Article
Dentistry, Oral Surgery & Medicine
Honglin Liao, Yuxue Luo, Li Long, Jiakuan Peng, Xuemei Qiu, Peiyang Yuan, Hao Xu, Lu Jiang
Summary: The study found that anxiety levels were higher in OLP patients compared to healthy individuals, with female patients showing higher levels of anxiety. Gender had an impact on anxiety levels among OLP patients. The research suggests that OLP patients can be classified into weakly anxiety-related or highly anxiety-related types.
Review
Dentistry, Oral Surgery & Medicine
Asma El-Howati, Martin H. Thornhill, Helen E. Colley, Craig Murdoch
Summary: Oral lichen planus (OLP) is a T cell-mediated inflammatory disease of the oral mucosa. The mechanisms of pathogenesis are still not fully understood, but evidence suggests a chronic, dysregulated immune response leading to increased expression of cytokines, chemokines, and adhesion molecules. CD8+ cytotoxic and CD4+ Th1 polarised T cells are the main lymphocytes involved, but recent evidence indicates the involvement of other T cell subsets.
Review
Pharmacology & Pharmacy
Jie Bao, Chu Chen, Jiayu Yan, Yueqiang Wen, Jiamin Bian, Mengting Xu, Qin Liang, Qingmei He
Summary: This study systematically reviewed the efficacy and safety of antioxidants for patients with Oral lichen planus (OLP). The findings showed that antioxidant therapy could significantly reduce pain score, clinical score, and improve pain resolution rate and clinical resolution rate for OLP patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Maryam Mardani, Hossein Mofidi, Ladan Dastgheib, Sara Ranjbar, Nasrin Hamidizadeh
Summary: The study found that serum IL-23 levels were significantly higher in patients with oral lichen planus compared to the control group, indicating a key role of IL-23 in the pathogenesis of oral lichen planus. Additionally, there were significant differences in IL-23 serum levels between patients with cutaneous lichen planus and healthy controls, as well as between patients with cutaneous lichen planus and patients with oral lichen planus.
MEDIATORS OF INFLAMMATION
(2021)
Article
Oncology
Xinjia Cai, Jianyun Zhang, Heyu Zhang, Tiejun Li
Summary: This study investigated the association between oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC) in a retrospective cohort of 3568 patients. The findings suggest that not all cases of OSCC are transformed from OLP, indicating that the previous understanding of OLP transformation may have been overestimated. Strict diagnostic criteria for OLP and close surveillance are important in correctly identifying the origin of OSCC and avoiding overestimation of the risk of OLP transformation.
Article
Oncology
Katharina Theresa Obermeier, Sabina Noreen Wuersching, Paris Liokatis, Wenko Smolka, Philipp Poxleitner, Christin Kleye, Michael Ehrenfeld, Maximilian Kollmuss, Sven Otto
Summary: Oral lichen ruber planus (OLP) is a chronic inflammatory disease of the oral mucosa that can progress to oral squamous cell carcinoma (OSCC) in a small percentage of cases. Surgical treatment, including tumor resection and neck dissection, is recommended. This study examined 103 OLP patients and compared their lymph node metastasis and survival rates with a group of OSCC patients without OLP. The analysis showed that patients with OLP had a significantly lower risk of lymph node metastasis compared to those without OLP.
Review
Medicine, General & Internal
Katharina Boch, Ewan A. Langan, Khalaf Kridin, Detlef Zillikens, Ralf J. Ludwig, Katja Bieber
Summary: Lichen planus is a T cell-mediated disease affecting the skin and mucous membranes, characterized by inflammatory infiltrate and basal layer degeneration. While usually self-limiting, it can cause significant morbidity. Current treatment includes corticosteroids, but new options like Janus kinase inhibitors and biologics may lead to a change in treatment landscape.
FRONTIERS IN MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Rakefet Czerninski, Zinat Awadieh, Svetlana Feldman, Naama Keshet, Abraham Zlotogorski, Yuval Ramot
Summary: This study describes familial OLP in 20 families, predominantly Jewish. The high prevalence of hypothyroidism and oral squamous cell carcinoma in familial OLP patients suggests a potential predisposition to malignant transformation in this high-risk group.
Article
Immunology
Qionghua Li, Fei Wang, Yujie Shi, Liang Zhong, Shumin Duan, Wenjing Kuang, Na Liu, En Luo, Yu Zhou, Lu Jiang, Hongxia Dan, Xiaobo Luo, Dunfang Zhang, Qianming Chen, Xin Zeng, Taiwen Li
Summary: This study characterized the mucosal immune microenvironment of oral lichen planus (OLP) using single-cell RNA sequencing and immune repertoire sequencing. Activated tissue-resident memory CD8+ T cells were found in OLP tissues, along with clonal expansion of T cell receptor repertoires and BCR clonal expansion. Fibroblasts were identified as potential promoters of immune cell recruitment into connective tissue in OLP.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yunshan Li, Yaodong He, Junwei Xiang, Linfei Feng, Yuanyin Wang, Ran Chen
Summary: Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), play important regulatory roles in eukaryotes by post-transcriptionally inhibiting gene expression. The role and mechanisms of miRNAs in oral lichen planus (OLP) are still unclear, but they show potential as biomarkers for OLP diagnosis and therapeutic targets.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Masoud Hatami, Mahya Rezaei, Masoud Sadeghi, Jyothi Tadakamadla, Filiz Namdar Pekiner, Hamid Reza Mozaffari
Summary: This study compared the salivary and serum levels of TAC and CRP between OLP patients and controls through a meta-analysis, indicating significantly lower TAC levels and higher CRP levels in OLP patients.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Cristovao Antunes de lanna, Beatriz Nascimento Monteiro da Silva, Andreia Cristina de Melo, Martin H. Bonamino, Lisia Daltro Borges Alves, Luis Felipe Ribeiro Pinto, Abel Silveira Cardoso, Heliton Spindola Antunes, Mariana Boroni, Daniel Cohen Goldemberg
Summary: By comparing the gene expression profiles of Oral Lichen Planus and Oral Squamous Cell Carcinoma, similarities were found in processes such as keratinization, cell proliferation, and immune response. Key tumor suppressors and oncogenes were dysregulated in both diseases.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
M. Contaldo, R. Grassi, F. Fiori, G. M. Nardi, R. Borgia, A. Romano, R. Serpico, M. Petruzzi
Summary: Oral Lichen planus is an immune-mediated disease with unknown causes that affects the oral mucous. Human papillomavirus infection may be correlated with Oral Lichen Planus.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Biochemistry & Molecular Biology
Lara Marie DeAngelis, Nicola Cirillo, Alexis Perez-Gonzalez, Michael McCullough
Summary: This study used multiplex immunohistochemistry (mIHC) to investigate the presence and abundance of mucosal-associated invariant T (MAIT) cells in oral lichen planus (OLP) tissue samples, as well as their relationship with Candida infection and symptoms. The results showed the presence of MAIT cell phenotypes in OLP tissue, with significant differences in the percentage of positive cells between different OLP groups. The relative abundance of triple-stained cells also varied significantly. Reduced percentage of certain cells was observed in symptomatic OLP with and without Candida, suggesting a potential role of these cells in OLP pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Won Jung, Sungil Jang
Summary: Oral lichen planus is a chronic inflammatory disease with an unknown cause. Dysbiosis in the oral microbiome and functional abnormalities in the oral mucosa play important roles in its development.
Review
Substance Abuse
Lorena C. Mariano, Saman Warnakulasuriya, Kurt Straif, Luis Monteiro
Summary: The systematic review and meta-analysis study support a causal association between SHS exposure and oral cancer. Individuals exposed to SHS, particularly for more than 10 or 15 years, have an increased risk of developing oral cancer. These findings could inform public health professionals, researchers, and policymakers in implementing effective SHS exposure prevention programs globally.
Review
Dentistry, Oral Surgery & Medicine
Teresa De Porras-Carrique, Pablo Ramos-Garcia, Manuel Aguilar-Diosdado, Saman Warnakulasuriya, Miguel Angel Gonzalez-Moles
Summary: There is a high prevalence and frequent association between OLP and autoimmune disorders, especially thyroid disease and diabetes mellitus.
Article
Dentistry, Oral Surgery & Medicine
S. Warnakulasuriya, T. H. H. Chen
Summary: Areca nut chewing is a major risk factor for oral cancer, especially in South Asian and East Asian populations. The risk of oral cancer increases with the daily amount of betel quid chewed and the duration of chewing. About half of oral cancers in India and Taiwan are attributed to betel quid chewing. Oral leukoplakia and oral submucous fibrosis are potential precursors of oral cancer caused by areca nut chewing. Quitting areca nut chewing may reduce the risk of oral cancer.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Necla Asli Kocak-Oztug, Gamze Zeynep Adem-Siyli, Orkhan Abishev, Sule Batu, Yegane Guven, Ali Cekici, Aslan Y. Gokbuget, Erhan Firatli, Serdar Cintan
Summary: This study compared the peri-implant crevicular fluid biomarker levels, peri-implant status, and marginal bone level differences between implants restored with nonplatform-switched and platform-switched abutments. The results showed that platform-switched abutments were superior in preserving marginal bone level. Higher MCP-1 levels and altered RANKL/OPG ratio in the nonplatform-switched group may be associated with subclinical peri-implant bone remodeling.
BIOMED RESEARCH INTERNATIONAL
(2022)
Editorial Material
Medicine, General & Internal
Agostino Guida, Saman Warnakulasuriya
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Public, Environmental & Occupational Health
Adalberto M. Filho, Michelle C. Turner, Saman Warnakulasuriya, David B. Richardson, Bayan Hosseini, Farin Kamangar, Akram Pourshams, Vikash Sewram, Deirdre Cronin-Fenton, Arash Etemadi, Deborah C. Glass, Afarin Rahimi-Movaghar, Mahdi Sheikh, Reza Malekzadeh, Mary K. Schubauer-Berigan
Summary: The International Agency for Research on Cancer (IARC) recently evaluated the carcinogenicity of opium consumption. This study conducted an extended systematic review and meta-analysis to assess the relationship between opium consumption and selected cancers. The findings provide robust evidence of an adverse association between opium consumption and cancers of the urinary bladder, larynx, lung, esophagus, pancreas, and stomach.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Lucas Lacerda de Souza, Felipe Paiva Fonseca, Anna Luiza Damaceno Araujo, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Syed Ali Khurram, Luiz Paulo Kowalski, Harim Tavares dos Santos, Saman Warnakulasuriya, James Dolezal, Alexander. T. T. Pearson, Alan Roger Santos-Silva
Summary: Oral potentially malignant disorders are precursor lesions with the potential to transform into oral cancer. Risk factors contribute to the development of these disorders and the risk of malignant transformation. Early diagnosis is crucial for improving prognosis, and the integration of machine learning into clinical examination has shown promise in the detection of early cancer.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Letter
Oncology
Saman Warnakulasuriya
Article
Pediatrics
Yelda Kasimoglu, Simin Kocaaydin, Sule Batu, Gokhan Ince, Elif Bahar Tuna-Ince
Summary: The aim of this study was to assess the effects of a human-like robot on behavior guidance during children's dental treatment. The results showed that the robot was effective in reducing dental anxiety and pulse rates in children aged 6-10 years. The findings suggest that humanoid robots can play a positive role in pediatric dental care.
JOURNAL OF PEDIATRIC RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Irosha Perera, Hemantha Amarasinghe, Ruwan D. Jayasinghe, Iresha Udayamalee, Nadeena Jayasuriya, Saman Warnakulasuriya, Newell W. Johnson
Summary: Oral cancer is the most common malignancy among Sri Lankan males and a top 10 cancer among females. Despite being preventable and controllable, contextual factors and social determinants consistently hinder progress in addressing oral cancer inequalities. This review aims to critically analyze oral cancer epidemiology and inequalities in Sri Lanka, using multiple data sources.
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Saman Warnakulasuriya
Review
Dentistry, Oral Surgery & Medicine
Lady P. A. Arboleda, Thais C. E. Pereira, Joel B. Epstein, Cesar A. Migliorati, Saman Warnakulasuriya, Marcio Diniz-Freitas, Marcio A. Lopes, Alan R. Santos-Silva
Summary: This scoping review examines the communication of oral potentially malignant disorders (OPMDs) and their impacts on patients. Five publications were analyzed and differences in study design, population, OPMDs assessed, and outcomes of professional-patient communication were found. There is a need to standardize strategies for OPMD communication as it could lead to better clinical outcomes. Although further research is needed, a brief list of recommended communication aspects is proposed.
Review
Medicine, General & Internal
Kalpani Senevirathna, Roshan Pradeep, Yovanthi Anurangi Jayasinghe, Shalindu Malshan Jayawickrama, Rasika Illeperuma, Saman Warnakulasuriya, Ruwan Duminda Jayasinghe
Summary: Oral cancers are common in Southeast Asia due to the habit of betel quid and smokeless tobacco use. Areca nut, the main ingredient in betel quid, contains alkaloids that have been associated with addiction and carcinogenicity. Recent studies have shown cellular and molecular effects induced by areca nut, including promoting epithelial-mesenchymal transition, autophagy initiation, tissue hypoxia, genotoxicity, cytotoxicity, and cell death. Clinical research also supports these harmful effects. The carcinogenicity of areca nut based on experimental studies is discussed in this review.
CLINICS AND PRACTICE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Elis Angela Batistella, Rogerio Gondak, Elena Riet Correa Rivero, Saman Warnakulasuriya, Eliete Guerra, Andre Luis Porporatti, Graziela De Luca Canto
Summary: This study compared the proportion of tobacco and alcohol consumption among young and older oral squamous cell carcinoma patients. The results showed that smoking and alcohol consumption were more prevalent among older patients compared to younger patients.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Eduardo David Piemonte, Jeronimo Pablo Lazos, Gerardo Marcelo Gilligan, Rene Luis Panico, Laura Cecilia Werner, Yi-Hsin Yang, Saman Warnakulasuriya
Summary: This study found an association between chronic mechanical irritation (CMI) and oral squamous cell carcinoma (OSCC) and analyzed the influence of CMI on other important risk factors for OSCC. CMI was identified as an independent risk factor for OSCC and had an enhancing effect among tobacco and alcohol users.
CLINICAL ORAL INVESTIGATIONS
(2022)
