Letter
Oncology
Carla Isabelly Rodrigues-Fernandes, Lady Paola Aristizabal Arboleda, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Alan Roger Santos-Silva
Summary: This report describes an uncommon case of verrucous carcinoma in the oral cavity with a unique presentation of proliferative verrucous leukoplakia. It highlights the importance of considering verrucous carcinoma in the differential diagnosis of multiple leukoplakias, especially in elderly patients.
Review
Oncology
Gaspare Palaia, Amelia Bellisario, Riccardo Pampena, Roberto Pippi, Umberto Romeo
Summary: PVL, a rare subtype of oral leukoplakia, has a high risk of malignant transformation, with almost 50% progressing to OSCC. Female patients, especially elderly non-smokers and non-drinkers, are at higher risk for this transformation.
Article
Biochemistry & Molecular Biology
Mariana Paravani Palacon, Camila de Oliveira Barbeiro, Darcy Fernandes, Mariel Ruivo Biancardi, Heitor Albergoni Silveira, Tulio Morandin Ferrisse, Jorge Esquiche Leon, Omar Kujan, Andreia Bufalino
Summary: This study aimed to evaluate the density of dendritic cells (DCs) and macrophages in oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL) through immunohistochemical analysis. The results showed a reduction in CD208+ cells in the subepithelial area of OL and PVL compared to the control group. Additionally, a higher density of FXIIIa+ and CD163+ cells was found in the subepithelial area of PVL compared to OL and control. Macrophages play a role in the defense against PVL antigens, indicating a distinct activation pattern of the innate immune system in PVL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
U. Alkan, G. Bachar, Y. Nachalon, A. Zlotogorsky, E. G. Levin, I. Kaplan
Summary: This retrospective study compares the clinicopathological features of proliferative verrucous leukoplakia, leukoplakia without dysplasia, oral lichen planus/oral lichenoid lesions, and verrucous carcinoma. The findings suggest that proliferative verrucous leukoplakia has persistent aggressive behavior and a high malignant transformation rate, emphasizing the need for detailed definition and long-term close monitoring.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Review
Medicine, General & Internal
Abdullah Alsoghier, Hamad AlBagieh, Lujain AlSahman, Rana Alshagroud, Roba AlSahman
Summary: Proliferative verrucous leukoplakia (PVL) is a rare and aggressive lesion that is resistant to treatment and has a high risk of malignant transformation. Diagnosing PVL is challenging due to lack of awareness about oral white lesions. Early detection and complete excision are recommended for better treatment outcomes. This case report aims to raise awareness of PVL among clinicians by presenting its typical clinical and histologic features.
Review
Dentistry, Oral Surgery & Medicine
Pablo Ramos-Garcia, Miguel angel Gonzalez-Moles, Fernanda Weber Mello, Jose V. Bagan, Saman Warnakulasuriya
Summary: This study investigated the malignant transformation of oral proliferative verrucous leukoplakia, finding that females and gingiva were more commonly affected. The pooled proportion of malignant transformation was 43.87%, with conventional squamous cell carcinoma being the most frequent histopathological subtype. No conclusive results were found between malignant transformation and sex, age, tobacco, or alcohol consumption.
Article
Immunology
Darcy Fernandes, Camila de Oliveira Barbeiro, Mariana Paravani Palacon, Mariel Ruivo Biancardi, Tulio Morandin Ferrisse, Heitor Albergoni Silveira, Rogerio Moraes Castilho, Luciana Yamamoto de Almeida, Jorge Esquiche Leon, Andreia Bufalino
Summary: Oral leukoplakia and proliferative verrucous leukoplakia are potential malignant oral disorders, with the latter showing a more aggressive clinical behavior. This study evaluated the density of T cells and cytokines in dysplastic lesions from patients with these disorders, and investigated the effects of dysplastic keratinocyte-derived soluble products on peripheral blood mononuclear cells. The results showed an increase in CD8 T cell number and alterations in certain cytokine levels in proliferative verrucous leukoplakia compared to oral leukoplakia.
Review
Oncology
Qixin Liu, Ziheng Peng, Liangfang Shen, Lin Shen
Summary: Ki-67 overexpression is associated with poor overall survival rates in melanoma patients, but not correlated with PFS and RFS rates. Ki-67 expression levels are associated with tumor thickness.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Miguel Angel Gonzalez-Moles, Saman Warnakulasuriya, Pablo Ramos-Garcia
Summary: Proliferative verrucous leukoplakia patients with oral carcinoma (PVL-OC) have a lower mortality rate compared to conventional oral cancer, indicating favorable prognostic parameters.
Article
Dentistry, Oral Surgery & Medicine
Jasbir D. Upadhyaya, Sarah G. Fitzpatrick, Mohammed N. Islam, Indraneel Bhattacharyya, Nagamani Narayana, Donald M. Cohen
Summary: This study highlights 30 cases of marginal gingival leukoplakia, showing characteristics of benign lesions, premalignant lesions, and malignant tumors. Most patients presented with well-demarcated white lesions on the gingival margin, some forming a ring around the tooth collar, with recurrent or multifocal involvement.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Otorhinolaryngology
Monica Pentenero, Patrizio Castagnola, Faride Victoria Castillo, Elena Isaevska, Samuele Sutera, Sergio Gandolfo
Summary: This prospective observational study examined the factors associated with malignant transformation in localized oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL). Data on demographics, clinical characteristics, histology, and DNA ploidy status were collected. The presence of OED, DNA ploidy, clinical presentation, and lesion site were found to be associated with malignant transformation in patients with OL, while none of these predictors were associated with PVL. The study suggests that DNA ploidy may be able to identify a subset of OL with low or minimal risk of malignant transformation, but it is not a reliable predictor in PVL patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Review
Dentistry, Oral Surgery & Medicine
Isabel Schausltz Pereira Faustino, Mariana de Pauli Paglioni, Bruno Augusto Linhares de Almeida Mariz, Ana Gabriela Costa Normando, Maria Eduarda Perez-de-Oliveira, Maria Georgaki, Nikolaos G. Nikitakis, Pablo Agustin Vargas, Alan Roger Santos-Silva, Marcio Ajudarte Lopes
Summary: This study evaluated the prognostic outcomes of PVL-derived oral squamous cell carcinomas (P-OSCC) and found that P-OSCC has better clinical prognostic characteristics compared to conventional OSCC. The common prognostic outcomes are recurrence and new primary tumors, while metastasis is rare. Most patients have an average survival period of 5 years.
Article
Oncology
Yujie Yan, Zhenglei Li, Xin Tian, Xin Zeng, Qianming Chen, Jiongke Wang
Summary: Non-invasive photodynamic therapy (PDT) is an effective method for selectively treating proliferative verrucous leukoplakia (PVL), but the hyperkeratosis of lesions limits the penetration of photosensitizers. Laser-assisted PDT can improve the delivery of photosensitizers and their accumulation in tissues, achieving satisfactory clinical results.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Oncology
Alejandro Herreros-Pomares, Carlos Llorens, Beatriz Soriano, Feiyu Zhang, Sandra Gallach, Leticia Bagan, Judith Murillo, Eloisa Jantus-Lewintre, Jose Bagan
Summary: The oral microbiome composition and diversity were significantly different between PVL patients and healthy individuals, with potentially protumorigenic pathogens more abundant in PVL patients. Further studies are needed to explore the implications of these findings and the potential use of oral microbiota-based biomarkers in predicting risks for PVL development.
Article
Oncology
Chung-Man Moon, Yun Young Lee, Doo-Young Kim, Woong Yoon, Byung Hyun Baek, Jae-Hyun Park, Suk-Hee Heo, Sang-Soo Shin, Seul Kee Kim
Summary: This study aimed to predict the expression of Ki-67 proliferative index and p53 tumor suppressor protein in meningioma patients using preoperative multiparametric magnetic resonance imaging (mpMRI)-based clinical-radiomic analysis combined with machine learning (ML) algorithms. The results showed that larger tumor volumes, irregular tumor margin, and unclear tumor-brain interface were independently associated with high Ki-67 expression, while the presence of necrosis and the dural tail sign were independently associated with positive p53 expression. A model combining clinical and radiological features yielded better performance, providing a novel non-invasive strategy for assessing cell proliferation.
FRONTIERS IN ONCOLOGY
(2023)
Review
Pathology
Amanda Almeida Leite, Bruno Augusto Linhares Almeida Mariz, Leticia Almeida Oliveira, Jose Narciso Rosa Assuncao Junior, Oslei Paes de Almeida, Pablo Agustin Vargas
Summary: Hybrid peripheral nerve sheath tumors, an extremely rare type of tumor, can occur within the oral cavity. Recognizing them as a distinct clinicopathological entity is important.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Editorial Material
Dentistry, Oral Surgery & Medicine
Luccas Lavareze, Joao Figueira Scarini, Reydson Alcides de Lima-Souza, Erika Said Abu Egal, Diego Tetzner, Amanda Almeida Leite, Pablo Agustin Vargas, Albina Altemani, Fernanda Viviane Mariano
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2023)
Article
Neurosciences
Caetano M. Ranieri, Renan C. Moioli, Patricia A. Vargas, Roseli A. F. Romero
Summary: This paper addresses the issue of behaviour selection in human-robot interaction by presenting an initial neurorobotics model. The model combines computational models of the basal ganglia-thalamus-cortex circuit with human activity recognition techniques. Initial results show that this model has advantages, especially in the coupling between accurate activity recognition and computational models of more complex animals.
COGNITIVE NEURODYNAMICS
(2023)
Letter
Pathology
Paulo Victor Mendes Penafort, Amanda Almeida Leite, Fernando Noronha-Junior, Pablo Agustin Vargas
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Vanesa Pereira Prado, Gabriel Landini, Adalberto Mosqueda Taylor, Pablo Vargas, Ronell Bologna Molina
Summary: This study investigates the expression of CD34 marker in primordial odontogenic tumour and compares it with ameloblastic fibroma and normal tooth germ. The results reveal unique expression patterns and higher cellularity in primordial odontogenic tumour, supporting the idea that it is a distinct entity.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Review
Oncology
Vivian Petersen Wagner, Renata Ferrarotto, Pablo Agustin Vargas, Manoela Domingues Martins, Colin D. Bingle, Lynne Bingle
Summary: Adenoid cystic carcinoma (ACC) has a significant patient population that lacks effective systemic therapy. We reviewed ACC clinical trials on ClinicalTrials.gov and found that most trials were one-arm phase II trials enrolling advanced, recurrent/metastatic, incurable ACC cases. Small-molecule inhibitors, such as Apatinib, Axitinib, and Lenvatinib, showed promising results. However, more efforts are urgently needed in this field to improve the overall median time to progression.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Review
Medical Laboratory Technology
Fernanda Aragao Felix, Ana Carolina Velasco Ponde de Sena, Jose Alcides Almeida de Arruda, Thalita Soares Tavares, Amanda Leal Rocha, Carla Isabelly Rodrigues-Fernandes, Cinthia Veronica Bardalez Lopez de Caceres, Pablo Agustin Vargas, Lucas Guimaraes Abreu, Tania Mara Pimenta Amaral, Denise Vieira Travassos, Silvia Ferreira de Sousa, Felipe Paiva Fonseca, Tarcilia Aparecida Silva, Ricardo Alves Mesquita
Summary: This study reviews the existing data on fine-needle aspiration cytology for the diagnosis of plasma cell neoplasms of the head and neck region and concludes that cytological analysis can be a valuable tool in the initial diagnosis, particularly when using a cell block.
DIAGNOSTIC CYTOPATHOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Bruno Cesar da Costa, Mauricio Rocha Dourado, Everton Freitas de Moraes, Luana Mari Panini, Amr Elseragy, Fabio Haach Teo, Gustavo Narvaes Guimaraes, Renato Assis Machado, Maija Risteli, Clarissa Araujo Gurgel Rocha, Livia Maris Ribeiro Paranaiba, Wilfredo Alejandro Gonzalez-Arriagada, Sabrina Daniela da Silva, Ana Lucia Carrinho Ayroza Rangel, Marcelo Rocha Marques, Tuula Salo, Ricardo D. Coletta
Summary: This study explored the prognostic impact of HSP47 in oral squamous cell carcinomas (OSCC) and the functional effects of its inhibition on OSCC cells. The results showed that HSP47 was overexpressed in OSCC samples and its overexpression was significantly associated with poor survival. Furthermore, the knockdown of HSP47 impaired the proliferation, migration, and invasion of OSCC cells.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Eder Silva da Dolens, Everton Freitas de Morais, Livia Maris Ribeiro Paranaiba, Ana Lucia Carrinho Ayroza Rangel, Alhadi Almangush, Tuula Salo, Peter A. Brennan, Ricardo D. Coletta
Summary: This study investigates the impact of neural invasion on prognosis in oral squamous cell carcinomas and compares intraneural invasion with perineural invasion. The results show that intraneural invasion is significantly associated with prognosis, while perineural invasion is not. This suggests that the association of intraneural invasion with other clinical and pathological prognostic factors should be considered in determining the optimal treatment protocol and prognosis of patients with oral squamous cell carcinomas.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Lilianny Querino Rocha de Oliveira, Alhadi Almangush, Ahmed Al-Samadi, Tuula Salo, Ricardo D. Coletta
Summary: In the past few decades, there has been a strong focus on identifying biomarkers for therapy response and prognosis in oral squamous cell carcinomas. Although several biomarkers have been identified, only a few are currently used in routine practice. This review summarizes the recent advances in oral squamous cell carcinoma biomarkers, including clinical and histopathological features, cancer cells, and microenvironment components. The main challenges in translating these potential biomarkers into clinical application are also discussed.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Editorial Material
Dentistry, Oral Surgery & Medicine
Amanda Almeida Leite, Tulio de Lucena Pires, Luan Cesar Silva, Paulo Victor Mendes Penafort, Pablo Agustin Vargas
Review
Oncology
Anna Luiza Damaceno Araujo, Matheus Cardoso Moraes, Maria Eduarda Perez-di-Oliveira, Viviane Mariano da Silva, Cristina Saldivia-Siracusa, Caique Mariano Pedroso, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Sara Kochanny, Alexander Pearson, Syed Ali Khurram, Luiz Paulo Kowalski, Cesar Augusto Migliorati, Alan Roger Santos-Silva
Summary: The aim of this systematic review was to summarize machine learning models used for predicting treatment-related toxicities in head and neck cancer and understand the impact of image biomarkers in these prediction models. A total of 28 studies with 4,713 patients were included, and the results showed that prediction models with image biomarkers were not superior to those without biomarkers. The heterogeneity of the studies and the lack of standardized metrics limited proper comparison, and the evidence was appraised as of low certainty.
Article
Dentistry, Oral Surgery & Medicine
Luiz Arthur Barbosa da Silva, Lucas Melo da Costa, Ana Camila Pereira Massetti, Laudenice de Lucena Pereira, Ericka Janine Dantas da Silveira, Tuula Anneli Salo, Ricardo Della Coletta, Marcia Cristina da Costa Miguel
Summary: Heat shock factor 1 is overexpressed in oral squamous cell carcinoma and its silencing can inhibit cell proliferation, invasion, and epithelial-mesenchymal transition. Therefore, targeting this protein may be a therapeutic approach to control the progression of oral squamous cell carcinoma.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Monica Hermann Spiguel, Lauren Frenzel Schuch, Luan Nathiel Kovalski, Julia Turra Ribeiro, Bruna Barcelos So, Felipe Martins Silveira, Pablo Agustin Vargas, Marco Antonio Trevizani Martins, Virgilio Gonzales Zanella, Pedro Bandeira Aleixo, Vivian Petersen Wagner, Manoela Domingues Martins
Summary: This study conducted a systematic review of head and neck Ewing sarcoma, with a focus on demographic and clinical features, histopathological findings, treatment, follow-up, and survival rate. A total of 227 cases were described in 186 studies, with an average age of 22.7 years and a slightly higher prevalence in males. The respiratory tract was the most common site, followed by the jawbones. Multimodal treatment regimens were used, and the overall survival rate was found to be lower in older patients with distant metastasis (p < 0.05).
Review
Pathology
Daniela Giraldo-Roldan, Brendo Vinicius Rodrigues Louredo, Paulo Victor Mendes Penafort, Helder Antonio Rebelo Pontes, Aline Pinheiro Alves, Fernando C. A. Lima, Thamyres Campos Fonseca, Aline Correa Abrahao, Mario Jose Romanach, Felipe Paiva Fonseca, Wilson A. Delgado, Liam Robinson, Willie F. P. Van Heerden, Oslei Paes de Almeida, Pablo Agustin Vargas
Summary: Low-grade myofibroblastic sarcoma (LGMS) is a tumor composed of myofibroblasts with a high tendency for local recurrence and a low probability of distant metastases. This study reports 13 new cases of LGMS in the oral and maxillofacial region, with clinical, radiographic, histopathological, and immunohistochemical findings evaluated. LGMS predominantly affects young adult females in the maxillary region. Immunohistochemical study is crucial for the diagnosis, and complete surgical excision is the treatment of choice.
HEAD & NECK PATHOLOGY
(2023)
