Article
Otorhinolaryngology
Alexander Denissoff, Teemu Huusko, Sami Ventela, Solja Niemela, Johannes Routila
Summary: This study found that a history of severe harmful alcohol use and current alcohol consumption of at least 10 units per week were associated with overall survival in patients with head and neck squamous cell carcinoma. Furthermore, even moderate alcohol consumption of 10-20 units per week increased the risk of mortality. This highlights the importance of risk assessment and intervention for alcohol consumption.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Oncology
Connor L. Pratson, Michael C. Larkins, Brandon H. Karimian, Caitrin M. Curtis, Pamela A. Lepera, Brian N. Brodish, Andrew W. Ju
Summary: There is a lack of information on the demographic factors associated with the development of neck fibrosis in head and neck cancer patients following radiotherapy. Factors such as smoking, alcohol use, recurrent disease, age under 60, and non-Caucasian race are associated with an increased risk of fibrosis. Identification and intervention targeting these risk factors in patients prior to treatment could improve long-term quality of life for HNC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Aviane Auguste, Clarisse Joachim, Jacqueline Deloumeaux, Stanie Gaete, Leah Michineau, Cecile Herrmann-Storck, Suzy Duflo, Daniele Luce
Summary: The study found that in the French West Indies, smoking, drinking, high-risk HPV, family history, low BMI, and certain occupations are significantly associated with HNSCC incidence. The majority of HNSCC cases were attributed to smoking and alcohol, with an overall PAF of 89.0%. The impact was greater in men, especially in terms of smoking and drinking.
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Oncology
Sanjana Balachandra, Rebecca L. Eary, Rebecca Lee, Erin M. Wynings, David J. Sher, Teena Sura, Yulun Liu, Brittny N. Tillman, Baran D. Sumer, Elizabeth Mayfield Arnold, Jasmin A. Tiro, Simon C. Lee, Andrew T. Day
Summary: The study found that head and neck cancer survivors have higher rates of smoking, heavy drinking, and high mental health burden compared to survivors of other cancers. There is a bidirectional relationship between high mental health burden and smoking/heavy drinking, and nonpartnered marital status and insurance status are associated with these adverse factors.
Review
Oncology
Antra, Palak Parashar, Hungharla Hungyo, Anuja Jain, Shandar Ahmad, Vibha Tandon
Summary: Head and neck squamous cell carcinomas (HNSCC) pose major challenges in treatment due to their heterogeneity, late-stage diagnosis, and high recurrence rate. Current biomarkers for diagnosis and prognosis of HNSCC mainly rely on smoking as the major risk factor. This review focuses on the differential environment and gene mutations of HNSCC in Indian patients who consume smokeless tobacco. It reveals frequent mutations in genes involved in DNA repair, cell proliferation, cell death, metastasis, lymphocyte proliferation, cell-cell adhesion, miRNA processing, and inflammatory responses in Indian HNSCC patients.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Oncology
Chung-Man Moon, Yun Young Lee, Doo-Young Kim, Woong Yoon, Byung Hyun Baek, Jae-Hyun Park, Suk-Hee Heo, Sang-Soo Shin, Seul Kee Kim
Summary: This study aimed to predict the expression of Ki-67 proliferative index and p53 tumor suppressor protein in meningioma patients using preoperative multiparametric magnetic resonance imaging (mpMRI)-based clinical-radiomic analysis combined with machine learning (ML) algorithms. The results showed that larger tumor volumes, irregular tumor margin, and unclear tumor-brain interface were independently associated with high Ki-67 expression, while the presence of necrosis and the dural tail sign were independently associated with positive p53 expression. A model combining clinical and radiological features yielded better performance, providing a novel non-invasive strategy for assessing cell proliferation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Kristen McCarter, Amanda L. Baker, Luke Wolfenden, Chris Wratten, Judith Bauer, Alison K. Beck, Erin Forbes, Gregory Carter, Lucy Leigh, Christopher Oldmeadow, Ben Britton
Summary: This study investigates patterns of smoking and other health factors in head and neck cancer patients throughout treatment, follow-up, and survivorship. Results show increased rates of smoking and hazardous alcohol use post radiotherapy, as well as common occurrence of fatigue and unhealthy behaviors in long-term follow-up. These findings suggest the need for intervention beyond treatment to improve long-term health outcomes in patients.
CANCER EPIDEMIOLOGY
(2022)
Review
Psychology, Multidisciplinary
Anem Iftikhar, Mohammad Islam, Simon Shepherd, Sarah Jones, Ian Ellis
Summary: Lifestyle factors, including alcohol consumption and smoking, play a significant role in the development of head and neck cancers. Promoting healthy lifestyle choices is crucial for improving health and preventing diseases. Stress is known to contribute to the adoption of unhealthy habits such as alcohol and smoking. Understanding the impact of stress on lifestyle choices and exploring the underlying mechanisms can facilitate the development of prevention measures.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
Lara Nokovitch, Yonjae Kim, Philippe Zrounba, Pierre-Eric Roux, Marc Poupart, Rabiha Giagnorio, Dominique Triviaux, Charles Maquet, Jennifer Thollin, Nathalie Arantes, Nathalie Thomas, Beatrice Fervers, Sophie Deneuve
Summary: The aim of this study was to evaluate the evolution of tobacco/alcohol consumption and dependence, as well as social deprivation, in survivors of head and neck squamous cell carcinoma (HNSCC) when addressed from the time of diagnosis. The results showed that addictions and social deprivation tend to improve when taken care of from the diagnosis. The most dependent patients and those with multiple frailties are at highest risk of cessation failure.
Article
Oncology
M. Bryant Howren, Alan J. Christensen, Nitin A. Pagedar
Summary: This study aimed to explore the co-occurrence of alcohol and tobacco use problems in patients with head and neck cancer (HNC) and their associations with health-related quality of life (HRQOL). The results showed that 13.0% of HNC patients exhibited both problem alcohol and tobacco use at diagnosis. These patients had lower HRQOL scores in multiple HNC-specific domains during the first year postdiagnosis.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Biochemistry & Molecular Biology
Andrea Sacconi, Paola Muti, Claudio Pulito, Giulia Urbani, Matteo Allegretti, Raul Pellini, Nikolay Mehterov, Uri Ben-David, Sabrina Strano, Paolo Bossi, Giovanni Blandino
Summary: This study identified immune gene signature sets associated with TP53 status and co-mutations that classify HNSCC patients more accurately. These biomarkers can be easily implemented in a clinical setting.
Article
Oncology
Cheng Song, Yahan Chen, Youlin Qiao
Summary: A study found that the preventable burden of head and neck cancer caused by tobacco and alcohol is increasing in China, particularly for oral cancer. This highlights the need to reconsider restrictions on tobacco and alcohol and develop effective prevention and control strategies for head and neck cancer.
Review
Oncology
N. Ari Wijetunga, Yao Yu, Luc G. Morris, Nancy Lee, Nadeem Riaz
Summary: Recent advances in sequencing technologies have helped unravel the complex interactions between HPV virus, tumor, host factors, and tumor microenvironment (TME) in head and neck squamous cell carcinoma (HNSCC), shedding light on the interaction of the immune system with these malignancies.
Editorial Material
Oncology
Vitor Bonetti Valente, Bruna Mantovan Mazzon, Francisco Urbano Collado, Sebastiao Conrado Neto, Maria Lucia Marcal Mazza Sundefeld, Eder Ricardo Biasoli, Glauco Issamu Miyahara, Daniel Galera Bernabe
Summary: Tobacco and alcohol consumption are major risk factors for head and neck cancer (HNC). However, there is a subset of HNC patients who do not smoke or drink (NSND) and their clinical and prognostic features differ from those who do. This study examined the differences between NSND and smoking and/or drinking (SD) HNC patients and found that NSND patients were more likely to be women and elderly, had higher rates of oral cavity tumors, advanced clinical staging, and absence of second primary tumors. NSND patients had higher tumor recurrence rates but also higher overall and specific survival rates at 5-year follow-up. NSND patients also had a distinct tumor profile compared to SD patients. These findings suggest that the clinicopathological features of NSND patients should be considered in the management of HNC.