Journal
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Volume 62, Issue -, Pages 50-58Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2018.08.009
Keywords
Genistein; Chitosan; Microcapsules; Inflammation; Oxidative Stress; Food
Funding
- Agenda Nacional de Promotion Cientifica y Tecnologica (FONCYT) [PICT 0117 2016, PICT 1068 2013]
- Consejo Nacional de lnvestigaciones Cientificas y Tecnologicas (CONICET)
- Secretaria de Ciencia y Tecnologia de la Universidad Nacional de Cordoba (SECYT-UNC)
- CONICET
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We used water-soluble Chitosan obtained by Maillard reaction with glucosamine to microencapsulate soy genistein (Ge) and preserve its biological activity for oral administration. Release of Ge was pH dependent with a super Case II mechanism at pH 1.2 and an anomalous transport with non-Fickian kinetics at pH 6.8. Microencapsulated Ge retained its antioxidant properties in vitro and its daily administration to mice attenuated clinical signs of acute colitis, limited inflammatory reaction and reduced oxidative stress and tissue injury as well. Remarkably, after feeding microencapsulated Ge the production of IL-10 in colonic tissue was restored to levels of untreated controls. According to statistical multivariate analysis, this cytokine was the parameter with the highest influence on the inflammatory/oxidative status. Microencapsulation of Ge with derivatized Chitosan becomes an interesting alternative to develop therapeutic approaches for oxidative inflammatory diseases; our findings suggest that the soy isoflavone could be incorporated into any functional food for application in intestinal inflammation. (C) 2018 Elsevier Inc. All rights reserved.
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