Journal
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
Volume 50, Issue 5, Pages 550-560Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JOM.0b013e318162f640
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Objective: The investigation updates the mortality experience through 2002 for a cohort of workers exposed to acrylonitrile (AN). Methods: Standardized mortality ratios (SMR) were estimated based on two reference populations: the US population and a regional employee population. Exposure-response analyses were conducted using Cox regression models for cumulative and mean intensity exposure measures. Results: In the cohort of 2548 workers, 839 deaths have occurred with 91 deaths due to respiratory system cancer. Most standardized mortality ratio estimates are at or near no-effects levels. Hazard ratio (HR) estimates indicate no increased mortality risk for respiratory system cancer (adjusted HR = 0.96, 95 % confidence interval: 0.74, 1.25). Conclusions: In summary, no mortality outcome of a priori interest, principally respiratory system cancer, is associated with increased AN exposure among fiber production workers over five decades of follow-up.
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