Article
Biochemistry & Molecular Biology
Jaroslav Nunvar, Lucie Pagacova, Zuzana Vojtechova, Nayara Trevisan Doimo de Azevedo, Jana Smahelova, Martina Salakova, Ruth Tachezy
Summary: Our study found that the degree of miRNA deregulation varies significantly among tumors at different locations, and the deregulated miRNAs are largely tumor-specific, with no miRNA shared by all four types of HPV-positive tumors.
Article
Radiology, Nuclear Medicine & Medical Imaging
Leehi Joo, Yun Jung Bae, Young Jun Choi, Yoon Se Lee, Sae Rom Chung, Chong Hyun Suh, Seon-Ok Kim, Jung Hwan Baek, Jeong Hyun Lee
Summary: A risk scoring system based on clinical and imaging findings was developed and validated to predict lymph node metastasis from HPV+ oropharyngeal squamous cell carcinomas. The system showed good discriminative ability and calibration in both training and test sets, and is expected to aid in clinical decision-making.
EUROPEAN RADIOLOGY
(2021)
Article
Ophthalmology
Ingvild Ramberg, Filipe Garrett Vieira, Peter Bjerre Toft, Christian von Buchwald, Mikkel Funding, Finn Cilius Nielsen, Steffen Heegaard
Summary: The study has identified two potentially distinct distributions of somatic mutations in conjunctival SCC based on HPV status, indicating the significant role of HPV in carcinogenesis in certain cases.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Oncology
Yong Lu, Gary M. Clifford, Christopher K. Fairley, Andrew E. Grulich, Suzanne M. Garland, Fei Xiao, Yuan Wang, Huachun Zou
Summary: This study provides updated information on the prevalence of HPV and p16(INK4a) in oropharyngeal SCC, and highlights the importance of HPV vaccination in preventing a significant proportion of these cases.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Microbiology
Rances Blanco, Diego Carrillo-Beltran, Juan P. Munoz, Julio C. Osorio, Julio C. Tapia, Veronica A. Burzio, Ivan Gallegos, Gloria M. Calaf, Paola Chabay, Francisco Aguayo
Summary: This study reveals the co-presence of high-risk HPV and EBV in low- and high-grade cervical lesions as well as cervical cancer in Chilean women. Furthermore, the expression of EBV lytic gene BARF1 is associated with changes in tumor behavior in cervical cancer cells.
Article
Oncology
Ching-Mei Chen, Tian-Huei Chu, Chih-Chi Chou, Chih-Yen Chien, Jian-Shiang Wang, Chao-Cheng Huang
Summary: The study indicates that exosomal miR-155 and miR-21 are upregulated in OSCC patients, while miR-126 is downregulated. MiR-155 and miR-21 promote cell proliferation and invasion by suppressing PTEN and Bcl-6 tumor suppressors, while miR-126 inhibits oncogenic behaviors and EGFL7 expression. Exosomal miRNAs in blood may serve as biomarkers for the diagnosis and prognosis of OSCC.
Article
Oncology
Kathleen R. Bartemes, Benjamin R. Gochanour, David M. Routman, Daniel J. Ma, Karen A. Doering, Kelli N. Burger, Patrick H. Foote, William R. Taylor, Douglas W. Mahoney, Calise K. Berger, Xiaoming Cao, Sara S. Then, Travis J. Haller, Alyssa M. Larish, Eric J. Moore, Joaquin J. Garcia, Rondell P. Graham, Jamie N. Bakkum-Gamez, John B. Kisiel, Kathryn M. Van Abel
Summary: This study aimed to find novel biomarkers for early identification of human papillomavirus associated oropharyngeal squamous cell carcinoma (HPV (+) OPSCC). By evaluating the expression of 21 methylated DNA markers in tissues, it was found that most markers had higher discrimination in HPV (+) cervical squamous cell carcinoma (CSCC) than in HPV (+) OPSCC.
Article
Multidisciplinary Sciences
Qi Song, Ye Yang, Dongxian Jiang, Zhaoyu Qin, Chen Xu, Haixing Wang, Jie Huang, Lingli Chen, Rongkui Luo, Xiaolei Zhang, Yufeng Huang, Lei Xu, Zixiang Yu, Subei Tan, Minying Deng, Ruqun Xue, Jingbo Qie, Kai Li, Yanan Yin, Xuetong Yue, Xiaogang Sun, Jieakesu Su, Fuchu He, Chen Ding, Yingyong Hou
Summary: Squamous cell carcinomas (SCCs) are aggressive cancers that can occur in multiple organs. This study analyzed the proteome of SCCs from 17 different organs and found common dysregulated proteins regardless of location. The comparison between SCCs and adenocarcinomas identified distinct pathways and molecules that play consistent adverse or opposite prognostic roles in the two subtypes. Additionally, the study revealed the importance of lipid metabolism in rare SCCs and discovered potential druggable targets. Overall, this proteomic analysis provides valuable insights into SCCs and adenocarcinomas and serves as a public resource for further research.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Valeri Roschenko, Abdallah M. Ayoub, Konrad Engelhardt, Jens Schaefer, Muhammad Umair Amin, Eduard Preis, Robert Mandic, Udo Bakowsky
Summary: Infection with HPV is a major risk factor for head and neck squamous cell carcinomas (HNSCCs), but photodynamic therapy (PDT) using CUR-LCNPs shows promise as an alternative treatment regardless of HPV status.
Article
Oncology
Henrike Reder, Steffen Wagner, Nora Wuerdemann, Christine Langer, Sarah Sandmann, Andreas Braeuninger, Martin Dugas, Stefan Gattenloehner, Claus Wittekindt, Jens Peter Klussmann
Summary: Patients with HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma have significantly different overall survival rates, but those with HPV+OPSCC who develop local/distant recurrence show a mutation pattern similar to HPV-OPSCC, impacting disease severity. Despite similar overall mutation counts, specific mutations rather than the number of mutations may be important for disease progression.
Article
Medicine, General & Internal
Rongrong Jin, Xumei Yang, Jingjing Bao, Wenyan Zhang, Rongrong Dou, Donglan Yuan, Qinxin Yang, Lin Jiang, Hong Yu
Summary: The study investigated the distribution of HPV genotypes in patients with cervical lesions in Taizhou, China, revealing a high prevalence of HPV infections with variations in genotype distribution. Routine HPV tests covering all common genotypes are essential in clinical practice.
Article
Microbiology
Abbas Karimi, Elham Mohebbi, Sandrine Mckay-Chopin, Hamideh Rashidian, Maryam Hadji, Vahideh Peyghambari, Maryam Marzban, Ahmad Naghibzadeh-Tahami, Mahin Gholipour, Farin Kamangar, Massimo Tommasino, Tarik Gheit, Kazem Zendehdel
Summary: This study analyzed the detection of alpha-, beta-, and gamma-HPVs in oral rinse samples of HNSCC cases and controls in Iran, finding that the contribution of alpha-HPVs to HNSCC in Iran is lower than global prevalence, and high-risk alpha-HPVs or cutaneous beta- and gamma-HPVs were not associated with HNSCC development.
MICROBIOLOGY SPECTRUM
(2022)
Review
Biology
Delphine Avril, Jean-Philippe Foy, Jebrane Bouaoud, Vincent Gregoire, Pierre Saintigny
Summary: This article aims to review recently proposed biomarkers of radioresistance in HPV-negative HNSCC, which can be useful for stratifying tumor patients based on their predicted level of radioresistance.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Pathology
Nina Gale, Mario Poljak, Metka Volavsek, Lea Hosnjak, Dane Velkavrh, Luka Bolha, Kristina Fujs Komlos, Primoz Strojan, Aleksandar Anicin, Nina Zidar
Summary: The study evaluated the transcriptional activity of high-risk HPV in oropharyngeal squamous cell carcinomas and found that HPV positivity is significant for predicting patient survival.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Loretto J. Carvajal, Jaimie Z. Shing, Juan C. Vanegas, Emmanuel Gonzalez, Diego Guillen, Monica S. Sierra, Allan Hildesheim, Carolina Porras, Rolando Herrero, Guillermo Torres, Meredith S. Shiels, Alejandro Calderon, Aimee R. Kreimer
Summary: This study investigated the incidence and trends of head and neck cancer in Costa Rica, specifically focusing on the potentially human papillomavirus (HPV)-related and HPV-unrelated head and neck squamous cell carcinomas (HNSCC). The findings showed a decreasing incidence of HNSCC overall, but an increasing trend for HPV-related HNSCCs. This study is important for understanding the epidemiology of head and neck cancer and the impact of HPV.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biochemical Research Methods
Shanshan Li, Zhifeng Luo, Shuhui Meng, Xiaofen Qiu, Fengping Zheng, Weier Dai, Xinzhou Zhang, Weiguo Sui, Qiang Yan, Donge Tang, Yong Dai
Summary: The study investigated proteomic and phosphoproteomic alterations in renal biopsy tissues of membranous nephropathy patients, revealing differential phosphorylation levels of multiple phosphoproteins associated with cellular processes and biological regulation, with most located in the nucleus. The complex protein-protein interaction network and potential signaling pathways identified provide insight into the pathogenic mechanisms of membranous nephropathy.
PROTEOMICS CLINICAL APPLICATIONS
(2022)
Article
Endocrinology & Metabolism
Chunhong Li, Yueying Xiang, Yanyan Zhang, Donge Tang, Yan Chen, Wen Xue, Xiaobin Wang, Jiejing Chen, Yong Dai
Summary: This study characterized mtDNA polymorphisms in patients with T2D and identified 10 mtDNA variants associated with the disease. The findings contribute to the understanding of the role of mtDNA in the pathophysiology of T2D and suggest potential molecular biomarkers for early diagnosis of T2D.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2022)
Article
Immunology
Zongchao Yu, Xiaoping Hong, Xiaoli Zhang, Fengping Zheng, Fanna Liu, Huixuan Xu, Chengxin Zhu, Wanxia Cai, Dongzhou Liu, Lianghong Yin, Bo Hu, Donge Tang, Yong Dai
Summary: This study investigated potential pathways involved in the pathogenesis of new-onset ankylosing spondylitis (AS) through systematic proteomic and phosphorylation analyses, and identified proteins that could be used as candidate markers for AS diagnosis and new therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Hongwei Wu, Jingjing Dong, Haiyan Yu, Kang Wang, Weier Dai, Xinzhou Zhang, Nan Hu, Lianghong Yin, Donge Tang, Fanna Liu, Yong Dai
Summary: This study integrated single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) to investigate the transcriptional program and chromosomal accessibility of peripheral mononuclear cells (PBMCs) in maintenance hemodialysis patients. The study found that hemodialysis suppressed the expression of immune-related genes in CD4+ T cells and monocytes, inhibited downstream pathways of T cell receptor signaling, and altered cellular communication patterns between PBMC subgroups. Additionally, hemodialysis affected the chromatin accessibility profile and expression of transcription factors. This study provides a valuable framework for studying hemodialysis-related immune dysregulation and identifies potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Wenbiao Chen, Donge Tang, Junqi Lin, Xiaoming Huang, Shaoming Lin, Guanle Shen, Yong Dai
Summary: This study investigated the biological function of circSHKBP1 in NSCLC and found that it enhanced proliferation, migration, invasion, and stemness of NSCLC cells. The study also identified the miR-1294/PKM2 axis as the mechanism by which circSHKBP1 regulates NSCLC progression. These findings suggest that circSHKBP1 may serve as a potential prognostic biomarker and therapeutic target for NSCLC.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Review
Immunology
Yixi Li, Donge Tang, Lianghong Yin, Yong Dai
Summary: Lupus nephritis (LN) is a complex autoimmune disease, and recent research has shown the potential of regulatory T (Treg) cell therapy in treating autoimmune diseases. However, there is limited understanding of Treg cell therapy for LN patients. This review aims to summarize new insights into Treg-targeting techniques in LN patients.
AUTOIMMUNITY REVIEWS
(2022)
Article
Rheumatology
Huixuan Xu, Haiyan Yu, Fengping Zheng, Cantong Zhang, Wanxia Cai, Xinzhou Zhang, Donge Tang, Yong Dai
Summary: This study provides a new perspective for understanding the pathophysiology of chronic hepatitis B (CHB) by analyzing the gene regulatory network in CHB patients using single-cell ATAC sequencing. The specific cell types associated with CHB were found to be located in B-0 and T-3. The regulatory network of the hepatitis B signal pathway composed of genes linked to the differentially expressed peaks of these two CHB disease-specific cell types was drawn.
CLINICAL RHEUMATOLOGY
(2022)
Article
Immunology
Yafang Zhong, Wei Zhang, Xiaoping Hong, Zhipeng Zeng, Yumei Chen, Shengyou Liao, Wanxia Cai, Yong Xu, Gang Wang, Dongzhou Liu, Donge Tang, Yong Dai
Summary: Our study identified ABCB1, IFI27, and PLSCR1 as potential diagnostic genes for Chinese SLE patients and uncovered their most relevant immune cells. The findings in this paper provide possible biomarkers for diagnosing Chinese SLE patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Haiyan Yu, Donge Tang, Hongwei Wu, Chunhong Li, Yongping Lu, Fang He, Xiaogang Zhang, Yane Yang, Wei Shi, Wenlong Hu, Zhipeng Zeng, Weier Dai, Minglin Ou, Yong Dai
Summary: This study used integrated single-cell RNA sequencing and single-cell transposase-accessible chromatin sequencing analyses to investigate cellular heterogeneity and transcriptional regulatory networks during human spine development. The findings revealed that fibroblasts with stem cell characteristics can differentiate into chondrocytes and neurons may originate from neuroendocrine cells. The interaction between macrophages and neurons involving NRP2_SEMA3C and CD74_APP is crucial for spinal cord development.
Article
Oncology
Wei Zhang, Yutong Shi, Shumeng Niu, Lintai Li, Liewen Lin, Xucan Gao, Wanxia Cai, Yumei Chen, Yafang Zhong, Donge Tang, Min Tang, Yong Dai
Summary: According to the research, the reduced expression of GSTM2 in colorectal cancer is associated with lower overall survival rate of patients. The study uncovered potential regulatory mechanisms of GSTM2 in colorectal cancer, including deletion on the genome and up-regulation of other genes. Moreover, GSTM2 might be involved in immune-related pathways and regulate the development of tumors by modulating the immune microenvironment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Wencong Song, Chunhong Li, Jie Qiu, Jiyou Dong, Dongzhou Liu, Yong Dai
Summary: This study examined the expression profiles of exosomal miRNAs and proteins in the plasma of SLE patients and healthy subjects and discussed the underlying signaling network of circulating exosomes. The study identified differentially expressed exosomal miRNAs and proteins in SLE patients and healthy controls, as well as consensus molecules and signaling pathways. These findings indicate the potential application of exosomes in the clinical treatment and diagnosis of SLE disease.
Article
Rheumatology
Fengping Zheng, Lishan Tan, Fan Zhang, Sanmu Li, Zhiwei Lai, Huixuan Xu, Zuying Xiong, Yong Dai
Summary: This study investigated the role of circRNA in systemic lupus erythematosus (SLE) by analyzing its expression in plasma and peripheral blood mononuclear cells (PBMCs). Differentially expressed circRNAs were identified and their potential diagnostic and pathogenic roles in SLE were explored through network analysis.
CLINICAL RHEUMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Wenjun Pu, Xi Wang, Xiaoni Zhong, Dong Zhao, Zhipeng Zeng, Wanxia Cai, Yafang Zhong, Jianrong Huang, Donge Tang, Yong Dai
Summary: This study analyzed and compared the spatial distribution of metabolites in healthy control and hepatitis B cirrhosis tissue samples using LC-MS/MS and mass spectrometry imaging system. The results showed that hepatitis B cirrhosis induced region-specific autophagy and dysregulation of unsaturated fatty acids, amino acids, and phosphatidylcholines metabolism. The mass spectrometry imaging system provided additional metabolites' spatial information, which can promote biomarker screening technology and support the exploration of novel mechanisms in liver cirrhosis.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Yan Yang, Chiyu Ma, Shishi Li, Wanxia Cai, Weier Dai, Xinzhou Zhang, Lianghong Yin, Donge Tang, Fanna Liu, Yong Dai
Summary: By analyzing the microbiota and serum metabolites in urine samples from patients with diabetic kidney disease (DKD), it was found that DKD patients had a different urinary microbiota compared to the healthy controls, with the most abundant microbiota being Proteobacteria and Acidobacteria. Short-chain fatty acids and protein-bound uremic toxins were shown to be specific to DKD. Furthermore, the study revealed that the metabolism of arginine and proline may play a major role in the regulation of DKD.
Article
Biochemistry & Molecular Biology
Yingwei Zhang, Zeyu Zhang, Chundi Li, Donge Tang, Yong Dai
Summary: This study demonstrated that Empagliflozin treatment can significantly improve the metabolites involved in fatty acid oxidation pathway in the heart of db/db diabetic mice, suggesting its potential therapeutic intervention for diabetic cardiomyopathy.
