Review
Biochemistry & Molecular Biology
Tiziana Ciarambino, Pietro Crispino, Gaetano Leto, Erika Mastrolorenzo, Ombretta Para, Mauro Giordano
Summary: Gender differences play an important role in the pathophysiology and treatment of many diseases. They are not only determined by genetic makeup but also influenced by socio-cultural habits, behaviors, and lifestyles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Trine Damsted Rasmussen, Sarah Fredsted Villadsen, Anne Vinkel Hansen, Laust H. Mortensen, Claus Thorn Ekstrom, Signe Smith Jervelund, Anne-Marie Nybo Andersen
Summary: This study evaluated the impact of the MAMAACT antenatal care intervention on perinatal health outcomes and reducing ethnic and social disparities in Denmark. The intervention, which included training for midwives, dialogue meetings, and health education materials, did not improve the overall composite perinatal mortality and morbidity outcome. Contextual factors, such as organizational barriers in antenatal care, may have hindered the effectiveness of the intervention.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Acoustics
A. Arechvo, D. A. Nikolaidi, M. M. Gil, V. Rolle, A. Syngelaki, R. Akolekar, K. H. Nicolaides
Summary: This study aimed to examine the relationship between the English index of multiple deprivation (IMD) and the incidence of stillbirth and evaluate whether IMD contributes to the prediction of stillbirth provided by maternal demographic characteristics and elements of medical history. The study found that women living in the most deprived areas in South East England had higher rates of stillbirth, particularly placental dysfunction-related stillbirth. However, including IMD in stillbirth screening did not improve the prediction provided by race, other maternal characteristics, and elements of medical history.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Medicine, General & Internal
Kymberleigh A. Pagel, Hoyin Chu, Rashika Ramola, Rafael F. Guerrero, Judith H. Chung, Samuel Parry, Uma M. Reddy, Robert M. Silver, Jonathan G. Steller, Lynn M. Yee, Ronald J. Wapner, Matthew W. Hahn, Sriraam Natarajan, David M. Haas, Predrag Radivojac
Summary: This cohort study found that the addition of polygenic risk scores (PRS) was associated with the stratified risk of gestational diabetes (GD) diagnosis among high-risk patient subgroups, suggesting the benefits of targeted PRS ascertainment to encourage early intervention.
Article
Endocrinology & Metabolism
Vince Fazekas-Pongor, Mark M. Svebis, David Major, Katalin Partos, Norbert Dosa, Agota Meszaros, Viktor J. Horvath, Beatrix A. Domjan, Laszlo Zsirai, Adam G. Tabak
Summary: This study aimed to compare the frequency and trends of pregnancy outcomes in type 1 diabetes pregnancies and control pregnancies from 1996 to 2018. The results showed that type 1 diabetes pregnancies had higher risks of stillbirth, perinatal mortality, large for gestational age, caesarean section, NICU admission, and low APGAR scores compared to controls. The risk of congenital malformations was also increased, while the risk of SGA was decreased. However, improvements were observed in caesarean section rates, low APGAR scores, and NICU admissions over time.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pediatrics
Demeke Mesfin Belay, Wubet Alebachew Bayih, Abebaw Yeshambel Alemu, Amare Simegn Ayele, Demewoz Kefale Mekonen, Binyam Minuye Birhane
Summary: This study aimed to estimate the pooled prevalence of stillbirth among diabetic mothers in Ethiopia and its determinants. The national prevalence of stillbirth among diabetic mothers was found to be 2.39%, with factors such as younger age, gestational age of less than 37 weeks, and being a housewife significantly associated with stillbirth.
FRONTIERS IN PEDIATRICS
(2021)
Article
Obstetrics & Gynecology
Helmut J. Kleinwechter, Katharina S. Weber, Nina Mingers, Babett Ramsauer, Ute M. Schaefer-Graf, Tanja Groten, Bettina Kuschel, Clara Backes, Constanze Banz-Jansen, Martin A. Berghaeuser, Irene A. Brotsack, Iris Dressler-Steinbach, Charlotte Engelbrecht, Sarah Engler-Hauschild, Teresa-Mira Gruber, Vanessa Hepp, Elsa Hollatz-Galuschki, Antonella Iannaccone, Anja Jebens, Constantin S. von Kaisenberg, Lisa Kaup, Corinna Keil, Carolin Kladt, Thomas Kolben, Katrina Kraft, Mirjam Kunze, Julia Lastinger, Katharina Luedemann, Jula Manz, Christine A. Morfeld, Olaf Parchmann, Lena Pfaff, Kristin Reinhardt, Anne Runkel, Markus Schmidt, Marina Sourouni, Johanna Stelbrink, Johannes Stubert, Florian M. Stumpfe, Anna Treptow, Mario Ruediger, Ulrich Pecks
Summary: This study aimed to investigate whether gestational diabetes mellitus is an independent risk factor for adverse maternal and fetal and neonatal outcomes in pregnant women with COVID-19. The results showed that gestational diabetes mellitus combined with preconceptional overweight or obesity independently increased the risk of severe course of COVID-19 in pregnant women.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Zhenyu Wang, Jia Chen, Tuhong Long, Lixuan Liang, Caijuan Zhong, Yingtao Li
Summary: We analyzed the clinical characteristics of patients with diabetes in pregnancy (DIP) associated with stillbirth and found that hypertensive disorders, placenta previa, placental abruption, fetal malformation, high plasma glucose levels, and polyhydramnios were associated with higher incidences of stillbirth in DIP. Antenatal plasma glucose levels and HbA1c were significantly associated with stillbirth in DIP. Age, hypertensive disorders, body mass index, preeclampsia, and diabetic ketoacidosis were positively correlated with the occurrence of stillbirth in DIP. Controlling perinatal plasma glucose, managing comorbidities/complications, and timely termination of pregnancy can reduce the incidence of stillbirths associated with DIP.
Review
Medicine, Research & Experimental
Yinai Liu, Qianqian Chen, Yaoqi Li, Liuliu Bi, Zhiying He, Chuxiao Shao, Libo Jin, Renyi Peng, Xingxing Zhang
Summary: Diabetes is a serious disease that threatens global human health. Insulin is the most effective treatment, but it can cause hypoglycemia and insulin resistance. Recent studies have found that fibroblast growth factors can safely and effectively reduce hyperglycemia, providing a new approach for diabetes treatment.
Review
Endocrinology & Metabolism
Matladi Masete, Stephanie Dias, Nompumelelo Malaza, Sumaiya Adam, Carmen Pheiffer
Summary: Maternal diabetes, especially pregestational type 1 and type 2 diabetes, is associated with more frequent and severe pregnancy complications compared to gestational diabetes. Recent studies have shown the potential role of miRNAs in the pathophysiology of pregnancy-related disorders, including diabetes. However, there is a lack of miRNA profiling studies in pregnancies complicated by pregestational diabetes, highlighting the need for further research in this area.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Sukainah Al Khalaf, Karolina Kublickiene, Marius Kublickas, Ali S. Khashan, Alexander E. P. Heazell
Summary: The study found that women with a history of stillbirth in the first two pregnancies have an increased risk of stillbirth or other adverse outcomes in the third pregnancy. Additional surveillance is recommended for these women.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Rebecca L. Williamson, Elizabeth A. McCarthy, Jeremy J. Oats, Leonid Churilov, Martha Lappas, Alexis Shub
Summary: This study compared obstetric and perinatal outcomes for women with pre-existing diabetes delivering in rural vs metropolitan hospitals in Victoria, Australia. The results show that women delivering in rural hospitals had higher rates of adverse perinatal outcomes and more maternal risk factors compared to their metropolitan counterparts, suggesting a need to improve care for women with pre-existing diabetes in rural Victoria.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2021)
Article
Medicine, General & Internal
Jasmina Kevric, Katherine Suter, Russell Hodgson, Grace Chew
Summary: This study investigated the incidence of infertility, pregnancy complications, and breastfeeding practices among Australian and New Zealand doctors. The results showed that female doctors delay family planning due to work-related demands, resulting in higher rates of infertility and pregnancy complications.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Teresa Salvatore, Raffaele Galiero, Alfredo Caturano, Erica Vetrano, Giuseppe Loffredo, Luca Rinaldi, Christian Catalini, Klodian Gjeloshi, Gaetana Albanese, Anna Di Martino, Giovanni Docimo, Celestino Sardu, Raffaele Marfella, Ferdinando Carlo Sasso
Summary: Diabetic patients are often affected by coronary microvascular dysfunction, a complex condition whose pathogenesis involves hyperglycemia and insulin resistance. This dysfunction contributes to cardiac events and heart failure, and no specific treatment exists. However, certain antidiabetic drugs may have protective effects.
Review
Endocrinology & Metabolism
Marilia Silva Paulo, Noor Motea Abdo, Rita Bettencourt-Silva, Rami H. Al-Rifai
Summary: Gestational Diabetes Mellitus (GDM) prevalence in Europe is around 11%, with the highest prevalence in pregnant women in Eastern European countries reaching 31.5%. Findings highlight the need for vigilant public health awareness campaigns about the risk factors associated with developing GDM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
