Journal
JOURNAL OF ORAL PATHOLOGY & MEDICINE
Volume 38, Issue 6, Pages 535-539Publisher
WILEY
DOI: 10.1111/j.1600-0714.2009.00762.x
Keywords
carcinoma; maspin; oral squamous cell; serine protease inhibitor; tumor suppressor
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Funding
- Ministry of Education, Science, Sports and Culture of Japan [19890085]
- Grants-in-Aid for Scientific Research [19890085] Funding Source: KAKEN
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Objective: Maspin, a 42-kDa protein, belongs to the serpin family of protease inhibitors and is known to have tumor-suppressor function. In this study, we investigated the interrelationship between clinicopathologic findings and maspin expression in oral squamous cell carcinoma (OSCC). Methods: Using immunohistochemical techniques to examine the expression levels of maspin in OSCC, maspin expression in OSCC was detected in 46 (64.8%) of 71 cases. We also compared the clonicopathologic features of OSCC cases with maspin expression levels. Moreover, we examined expression of maspin in eight cell lines derived from OSCC using reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blotting. Results: There was a significant correlation between decreased maspin expression and T-category (P < 0.01), lymph metastasis (P < 0.0001), and mode of invasion (P < 0.0001). Patients with positive maspin expression had a significantly better prognosis (P < 0.001). Lower expression of maspin was also seen in cell lines derived from grade 4D, which shows stronger invasive potential than other grades of OSCC. Conclusion: Maspin may be a useful marker to identify the potential for progression in OSCC.
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