Review
Ophthalmology
Ziyan Cai, Mengdan Cao, Ke Liu, Xuanchu Duan
Summary: In OAG/OHT patients, there was no significant difference in responsiveness to the four PGAs; bimatoprost had a better IOP-reducing efficacy than latanoprost in this population; in LNRs, bimatoprost showed better IOP reduction compared to latanoprost and travoprost; no serious adverse events were observed during treatment with any of the medications studied.
JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Ahmed Essam Faseeh, Riham S. H. M. Allam, Ahmed B. Shalash, Mai Nasser Abd Elmohsen
Summary: This study compared the efficacy of latanoprost, travoprost, and tafluprost in reducing diurnal intraocular pressure fluctuations in patients with POAG. Results showed similar and significant reductions in IOP and IOP fluctuations for all three drugs, with comparable tolerability in terms of side effects.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Joon-Mo Kim, Kyung-Rim Sung, Hwang-Ki Kim, Sang-Woo Park, Eun-Ji Lee, Jin-Wook Jeoung, Hae-Young Lopilly Park, Jaehong Ahn, Chungkwon Yoo, Chan-Yun Kim
Summary: This multicenter retrospective cohort study compared the effectiveness and safety of long-term tafluprost, travoprost, or latanoprost in patients with primary open-angle glaucoma (POAG) or normal-tension glaucoma (NTG). The study found that all three prostaglandin analogs showed similar effects in patients with POAG or NTG, with good long-term safety profiles.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Casey J. Keuthan, Julie A. Schaub, Meihan Wei, Weixiang Fang, Sarah Quillen, Elizabeth Kimball, Thomas V. Johnson, Hongkai Ji, Donald J. Zack, Harry A. Quigley
Summary: The level of intraocular pressure (IOP) is a major risk factor for glaucomatous optic neuropathy. This study found that the unmyelinated optic nerve region is differentially susceptible to IOP-induced damage compared to the myelinated region. Gene expression patterns in the unmyelinated optic nerve showed significant differences compared to the myelinated optic nerve and retina. Changes in gene expression induced by optic nerve injury were more extensive in the myelinated region than the unmyelinated region.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Ophthalmology
Anthony Arnold
Summary: The vascular supply of the optic nerve head is complex and remains unclear. Over the past 50 years, conflicting theories have evolved due to different research techniques used to study the contributions of various blood vessels.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Immunology
Wenwen Lai, Jie Huang, Wangyi Fang, Saiyue Deng, Yi Xie, Wei Wang, Tong Qiao, Gezhi Xu, Xiaowei Wang, Fengfei Ding
Summary: This study investigates the role of optic nerve head (ONH) in defense against vitreous inflammation. The researchers found that while the retina showed signs of inflammation, the posterior optic nerve and the optic nerve head showed no signs of inflammation or infiltration of inflammatory cells. The study also found that the astrocytes in the ONH changed their spatial orientation in response to inflammation. The findings suggest that glial responses in the ONH may serve as a barrier to inflammation for the central nervous system.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Ophthalmology
Jing Zhao, Graydon Gonsalvez, Manuela Bartoli, Barbara A. Mysona, Sylvia B. Smith, Kathryn E. Bollinger
Summary: The study evaluated the ability of S1R to modulate reactivity responses of optic nerve head astrocytes (ONHAs) and found that S1R activation enhanced ONHA reactivity characteristics, which may have important implications for the survival of retinal ganglion cells.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Mona Safizadeh, Amirreza Shaabani, Alireza Kamalipour, Masoud Aghsaei Fard, Kaileen Yeh, Mehdi Yaseri, Nikoo Hamzeh, Nassim Khatibi, Harsha Laxmana Rao, Robert Weinreb, Sasan Moghimi
Summary: OCTA can be used to detect reduced capillary density in fellow eyes of PXG patients, enabling earlier detection of glaucomatous loss in pseudoexfoliation disease and enhancing disease management.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Ji-Ah Kim, Eun Ji Lee, Tae-Woo Kim, Hee Kyung Yang, Jeong-Min Hwang
Summary: The microvasculature of the optic nerve head and peripapillary tissues in eyes with normal-tension glaucoma (NTG) and nonarteritic anterior ischemic optic neuropathy (NAION) was compared using optical coherence tomography angiography (OCTA). Despite similar levels of retinal nerve fiber layer loss and vessel density decreases in the peripapillary retina, there were differences in vessel densities in the optic nerve head between NTG and NAION eyes, suggesting distinct mechanisms of vascular impairment and optic nerve head damage in each condition.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Eugene A. Lowry, Steven L. Mansberger, Stuart K. Gardiner, Hongli Yang, Facundo Sanchez, Juan Reynaud, Shaban Demirel, Claude F. Burgoyne, Brad Fortune
Summary: The frequency and severity of optic nerve head prelaminar schisis were found to be greater in glaucoma and glaucoma suspect eyes compared to healthy control eyes, and were associated with markers of glaucoma severity.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Liam K. Fisher, Xiaofei Wang, Tin A. Tun, Hsi-Wei Chung, Dan Milea, Michael J. A. Girard
Summary: The study assessed gaze evoked deformations of the optic nerve head in thyroid eye disease (TED) using computational modeling and optical coherence tomography (OCT). The results showed that TED can cause increased gaze-evoked deformations of the ONH.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Cell Biology
Andrea E. Dillinger, Gregor R. Weber, Matthias Mayer, Magdalena Schneider, Corinna Goeppner, Andreas Ohlmann, Mikhail Shamonin, Gareth J. Monkman, Rudolf Fuchshofer
Summary: Primary open-angle glaucoma is a neurodegenerative disease that is associated with structural changes in the optic nerve head and extracellular matrix. The molecular factors involved in this remodeling process, particularly TGF-beta 2 and CCN2/CTGF, play important roles in the pathogenesis of the disease. Understanding the function of CCN2/CTGF in normal and pathological conditions could provide insights into the development of new therapeutic approaches for glaucoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Emma K. Geiduschek, Colleen M. Mcdowell
Summary: Glaucoma is a progressive disease that leads to irreversible blindness. Understanding the cellular mechanisms behind optic nerve head damage during disease progression can help identify new drug targets and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Thanadet Chuangsuwanich, Tin A. Tun, Fabian A. Braeu, Xiaofei Wang, Zhi Yun Chin, Satish K. Panda, Martin Buist, Dan Milea, Nicholas Strouthidis, Shamira Perera, Monisha Esther Nongpiur, Tin Aung, Michael J. A. Girard
Summary: This study aimed to assess the strains in optic nerve head (ONH) induced by intraocular pressure (IOP) and gaze in subjects with high-tension glaucoma (HTG) and normal-tension glaucoma (NTG). The results showed that NTG subjects experienced higher strains due to gaze, while HTG subjects experienced higher strain due to IOP elevation, and these differences were most pronounced in the lamina cribrosa (LC) tissue.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Oncology
Ibrahim Ozdemir, Huseyin Murat Bulut, Suecattin Ilker Kocamis
Summary: This study suggests that oral isotretinoin therapy may lead to significant thickening of the retinal nerve fiber layer in patients with small optic disc area.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)