Article
Obstetrics & Gynecology
Gai Li Meng, Qi Wang, Ru Kang, Xiao Yue Cheng, Jun Lan Yang, Yun Xie
Summary: This study explored the prevalence and characteristics of gestational diabetes mellitus (GDM) in Xi'an from 2015 to 2021 and provided a clinical basis for the management of GDM. The results showed that the prevalence of GDM in Xi'an urban area was 24.66% and exhibited an increasing trend annually. After the implementation of the universal two-child policy, the proportion of pregnant women aged 31-42 years significantly increased. The management of GDM should focus on older pregnant women and those with multiple abnormal OGTT values.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Endocrinology & Metabolism
Lore Raets, Marie Vandewinkel, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Nele Roggen, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick van den Bruel, Anne Loccufier, Annouschka Laenen, Roland Devlieger, Chantal Mathieu, Katrien Benhalima
Summary: The study found that women who preferred the two-step screening strategy (GCT and OGTT) were less likely to be from a minority ethnic background, had a lower prevalence of previous GDM, were less overweight or obese, and were less insulin resistant in early pregnancy. The two-step screening strategy was preferred overall, but women who chose the one-step screening strategy were more likely to opt for an OGTT and experienced less discomfort during the procedure.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Shan Wu, Linghui Li, Kai-Lun Hu, Siwen Wang, Runju Zhang, Ruixue Chen, Le Liu, Danni Wang, Minge Pan, Bo Zhu, Yue Wang, Changzheng Yuan, Dan Zhang
Summary: This study aims to develop a reliable prediction model for gestational diabetes mellitus (GDM) in early pregnancy. Logistic regression analysis was used to construct the prediction model utilizing results from an oral glucose tolerance test (OGTT) and baseline characteristics. Model performance was assessed and visualized using ROC curve, Hosmer-Lemeshow test, decision clinical analysis, and a nomogram. Internal and external validation confirmed the stability of the model.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Esther Maor-Sagie, Mordechai Hallak, Yoel Toledano, Rinat Gabbay-Benziv
Summary: This study aimed to evaluate the association between oGTT performed after 28 weeks and the risk of T2DM. The results showed that late oGTT had lower rates of GDM and T2DM. However, once GDM was diagnosed, regardless of oGTT timing, the risk of T2DM was increased.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Daryl J. Selen, Tanayott Thaweethai, Carolin C. M. Schulte, Sarah Hsu, Wei He, Kaitlyn James, Anjali Kaimal, James B. Meigs, Camille E. Powe
Summary: Gestational glucose intolerance (GGI), an abnormal initial gestational diabetes mellitus (GDM) screening test without a GDM diagnosis, is associated with an increased risk of future diabetes. Individuals with GGI have a higher risk of developing diabetes compared to those with normal glucose tolerance during pregnancy. Routine clinical data can be used to identify this unrecognized group who may benefit from enhanced diabetes screening and prevention.
Article
Nutrition & Dietetics
Farah Yasmin Hasbullah, Barakatun-Nisak Mohd Yusof, Sangeetha Shyam, Rohana Abdul Ghani, Hannah Izzati Mohamed Khir
Summary: This study examined the association between dietary patterns and abnormal glucose tolerance (AGT) in women post-gestational diabetes mellitus. It found that the "cereals-confectionaries" dietary pattern was significantly associated with AGT. Therefore, targeted lifestyle modifications, including dietary interventions, are needed for women post-gestational diabetes to reduce the risk of AGT.
Article
Endocrinology & Metabolism
Xin Zhao, Jianbin Sun, Ning Yuan, Xiaomei Zhang
Summary: This study explores the association between thyroid hormones and gestational diabetes mellitus in euthyroid pregnant women and finds that the ratio of free triiodothyronine-to-free thyroxine is an independent risk factor for gestational diabetes mellitus and has the potential to be a predictor for gestational diabetes mellitus in euthyroid pregnant women.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Nana Liu, Yin Sun, Yaxin Wang, Liangkun Ma, Suhan Zhang, Hang Lin
Summary: This study aimed to investigate the composition of intestinal microbiota and its longitudinal variation between the second trimester (T2) and the third trimester (T3) in women with gestational diabetes mellitus (GDM) and pregnant women with normal glucose tolerance. Fecal samples were collected from both groups, and the results showed that the dominant phyla did not significantly change between T2 and T3 in both groups. However, there were significant differences in the relative abundances of certain genera and phyla between the GDM group and the control group. The study concluded that while the composition of intestinal microbiota was stable over time, it differed between women with GDM and those with normal glucose tolerance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Silas Alegu Nwali, Robinson Chukwudi Onoh, Ikechukwu Bo Dimejesi, Vitus Okwuchukwu Obi, Sunday Emmanuel Jombo, Oghenevwogaga Obukohwo Edenya
Summary: Comparing universal screening with selective risk factor based screening for GDM, the former was found to be more effective in diagnosing GDM. Universal screening with one step 75g OGTT is recommended for pregnant women, and further studies are needed to compare pregnancy outcomes for women diagnosed with GDM with and without risk factors.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Daria Di Filippo, Amanda Henry, Chloe Bell, Sarah Haynes, Melissa Han Yiin Chang, Justine Darling, Alec Welsh
Summary: This study aimed to evaluate the acceptability of Freestyle Libre Pro 2 as a diagnostic test for gestational diabetes mellitus (GDM), and to validate its results with OGTT and GDM risk factors. The results showed that CGM was a more acceptable alternative for GDM diagnosis. Triangulation analysis revealed both false positive and false negative results from OGTT screening.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Nutrition & Dietetics
Shaofeng Huo, Liang Sun, Geng Zong, Xia Shen, He Zheng, Qianlu Jin, Huaixing Li, Huiyong Yin, Xu Lin
Summary: This study aimed to characterize plasma metabolomic profiles during an oral glucose tolerance test (OGTT) in Chinese individuals with different glycemic statuses. The results showed distinct metabolite responses in individuals with type 2 diabetes (T2D), with certain metabolites significantly higher at 2 hours post-OGTT. Differences in metabolite levels were also observed between T2D, prediabetes, and normal glucose subjects, suggesting potential implications for glucose homeostasis.
Article
Nutrition & Dietetics
Chunmei Mi, Hong Liu, Hongying Peng, Chunxia Cheng, Meng Wang, Hua Liu, Guo Feng, Jinru Wu, Hao Nie, Min Liu
Summary: The study revealed a correlation between maternal body mass index and oral glucose tolerance test results, indicating that women who were overweight before pregnancy were more likely to develop hyperglycemia. Additionally, abnormal 2-hour postprandial glucose levels during gestational oral glucose tolerance test may influence postpartum oral glucose tolerance test outcomes.
FRONTIERS IN NUTRITION
(2021)
Article
Obstetrics & Gynecology
Donald R. Coustan, Alan R. Dyer, Boyd E. Metzger
Summary: The common approach in the United States for detecting gestational diabetes involves a 2-step protocol, while the International Association of Diabetes and Pregnancy Study Groups recommends a diagnostic test without screening. Both methods have different criteria and implications for identifying gestational diabetes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mattia Barbot, Alessandro Mondin, Daniela Regazzo, Valentina Guarnotta, Daniela Basso, Carla Giordano, Carla Scaroni, Filippo Ceccato
Summary: Cushing's disease (CD) can cause diabetes mellitus (DM) through different mechanisms. This study evaluated the hormonal response to a mixed meal tolerance test (MMTT) in CD patients and analyzed the effect of pasireotide (PAS) on glucose homeostasis. The results showed that DM+ patients had higher BMI, waist circumference, glycemia, HbA1c, ACTH levels, and insulin resistance indexes compared to DM- patients. DM+ patients also exhibited increased C-peptide and glucose area under the curve (AUC) during MMTT, with a blunted glucagon-like peptide (GIP) response. After two months of PAS treatment, patients showed an increase in fasting glycemia and HbA1c, but the glucose trend after meals did not worsen. PAS treatment also resulted in reduced insulin secretion and resistance indexes. No significant differences were observed in incretin response to MMTT during PAS therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medical Laboratory Technology
A. Arbiol-Roca, E. A. Perez-Hernandez, N. Aisa-Abdellaoui, T. Valls-Guallar, F. Galvez-Carmona, E. Mariano-Serrano, M. Medina-Casanovas, M. R. Ruiz-Morer
Summary: The study found that HbA1c can be used as a biomarker for screening GDM and reduce the need for GCT. However, the accuracy of the HbA1c test is not sufficient to be used as the sole diagnostic method, and combining it with OGTT may be more effective.
CLINICAL BIOCHEMISTRY
(2021)
