Article
Biochemistry & Molecular Biology
Charlotte K. Boughton, Afroditi Tripyla, Sara Hartnell, Aideen Daly, David Herzig, Malgorzata E. Wilinska, Cecilia Czerlau, Andrew Fry, Lia Bally, Roman Hovorka
Summary: In this study, fully closed-loop insulin therapy was found to improve glucose control and reduce hypoglycemia compared to standard insulin therapy in adult outpatients with type 2 diabetes requiring dialysis. The trial demonstrated increased time in target glucose range and decreased risk of hypoglycemia in patients with type 2 diabetes who require dialysis.
Article
Medicine, General & Internal
Keisuke Endo, Takahito Itoh, Masaya Tanno, Kouhei Ohno, Hiroyuki Hotta, Nobuo Kato, Tomoaki Matsumoto, Hitoshi Ooiwa, Hirofumi Kubo, Takayuki Miki
Summary: Despite advances in treatments for diabetes mellitus, severe acute glycemic crises still occur. This study investigated the characteristics of patients transported to an emergency department due to acute glycemic crises, finding that patients with hyperglycemia were younger, more likely to be hospitalized, and had poorer prognosis compared to those with hypoglycemia, mainly due to interrupted treatment, forgetting insulin injection, and infection.
Article
Public, Environmental & Occupational Health
Linhua Pi, Xiajie Shi, Zhen Wang, Zhiguang Zhou
Summary: A meta-analysis of randomized controlled trials showed that smartphone apps did not significantly improve glycemic control in young patients with type 1 diabetes, but auxiliary-style apps with insulin or carbo calculators were beneficial in reducing HbA1c.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Hae Hyuk Jung
Summary: This study aimed to investigate the association between glycemic control and the progression of diabetic kidney disease. It found that intensive glucose control may not offer increased protection for the progression of established diabetic kidney disease, however, careful glycemic control could still improve overall outcomes, particularly among patients with chronic kidney disease.
Review
Endocrinology & Metabolism
K. Hidayat, Q. -L. Fang, B. -M. Shi, L. -Q. Qin
Summary: Both increased HbA1c levels and hypoglycemia may increase the risk of fracture in patients with DM. The positive association between HbA1c levels and the risk of fracture appears to be, in part, explained by hypoglycemia-induced falls, possibly due to insulin use.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Subhash Chander, Vishal Deepak, Roopa Kumari, Lorenzo Leys, Hong Yu Wang, Puja Mehta, F. N. U. Sadarat
Summary: It is necessary to estimate the impact of glycemic control on mortality rates among inpatients with COVID-19. Hyperglycemia in COVID-19 patients is associated with increased mortality risk, and glycemic control may improve outcomes. However, the optimal target range for blood glucose levels in critically ill COVID-19 patients remains unclear, and further research is needed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Anesthesiology
Roland Kaddoum, Amro Khalili, Fadia M. Shebbo, Nathalie Ghanem, Layal Abou Daher, Arwa Bou Ali, Nour El Hage Chehade, Patrick Maroun, Marie T. Aouad
Summary: This study investigated the use of an automated glucose control pump in open heart surgery patients and found that it can effectively maintain blood glucose levels and reduce the incidence of hyperglycemic events.
BMC ANESTHESIOLOGY
(2022)
Review
Medicine, General & Internal
Jingjing Song, Hongying Bai, Hui Xu, Yuanyuan Xing, Si Chen
Summary: This meta-analysis found that higher variability of HbA1c is associated with an increased incidence of dementia in patients with diabetes.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Gebrehiwot Lema Legese, Getahun Asres, Shitaye Alemu, Tesfaye Yesuf, Yeabsira Aklilu Tesfaye, Tsegaw Amare
Summary: This study aims to identify determinants of poor glycemic control among type 2 diabetes mellitus patients at a diabetes mellitus clinic in University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. A hospital-based case-control study was conducted, and a total of 90 cases and 90 controls with type 2 diabetes were recruited. The results showed that age less than 65 years, inadequate physical exercise, presence of comorbidities, non-adherence to anti-diabetes medications, persistent proteinuria, and high-density lipoprotein less than 40 mg/dl were the determinants of poor glycemic control. Therefore, targeted educational and behavioral modification programs should be practiced to improve glycemic control.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Wei-Lun Wen, Hui-Chun Huang, Hsiu-Chu Lin, Wan-Ching Lo, Szu-Chia Chen, Mei-Yueh Lee
Summary: In patients newly diagnosed with T2DM, glycemic durability is negatively associated with higher glycemic burden.
Article
Medicine, General & Internal
Ildiko Lingvay, Marisse Asong, Cyrus Desouza, Pierre Gourdy, Soumitra Kar, Andre Vianna, Tina Vilsboll, Siri Vinther, Yiming Mu
Summary: Once-weekly insulin icodec may serve as a simpler alternative to daily basal insulin for patients with type 2 diabetes. In this study, once-weekly icodec demonstrated superior reduction in HbA1c compared to once-daily degludec after 26 weeks of treatment in insulin-naive type 2 diabetes patients, with no difference in weight change but a slightly higher rate of combined level 2 or 3 hypoglycemic events.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Ildiko Lingvay, Marisse Asong, Cyrus Desouza, Pierre Gourdy, Soumitra Kar, Andre Vianna, Tina Vilsboll, Siri Vinther, Yiming Mu
Summary: Once-weekly insulin icodec could be a simpler dosing alternative to daily basal insulin for type 2 diabetes patients. The study compared the efficacy and safety of once-weekly icodec with once-daily insulin degludec and found that icodec was superior in reducing HbA1c levels after 26 weeks, with no difference in weight change but a slightly higher rate of hypoglycemic events in the icodec group.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Coralie Amadou, Vincent Melki, Jennifer Allain, Sylvaine Clavel, Didier Gouet, Lucy Chaillous, Bogdan Catargi, Pauline Schaeplynck-Belicard, Catherine Petit, Charles Thivolet, Alfred Penfornis
Summary: This study compares the performance and patient satisfaction of the A7+TouchCare insulin pump with the Omnipod system. The results show that the A7+TouchCare insulin pump performs equally as well as the Omnipod pump and is equally satisfactory to patients.
Article
Critical Care Medicine
Jan Gunst, Astrid De Bruyn, An Jacobs, Lies Langouche, Inge Derese, Karolijn Dulfer, Fabian Gueiza, Gonzalo Garcia Guerra, Pieter J. Wouters, Koen F. Joosten, Sascha C. Verbruggen, Ilse Vanhorebeek, Greet van den Berghe
Summary: Delaying parenteral nutrition in critically ill children can improve recovery and protect against long-term emotional and behavioral problems. However, this intervention increases the risk of hypoglycemia, which may have negative effects. Hypoglycemia in the PICU is associated with worse neurodevelopmental outcomes, particularly in cases of spontaneous/recurrent hypoglycemia.
Article
Endocrinology & Metabolism
Wenping Liu, Ting Chen, Bingjin Liang, Yanran Wang, Haoyu Jin
Summary: Artificial pancreas is a useful tool for maintaining the blood glucose of type 1 diabetes patients. A smart controller based on general predictive control has been developed and approved by FDA. Tested under strict conditions, the controller exhibited good performance and achieved automatic control of blood glucose for T1D patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
