Article
Ophthalmology
Swati Singh, Sayan Basu
Summary: This study examined the ultrastructural features of the lacrimal glands in patients with severe dry eye due to SJS using transmission electron microscopy. The results showed that SJS patients exhibited alterations in nuclear chromatin, as well as loss of endoplasmic reticulum and mitochondria in the cytoplasm. These structural changes may be associated with severe dry eye in SJS patients.
Article
Ophthalmology
Ritika Mullick, Sriram Annavajjhala, Prashansa Thakur, Ayushi Mohapatra, Rohit Shetty, Sharon D'Souza
Summary: The study demonstrated that the use of 0.05% cyclosporine and osmoprotective lubricating eye drops is effective in treating patients with dry eye disease, reducing ocular surface inflammation and improving symptoms of the disease.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Madhuri Amulya Koduri, Deeksha Prasad, Tejaswini Pingali, Vijay Kumar Singh, Swapna S. Shanbhag, Sayan Basu, Vivek Singh
Summary: This study compares different methods of extracting tear proteins from the Schirmer's strip and finds that the highest protein yield is obtained by incubating the strip in 100 mM ammonium bicarbonate (ABC) with 0.25% Nonidet P-40 (NP-40) at 4 degrees Celsius for an hour. Mass spectrometry analysis reveals unique protein signatures in tear samples from Stevens-Johnson syndrome (SJS) and dry eye disease (DED) patients. This study will contribute to the better design of tear protein-based experimental studies.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yi-Zhou Chen, Zhi-Yu Chen, Yu-Jun Tang, Cheng-Han Tsai, Yu-Lun Chuang, Erh-Hsuan Hsieh, Lachlan Tucker, I-Chan Lin, Ching-Li Tseng
Summary: The study demonstrates that adding Lutein to artificial tears as eye drops could effectively prolong drug ocular retention time and reduce inflammation in DES mice.
Article
Dermatology
Tejas K. Patel, Parvati B. Patel, Sejal Thakkar
Summary: The study conducted a network meta-analysis to compare the effectiveness of interventions in reducing mortality in patients with toxic epidermal necrolysis (TEN). The results showed that cyclosporine was the most effective treatment, followed by steroid+intravenous immunoglobulin and etanercept. The analysis also indicated no inconsistencies between direct and indirect estimates for any of the treatment pairs.
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
(2021)
Review
Dermatology
Lindsey J. Gaghan, Margaret M. Coates, Lauren N. Crouse, Jayson Miedema, Julie E. Mervak, Carolyn M. Ziemer
Summary: This article reports a case of photodistributed SJS/TEN and highlights the similarities with other cases reported in the literature. A literature review revealed 8 previously reported cases of photodistributed SJS or TEN in healthy individuals. Most of these cases were young women who had exposure to UV radiation 24 to 72 hours prior to the onset of symptoms.
Letter
Dermatology
Melanie M. Miller, Sonia Kamath, Meagan Hughes, Nicole Harter, Minnelly Luu
Summary: This cohort study examines the relationship between etanercept treatment and outcomes of reactive infectious mucocutaneous eruption in hospitalized children and adolescents.
Article
Oncology
Christine Jane Kurian, Akshay Desai, William Rafferty, Ahmed Kamel Abou Hussein
Summary: This article describes the first documented case of Stevens-Johnson Syndrome (SJS) associated with alpelisib treatment. The patient experienced severe whole-body rash and buccal mucosa ulceration, but achieved remarkable improvement with the use of steroids. The authors emphasize the need for long-term monitoring of patients experiencing SJS side effects.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Wenyan Peng, Xiuying Jiang, Lei Zhu, Xiaofeng Li, Qizhi Zhou, Ying Jie, Zhipeng You, Miaoqin Wu, Xiuming Jin, Xiaoyi Li, Shiyou Zhou
Summary: The study confirmed the efficacy and safety of CyclAGel 0.05% taken once nightly in treating moderate-to-severe dry eye disease, with significant improvements in ICSS score observed in patients within 84 days. The treatment group also showed noticeable improvements in tear production and symptoms compared to the control group.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Ophthalmology
Leangelo N. Hall, Swapna S. Shanbhag, Ramy Rashad, James Chodosh, Hajirah N. Saeed
Summary: The study evaluated the effect of systemic cyclosporine on ocular disease in SJS/TEN patients and found no significant association between the use of systemic cyclosporine and chronic ocular complications in this small cohort.
Article
Dermatology
Nicolas Glasson, Cecile De Sandre, Olivier Pantet, Antoine Reinhard, Karma Lambercy, Kishore Sandu, Francois Gorostidi
Summary: This study evaluated ENT mucosal lesions in severe toxic epidermal necrolysis patients and proposed a management algorithm to prevent long-term debilitating sequalae of these lesions.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Ophthalmology
Mingjun Gao, Lin Zhao, Ran Liang, Qing Zhu, Qi Zhao, Xiaodan Kong
Summary: This study evaluated the efficacy and safety of 0.05% cyclosporine eye drops for the treatment of primary Sjogren's syndrome-associated dry eye. The results showed that 0.05% cyclosporine effectively reduced symptoms and improved signs without serious adverse events.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Oncology
Andrej Cokan, Vida Gavric Lovrec, Iztok Takac
Summary: A case of a late-stage ovarian cancer patient developing Stevens-Johnson syndrome was reported, with emphasis on the importance of maintaining a high level of alertness for diagnosing and treating this disease due to its high mortality rate.
Article
Ophthalmology
Mehmet Ozgur Cubuk, Ahmet Yucel Ucgul, Armagan Ozgur, Kemal Ozulken, Erdem Yuksel
Summary: The study concluded that topical cyclosporine A (CsA) was more effective in treating dry eye in patients with non-Sjogren's syndrome (NSS).
INTERNATIONAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Jonghwa Kim, Tae Kyu Moon, Hyeon Jeong Yoon, Yong Sok Ji, Kyung Chul Yoon
Summary: The study showed that switching from CsA AE to CsA CE was effective in improving ocular symptoms and conjunctival staining in patients with dry eye associated with Sjogren's syndrome. Additionally, corneal staining was decreased in patients with severe keratitis.
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
(2021)