Article
Nutrition & Dietetics
Xiong-Fei Pan, Jae Jeong Yang, Xiao-Ou Shu, Steven C. Moore, Nicholette D. Palmer, Marta Guasch-Ferre, David M. Herrington, Sei Harada, Heather Eliassen, Thomas J. Wang, Robert E. Gerszten, Demetrius Albanes, Ioanna Tzoulaki, Ibrahim Karaman, Paul Elliott, Huilian Zhu, Lynne E. Wagenknecht, Wei Zheng, Hui Cai, Qiuyin Cai, Charles E. Matthews, Cristina Menni, Katie A. Meyer, Loren P. Lipworth, Jennifer Ose, Myriam Fornage, Cornelia M. Ulrich, Danxia Yu
Summary: The study showed that circulating choline, carnitine, and DMG were associated with unfavorable cardiometabolic risk profiles, while circulating betaine was associated with a favorable cardiometabolic risk profile.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Xiaoying Liu, Bu B. Yeap, Kaye E. Brock, Itamar Levinger, Jonathan Golledge, Leon Flicker, Tara C. Brennan-Speranza
Summary: The study found that lower levels of serum ucOC and cOC, as well as %cOC, were associated with less favorable metabolic parameters and a higher risk of MetS. Conversely, a lower proportion of ucOC was linked to better metabolic parameters and reduced risk of MetS. Further research is needed to determine if ucOC and cOC are suitable biomarkers for cardiometabolic risk in men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Xiaoying Liu, Bu B. Yeap, Kaye E. Brock, Itamar Levinger, Jonathan Golledge, Leon Flicker, Tara C. Brennan-Speranza
Summary: The study demonstrated that lower levels of serum ucOC or cOC were associated with less favorable metabolic parameters and a higher risk of MetS, while a lower proportion of ucOC was associated with better metabolic parameters and lower MetS risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Kalhari Bandara Goonewardene, Naama Karu, Khawaja Ashfaque Ahmed, Shelly Popowich, Betty Chow-Lockerbie, Lisanework E. Ayalew, Ruwani Karunarathna, Thushari Gunawardana, Mengying Liu, Suresh K. Tikoo, Marianna Foldvari, Philip Willson, Rupasri Mandal, David S. Wishart, Susantha Gomis
Summary: Synthetic CpG-ODNs can enhance antimicrobial immunity in neonatal chicks by altering metabolic pathways and supporting immune cell function through changes in nutrient uptake and cell proliferation triggered by the innate immune response. The study highlights the potential of CpG-ODNs to modulate immunometabolic interactions in establishing immunity against pathogens in chicks.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Anthea Van Parys, Maria Sandvik Braekke, Therese Karlsson, Kathrine J. Vinknes, Grethe S. Tell, Teresa R. Haugsgjerd, Per Magne Ueland, Jannike Oyen, Jutta Dierkes, Ottar Nygard, Vegard Lysne
Summary: This study investigated the dietary intake of choline and its association with one-carbon metabolites and lipids in community-dwelling adults in Norway. The findings suggest that choline intake is correlated with the concentration of most metabolites involved in one-carbon and lipid metabolism.
JOURNAL OF NUTRITION
(2022)
Article
Endocrinology & Metabolism
Mohammad Sadegh Pour Abbasi, Ayda Zahiri Tousi, Yalda Yazdani, Sahar Vahdat, Farshad Gharebakhshi, Negin Nikrad, Ali Manzouri, Abnoos Mokhtari Ardekani, Faria Jafarzadeh
Summary: This study aimed to evaluate dietary choline and betaine intakes in obese individuals and their association with serum lipids, blood pressure, and glycemic markers. The results showed that higher intakes of choline and betaine were associated with lower blood pressure and LDL concentrations in obese individuals.
BMC ENDOCRINE DISORDERS
(2023)
Article
Nutrition & Dietetics
Monika A. Mlodzik-Czyzewska, Anna M. Malinowska, Artur Szwengiel, Agata Chmurzynska
Summary: The study examined the associations between plasma levels of trimethylamine N-oxide (TMAO), choline, and betaine with anthropometric measurements. Higher plasma choline was associated with higher BMI, body weight, body fat mass, and waist circumference, while higher choline intake was associated with lower body fat mass and waist circumference. Plasma betaine was found to be associated with lower BMI and body weight in men only. These associations appear to be sex-specific.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Medical Laboratory Technology
Ichiro Wakabayashi
Summary: This study found an association between polycythemia and cardiometabolic risk factors, including visceral obesity, hypertension, dyslipidemia, diabetes, and metabolic syndrome, in the general population. This association was independent of smoking.
CLINICA CHIMICA ACTA
(2022)
Article
Public, Environmental & Occupational Health
Yang Zhao, Puhong Zhang, John Tayu Lee, Brian Oldenburg, Alexander van Heusden, Tilahun Nigatu Haregu, Haipeng Wang
Summary: Metabolic multimorbidity is associated with increased healthcare service utilization, higher outpatient expenditure, and difficulties in activities of daily living among Chinese adults. China's healthcare systems should consider new models to manage metabolic multimorbidity effectively.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Endocrinology & Metabolism
Monika A. Mlodzik-Czyzewska, Artur Szwengiel, Anna M. Malinowska, Agata Chmurzynska
Summary: The study compared biomarkers of one-carbon metabolism, lipid metabolism, and fatty liver in individuals with normal and increased body weight. Results showed differences in associations between OCM markers, fatty liver indices, and blood lipids among subjects with normal and excessive body weight, with higher choline and L-carnitine levels observed in overweight/obese participants.
ANNALS OF NUTRITION AND METABOLISM
(2021)
Article
Nutrition & Dietetics
Carolina Molto-Puigmarti, Rima Obeid, Monique Mommers, Simone J. P. M. Eussen, Carel Thijs
Summary: Adequate choline and betaine levels during pregnancy are essential for fetal growth and development. Maternal plasma choline and betaine levels in the third trimester were found to be positively associated with childhood anthropometric measures, with some associations persisting up to 8 years of age, particularly in boys. Further studies are needed to explore the validity of maternal plasma choline and betaine concentrations as markers of maternal intake and fetal transfer.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Multidisciplinary Sciences
Xuejuan Xu, Nuo Xu, Ying Wang, Jinsong Chen, Lushi Chen, Shengjian Zhang, Jingxian Chen, Hongwen Deng, Xiaojun Luan, Jie Shen
Summary: The study aimed to investigate the longitudinal associations between bone mineral densities (BMDs) and appendicular skeletal muscle (ASM) mass in Chinese middle-aged and elderly men. Three different indicators were used to define ASM mass, and a linear relationship was found between BMDs and ASM mass. The results showed that SMI was more sensitive in screening for low lean mass, and skull BMD was negatively associated with ASM mass while BMDs throughout the rest of the body were positively correlated with ASM mass.
Article
Geriatrics & Gerontology
Priya Palta, Brady Rippon, Mouna Tahmi, Greysi Sherwood, Luisa Soto, Fernando Ceballos, Krystal Laing, Hengda He, Christiane Reitz, Qolamreza Razlighi, Jeanne A. Teresi, Herman Moreno, Adam M. Brickman, Jose A. Luchsinger
Summary: MetS was not associated with AD neuropathology in late middle age, and among MetS components, elevated glucose was related to lower Aβ burden while glucose and triglycerides were related to smaller cortical thickness.
NEUROBIOLOGY OF AGING
(2021)
Article
Biochemistry & Molecular Biology
Rong-zhu Huang, Jing-fei Ma, Si Chen, Yu-ming Chen, Ai-ping Fang, Xiao-ting Lu, Zi-hui Huang, Hui-lian Zhu, Bi-xia Huang
Summary: The impact of betaine on hypertension development and the association between serum betaine and blood pressure were investigated using data from a community-based study in China. The results showed that higher levels of serum betaine were associated with lower systolic blood pressure, diastolic blood pressure, and pulse pressure. Additionally, a nonlinear association was found between serum betaine and the risk of hypertension, with higher betaine levels linked to lower hypertension risk in individuals with relatively low betaine concentrations.
Article
Endocrinology & Metabolism
Ruixin He, Ruizhi Zheng, Jie Li, Qiuyu Cao, Tianzhichao Hou, Zhiyun Zhao, Min Xu, Yuhong Chen, Jieli Lu, Tiange Wang, Yu Xu, Yufang Bi, Weiqing Wang, Mian Li, Yan Liu, Guang Ning
Summary: The study found associations between diabetes metabolic components and cognitive function in key domains, particularly among non-obese adults. Metformin use was positively associated with cognition.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Teresa R. Haugsgjerd, Grace M. Egeland, Ottar K. Nygard, Jannicke Igland, Gerhard Sulo, Vegard Lysne, Kathrine J. Vinknes, Kjetil Bjornevik, Grethe S. Tell
Summary: The study suggests that increasing intake of high-glycemic carbohydrates and reducing saturated fatty acids, specifically those from cheese, are associated with higher risk of coronary heart disease. Substituting carbohydrates with total fat, but not saturated fatty acids, is significantly linked to lower risk of CHD.
PUBLIC HEALTH NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Sigrun Halvorsen, Soren P. Johnsen, Morten Madsen, Marie Linder, Gerhard Sulo, Waleed Ghanima, Gunnar Gislason, Stefan H. Hohnloser, Aaron Jenkins, Faris Al-Khalili, Grethe S. Tell, Vera Ehrenstein
Summary: This study evaluated the risk of stroke/systemic embolism and bleeding in anticoagulation-naive patients with atrial fibrillation using non-vitamin K antagonist oral anticoagulants compared to warfarin. The results showed that patients initiating dabigatran, apixaban, and rivaroxaban had similar rates of stroke/systemic embolism to patients initiating warfarin. Rates of major bleeding were lower with apixaban and dabigatran, and higher with rivaroxaban, compared to warfarin.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2022)
Article
Nutrition & Dietetics
Anthea Van Parys, Maria Sandvik Braekke, Therese Karlsson, Kathrine J. Vinknes, Grethe S. Tell, Teresa R. Haugsgjerd, Per Magne Ueland, Jannike Oyen, Jutta Dierkes, Ottar Nygard, Vegard Lysne
Summary: This study investigated the dietary intake of choline and its association with one-carbon metabolites and lipids in community-dwelling adults in Norway. The findings suggest that choline intake is correlated with the concentration of most metabolites involved in one-carbon and lipid metabolism.
JOURNAL OF NUTRITION
(2022)
Letter
Cardiac & Cardiovascular Systems
Ester Kringeland, Grethe S. Tell, Helga Midtbo, Jannicke Igland, Teresa R. Haugsgjerd, Eva Gerdts
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Maryam Saeed, Lars C. Stene, Anna Reisaeter, Trond G. Jenssen, Grethe S. Tell, German Tapia, Geir Joner, Torild Skrivarhaug
Summary: This study investigated the incidence of end-stage renal disease (ESRD) in patients with childhood-onset type 1 diabetes in Norway and examined the association of education and coronary heart disease (CHD) with ESRD. The results showed a 35-fold higher rate of ESRD in the diabetes patients compared to controls, higher education was associated with a lower risk of ESRD, and diagnosed CHD was associated with a 14-fold increased rate of ESRD.
ANNALS OF EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Maryam Saeed, Lars C. Stene, Inger Ariansen, Grethe S. Tell, German Tapia, Geir Joner, Torild Skrivarhaug
Summary: This study aimed to investigate the incidence and risk factors of acute myocardial infarction (AMI) in patients with type 1 diabetes. The findings showed a nine-fold increased risk of AMI in subjects with type 1 diabetes compared to controls, and a three-fold higher risk in individuals with lower education. These results highlight the importance of prevention of cardiovascular disease and personalized diabetes education based on patients' educational background.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Rheumatology
C. L. Alsing, T. W. Nystad, J. Igland, C. G. Gjesdal, H. Midtbo, G. S. Tell, B. T. Fevang
Summary: Incidence rates and excess events of AMI and IHD in RA patients declined from 1972 to 2017. There were no excess AMI or IHD events in RA patients diagnosed after 1998 compared with the general population.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2022)
Article
Medicine, General & Internal
Kristin Holvik, Vidar Hjellvik, Oystein Karlstad, Nina Gunnes, Mari Hoff, Grethe S. Tell, Haakon E. Meyer
Summary: The association between the prescription-based Rx-Risk Comorbidity Index and mortality by history of hip fracture was studied in a prospective study using nationwide registry data in Norway. It was found that history of hip fracture and comorbidity assessed by Rx-Risk are independent risk factors for mortality in the community-dwelling older population in Norway, with comorbidity explaining a quarter of the excess mortality in persons with a history of hip fracture.
Article
Medicine, General & Internal
Hilde Kristin Refvik Riise, Jannicke Igland, Gerhard Sulo, Marjolein Memelink Iversen, Marit Graue, Anne Eskild, Grethe Seppola Tell, Anne Kjersti Daltveit
Summary: Women with pre-eclampsia have an increased risk of cardiovascular disease (HR 2.16), especially when accompanied by a large for gestational age offspring (HR 2.57). Diabetes during pregnancy also increases the risk of CVD, but it is not affected by offspring weight.
Article
Public, Environmental & Occupational Health
Emilie R. Hegelund, Lars J. Kjerpeseth, Laust H. Mortensen, Jannicke Igland, Trygve Berge, Mariam Anjum, Grethe S. Tell, Inger Ariansen
Summary: The study found that the cumulative prevalence of atrial fibrillation in the Danish population is around 3.0%, but the incidence has decreased since 2015. Methodological choices, particularly regarding the strictness of case definition and the length of the washout period, substantially influence the reported estimates.
CLINICAL EPIDEMIOLOGY
(2022)
Article
Peripheral Vascular Disease
Ester Kringeland, Eva Gerdts, Arve Ulvik, Grethe S. Tell, Jannicke Igland, Teresa R. Haugsgjerd, Per Magne Ueland, Helga Midtbo
Summary: The aim of this study was to examine the associations between sex-specific circulating markers of inflammation and blood pressure in midlife. The results showed that higher levels of hs-CRP were significantly associated with higher systolic and diastolic blood pressure in women, but not in men. Additionally, higher levels of neopterin were associated with higher diastolic blood pressure in women, and higher PAr index was associated with higher blood pressure in both men and women.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Medicine, General & Internal
Indu Dhar, Vegard Lysne, Arve Ulvik, Gard F. T. Svingen, Eva R. Pedersen, Espen O. Bjornestad, Thomas Olsen, Robert Borsholm, Johnny Laupsa-Borge, Per M. Ueland, Grethe S. Tell, Rolf K. Berge, Gunnar Mellgren, Kaare H. Bonaa, Ottar K. Nygard
Summary: In this study, elevated plasma MMA levels were found to be associated with increased risk of acute myocardial infarction (AMI) and mortality in patients with suspected or verified coronary heart disease (CHD). This finding provides new insights for the prevention and treatment of cardiovascular diseases.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Genetics & Heredity
Anders Hovland, Liv J. Mundal, Marit B. Veierod, Kirsten B. Holven, Martin Proven Bogsrud, Grethe S. Tell, Trond P. Leren, Kjetil Retterstol
Summary: Familial hypercholesterolemia (FH) patients have a significantly increased risk of a broad range of atherosclerotic cardiovascular diseases (ASCVD), particularly acute myocardial infarction (AMI) and aortic valve stenosis. However, FH patients do not seem to have an increased risk of ischemic stroke.
FRONTIERS IN GENETICS
(2022)
Article
Peripheral Vascular Disease
Annabel Eide Ohldieck, Ester Kringeland, Helga Midtbo, Grethe S. Tell, Eva Gerdts
Summary: This study aimed to identify modifiable risk factors in early midlife associated with incident hypertension 26 years later in women and men. The results showed that high-normal blood pressure in midlife was a significantly stronger risk factor for the development of hypertension in women than in men during follow-up, independent of body mass index.
Meeting Abstract
Cardiac & Cardiovascular Systems
A. E. Ohldieck, E. Kringeland, H. Midtbo, G. S. Tell, E. Gerdts
EUROPEAN HEART JOURNAL
(2022)