Article
Biochemistry & Molecular Biology
Lucia A. Seale, Ashley N. Ogawa-Wong, Ligia M. Watanabe, Vedbar S. Khadka, Mark Menor, Daniel J. Torres, Bradley A. Carlson, Dolph L. Hatfield, Marla J. Berry
Summary: Selenoproteins are proteins containing the selenium-containing amino acid selenocysteine and play important roles in various tissues. Mouse models with targeted deletion of Trsp in brown adipocytes showed increased triglyceride accumulation in BAT and mild hypothyroidism in males, with no significant changes in adaptive thermogenesis markers under acute cold exposure. The loss of Trsp affected specific gene transcripts in BAT, suggesting a role in thyroid hormone dysfunction in brown adipocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Sanil Patel, Njeri Z. R. Sparman, Douglas Arneson, Alexandra Alvarsson, Luis C. Santos, Samuel J. J. Duesman, Alessia Centonze, Ephraim Hathaway, In Sook Ahn, Graciel Diamante, Ingrid Cely, Chung Hwan Cho, Noble Kumar Talari, Abha K. K. Rajbhandari, Leigh Goedeke, Peng Wang, Atul J. J. Butte, Cedric Blanpain, Karthickeyan Chella Krishnan, Aldons J. J. Lusis, Sarah A. A. Stanley, Xia Yang, Prashant Rajbhandari
Summary: The mammary gland ductal epithelial cells regulate cold-induced adipocyte UCP1 expression and control adipose thermogenesis through the secretion of mammokines. These findings suggest that sympathetic nerve-activated glandular epithelium plays a crucial role in adipocyte UCP1 expression and has implications for energy expenditure and subcutaneous fat loss.
Review
Cell Biology
Nikita Thakkar, Ye Bin Shin, Hoon-Ki Sung
Summary: The mammary gland is a complex organ that can be regulated by nutritional stimuli, affecting glandular function and disease development. Obesity increases the risk of breast cancer, while fasting or calorie restriction may have a negative impact on mammary tumor progression. However, the specific effects of fasting on the mammary microenvironment are still not well understood.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Georgia Colleluori, Jessica Perugini, Giorgio Barbatelli, Saverio Cinti
Summary: The mammary gland is an exocrine gland responsible for milk production in female mammals, composed mainly of epithelial cells and adipocytes. It displays highly plastic properties during different stages of the lactation cycle and requires close association with adipocytes for proper development. The role of adipocytes in mammary gland development and diseases like obesity and breast cancer deserves further investigation.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Agriculture, Dairy & Animal Science
Yongliang Fan, Long Jin, Zhiping He, Tiantian Wei, Tingting Luo, Jiaman Zhang, Can Liu, Changjiu Dai, A. Chao, Yan Liang, Xuan Tao, Xuebin Lv, Yiren Gu, Mingzhou Li
Summary: Studying the composition and developmental mechanisms in mammary gland is important for newborn health. The transcriptomic dataset of porcine mammary gland cells revealed distinct phenotypic and transcriptional signatures at different developmental stages, showing differentiation and proliferation processes of adipocytes and epithelial cells.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Ruiqi Liu, Huan Hu, Melissa McNeil, Jiuzhi Xu, Xueyun Bi, Pengbo Lou, Christian F. Guerrero-Juarez, Xing Dai, Maksim Plikus, Jianwei Shuai, Zhengquan Yu, Cong Lv
Summary: During pregnancy, Nfatc1 reporter-marked basal epithelial cells, which are dormant mammary stem/progenitor cells, play an important role in the development of mammary lobuloalveoli.
Article
Biochemistry & Molecular Biology
Genevra Kuziel, Brittney N. Moore, Grace P. Haugstad, Lisa M. Arendt
Summary: Obesity increases the risk of breast cancer, and this is partly due to chronic inflammation and fibrosis in the mammary gland. In this study, the researchers used a high-fat diet model and genetically modified mice to investigate the role of immune cells in obesity-induced fibrosis. They found that obesity increased the recruitment of a specific population of cells, called fibrocytes, which contributed to the formation of myofibroblasts and fibrosis in the mammary gland. Transplanting myeloid progenitor cells, which give rise to fibrocytes, into obese mice further increased myofibroblast formation. These findings suggest that obesity enhances the recruitment of fibrocytes and promotes fibrosis in the mammary gland.
Review
Cell Biology
Amita G. Ghadge, Pallave Dasari, Jennifer Stone, Erik W. Thompson, Rebecca L. Robker, Wendy Ingman
Summary: The association between mammographic density and breast cancer risk has been well-established, with puberty identified as a critical time for breast development and adult mammographic density. The molecular and cellular mechanisms underlying the development of high mammographic density are still not fully understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kiko Hasegawa, Nobuyuki Takenaka, Kenya Tanida, Man Piu Chan, Mizuki Sakata, Atsu Aiba, Takaya Satoh
Summary: Rac1 is involved in insulin-dependent glucose uptake and lipogenesis in white adipocytes, and its deficiency may result in reduced insulin responsiveness and atrophy of white adipose tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Marie Rebeaud, Caroline Bouche, Stephanie Dauvillier, Camille Attane, Carlo Arellano, Charlotte Vaysse, Frederique Fallone, Catherine Muller
Summary: Obesity is a negative prognostic factor for breast cancer, but the underlying biological mechanisms are largely unknown. This study suggests that altered transfer of free fatty acids (FFA) between adipocytes and tumor cells might contribute to tumor progression in obese conditions. A 3D model using a fibrin matrix is introduced as an alternative for studying the interaction between mammary adipocytes (M-Ads) and cancer cells, showing FFA transfer and its amplification by obesity.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jiang Nan-Nan, Liu Jian-Xin, Shi Heng-Bo
Summary: The mammary gland is crucial for providing sufficient nutrients to the offspring through milk secretion. Its development through different stages is important for lactation and offspring survival.
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Ping-Chih Ho, Jessica Dauz Bihuniak, Andrew N. Macintyre, Matthew Staron, Xiaojing Liu, Robert Amezquita, Yao-Chen Tsui, Guoliang Cui, Goran Micevic, Jose C. Perales, Steven H. Kleinstein, E. Dale Abel, Karl L. Insogna, Stefan Feske, Jason W. Locasale, Marcus W. Bosenberg, Jeffrey C. Rathmell, Susan M. Kaech
Article
Biochemistry & Molecular Biology
Edgardo Rodriguez-Carballo, Beatriz Gamez, Andres Mendez-Lucas, Manuela Sanchez-Freutrie, Antonio Zorzano, Ramon Bartrons, Soledad Alcantara, Jose Carlos Perales, Francesc Ventura
Article
Biochemistry & Molecular Biology
Jana Semakova, Petra Hyrossova, Andres Mendez-Lucas, Ernest Cutz, Jordi Bermudez, Shawn Burgess, Soledad Alcantara, Jose C. Perales
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2017)
Correction
Multidisciplinary Sciences
Paula Lopez-Serra, Miguel Marcilla, Alberto Villanueva, Antonio Ramos-Fernandez, Anna Palau, Lucia Leal, Jessica E. Wahi, Fernando Setien-Baranda, Karolina Szczesna, Catia Moutinho, Anna Martinez-Cardus, Holger Heyn, Juan Sandoval, Sara Puertas, August Vidal, Xavier Sanjuan, Eva Martinez-Balibrea, Francesc Vinals, Jose C. Perales, Jesper B. Bramsem, Torben F. Orntoft, Claus L. Andersen, Josep Tabernero, Ultan McDermott, Matthew B. Boxer, Matthew G. Vander Heiden, Juan Pablo Albar, Manel Esteller
NATURE COMMUNICATIONS
(2016)
Article
Neurosciences
Zaida Alvarez, Petra Hyrossova, Jose Carlos Perales, Soledad Alcantara
Article
Multidisciplinary Sciences
Jitka Soukupova, Andrea Malfettone, Petra Hyrossova, Maria-Isabel Hernandez-Alvarez, Irene Penuelas-Haro, Esther Bertran, Alexandra Junza, Jordi Capellades, Gianluigi Giannelli, Oscar Yanes, Antonio Zorzano, Jose Carlos Perales, Isabel Fabregat
SCIENTIFIC REPORTS
(2017)
Article
Gastroenterology & Hepatology
Elena Ferrer-Picon, Isabella Dotti, Ana M. Corraliza, Aida Mayorgas, Miriam Esteller, Jose Carlos Perales, Elena Ricart, Maria C. Masamunt, Anna Carrasco, Eva Tristan, Maria Esteve, Azucena Salas
INFLAMMATORY BOWEL DISEASES
(2020)
Article
Medicine, Research & Experimental
Marc Arago, Juan Moreno-Felici, Sonia Abas, Sergio Rodriguez-Arevalo, Petra Hyrossova, Agnes Figueras, Francesc Vinals, Belen Perez, Maria Loza, Jose Brea, Pedro Latorre, Jose A. Carrodeguas, Pablo M. Garcia-Roves, Carlos Galdeano, Tiziana Ginex, Francisco J. Luque, Carmen Escolano, Jose C. Perales
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Cell Biology
Juan Moreno-Felici, Petra Hyrossova, Marc Arago, Sergio Rodriguez-Arevalo, Pablo M. Garcia-Roves, Carmen Escolano, Jose C. Perales
Article
Medicine, Research & Experimental
Alvaro Lahiguera, Petra Hyrossova, Agnes Figueras, Diana Garzon, Roger Moreno, Vanessa Soto-Cerrato, Iain McNeish, Violeta Serra, Conxi Lazaro, Pilar Barretina, Joan Brunet, Javier Menendez, Xavier Matias-Guiu, August Vidal, Alberto Villanueva, Barbie Taylor-Harding, Hisashi Tanaka, Sandra Orsulic, Alexandra Junza, Oscar Yanes, Cristina Munoz-Pinedo, Luis Palomero, Miquel Angel Pujana, Jose Carlos Perales, Francesc Vinals
EMBO MOLECULAR MEDICINE
(2020)
Article
Oncology
Petra Hyrossova, Marc Arago, Juan Moreno-Felici, Xiarong Fu, Andres Mendez-Lucas, Pablo M. Garcia-Roves, Shawn Burgess, Agnes Figueras, Francesc Vinals, Jose C. Perales
Summary: PEPCK-M is implicated in the regulation of tumor growth phases and proteostasis mechanisms, with its activity affecting cell anabolism and survival. Inhibition or silencing of PEPCK-M under abundant glucose conditions leads to TCA cycle blockade and increased ROS, while downregulation of PKC-zeta tumor suppressor in glucose-limiting conditions enhances cell survival. The interplay between PEPCK-M and PKC-zeta highlights their co-regulation in glucose-deficient environments.
CANCER & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Norma Dahdah, Alba Gonzalez-Franquesa, Sara Samino, Pau Gama-Perez, Laura Herrero, Jose Carlos Perales, Oscar Yanes, Maria Del Mar Malagon, Pablo Miguel Garcia-Roves
Summary: The study found that different tissues have specific lipid profiles regulated by caloric intake and dietary composition. Under different dietary and lifestyle conditions, the lipidome of different tissues showed distinct patterns of changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Carmen Herranz, Francesca Mateo, Alexandra Baiges, Gorka Ruiz de Garibay, Alexandra Junza, Simon R. Johnson, Suzanne Miller, Nadia Garcia, Jordi Capellades, Antonio Gomez, August Vidal, Luis Palomero, Roderic Espin, Ana Extremera, Eline Blommaert, Eva Revilla-Lopez, Berta Saez, Susana Gomez-Olles, Julio Ancochea, Claudia Valenzuela, Tamara Alonso, Piedad Ussetti, Rosalia Laporta, Antoni Xaubet, Jose A. Rodriguez-Portal, Ana Montes-Worboys, Carlos Machahua, Jaume Bordas, Javier A. Menendez, Josep M. Cruzado, Roser Guiteras, Christophe Bontoux, Concettina La Motta, Aleix Noguera-Castells, Mario Mancino, Enrique Lastra, Raul Rigo-Bonnin, Jose C. Perales, Francesc Vinals, Alvaro Lahiguera, Xiaohu Zhang, Daniel Cuadras, Coline H. M. van Moorsel, Joanne J. van der Vis, Marian J. R. Quanjel, Harilaos Filippakis, Razq Hakem, Chiara Gorrini, Marc Ferrer, Aslihan Ugun-Klusek, Ellen Billett, Elzbieta Radzikowska, Alvaro Casanova, Maria Molina-Molina, Antonio Roman, Oscar Yanes, Miquel A. Pujana
Summary: Inhibition of mTOR is the standard treatment for LAM, but its efficacy varies and some patients still experience declining lung function. The heterogeneous symptoms and lack of non-invasive tests make diagnosis and monitoring of LAM challenging. Monoamine-derived biomarkers may offer preclinical evidence for novel therapeutic approaches.
EMBO MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Petra Hyrossova, Marc Arago, Cristina Munoz-Pinedo, Francesc Vinals, Pablo M. Garcia-Roves, Carmen Escolano, Andres Mendez-Lucas, Jose C. Perales
Summary: Under glucose restriction, cells undergo entosis, a cannibalistic process, to withstand metabolic stress. Reduced protein glycosylation and the involvement of PEPCK-M in this survival program play crucial roles. These findings have implications for tumor metabolism and treatment strategies.
CELL DEATH & DISEASE
(2022)
Meeting Abstract
Cell & Tissue Engineering
Z. Alvarez, O. Castano, M. A. Mateos-Timoneda, J. C. Perales, P. Hyrossova, S. Alcantara, E. Engel
TISSUE ENGINEERING PART A
(2015)