☆ 4.2 Article

Influence of Race and Age on Aqueous Humor Levels of Transforming Growth Factor-Beta 2 in Glaucomatous and Nonglaucomatous Eyes

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS (2011)

Journal

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Volume 27, Issue 5, Pages 477-480

Publisher

MARY ANN LIEBERT INC

DOI: 10.1089/jop.2010.0100

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Funding

National Institute of Aging
Research to Prevent Blindness, Inc., New York, NY

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Abstract

Purpose: To evaluate the influence of race and age on aqueous humor levels of transforming growth factor-beta 2 (TGF-beta 2). Methods: Patients >40 years of age and undergoing cataract or glaucoma surgery without associated significant intraocular pathology were selected for this study. In bilateral cases, only the first operated eye was included for evaluation. At the time of surgery, a small amount of aqueous was withdrawn. The concentration of total TGF-beta 2 was measured by enzyme-linked immunosorbent assay in duplicate by a masked observer. Results: Fifty-five aqueous humor samples were analyzed from subjects with an average age of 68.05 +/- 10.94 years. Overall median TGF-beta 2 concentration was 247.03 pg/mL. The median concentration of TGF-beta 2 was higher in eyes with glaucoma than in eyes without glaucoma (269.39 vs. 165.56 pg/mL, respectively; P = 0.001). Subgroup analysis found no significant difference between African American and Caucasian American subjects in the nonglaucomatous or glaucomatous subgroups. Age showed positive correlation with TGF-beta 2 in nonglaucomatous eyes (r(2) = 0.44, P = 0.019). No correlation between age and TGF-beta 2 was noted in the glaucoma group (r(2) = 0.02, P = 0.343). Conclusion: The aqueous humor concentration of TGF-beta 2 was significantly higher in eyes with glaucoma than in eyes without glaucoma. No significant difference between the aqueous humor levels of TGF-beta 2 from African American and Caucasian American subjects could be measured. However, a significant and positive correlation between age and aqueous humor concentration of TGF-beta 2 in the eyes of nonglaucomatous subjects was measured. These results are consistent with the idea that elevated levels of TGF-beta 2 within the anterior segment contribute to the development of glaucoma. In addition, the increased risk for developing glaucoma as one ages may in part be related to the rise of this cytokine.

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Elevated tissue transglutaminase levels in aqueous humor of congenital cataractous eyes with long axial length

Tianke Yang, Xiyue Zhou, Hongzhe Li, Fan Fan, Jianing Yang, Xiaolei Lin, Xin Liu, Yi Luo

Summary: This study investigated the distribution of axial length (AL) and posterior staphyloma (PS) in congenital cataract (CC) patients. It also evaluated the correlation between AL and the concentration of tissue transglutaminase (TGM2) in the aqueous humor (AH) of cataractous eyes. The results showed that the presence of PS in congenital cataractous eyes was 11.02% and the presence of PS + LAL was 29.06%. The concentration of TGM2 in the AH was positively correlated with AL in the patients' eyes.

HELIYON (2023)