Association Between Shiftwork and Glomerular Filtration Rate in Police Officers

Objective: To investigate associations between shiftwork and glomerular filtration rate among white/Hispanic (n = 273) and African American (n = 81) police officers. Methods: Analysis of variance/analysis of variance was utilized to compare mean values of estimated glomerular filtration rate (eGFR) across shiftwork categories. Results: Shiftwork was significantly associated with eGFR among white/Hispanic officers only: day (88.6 +/- 2.8), afternoon (90.6 +/- 2.9), and night shift (83.1 +/- 3.1 mL/min/1.73 m(2)); afternoon versus night, P = 0.007. Percentage of hours worked on the night shift was inversely associated with mean levels of eGFR, trend P = 0.001. Body mass index modified the association between shiftwork and eGFR (interaction P = 0.038). Among officers with body mass index 25 kg/m(2) or higher, those who worked the night shift had the lowest mean eGFR (afternoon vs night, P = 0.012; day vs night, P = 0.029). Conclusions: Night-shift work was associated with decreased kidney function among white/Hispanic officers. Longitudinal studies are warranted among all races.