Article
Food Science & Technology
Neha Baliyan, Antim Kumar Maurya, Anil Kumar, Vijai Kant Agnihotri, Rakshak Kumar
Summary: This study isolated probiotic strains from raw cow milk of the Lahaul valley capable of producing cis-9, trans-11 CLA isomer, and exhibiting antioxidant and food formulation abilities. Genome sequencing revealed the presence of antibiotic-resistance and virulence genes in Enterococcus faecalis LJM:05. The strain Latilactobacillus curvatus LGM:16 was used to develop curdled milk with superior probiotic features, antioxidant activity, and CLA-producing ability.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Saori Hata, Kazunori Kikuchi, Kuniyuki Kano, Haruka Saito, Yuriko Sobu, Shoichi Kinoshita, Takashi Saito, Takaomi C. Saido, Yoshitake Sano, Hidenori Taru, Junken Aoki, Hiroto Komano, Taisuke Tomita, Shunji Natori, Toshiharu Suzuki
Summary: The study shows that c9,t11 CLA can suppress the generation of neurotoxic A beta protein in mouse neurons by affecting the localization of BACE1 and APP in different intracellular compartments.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Chunlei Yang, Binna Zhu, Shijie Ye, Zhengwei Fu, Jinjun Li
Summary: The study found that trans-10,cis-12-CLA had better anti-inflammatory effects compared to cis-9,trans-11-CLA by downregulating genes related to inflammation, cell proliferation, and migration in RECs. Additionally, trans-10,cis-12-CLA significantly suppressed biological signals in response to LPS in RECs. Furthermore, pretreatment with trans-10,cis-12-CLA reduced the expression of lipogenic genes and biosynthesis of unsaturated fatty acids in RECs, indicating distinct isomer differences in regulating inflammatory responses and adipocytokine signaling.
Article
Agriculture, Multidisciplinary
Chen Duan, Cong Yin, Zewei Ma, Fan Li, Fenglin Zhang, Qiang Yang, Mingfa Lin, Shengchun Feng, Canjun Zhu, Lina Wang, Xiaotong Zhu, Ping Gao, Qingyan Jiang, Gang Shu, Songbo Wang
Summary: The study found that the t10, c12-CLA isomer enhances exercise endurance and promotes the formation of oxidative skeletal muscle fiber type in mice through increased TLR4 signaling.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Multidisciplinary
Baixi Zhang, Lijuan Ni, Xiaoshu Tang, Xuemei Chen, Bo Hu
Summary: This study achieved a high yield of t10, c12-CLA through genetic modification and reduced its degradation rate. The highest t10, c12-CLA yield reported to date was obtained in a bioreactor using low-cost carbon sources.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Yu Fujita, Kuniyuki Kano, Shigenobu Kishino, Toshihiro Nagao, Xuefeng Shen, Chiharu Sato, Hatsune Hatakeyama, Yume Ota, Sho Niibori, Ayako Nomura, Kota Kikuchi, Wataru Yasuno, Sho Takatori, Kazunori Kikuchi, Yoshitake Sano, Taisuke Tomita, Toshiharu Suzuki, Junken Aoki, Kun Zou, Shunji Natori, Hiroto Komano
Summary: Dietary intake of c-9, t-11-CLA showed positive effects on an Alzheimer's disease mouse model, including decreasing amyloid-beta levels and suppressing inflammation.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Caglar Berkel, Ercan Cacan
Summary: Certain dietary supplements and caloric-restricted diets can promote weight loss by increasing CNDP2 expression in adipose tissue, leading to the synthesis of Lac-Phe that suppresses feeding and obesity. The effect of t10-c12 conjugated linoleic acid on CNDP2 expression may be isomer-specific. Understanding the regulation of CNDP2 expression in diverse tissues is important for the treatment of obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Anima Srivastava, Sachin Kumar, Ashish Tyagi, Neeraj Shrivastava, Ajit Varma, Amrish Kumar Tyagi
Summary: This study identified a rumen-origin B. fibrisolvens strain that can produce high levels of c9, t11 CLA, and demonstrated its potential as a probiotic supplement for animals to maintain a steady supply of natural c9, t11 CLA in the host.
CURRENT RESEARCH IN BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huan-Hua Xu, Liang Yang, Ming-Xia Tang, An-Ping Ye, Bo-Dan Tu, Zhen-Hong Jiang, Jian-Feng Yi
Summary: This study found that the degree of isomerization of lobeline has a significant impact on its respiratory excitatory effects. The respiratory excitatory effect was significantly reduced with the administration of trans-lobeline injections compared to cis-lobeline injections. The study also discovered that isomerization is a one-way reaction catalyzed by temperature, with pH as the key factor. Lobeline, as a nonselective antagonist with high affinity for nicotinic acetylcholine receptors, has shown potential in the treatment of addiction and nervous system disorders.
Article
Cell Biology
Danielle Storino de Freitas, Guilherme Antonio de Gouvea Lopes, Barbara Rodrigues Nascimento, Breno Augusto Magalhaes, Ana Paula Madureira, Paulo Henrique Almeida Campos-Junior
Summary: This study evaluated the effects of CLA gastric administration on reproductive parameters and ovarian morphophysiology in mice, showing no side effects and a potential enhancement of transgenerational fertility.
Article
Biochemistry & Molecular Biology
E. D. Da Silva, E. C. Sandri, L. A. Fernandes, P. C. Carraro, D. E. De Oliveira
Summary: This study investigated the expression of genes responsible for cell cycle regulation and apoptosis in different types of mammary tumors when treated with CLA isomers cis-9, trans-11 and trans-10, cis-12. The results showed that cis-9, trans-11 stimulated apoptotic genes in mammary tubulopapillary carcinoma but had the opposite effect in anaplastic carcinoma. On the other hand, trans-10, cis-12 stimulated cell cycle progression genes and may have antiapoptotic effects, especially in anaplastic carcinoma.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Yu Rao, Shi-Li Li, Mei-Juan Li, Bao-Zhu Wang, Yang-Yang Wang, Lu-Wen Liang, Shuai Yu, Zong-Ping Liu, Sheng Cui, Ke-Mian Gou
Summary: A transgenic mouse producing t10c12-CLA was generated by inserting the Pai expression cassette into the Rosa26 locus. Male offspring were used to investigate the long-term effects of t10c12-CLA. The study found that t10c12-CLA reduced plasma triglycerides levels, increased serum fibroblast growth factor 21, decreased white fat and increased brown fat, with enhanced thermogenesis in brown adipose tissues.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
P. G. Toral, G. Hervas, P. Frutos
Summary: The research compared the Delta(9)-desaturation in sheep and goats fed different diets and found that lipid supplementation did not have a significant effect on the endogenous synthesis of milk RA. Inherent interspecies differences were found in mammary lipogenesis, with sheep showing greater SCD activity compared to goats despite similar mRNA abundance of SCD1. Additionally, caprines had a higher transfer efficiency of isotopic tracer to milk compared to ovines, suggesting a greater efficiency in mammary fatty acid uptake from plasma in caprine.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
A. R. Bayat, A. Razzaghi, M. Sari, P. Kairenius, A. Troescher, E. Trevisi, J. Vilkki
Summary: The effects of milk fat depression induced by supplementing conjugated linoleic acid (CLA) or feeding a higher starch and oil containing diet (HSO) on metabolic changes in dairy cows after calving were studied. The results showed that HSO feeding decreased milk fat secretion and led to increased inflammatory and oxidative stress, but improved energy balance in early lactation.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Brenda Lee Simas Porto, Isaura Daniele Leite Faria, Jessica Cordeiro Queiroz de Souza, Olivia Brito de Oliveira Moreira, Marco Antonio Sundfeld da Gama, Marcone Augusto Leal de Oliveira
Summary: This study discusses an alternative method for the analysis of conjugated linoleic acid (CLA) in ruminant milk using fast gas chromatography (GC). The fatty acid methyl ester mixture obtained by alkaline catalysis was separated and quantified using a GC equipped with an ionic liquid SLB-IL111 chromatographic column. The results showed no significant differences compared to the recommended method, making the proposed method suitable for high-throughput analysis of numerous samples.
Article
Nutrition & Dietetics
Marta Periz, Maria J. Rodriguez-Lagunas, Francisco J. Perez-Cano, Ivan Best, Santiago Pastor-Soplin, Margarida Castell, Malen Massot-Cladera
Summary: Different cocoa populations showed protective effects in a rat model of allergic asthma by reducing IgE synthesis and alleviating allergic responses. Diets containing different Peruvian cocoa populations were found to decrease specific IgG1 levels, reduce granulocyte increase in BALF, prevent leukocyte infiltration in the trachea and nasal cavity, and lower IgA levels in fecal and BALF samples, suggesting their potential in preventing allergic asthma.
Article
Nutrition & Dietetics
Carla Morales-Ferre, Ignasi Azagra-Boronat, Malen Massot-Cladera, Sebastian Tims, Karen Knipping, Johan Garssen, Jan Knol, Angels Franch, Margarida Castell, Francisco J. Perez-Cano, Maria J. Rodriguez-Lagunas
Summary: In this study, the effects of a Lactofidus(TM), short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection in a rat model for early life diarrhea were analyzed. The supplementations significantly reduced the incidence and severity of diarrhea and showed various effects on immunoglobulin profiles, gut microbiota, and intestinal gene expression.
Article
Cell Biology
Malen Massot-Cladera, Maria del Mar Rigo-Adrover, Laura Herrero, Angels Franch, Margarida Castell, Jelena Vulevic, Francisco J. Perez-Cano, Maria J. Rodriguez Lagunas
Summary: B-GOS supplementation can reduce the incidence and severity of rotavirus-associated diarrhea and influence the immune response against rotavirus infections.
Article
Food Science & Technology
Ana Arias-Borrego, Francisco J. Soto Cruz, Marta Selma-Royo, Christine Bauerl, Elia Garcia Verdevio, Francisco J. Perez-Cano, Carles Lerin, Ines Velasco Lopez, Cecilia Martinez-Costa, M. Carmen Collado, Tamara Garcia-Barrera
Summary: This study investigates the impact of maternal SARS-CoV-2 infection on the elemental and metabolomic profiles of human milk (HM). It finds that COVID-19 significantly alters the composition of HM, with decreases in certain elements and significant changes in various metabolites.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Environmental Sciences
Anna M. Jambrina, Neus Rams, Pilar Rius, Maria Perello, Montserrat Girones, Clara Pareja, Francisco Jose Perez-Cano, Angels Franch, Manel Rabanal
Summary: This study describes a method for establishing a network of sentinel pharmacies in Southern Europe, which allows for effective monitoring of drug use issues and improving public health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Karla Rio-Aige, Marina Girbal, Marta Selma-Royo, Anna Parra-Llorca, Sonia Gonzalez, Cecilia Martinez-Costa, Margarida Castell, Maria Carmen Collado, Francisco J. Perez-Cano, Maria J. Rodriguez-Lagunas
Summary: Galectins have been recognized as important proteins for successful pregnancy, but little is known about their presence in breast milk and their role in early infancy. This study found that Gal-1, -3 and -9 were detected for the first time in transitional breast milk samples and were associated with certain maternal and infant characteristics.
Article
Biochemistry & Molecular Biology
Erika Cortes-Macias, Marta Selma-Royo, Karla Rio-Aige, Christine Bauerl, Maria Jose Rodriguez-Lagunas, Cecilia Martinez-Costa, Francisco J. Perez-Cano, Maria Carmen Collado
Summary: The study aimed to evaluate the impact of milk microbiota, cytokine, and adipokine profiles on the risk of overweight in infants at 12 months of life and identify possible mechanisms of host-microbe interactions. The findings indicated that milk microbiota and cytokines were associated with infant development. Further research is needed to understand the specific effects of milk microbiota and cytokines on infant growth and the risk of overweight.
Article
Nutrition & Dietetics
Patricia Ruiz-Iglesias, Sheila Estruel-Amades, Malen Massot-Cladera, Angels Franch, Francisco J. Perez-Cano, Margarida Castell
Summary: Stressful situations such as intense exercise can disrupt the immune system and gastrointestinal function. This study investigated the effect of hesperidin consumption in rats undergoing intense training and exhaustion tests. Results showed that while hesperidin did not prevent immune system changes, it enhanced IgA synthesis in the intestine, potentially strengthening the immune barrier in stressful situations.
Article
Medicine, General & Internal
Anna M. Jambrina, Alex Santoma, Andrea Rocher, Neus Rams, Gloria Cereza, Pilar Rius, Montserrat Girones, Clara Pareja, Angels Franch, Manel Rabanal
Summary: This study aimed to improve the efficacy and safety of medications by detecting and analyzing medication error reports. The study found that medication errors were more frequent in primary care centers and were mostly caused by incorrect, incomplete, illegible, or verbal medical prescriptions. Of the global notifications, 71.9% did not cause harm to the patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Patricia Ruiz-Iglesias, Malen Massot-Cladera, Francisco J. Perez-Cano, Margarida Castell
Summary: The aim of this study was to investigate the influence of flavonoid-enriched diets on immune alterations caused by intensive training and exhausting exercise. The results showed that a flavonoid diet could attenuate the increase in plasma cortisol, prevent the alterations in spleen Th cell proportion, and enhance serum immunoglobulin concentration and spleen natural killer cytotoxicity.
Article
Nutrition & Dietetics
Laura Saez-Fuertes, Ignasi Azagra-Boronat, Malen Massot-Cladera, Karen Knipping, Johan Garssen, Angels Franch, Margarida Castell, Francisco J. Perez-Cano, Maria J. Rodriguez-Lagunas
Summary: This study investigated the changes in intestinal gene expression after rotavirus infection and the effect of 2'-FL. The results showed that rotavirus infection upregulated host antiviral genes and downregulated genes involved in absorptive processes and intestinal maturation. Supplementation of 2'-FL reduced diarrhea symptoms caused by rotavirus infection, but had a similar effect on gene expression as in the control-infected group.
Editorial Material
Nutrition & Dietetics
Francisco J. Perez-Cano
Article
Nutrition & Dietetics
Sergio Martinez-Ruiz, Laura Saez-Fuertes, Sergi Casanova-Crespo, Maria J. Rodriguez-Lagunas, Francisco J. Perez-Cano, Josefa Badia, Laura Baldoma
Summary: This study investigated the effects of EVs from probiotic and commensal E. coli strains on healthy suckling rats during early life. The results showed that administration of EVs enhanced immune function and intestinal maturation in the animals.