Article
Endocrinology & Metabolism
Ning Huang, Lixue Chen, Ying Lian, Haining Wang, Rong Li, Jie Qiao, Hongbin Chi
Summary: The presence of thyroid autoimmunity in patients with infertility did not impair embryo quality or affect pregnancy outcomes, including clinical pregnancy, miscarriage, preterm delivery, and live birth. However, it decreased the number of oocytes retrieved and birth weight in twin pregnancy. Subgroup analysis showed no association between the types or titers of thyroid antibodies and adverse IVF/ICSI outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Mohan Wang, Xiao Yang, Linlin Li, Haibo Zhu, Hongguo Zhang, Yuting Jiang, Ruizhi Liu
Summary: This study aimed to explore the incidence and influencing factors for early pregnancy loss (EPL) in infertility patients with first pregnancy undergoing in vitro fertilization (IVF) embryo transfer cycles in Jilin province, China. The study found that age, obesity, embryo transfer date, endometrial thickness, and tubal factor were associated with early pregnancy loss.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Endocrinology & Metabolism
Ines Bucci, Cesidio Giuliani, Giulia Di Dalmazi, Gloria Formoso, Giorgio Napolitano
Summary: The regulation of the female reproductive system by thyroid hormones is crucial for normal menstrual function, fertility, and successful pregnancy. Thyroid autoimmunity (TAI) is prevalent among women and is associated with infertility and negative reproductive outcomes. The role of TAI, especially in the absence of thyroid dysfunction, in assisted reproductive technology (ART) is still controversial.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Ning Huang, Lixue Chen, Ying Lian, Hongbin Chi, Jie Qiao
Summary: This study aimed to investigate the impact of TSH levels after controlled ovarian hyperstimulation (COH) on IVF/ICSI outcomes. The results showed that mildly elevated TSH levels did not affect IVF/ICSI outcomes, but strict control of TSH levels may increase the risk of preterm delivery.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Francesca Orsolini, Elena Gianetti, Chiara Terrenzio, Lucia Montanelli, Elena Benelli, Brunella Bagattini, Emilio Fiore, Massimo Tonacchera
Summary: This study evaluated the role of thyroid autoantibodies in adverse pregnancy outcomes. The results showed that the presence and titer of thyroid autoantibodies do not have a negative impact on gestation if thyroid function is adequately controlled. Although not significant, suboptimal thyroid hormone status may have a greater impact on pregnancy outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Yalong Liu, Zining He, Ning Huang, Lin Zeng, Yang Wang, Rong Li, Hongbin Chi
Summary: This study aimed to investigate the impact of thyroid autoimmunity and total 25-hydroxyvitamin D concentration on early pregnancy outcomes in women undergoing in vitro fertilization/intracytoplasmic sperm injection. The study found that patients with thyroid autoimmunity had lower vitamin D serum concentrations and fewer good-quality embryos. Aging was also found to adversely affect clinical and ongoing pregnancy in this population.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Sofia Gill, Versha Cheed, Victoria A. H. Morton, Dayna Gill, Kristien Boelaert, Shiao Chan, Arri Coomarasamy, Rima K. Dhillon-Smith
Summary: This study found that approximately 7% of euthyroid TPOAb-positive women developed hypothyroidism within 1 year preconception or in pregnancy. Women with treated hypothyroidism had lower conception rates compared to euthyroid women, but the live birth rates were similar.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Integrative & Complementary Medicine
Xue Zhou, Xiuling Li, Hui Ding, Ying Lu
Summary: Acupuncture may improve pregnancy outcomes in in-vitro fertilization as an adjuvant therapy, but there is no significant difference compared to sham-controls.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2022)
Article
Obstetrics & Gynecology
Kyoung Yong Moon, Haerin Paik, Byung Chul Jee, Seok Hyun Kim
Summary: This study investigated the impact of thyroid autoantibodies and serum TSH levels on clinical IVF outcomes. Results showed that thyroid autoantibodies did not affect clinical IVF outcomes, but women with serum TSH levels above 3.4 mIU/mL demonstrated poor IVF outcomes.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2023)
Article
Endocrinology & Metabolism
Lennart Blomqvist, Helena F. Nystrom, Margareta Hellgren, Annika Strandell
Summary: The presence of TPO-ab may contribute to an increased risk of first-trimester miscarriage in women with at least three recurrent unexplained pregnancy losses. TSH levels in the range of 2.5-4.0 mU/L do not seem to increase the risk of miscarriage.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jie Bao, Lixue Chen, Yongxiu Hao, Hongping Wu, Xiaojin He, Chuncheng Lu, Xinhua Ji, Jie Qiao, Yuanyuan Wang, Hongbin Chi
Summary: The study investigated the prevalence and prognosis of congenital anomalies in IVF/ICSI pregnancies, finding that pregnancies with higher fertilization failure rates were more likely to have poor prognoses for fetuses or neonates with congenital anomalies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Yan Ouyang, Yangqin Peng, Senmao Zhang, Fei Gong, Xihong Li
Summary: A convenient scoring system based on simple demographics was developed to predict early pregnancy loss (EPL). The study included 13,977 women who underwent transvaginal ultrasound scans after in vitro fertilization-embryo transfer. The scoring system showed high predictive accuracy, with a sensitivity of 62.84% and specificity of 98.79% in the training set.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Alessandro Dal Lago, Francesco Galanti, Donatella Miriello, Antonella Marcoccia, Micol Massimiani, Luisa Campagnolo, Costanzo Moretti, Rocco Rago
Summary: The study showed that adjuvant therapy with LT4 in women with autoimmune thyroid disease significantly improved pregnancy outcomes, reduced miscarriage rates, and increased full-term pregnancies. In women over 35 years old, LT4 treatment significantly decreased the miscarriage rate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Shaomi Zhu, Yiyue Fan, Ling Lan, Tianqing Deng, Qinxiu Zhang
Summary: The study aimed to explore the risk factors affecting the incidence of heterotopic pregnancy (HP) after in vitro fertilization-embryo transfer (IVF-ET) and the pregnancy outcomes after surgical treatment of HP. The results showed that a history of previous ectopic pregnancies, multiple abortions, tubal infertility, and multiple-embryo transfer were significant risk factors for HP following IVF-ET. In patients with HP treated by surgery, shorter operative duration, smaller size of the ectopic mass, and location in the ampulla of the fallopian tube were associated with better reproductive prognosis.
FRONTIERS IN MEDICINE
(2022)
Article
Endocrinology & Metabolism
Sofie Bliddal, Arash Derakhshan, Yi Xiao, Liang-Miao Chen, Tuija Mannisto, Ghalia Ashoor, Fangbiao Tao, Suzanne J. Brown, Marina Vafeiadi, Sachiko Itoh, Elena Nikolaevna Grineva, Peter Taylor, Farkhanda Ghafoor, Bijay Vaidya, Andrew Hattersley, Lorena Mosso, Emily Oken, Reiko Kishi, Erik K. Alexander, Spyridoula Maraka, Kun Huang, Layal Chaker, Judit Bassols, Amna Pirzada, Abel Lopez-Bermejo, Laura Boucai, Robin P. Peeters, Elizabeth N. Pearce, Scott McGill Nelson, Leda Chatzi, Tanja G. Vrijkotte, Polina V. Popova, John P. Walsh, Kypros H. Nicolaides, Eila Suvanto, Xuemian Lu, Victor J. M. Pop, Julie Lyng Forman, Tim I. M. Korevaar, Ulla Feldt-Rasmussen
Summary: This meta-analysis of individual participant data shows that isolated thyroid peroxidase antibodies (TPOAbs) positivity and thyroglobulin antibodies (TgAbs) positivity during pregnancy are associated with an increase in thyrotropin (TSH), with a more significant effect observed in individuals positive for both antibodies. When adjusting for the other antibody, only TPOAbs remain associated with TSH, indicating a dose-dependent relationship. Further studies are needed to understand the differences between TPOAb- and TgAb-positive women.