Article
Environmental Sciences
Wen Gu, Ruifang Pang, Yuanyuan Chen, Fuchang Deng, Miao Zhang, Zijin Shao, Shuyi Zhang, Huawei Duan, Song Tang
Summary: Antimony (Sb) exposure poses a significant threat to human health. This study aimed to explore the pathophysiological mechanisms of acute hepatotoxicity induced by Sb exposure using an in vivo model. The results showed that short-term Sb exposure induced hepatotoxicity, possibly through glycolipid metabolism disorder. These findings provide important insights into the health risks of Sb pollution.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Review
Environmental Sciences
Rakesh K. Sindhu, Prabhjot Kaur, Parneet Kaur, Harmanpreet Singh, Gaber El-Saber Batiha, Inderjeet Verma
Summary: Free radicals or oxidative stress play a fundamental role in various neurological diseases. Antioxidant therapy shows potential in preventing, delaying, or ameliorating these disorders. However, optimal antioxidant options may vary depending on individual diseases.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cell & Tissue Engineering
Taisia Rolova, Sarka Lehtonen, Gundars Goldsteins, Pinja Kettunen, Jari Koistinaho
Summary: This review summarizes recent studies using iPSC-derived glial models of neurodegenerative diseases, highlighting the differences between human and mouse glial cells and the important role of glial cells in neurodegenerative diseases.
Article
Acoustics
Xiaowei Huang, Lili Niu, Long Meng, Zhengrong Lin, Wei Zhou, Xiufang Liu, Jiqing Huang, Derek Abbott, Hairong Zheng
Summary: Autophagy, the process of cellular self-digestion, plays a crucial role in eliminating abnormal proteins in mammalian cells. Studies have shown that low-intensity pulsed ultrasound (LIPUS) stimulation can enhance neuronal autophagy, indicating its potential as a safe and effective tool for activating autophagy in neurons.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Biology
Ashley M. Fields, Kevin Welle, Elaine S. Ho, Clementina Mesaros, Martha Susiarjo
Summary: Fields et al. investigate the impact of vitamin B6 deficiency on islet beta-cell proliferation during pregnancy, using vitamin B6-deficient mice. They find that gestational vitamin B6 deficiency decreases serotonin levels in pancreatic islets and reduces beta-cell proliferation, showing that vitamin B6 deficiency regulates maternal glucose tolerance in a serotonin-dependent manner.
COMMUNICATIONS BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Agnieszka Jankowska-Kulawy, Joanna Klimaszewska-Lata, Sylwia Gul-Hinc, Anna Ronowska, Andrzej Szutowicz
Summary: The human brain is the most diverse in terms of morphology, metabolism, and functional structure. Neurons secrete various neurotransmitters and regulate their own activity through synaptic connections. Other types of cells in the brain, such as glial cells and neurons, also play a role in regulating metabolism and influencing neuronal viability and neurotransmitter functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Nicola Alessio, Carmela Belardo, Maria Consiglia Trotta, Salvatore Paino, Serena Boccella, Francesca Gargano, Gorizio Pieretti, Flavia Ricciardi, Ida Marabese, Livio Luongo, Umberto Galderisi, Michele D'Amico, Sabatino Maione, Francesca Guida
Summary: Vitamin D deficiency leads to significant changes in microglia cells, suggesting a potential role of these cells in sensory dysfunctions associated with hypovitaminosis D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Chaohua Tang, Shuang Li, Kai Zhang, Jing Li, Yunsheng Han, Qingyu Zhao, Xiaoqing Guo, Yuchang Qin, Jingdong Yin, Junmin Zhang
Summary: A study using a pig model investigates the effects of selenium deficiency on the heart. The study reveals that selenium deficiency leads to cardiac oxidative stress, disordered energy production, lipid metabolic vulnerabilities, and inflammation initiation pathways. These findings provide potential targets for treating cardiac diseases induced by redox imbalance.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Food Science & Technology
Aftab Ahmed, Muhammad Awais Saleem, Farhan Saeed, Muhammad Afzaal, Ali Imran, Sidra Akram, Muzzamal Hussain, Aqsa Khan, Entessar Al Jbawi
Summary: Calcium is crucial for maintaining a good quality of life, especially in older age. Its deficiency can lead to various metabolic disorders such as dental issues, cataracts, cognitive changes, and osteoporosis. These deficiencies are more prevalent in females due to their higher calcium turnover, especially during pregnancy and lactation. Vitamin D plays a central role in calcium metabolism. Recent scientific interventions have linked calcium deficiency to several metabolic disorders in females, including hypertension, obesity, premenstrual dysphoric disorder, polycystic ovary syndrome (PCOS), multiple sclerosis, and breast cancer.
FOOD SCIENCE & NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Hendrik Nieraad, Nina Pannwitz, Natasja de Bruin, Gerd Geisslinger, Uwe Till
Summary: Disturbances in one-carbon metabolism can lead to altered levels of homocysteine, potentially contributing to various pathologies. Animal studies suggest a significant impact of high homocysteine on cognitive performance. Despite controversy, preclinical evidence points to a causal link between high homocysteine and cognition-related disorders.
Review
Medicine, Research & Experimental
Milijana Janjusevic, Giulia Gagno, Alessandra Lucia Fluca, Laura Padoan, Antonio Paolo Beltrami, Gianfranco Sinagra, Rita Moretti, Aneta Aleksova
Summary: Vitamin D regulates approximately 3% of the human genome by binding VDR and has pleiotropic effects in various physiological processes. It may play important roles in neurodegenerative and cardiovascular disorders.
Article
Nutrition & Dietetics
Elena Schnabel, Stefan Koelker, Florian Gleich, Patrik Feyh, Friederike Hoerster, Dorothea Haas, Junmin Fang-Hoffmann, Marina Morath, Gwendolyn Gramer, Wulf Roeschinger, Sven F. Garbade, Georg F. Hoffmann, Juergen G. Okun, Ulrike Muetze
Summary: Newborn screening programs are effective measures of secondary prevention and have been extended. This study evaluated the screening for several disorders and identified disease variants that can be treated with cofactors.
Article
Neurosciences
Kathryn S. Hatch, Si Gao, Yizhou Ma, Alessandro Russo, Neda Jahanshad, Paul M. Thompson, Bhim M. Adhikari, Heather Bruce, Andrew Van Der Vaart, Aristeidis Sotiras, Mark D. Kvarta, Thomas E. Nichols, Lianne Schmaal, L. Elliot Hong, Peter Kochunov
Summary: Metabolic illnesses have detrimental effects on the brain and are common comorbidities in mental illnesses. This study examines the effects of metabolic illnesses on brain structure using MRI and identifies a correlation between the regional effects of metabolic illnesses and major depressive disorder.
HUMAN BRAIN MAPPING
(2023)
Editorial Material
Multidisciplinary Sciences
Megan W. Bourassa, Gilles Bergeron, Kenneth H. Brown
Summary: Severe thiamine (vitamin B-1) deficiency, previously thought to mainly affect infants in low-income communities in Southeast Asia and adult alcoholics, may also impact other populations and result in long-lasting neurocognitive consequences. The scope of disorders associated with thiamine deficiency is broader than previously believed.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
John S. Munday, Fernanda Castillo-Alcala, Patricia Jaros
Summary: This study found that some rats in an oral safety study developed uroliths and two of them also developed pyelonephritis, which was believed to be related to vitamin A deficiency. Analysis of the diet revealed lower-than-expected levels of vitamin A, which may have contributed to the development of uroliths. This study highlights the importance of using high-quality diets in safety studies in rats.
Article
Endocrinology & Metabolism
N. Ghenimi, S. Alfos, A. Redonnet, P. Higueret, V. Pallet, V. Enderlin
JOURNAL OF NEUROENDOCRINOLOGY
(2010)
Article
Environmental Sciences
Wasif Khan, Nazar Zaki, Amir Ahmad, Jiang Bian, Luqman Ali, Mohammad Mehedy Masud, Nadirah Ghenimi, Luai A. Ahmed
Summary: Low birth weight (LBW) infants are a serious global public health concern. Predicting infant weight before birth can help identify risk factors and reduce morbidity and mortality. Existing machine learning algorithms for LBW prediction have shown good performance but need improvement for use in real-world clinical settings. To address this, we propose transforming tabular data into a knowledge graph to capture structural information and improve classification performance. Our method achieved the best performance on a real-life dataset, with a 6% improvement in the area under the curve compared to using the original risk factors. We also highlight the clinical relevance of our proposed model for its adaptation in clinical settings.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Education, Scientific Disciplines
Muhammad Jawad Hashim, Romona Govender, Nadirah Ghenimi, Alexander Kieu, Moien A. B. Khan
Summary: This study assessed the effectiveness of a new teaching format called LecturePlus in medical education. The results showed that LecturePlus resulted in improved learning outcomes among medical students.
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Article
Nutrition & Dietetics
Moien A. B. Khan, Ahmed BaHammam, Asma Amanatullah, Khaled Obaideen, Teresa Arora, Habiba Ali, Leila Cheikh Ismail, Dana N. Abdelrahim, Mohammed Al-Houqani, Kholoud Allaham, Rand Abdalrazeq, Wahid Sharif Aloweiwi, Somayea Sultana Mim, Ammar Mektebi, Sohrab Amiri, Sahabi Kabir Sulaiman, Syed Fahad Javaid, Mohammad Delwer Hossain Hawlader, Fatimah Isma'il Tsiga-Ahmed, Iffat Elbarazi, Saskiyanto Manggabarani, Gamechu Atomsa Hunde, Sabrina Chelli, Mitra Sotoudeh, MoezAlIslam Ezzat Faris
Summary: Optimum sleep duration during Ramadan fasting is significantly associated with sufficient physical activity and consuming plant-based proteins. Smoking is significantly associated with greater sleep disturbance and lower sleep quality. Consuming vegetables, fruits, dates, and plant-based proteins is associated with better sleep quality. Infrequent consumption of delivered food and infrequent screen time are also associated with better sleep quality. The impact of dining at home versus dining out on the three sleep parameters is conflicting.
FRONTIERS IN NUTRITION
(2023)
Article
Neurosciences
Marianne Husson, Valerie Enderlin, Andre Delacourte, Nadirah Ghenimi, Serge Alfos, Veronique Pallet, Paul Higueret
NEUROBIOLOGY OF DISEASE
(2006)