Article
Anatomy & Morphology
Ravichandran Doraisamy, Karthikeyan Ramaswami, Jeevithan Shanmugam, Rashmi Subramanian, Balasubramanian Sivashankaran
Summary: Research evaluated the association between FOK1/Taq1 genes and LDD. Results showed a significantly higher association of the dominant Taq1 genotype with LDD, while no association was found with the Fok1 genotype. These findings suggest genetic predisposition is an important risk factor for LDD.
Article
Clinical Neurology
Hang Shi, Lei Zhu, Zan-Li Jiang, Xiao-Tao Wu
Summary: The study identified low grade of surgical-level disc degeneration, senior grade of adjacent-level disc degeneration, a high DHI, and a large sROM as radiological independent risk factors for rLDH after PTED.
EUROPEAN SPINE JOURNAL
(2021)
Article
Medicine, General & Internal
Meng-Huang Wu, Christopher Wu, Jiann-Her Lin, Li-Ying Chen, Ching-Yu Lee, Tsung-Jen Huang, Yi-Chen Hsieh, Li-Nien Chien
Summary: This retrospective cohort study used the Taiwan National Health Insurance Research Database to investigate reoperation and joint replacement surgeries after short-segment lumbar spinal surgery. The results indicated that non-fusion surgery and spinal fusion without fixation are associated with higher risks for spine reoperation, while spine surgeries do not increase the risk for joint replacement surgeries.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marcus Raudner, Markus M. Schreiner, Tom Hilbert, Tobias Kober, Michael Weber, Anna Szelenyi, Reinhard Windhager, Vladimir Juras, Siegfried Trattnig
Summary: The study evaluated GRAPPATINI, an accelerated T-2 mapping sequence that combines undersampling and model-based reconstruction to facilitate clinical implementation of T-2 mapping of the lumbar intervertebral disc. Results showed that T2 values obtained using GRAPPATINI were significantly different for normal discs compared to bulging or herniated discs, as well as discs with and without annular tears. The study concluded that GRAPPATINI can be used as a quantitative imaging biomarker to detect disc pathologies while significantly reducing acquisition time.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Jian Wu, Yao Yao Liu, Huai Jian Jin, Zhong Wang, Ming Yong Liu, Peng Liu
Summary: The aim of this study was to investigate the long-term fate of intervertebral discs (IVDs) following a traumatic event and identify the risk factors for irrevocable degeneration. The results showed that injured posterior ligamentous complex and endplate injury were independent risk factors for disc degeneration in patients with traumatic thoracic or lumbar fracture.
EUROPEAN SPINE JOURNAL
(2022)
Article
Multidisciplinary Sciences
Rikuto Yoshimizu, Junsuke Nakase, Katsuhito Yoshioka, Kengo Shimozaki, Kazuki Asai, Mitsuhiro Kimura, Katsuhiko Kitaoka, Hiroyuki Tsuchiya
Summary: This study found that lumbar degeneration was common in children and adolescent weightlifters after 5 years, with 33% of participants showing lumbar disc herniation findings. Long-term high frequency weightlifting training during growth periods may increase the risk of developing low back pain.
Article
Orthopedics
Hao Meng, Yuan Gao, Peng Lu, Guang-Min Zhao, Zhi-Cheng Zhang, Tian-Sheng Sun, Fang Li
Summary: This study used direct repair plus intersegment pedicle screw fixation for the treatment of lumbar spondylolysis. Good surgical outcomes and high bony union rates were achieved with this technique. The duration of fixation was identified as a risk factor for facet joint degeneration.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Immunology
Linbang Wang, Tao He, Jingkun Liu, Jiaojiao Tai, Bing Wang, Lanyue Zhang, Zhengxue Quan
Summary: This study identified key genes involved in immune infiltration in the nucleus pulposus tissue in lumbar disc herniation (LDH) through bioinformatic analysis, revealing significant differences in immune infiltration profiles between the LDH and control groups. The study discussed the crucial roles of regulatory T cells and macrophages in the pathogenesis of LDH, and highlighted the TGF-beta and MAPK signaling pathways as potential diagnostic markers for LDH.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yuki Taniguchi, Toru Akune, Nao Nishida, Go Omori, H. A. Kim, Kazuko Ueno, Taku Saito, Takeshi Oichi, Asako Koike, Akihiko Mabuchi, Hiroyuki Oka, Shigeyuki Muraki, Yasushi Oshima, Hiroshi Kawaguchi, Kozo Nakamura, Katsushi Tokunaga, Sakae Tanaka, Noriko Yoshimura
Summary: A genome-wide association study identified a common SNP variant in ADAMTS17 associated with susceptibility to lumbar spondylosis, and the potential role of ADAMTS17-fibrillin network in intervertebral disc function in lumbar spondylosis development was demonstrated.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Yuki Taniguchi, Toru Akune, Nao Nishida, Go Omori, H. A. Kim, Kazuko Ueno, Taku Saito, Takeshi Oichi, Asako Koike, Akihiko Mabuchi, Hiroyuki Oka, Shigeyuki Muraki, Yasushi Oshima, Hiroshi Kawaguchi, Kozo Nakamura, Katsushi Tokunaga, Sakae Tanaka, Noriko Yoshimura
Summary: Using a genome-wide association study, researchers identified a SNP variant (rs2054564) in the ADAMTS17 gene associated with susceptibility to lumbar spondylosis. Replication analysis in Japanese and Korean cohorts confirmed this association. The study also provided evidence of the involvement of the ADAMTS17-fibrillin network in intervertebral disc function and the role of FBN1 in lumbar spondylosis development.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Masatsugu Tsukamoto, Tadatsugu Morimoto, Takaomi Kobayashi, Kazuki Muranaka, Tomohito Yoshihara, Kazumasa Maeda, Motoki Sonohata, Yuichi Kasai, Koji Otani, Masaaki Mawatari
Summary: This study evaluates the relationships between traction spur, Modic changes (MCs), and vacuum phenomenon (VP) and radiographic measurements in the lumbar spine. The results show a significant association between traction spur and translational motion, as well as between VP and vertical motion. These findings are important for identifying lumbar intervertebral instability.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Fengzhao Zhu, Yu Chen, Dongqing Jia, Yaqing Zhang, Yan Peng, Ya Ning, Xue Leng, Chencheng Feng, Yue Zhou, Changqing Li, Bo Huang
Summary: A preoperative lower LBP VAS score and moderate-to-severe multifidus fatty atrophy were associated with postoperative aggravated low back pain.
WORLD NEUROSURGERY
(2023)
Article
Multidisciplinary Sciences
Luis Becker, Lukas Schoennagel, Tim Victor Mihalache, Henryk Haffer, Friederike Schoemig, Hendrik Schmidt, Matthias Pumberger
Summary: Patients with LSTV exhibit reduced range of motion in the transitional segment and significantly increased motion distribution to the cranial adjacent segment in flexion-extension radiographs. These findings may explain the higher rates of degeneration within the segment.
Article
Computer Science, Artificial Intelligence
Yangjie Tang, Xiaofeng Wu, Ou-yang Lin, Zhong Li
Summary: This paper proposes a classifier that can perceive and predict the diagnostic ambiguity of lumber disc degeneration by integrating discal metabolomics, subjective probability quantification, and label distribution learning, demonstrating its feasibility in numerical experiments.
KNOWLEDGE-BASED SYSTEMS
(2022)
Article
Medicine, General & Internal
Mohammad Abid, Hameed Ullah Khan, Mohammad Huzea Abid, Adeel Ijaz, Muhammad Ahmad, Muhammad Tayyab Naeem, Hasan Raza
Summary: This retrospective study evaluated 80 patients aged 30-60 years and found that educationists and office workers are the main occupational groups at risk for lumbar disc herniation. Lifting weights greater than 10 kg while bending forward was identified as an important factor leading to lumbar disc nucleus pulposus herniation.
PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
(2021)