenmacher, Susanne Pungs, Frauke Devens, Grischa Toedt, Christof Hofele, Stefan Joos, Peter Lichter, Bernhard Radwirnmer
GENES CHROMOSOMES & CANCER
(2010)
Article
Otorhinolaryngology
K. Freier, S. Pungs, C. Flechtenmacher, C. Hofele
Article
Otorhinolaryngology
R. Seeberger, W. Kater, M. Schulte-Geers, O. C. Thiele, R. Davids, C. H. Hofele, K. Freier
Article
Dentistry, Oral Surgery & Medicine
Oliver C. Thiele, Kolja Freier, Christa Flechtenmacher, Stefan Rohde, Christof Hofele, Joachim Muhling, Robin Seeberger
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2010)
Article
Dentistry, Oral Surgery & Medicine
Robin Seeberger, Wolfgang Kater, Rolf Davids, Oliver C. Thiele, Boris Edelmann, Christof Hofele, Kolja Freier
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2011)
Article
Dentistry, Oral Surgery & Medicine
Oliver C. Thiele, Robin Seeberger, Christa Flechtenmacher, Christof Hofele, Kolja Freier
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2012)
Article
Dentistry, Oral Surgery & Medicine
Alexander J. Hassel, Daniel Danner, Kolja Freier, Christof Hofele, Kirsten Becker-Bikowski, Michael Engel
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2012)
Article
Dentistry, Oral Surgery & Medicine
Kolja Freier, Christof Hofele, Karl Knoepfle, Madeleine Gross, Frauke Devens, Gerhard Dyckhoff, Peter Plinkert, Peter Lichter, Christel Herold-Mende
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2010)
Article
Oncology
M. Knoedler, T. C. Gauler, V. Gruenwald, A. Matzdorff, M. Schroeder, A. Dietz, W. -O. Jordan, D. Arnold, B. Hennemann, C. Hofele, F. Weissinger, W. Eberhardt, U. Keilholz
Article
Oncology
Snjezana Janjetovic, Carsten Sticht, Karl Knoepfle, Stefan Joos, Christof Hofele, Peter Lichter, Kolja Freier
Article
Dentistry, Oral Surgery & Medicine
J. Moratin, A. Ledermann, A. D. Schulz, K. Metzger, O. Ristow, C. Hofele, M. Engel, J. Hoffmann, K. Freier, K. Lang, S. Adeberg, D. Horn, C. Freudlsperger
Summary: The study revealed a high rate of cervical metastases in patients with ACC of the minor salivary glands, which had a significant negative impact on survival rates. Most patients experienced disease recurrence during follow-up, predominantly with local recurrence, which could be successfully treated with surgery.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2021)
Article
Medicine, Research & Experimental
Oliver Ristow, Christof Hofele, Philipp Muench, Sylvia Danner, Anja Dietzel, Johannes Krisam, Christina Klose, Maximilian Pilz, Juergen Hoffmann, Christian Freudlsperger
Summary: The debate over the use of prolonged postoperative antibiotics in reducing surgical site infection rates continues among surgeons. This multicentre, randomised clinical trial aims to investigate the effectiveness of postoperative antibiotic prophylaxis in orthognathic surgery. With 1420 patients to be enrolled over 54 months, this study seeks to provide valuable insights for similar surgical procedures.
Meeting Abstract
Oncology
K. Becker-Bikowski, C. Zaldivar-Wither, K. Freier, C. Hofele