Article
Materials Science, Multidisciplinary
N. Aslan, B. Aksakal, B. Dikici, Z. A. Sinirlioglu
Summary: The effect of HA-based coatings reinforced with rGO on porous-Ti6Al4V alloys in terms of electrochemical corrosion and cell viability was investigated. The results showed that rGO reinforcements reduced the corrosion rate of the scaffolds, and the corrosion rate increased as the porosity content of the scaffolds increased. 0.5 and 1.0wt% rGO-HA coating groups had better cell viability.
JOURNAL OF MATERIALS SCIENCE
(2022)
Review
Engineering, Biomedical
Siyi Wang, Xiao Zhao, Yuchien Hsu, Yunjiao He, Feilong Wang, Fan Yang, Fanyu Yan, Dandan Xia, Yunsong Liu
Summary: Titanium and titanium alloys are commonly used in dental implants, but their inert surface leads to delayed osseointegration. Magnesium ions, known for promoting bone regeneration, have been extensively studied for surface modification of titanium implants. This systematic review summarizes the methods, effects, and clinical applications of magnesium-containing coatings for titanium implant surface modification.
ACTA BIOMATERIALIA
(2023)
Article
Pharmacology & Pharmacy
Isha Mutreja, Caixia Lan, Qishun Li, Conrado Aparicio
Summary: Developing antimicrobial surfaces, including antimicrobial peptide coatings, is a promising approach to overcome dental implant-associated infection. This study presents a fast and efficient chemoselective conjugation technique to coat titanium implant surfaces with antimicrobial peptides. The evaluated surfaces showed antibacterial potency against primary colonizers and pathogens of dental surfaces, as well as demonstrated long-term viability of human dental pulp stem cells.
Article
Biochemistry & Molecular Biology
Sanako Makishi, Taisuke Watanabe, Kotaro Saito, Hayato Ohshima
Summary: This study aimed to analyze the effects of HA/beta-TCP on osseointegration at the bone-implant interface after immediately placed implants in the maxillae of 4-week-old mice. The lack of HA/beta-TCP on the implant surface affects the OPN immunoreactivity at the bone-implant interface and the rate of direct osteogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Tomasz Moskalewicz, Maciej Warcaba, Lukasz Cieniek, Maciej Sitarz, Marta Gajewska, Aldo R. Boccaccini
Summary: The study focused on developing composite HA/SA coatings using EPD technique and characterizing their properties. The coatings exhibited different surface morphology and microstructure depending on the HA content in suspension. Surface preparation and HA content significantly influenced the adhesion of the coatings.
APPLIED SURFACE SCIENCE
(2021)
Review
Chemistry, Physical
Marija Djosic, Ana Jankovic, Vesna Miskovic-Stankovic
Summary: Current trends in biomaterials science focus on designing multifunctional implant coatings that can inhibit bacterial growth while promoting osseointegration to ensure prolonged implant functionality.
Article
Materials Science, Coatings & Films
I Mendolia, C. Zanca, F. Ganci, G. Conoscenti, F. Carfi Pavia, V Brucato, V La Carrubba, F. Lopresti, S. Piazza, C. Sunseri, R. Inguanta
Summary: In this study, coatings of brushite/hydroxyapatite/polyvinyl acetate were deposited on 304 stainless steel using the galvanic deposition method. The coatings showed low metal ion release and high cytocompatibility, making them effective in reducing corrosion and safe for contact with osteoblastic cells.
SURFACE & COATINGS TECHNOLOGY
(2021)
Review
Chemistry, Physical
Luca Fiorillo, Marco Cicciu, Tolga Fikret Tozum, Matteo Saccucci, Cristiano Orlando, Giovanni Luca Romano, Cesare D'Amico, Gabriele Cervino
Summary: In recent years, implantology has made significant progress, with the development of new alloys, surfaces, and geometries. This review analyzed the clinical differences between zirconia and titanium implants and found no statistically significant differences in fixed or overdenture restorations. However, there were concerns about the rigidity and potential fracture of zirconia.
Review
Materials Science, Multidisciplinary
Ziming Liao, Jingxuan Li, Yimeng Su, Fenyan Miao, Xiumei Zhang, Yu Gu, Jingjing Du, Ruiqiang Hang, Yan Wei, Weiyi Chen, Di Huang
Summary: Titanium and its alloys are commonly used in dental implants due to their excellent mechanical properties and biocompatibility. However, they have limited ability to bind to bone and poor antibacterial ability, leading to potential implant failure. The development of antibacterial hydroxyapatite coatings on titanium and its alloys can effectively address these issues. This review analyzes the research status and trends of such coatings and may provide valuable reference for the future preparation and application of high-performance and multi-functional dental implant coatings.
FRONTIERS OF MATERIALS SCIENCE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Andres Stricker, Thomas Bergfeldt, Tobias Fretwurst, Owen Addison, Rainer Schmelzeisen, Rene Rothweiler, Katja Nelson, Christian Gross
Summary: The study found exogenous metal contaminants and other impurities in commercial titanium dental implants, which may provoke immunological reactions despite conforming to standard compositions. Further investigation into the clinical relevance of these findings and discussion on the adjustment of industry standards are warranted.
Review
Materials Science, Multidisciplinary
Jaison Jeevanandam, Michael K. Danquah, Sharadwata Pan
Summary: Dental implants, typically made of titanium and its alloys, are commonly used to replace damaged or irregular teeth. Recently, nanobiomaterials with plant origins have shown enhanced biocompatibility and antimicrobial efficacy, making them potential non-toxic candidates for dental implants.
FRONTIERS IN MATERIALS
(2021)
Review
Biotechnology & Applied Microbiology
Xiaoxuan Lu, Zichen Wu, Kehui Xu, Xiaowei Wang, Shuang Wang, Hua Qiu, Xiangyang Li, Jialong Chen
Summary: Titanium and its alloys are widely used in orthopedic and dental implants due to their stable chemical properties and good biocompatibility. However, issues such as aseptic loosening and peri-implant infection still exist. Recent advancements in surface modification have provided strategies to enhance the bio-function and anti-infection properties of titanium implants, aiming to improve the interaction between these devices and the local biological environment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Puneet Bansal, Gurpreet Singh, Hazoor Singh Sidhu
Summary: Plasma-sprayed zinc oxide reinforced hydroxyapatite coatings were developed on a titanium alloy substrate at different weight percentages of ZnO powder to enhance mechanical properties and corrosion resistance. Increasing ZnO reinforcement led to higher surface hardness and lower surface roughness. All coated samples exhibited hydrophilic behavior, with the HA+12% ZnO coating showing the highest corrosion resistance among them.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Multidisciplinary Sciences
Yomna H. Shash, Mohamed T. El-Wakad, Mohamed A. A. El-Dosoky, Mohamed M. Dohiem
Summary: Fixed prostheses are common treatment options for edentulous patients, but researchers are exploring alternative materials due to limitations of titanium. This study used finite element analysis to evaluate the stress distribution in fixed prostheses with polymeric frameworks and different bone densities. The choice of framework material depended on spongy bone density. Soft frameworks were recommended for low-density cases to reduce stresses on bone tissues.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Yang Sun, Xing Zhang, Mingran Luo, Weifan Hu, Li Zheng, Ruqi Huang, Johannes Greven, Frank Hildebrand, Feng Yuan
Summary: This study successfully fabricated HA coatings on 3D-printed Ti scaffolds, with PSHA scaffolds showing superior bone repair capacity compared to EDHA scaffolds. While the EDHA technology is simpler, improvements are needed due to limitations in crystalline and HA structures.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Joo-Hyung Yoon, Dae-Won Kim, Suk Keun Lee, Seong-Gon Kim
Summary: This study revealed that systemic administration of 4HR increased the weight of the submandibular glands in male rats. Furthermore, the expression levels of testosterone and VEGF in the submandibular glands were increased due to 4HR administration.
HEAD & FACE MEDICINE
(2022)
Editorial Material
Chemistry, Multidisciplinary
Seong-Gon Kim
APPLIED SCIENCES-BASEL
(2023)
Review
Medicine, Research & Experimental
Yei-Jin Kang, Sang-Shin Lee, Seong-Gon Kim
Summary: A 75-year-old male patient presented with a 35-mm fluctuant lesion on the floor of the mouth. The lesion was a dome-shaped non-infiltrating angiolipoma, and it was successfully excised using an intraoral approach. This is the first reported case of this type of tumor being treated in this way in an elderly patient.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Seong-Gon Kim, Young-Wook Park, Ji-Hyeon Oh
Summary: This retrospective study analyzed the changes in condylar position following mandibular setback surgery with manual guidance. The results showed significant anterior-lateral-inferior movement of the condyle within 1 week after surgery, but the condyle returned to its original position over time.
APPLIED SCIENCES-BASEL
(2023)
Review
Chemistry, Multidisciplinary
Jwa-Young Kim, Yong-Chan Lee, Seong-Gon Kim, Umberto Garagiola
Summary: This comprehensive review explores the integration of 3D printing and Virtual Surgical Planning (VSP) in orthognathic and oral maxillofacial surgery, which enables personalized surgical methods, precise planning through tactile 3D models, and accurately designed surgical guides for improved patient-centric care and predictable outcomes.
APPLIED SCIENCES-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Jwa-Young Kim, Seong-Gon Kim, Umberto Garagiola
Summary: The potential of sericin, a protein derived from silkworms, is explored for bone graft applications due to its biocompatibility, hydrophilic nature, and cost-effectiveness. It has antioxidant, anti-inflammatory, and UV-resistant properties that contribute to a healthier bone-healing environment, and its incorporation into 3D-printed grafts could lead to personalized medical solutions. However, gaps still exist in our understanding of sericin's mechanism of action, its long-term biocompatibility in humans, and the best methods for incorporating it into graft materials.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Min Keun Kim, Min Ji Ham, Won Rae Kim, Hyung Giun Kim, Kwang Jun Kwon, Seong Gon Kim, Young Wook Park
Summary: This study aimed to evaluate the accuracy of three-dimensional surgical guides and titanium implants in a rabbit model, as well as the surgical outcomes of mandibulectomy and reconstructive surgery. The accuracy of the implants was within the acceptable error range, while the surgical accuracy varied in different measured areas. The angle between the mandibular lower borders showed the most sensitive results, and the distance between the lingual cusps of the first molars represented the most accurate outcomes. The angle between the mandibular lower borders was found to be a good indicator for evaluating reconstructive surgery outcomes.
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ji Hae Lee, HaeYong Kweon, Ji-Hyeon Oh, Seong-Gon Kim
Summary: This study evaluated the optimal scaffold material for silk sericin-based bone grafts using a critical-sized bone defect model in rat calvaria. The results showed that collagen exhibited better bone regeneration capability in silk sericin-based bone grafts compared to gelatin.
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Ji Hae Lee, HaeYong Kweon, Ji-Hyeon Oh, Yei-Jin Kang, Dae-Won Kim, Won-Geun Yang, Weon-Sik Chae, Seong-Gon Kim
Summary: The study demonstrates that pretreatment with 4-hexylresorcinol (4HR) increases the β-sheet structure of silk sericin, induces BMP-2 expression, and enhances bone regeneration ability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
Yong-Chan Lee, Seong-Gon Kim
Summary: Orthognathic surgery has traditionally relied on traditional surgical planning, but the advent of virtual surgical planning (VSP) and 3D printing technologies has revolutionized the field, bringing unprecedented precision and customization. VSP allows for real-time adjustments and reduces planning time, while 3D printing enhances the predictability of surgical outcomes. The integration of VSP and 3D printing offers innovative solutions that surpass the limitations of traditional methods.
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Dhouha Gaida, Young-Wook Park, Seong-Gon Kim
Summary: This study investigated the efficacy of 4-hexylresorcinol (4-HR) in mitigating taste bud apoptosis, specifically in relation to diabetes-induced taste issues. The findings highlight the significant deterioration of taste buds in diabetic rats and suggest the potential therapeutic benefits of 4-HR in improving taste perception.
APPLIED SCIENCES-BASEL
(2023)
Meeting Abstract
Cell & Tissue Engineering
Seong-Gon Kim, Ji-Hyeon Oh, Yei-Jin Kang, HaeYong Kweon
TISSUE ENGINEERING PART A
(2022)
Meeting Abstract
Cell & Tissue Engineering
Seong-Gon Kim, Yei-Jin Kang, HaeYong Kweon, Ji-Hyeon Oh
TISSUE ENGINEERING PART A
(2022)
Review
Dentistry, Oral Surgery & Medicine
Seong-Gon Kim
Summary: The regeneration of bone is a challenging topic for maxillofacial plastic and reconstructive surgeons. Successful bone regeneration requires timely provision of essential components, including cellular components, extracellular matrix, and inorganic components. Selection of appropriate methods for personalized bone regeneration is crucial.
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Seong-Gon Kim
Summary: 4-Hexylresorcinol is an amphiphilic organic compound that regulates microorganisms by inducing stress on the endoplasmic reticulum and altering protein folding. It inhibits the NE-kappa B signal pathway and TNF-alpha production, while increasing the production of angiogenesis and bone formation related proteins. It also demonstrates strong anti-inflammatory reaction and capillary regeneration in diabetic models, making it applicable for various types of surgical wounds.
MAXILLOFACIAL PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)