Journal
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
Volume 40, Issue 5, Pages 1167-1173Publisher
WILEY
DOI: 10.1111/jog.12327
Keywords
FAS; FAS; Ligand; polymorphism; pre-eclampsia
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Funding
- Zahedan University of Medical Sciences
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AimPre-eclampsia (PE) is a complex disorder of pregnancy with unknown etiology. FAS-mediated apoptosis is assumed to prevent the development of PE; therefore FAS and FASLigand may be represented as candidate genes involved in PE pathogenesis. In the present study, we evaluated the relation between FAS LigandA-670G (rs1800682) and FAS LigandC-844T (rs763110) gene polymorphisms with PE in southeast Iran. MethodsOne hundred and twenty-seven unrelated women with PE and 139 healthy control subjects were genotyped for the FASA-670G and FAS LigandC-844T polymorphisms by polymerase chain reaction restriction fragment length polymorphism method. ResultsThe AA, AG and GG genotype frequency of the FASA-670G polymorphism were 21.3%, 53.5% and 25.2% in pre-eclamptic women and 46.0%, 41.5% and 11.5% in controls and were statistically different (P=0.0001). The risk of PE was 2.7- and 4.7-fold higher in pregnant women with AG and GG genotypes respectively. Although the frequency TT genotype and T allele of FAS LigandC-844T gene polymorphism was higher in the PE group, the differences were not significant. ConclusionFAS A-670G polymorphism is associated with a higher risk for PE. There was no association between FAS LigandC-844T polymorphism and PE.
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