Article
Biochemistry & Molecular Biology
Clayton A. Whitmore, Mariam I. Boules, William J. Behof, Justin R. Haynes, Dmitry Koktysh, Adam J. Rosenberg, Mohammed N. Tantawy, Wellington Pham
Summary: This study reports the design and synthesis of a novel [C-11]promethazine PET radioligand for future in vivo studies, with high radiochemical purity and molar activity. The specificity of the probe was demonstrated through autoradiography using human hippocampal tissues.
Article
Plant Sciences
Jens Mincke, Jan Courtyn, Christian Vanhove, Stefaan Vandenberghe, Kathy Steppe
Summary: PET, with its high sensitivity and specificity for tumor detection, has become a standard and widely used molecular imaging technique. Despite the limited number of research groups worldwide conducting PET-based studies in plants, there is significant untapped potential for this technique to contribute extensively to plant science. The complexity of integrating methodological developments from multiple disciplines may be a barrier for some research groups, but with clear guidance on designing and executing PET scans, processing data, and using compartmental modeling, researchers are encouraged to explore the full potential of PET in studying plant dynamics, particularly carbon dynamics using (CO2)-C-11 tracing.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Neurosciences
Caroline Cristiano Real, Karina Henrique Binda, Majken Borup Thomsen, Thea Pinholt Lillethorup, David James Brooks, Anne Marlene Landau
Summary: Parkinson's disease is a debilitating neurodegenerative multisystem disorder that affects millions of individuals, but there is still no cure and early biomarkers are lacking. Animal models of PD have been crucial for understanding the disease mechanisms, identifying biomarkers, and evaluating therapies. Imaging biomarkers have been important tools for assessing disease progression and therapeutic response. The choice of the most appropriate animal model to answer research questions can be challenging, but when combined with molecular imaging, animal models can be powerful for assessing new therapies and early diagnosis.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Neurosciences
Takuya Toyonaga, Arman Fesharaki-Zadeh, Stephen M. Strittmatter, Richard E. Carson, Zhengxin Cai
Summary: The development of novel PET imaging agents for SV2A allowed for the in vivo detection of synaptic density changes, and preclinical SV2A PET imaging in animal models provides supporting information. This article discusses key considerations when designing preclinical SV2A PET imaging studies and strategies for data analysis, as well as the challenges and opportunities in small animal SV2A PET imaging.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Oncology
Ryan C. Perez, DaeHee Kim, Aaron W. P. Maxwell, Juan C. Camacho
Summary: The association between hypoxia, cancer aggressiveness, and decreased therapeutic response is well-established. This review aims to summarize the molecular pathways associated with tumor hypoxia and the use of PET and MRI techniques for imaging hypoxia in cancer. It also discusses future directions and challenges in this field.
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia C. Carmona-Bozo, Roido Manavaki, Ramona Woitek, Turid Torheim, Gabrielle C. Baxter, Corradina Caraco, Elena Provenzano, Martin J. Graves, Tim D. Fryer, Andrew J. Patterson, Fiona J. Gilbert
Summary: Through combined (18)F-FMISO-PET/MRI, we found a relationship between hypoxia and vascular function in breast cancer, highlighting the heterogeneity within tumour regions. Hypoxia was positively correlated with lesion size, but negatively correlated with DCE-MRI parameters.
EUROPEAN RADIOLOGY
(2021)
Article
Chemistry, Medicinal
Yu-Peng Zhou, Yang Sun, Kazue Takahashi, Vasily Belov, Nick Andrews, Clifford J. Woolf, Pedro Brugarolas
Summary: Neuropathic pain affects a significant portion of the adult population, and accurately monitoring biological changes is crucial for understanding its mechanisms and developing treatments. In this study, researchers developed two fluorinated derivatives of gabapentin and demonstrated their ability to bind to the alpha 2 delta-1 receptor, which is involved in neuropathic pain. Although these changes could not be visualized using PET, the study confirms the potential of alpha 2 delta-1 as a target for imaging neuropathic pain.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Nuclear Science & Technology
Hankyeol Song, In Soo Kang, Kyu Bom Kim, Chanwoo Park, Min Kyu Baek, Seongyeon Lee, Yong Hyun Chung
Summary: A novel rectangular-shaped PET system with an adjustable gantry (AGPET) has been developed, utilizing a new depth of interaction (DOI) method and digital time pickoff method. Experimental results demonstrate that the AGPET system provides higher sensitivity and resolution for small animal imaging.
NUCLEAR ENGINEERING AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Seiichi Yamamoto, Masao Yoshino, Kei Kamada, Ryuga Yajima, Akira Yoshikawa, Kohei Nakanishi, Jun Kataoka
Summary: Researchers developed an ultrahigh resolution, real time alpha-particle imaging system for observing the trajectories of alpha particles in a scintillator. The system is based on a magnifying unit, a cooled EM-CCD camera, and a 100-micrometer-thick Ce-doped GAGG scintillator plate. With this system, they were able to measure the trajectories of alpha particles in real time and observe the line shapes of the particles in the scintillator.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Yuan Huang, Junying Fan, Yi Li, Shaozhi Fu, Yue Chen, Jingbo Wu
Summary: The hypoxic state in solid tumors can lead to resistance to therapy and poor prognosis factors like metastasis and recurrence. Accurate quantification, mapping, and monitoring of hypoxia, as well as targeted therapy, are crucial for improving patient survival. PET imaging remains the most widely used method for evaluating tumor hypoxia, but further research is needed to improve methods for detecting tumor hypoxia.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiri Ferda, Eva Ferdova, Martin Vitovec, David Glanc, Hynek Mirka
Summary: Tissue hypoxia drives micro-environmental changes in malignant tumors, with rapid tumor cell proliferation leading to increased nutrient consumption. PET imaging, using probes like F-18-FDG, can assess glucose utilization and metabolic changes in response to hypoxic conditions. Identifying hypoxic tissue is crucial for planning therapy and can aid in overcoming drug and radiation resistance.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Chemistry, Medicinal
Petar Saric, Kathleen A. Young, Martin Rodriguez-Porcel, Panithaya Chareonthaitawee
Summary: Sarcoidosis is a systemic inflammatory disease that often affects the heart, leading to significant morbidity and mortality. Cardiac positron emission tomography (PET) has emerged as a key imaging modality for the diagnosis and management of cardiac sarcoidosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sara Narva, Marko P. Seppanen, Juho R. H. Raiko, Sarita J. Forsback, Katri J. Orte, Johanna M. Virtanen, Johanna Hynninen, Sakari Hietanen
Summary: This study aimed to evaluate the distribution of hypoxia in cervical cancer patients using F-18-EF5 as a hypoxia tracer with PET/MRI. The results showed significant correlations between F-18-EF5 hypoxic parameters and the size, localization, and immunohistochemistry results of tumors.
CLINICAL NUCLEAR MEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Daniel Aaron Vazquez-Matias, Erik F. J. de Vries, Rudi A. J. O. Dierckx, Janine Doorduin
Summary: Major depressive disorder is a growing and poorly understood pathology that requires research in animal paradigms due to technical and ethical limitations. PET imaging has been used in preclinical studies to investigate glucose metabolism, neuroreceptor populations, and the inflammatory response associated with depressive phenotypes. This review summarizes the findings in animal models and discusses the relevance of PET imaging for understanding depression and developing new therapies.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Multidisciplinary Sciences
Kel Vin Tan, Xinxiang Yang, Chung Ying Chan, Jingjing Shi, Hing-Chiu Chang, Keith Wan-Hang Chiu, Kwan Man
Summary: Preclinical experimental models of hepatocellular carcinoma (HCC) are important for studying tumorigenesis and evaluating therapeutic approaches. This study used non-invasive whole-body imaging to investigate tumor hypoxia and metabolism. The results showed that the hypoxia marker [(18) F]FMISO could effectively visualize tumor hypoxia, while [(18) F]FDG could not distinguish the degree of tumor hypoxia.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hanwen Zhang, Pooja Desai, Yusuke Koike, Jacob Houghton, Sean Carlin, Nidhi Tandon, Karim Touijer, Wolfgang A. Weber
JOURNAL OF NUCLEAR MEDICINE
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jason T. Lee, Hanwen Zhang, Maxim A. Moroz, Yury Likar, Larissa Shenker, Nikita Sumzin, Jose Lobo, Juan Zurita, Jeffrey Collins, R. Michael van Dam, Vladimir Ponomarev
MOLECULAR IMAGING AND BIOLOGY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Neeta Pandit-Taskar, Pat Zanzonico, Kevin D. Staton, Jorge A. Carrasquillo, Diane Reidy-Lagunes, Serge Lyashchenko, Eva Burnazi, Hanwen Zhang, Jason S. Lewis, Ronald Blasberg, Steven M. Larson, Wolfgang A. Weber, Shakeel Modak
JOURNAL OF NUCLEAR MEDICINE
(2018)
Article
Biochemical Research Methods
Hanwen Zhang, Ananda Kumar Kanduluru, Pooja Desai, Afruja Ahad, Sean Carlin, Nidhi Tandon, Wolfgang A. Weber, Philip S. Low
BIOCONJUGATE CHEMISTRY
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mark P. S. Dunphy, James J. Harding, Sriram Venneti, Hanwen Zhang, Eva M. Burnazi, Jacqueline Bromberg, Antonio M. Omuro, James J. Hsieh, Ingo K. Mellinghoff, Kevin Staton, Christina Pressl, Bradley J. Beattie, Pat B. Zanzonico, John F. Gerecitano, David P. Kelsen, Wolfgang Weber, Serge K. Lyashchenko, Hank F. Kung, Jason S. Lewis
Article
Oncology
Mark P. S. Dunphy, Christina Pressl, Nagavarakishore Pillarsetty, Milan Grkovski, Shanu Modi, Komal Jhaveri, Larry Norton, Bradley J. Beattie, Pat B. Zanzonico, Danuta Zatorska, Tony Taldone, Stefan O. Ochiana, Mohammad M. Uddin, Eva M. Burnazi, Serge K. Lyashchenko, Clifford A. Hudis, Jacqueline Bromberg, Heiko M. Schoder, Josef J. Fox, Hanwen Zhang, Gabriela Chiosis, Jason S. Lewis, Steven M. Larson
CLINICAL CANCER RESEARCH
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hanwen Zhang, Masatomo Maeda, Masahiro Shindo, Myat Ko, Mayuresh Mane, Christian Grommes, Wolfgang Weber, Ronald Blasberg
MOLECULAR IMAGING AND BIOLOGY
(2020)
Review
Oncology
Diane Abou, Nadia Benabdallah, Wen Jiang, Lu Peng, Hanwen Zhang, Alexandria Villmer, Mark S. Longtine, Daniel L. J. Thorek
FRONTIERS IN ONCOLOGY
(2020)
Article
Engineering, Biomedical
Jiang Yang, Tai Wang, Lina Zhao, Vinagolu K. Rajasekhar, Suhasini Joshi, Chrysafis Andreou, Suchetan Pal, Hsiao-ting Hsu, Hanwen Zhang, Ivan J. Cohen, Ruimin Huang, Ronald C. Hendrickson, Matthew M. Miele, Wenbo Pei, Matthew B. Brendel, John H. Healey, Gabriela Chiosis, Moritz F. Kircher
NATURE BIOMEDICAL ENGINEERING
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lu Peng, Benabdallah Nadia, Jiang Wen, Brian W. Simons, Zhang Hanwen, Robert F. Hobbs, Ulmert David, Brian C. Baumann, Russell K. Pachynski, Abhinav K. Jha, Daniel L. J. Thorek
Summary: Digital autoradiography (DAR) is a powerful tool for analyzing the distribution of radiopharmaceuticals in tissue sections. However, it has limitations such as low image resolution and high background noise. To address these issues, researchers have developed a content-adaptive restoration algorithm (PG-PEM) that can improve resolution, contrast, and the distribution of radiopharmaceuticals in DAR imaging.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Hua Zhu, Hanwen Zhang, Nina Zhou, Jin Ding, Jinquan Jiang, Teli Liu, Ziyu Liu, Feng Wang, Qian Zhang, Zhuochen Zhang, Shi Yan, Lei Li, Nadia Benabdallah, Hongjun Jin, Zhaofei Liu, Lisheng Cai, Daniel L. J. Thorek, Xing Yang, Zhi Yang
Summary: This study developed molecular imaging agents for targeting ACE2 in COVID-19 research, revealing high uptake in unexpected areas like the breast and reproductive system, and low uptake in pulmonary tissues. This novel method can aid in further SARS-CoV-2 research and enhance understanding of COVID-19.
Article
Multidisciplinary Sciences
Hanwen Zhang, Diane Abou, Peng Lu, Abbie Meghan Hasson, Alexandria Villmer, Nadia Benabdallah, Wen Jiang, David Ulmert, Sean Carlin, Buck E. Rogers, Norman F. Turtle, Michael R. McDevitt, Brian Baumann, Brian W. Simons, Farrokh Dehdashti, Dong Zhou, Daniel L. J. Thorek
Summary: Noninvasive imaging has great potential to guide α-particle therapy. In this study, [F-18]-PARPZ radiotracer was used to delineate castrate resistant prostate cancer xenografts, showing its ability to distinguish treated from control groups and further understand DNA damage response.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Abbie Hasson, Wen Jiang, Nadia Benabdallah, Peng Lu, Mark S. Longtine, Bradley J. Beattie, Lucy Summer, Hanwen Zhang, Richard L. Wahl, Diane S. Abou, Daniel L. J. Thorek
Summary: This study demonstrates novel methods to characterize Th-227 and Ra-223 and verifies their feasibility through purity evaluation of a Th-227-labeled protein construct. The results show that the gamma counter and alpha camera can rapidly and quantitatively distinguish the radionuclidic purity of Th-227 and Ra-223, while the radio-TLC has limited ability in describing purity.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)
Article
Chemistry, Multidisciplinary
Diane S. Abou, Nikki A. Thiele, Nicholas T. Gutsche, Alexandria Villmer, Hanwen Zhang, Joshua J. Woods, Kwamena E. Baidoo, Freddy E. Escorcia, Justin J. Wilson, Daniel L. J. Thorek
Summary: Targeted alpha therapy with [Ra-223]RaCl2 has been effective in treating castrate-resistant prostate cancer bone metastases, but efforts to direct [Ra-223]Ra2+ to non-osseous disease sites have had limited success. This study demonstrates the stability and efficiency of the radiocomplex [Ra-223][Ra(macropa)] in directing Ra-223 to non-bone metastases. Conjugation of macropa with beta-alanine and DUPA shows potential for delivering Ra-223 to metastases outside of the bone, expanding the therapeutic utility of this radiometal.
Article
Medicine, Research & Experimental
Jiang Yang, Chunhua Zhao, Jacky Lim, Lina Zhao, Ryan Le Tourneau, Qize Zhang, Damien Dobson, Suhasini Joshi, Jiadong Pang, Xiaodong Zhang, Suchetan Pal, Chrysafis Andreou, Hanwen Zhang, Moritz F. Kircher, Hans Schmitthenner
Summary: Most cancer therapeutic paradigms involve imaging and surgery, but current contrast agents have limitations. This study presents a synthesized NIR dye IRDye78 combined with a protein carrier for multimodal imaging, showing promising results in cancer visualization and clearance pathways modulation. The fluorophore-protein complex has great potential for clinical translation, offering an elegant workflow for guided surgical resection.
