Article
Oncology
Jihyun An, Minyoung Oh, Seog-Young Kim, Yoo-Jin Oh, Bora Oh, Ji-Hye Oh, Wonkyung Kim, Jin Hwa Jung, Ha Il Kim, Jae-Seung Kim, Chang Ohk Sung, Ju Hyun Shim
Summary: This study aimed to explore the genomic and molecular characteristics of hepatocellular carcinoma (HCC) with increased FDG uptake in PET and identify therapeutic targets based on these findings. The results showed that high FDG avidity was associated with worse recurrence-free survival after HCC resection. The upregulation of mTOR pathway genes in FDG-avid tumors was identified, and treatment with an mTOR inhibitor resulted in decreased FDG uptake and effective tumor control. This PET-based radiogenomic analysis may have implications for precision care of HCC patients.
CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Kazuo Narushima, Kiyohiko Shuto, Shinichi Okazumi, Gaku Ohira, Mikito Mori, Koichi Hayano, Noriyuki Yanagawa, Hisahiro Matsubara
Summary: This study retrospectively evaluated the preoperative PET scan results of 89 GIST patients and found that SUVmax was significantly correlated with tumor size, mitotic count, and Ki-67 index. When the SUVmax cutoff value was set at 5.68, the diagnostic accuracy for the high-risk group, recurrence group, and death group of GIST patients reached 86.5%, 76.4%, and 73.0% respectively. The group with SUVmax ≥ 5.68 had significantly lower 10-year relapse-free survival and overall survival compared to the group with SUVmax<5.68.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chunjuan Jiang, Liwei Zhao, Bowen Xin, Guang Ma, Xiuying Wang, Shaoli Song
Summary: This study explores the contribution of F-18-FDG PET/CT radiomic features for the preoperative prediction of HCC and ICC classification and MVI. The results show that the prediction model has high accuracy and sensitivity in predicting HCC and ICC classification, and PET features play a dominant role in the predictive power of the model. This prediction model provides a non-invasive biomarker for an earlier indication and comprehensive quantification of primary liver cancers.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Luca Filippi, Oreste Bagni, Ermanno Notarianni, Adelchi Saltarelli, Cesare Ambrogi, Orazio Schillaci
Summary: The study aimed to assess the role of PET/CT in hepatocellular carcinoma (HCC) patients and found that PET/CT had a significant impact on clinical management and patients' overall survival.
Article
Biochemistry & Molecular Biology
Tuo Shao, Zhen Chen, Ran Cheng, Lee Collier, Lee Josephson, Raymond T. Chung, Steven H. Liang
Summary: Hepatocellular carcinoma (HCC) is a prevalent liver malignancy with poor prognosis. This study aimed to visualize the expression and activity of hepatic monoacylglycerol lipase (MAGL) in HCC cells and patients' samples using positron emission tomography (PET) imaging. The results showed higher MAGL expression levels in HCC cells compared to normal liver cells. Additionally, HCC patients also exhibited increased uptake of the MAGL radio-ligand, suggesting its potential as an effective PET ligand for HCC diagnosis.
BIOORGANIC CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiaomiao Lu, Yu Long, Kevin Fan, Zhiwen Shen, Yongkang Gai, Qingyao Liu, Dawei Jiang, Weibo Cai, Chidan Wan, Xiaoli Lan
Summary: In this study, the performance of [Ga-68]Ga-PSMA-617 PET imaging on HCC was evaluated using different animal models, and its function was explored. The results showed that [Ga-68]Ga-PSMA-617 PET may be a promising imaging modality for HCC with high tumor uptake and specificity to tumor-associated endothelial cells.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Amanda Nguyen, Felipe Martinez, Ba D. Nguyen
Summary: This case report presents chest wall keloids detected on F-18-piflufolastat PET/CT during the evaluation of prostate cancer recurrence.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Chemistry, Analytical
Song Zhang, Jiangbo Jing, Lingchen Meng, Bin Xu, Xibo Ma, Wenjing Tian
Summary: A fluorescent probe NDSA-L5 was synthesized in this study, which can specifically bind to the overexpressed Glypican-3 (GPC-3) protein of HCC cells and show bright fluorescence. It has the potential application in early detection and surgical navigation for HCC cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kevin P. Labadie, Adrienne L. Lehnert, Aimee L. Kenoyer, Donald K. Hamlin, Andrew D. Ludwig, Alan F. Utria, Sara K. Daniel, Tara N. Mihailovic, Alexander Prossnitz, Johnnie J. Orozco, Yawen Li, D. Scott Wilbur, Robert S. Miyaoka, James O. Park
Summary: This study evaluated the use of a zirconium-89 radiolabeled glypican-3 targeting antibody conjugate (Zr-89-alpha GPC3) in positron emission tomography (PET) for detection of small GPC3(+) hepatocellular carcinoma (HCC). The results showed that Zr-89-alpha GPC3 accumulated well in GPC3(+) tumors and could detect sub-millimeter tumors. This technology has the potential to improve the diagnostic sensitivity of small HCC and select GPC3(+) tumors for targeted therapy.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Akihiko Sakata, Yasutaka Fushimi, Yoshiki Arakawa, Yoichi Shimizu, Yuji Nakamoto
Summary: Solitary intracranial tuberculomas are rare and often misdiagnosed as brain tumors. We present a case of intracranial tuberculous granuloma mimicking a high-grade glioma with avid uptake on F-18-fluoromisonidazole PET/CT. The hypoxic and necrotic condition inside the tuberculous granuloma may contribute to the high accumulation of F-18-fluoromisonidazole in this case.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Abarnaa Sivapathasundaram, Nicolas Golse, Alina Pascale, Emmanuel Durand, Mylene Sebagh, Florent L. Besson
Summary: Contrary to common belief, F-18-FDG/F-18-choline dual-tracer PET behavior is not a relevant surrogate of tumor differentiation in hepatocellular carcinoma (HCC). Future multitracer PET studies are necessary to improve our understanding of their biological significance in this field.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yong Yao, A. Cahid Civelek, Xiao-Feng Li
Summary: This review evaluates the application of 18F-FDG PET/CT in HCC, focusing on its visualization, management, and evaluation of biological properties. The results suggest that 18F-FDG PET/CT is valuable for visualizing and managing HCC, a negative test may indicate a better outcome, while 18F-FDG positive lesions are associated with a poorer prognosis.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Oncology
Tzu-Pei Su, Jen-Seng Huang, Pei-Hung Chang, Kar-Wai Lui, Jason Chia-Hsun Hsieh, Shu-Hang Ng, Sheng-Chieh Chan
Summary: The study compared the value of interim F-18-FLT-PET and F-18-FDG-PET in predicting treatment outcomes in patients with metastatic breast cancer, showing that F-18-FDG-PET had an advantage in predicting clinical response, survival, and progression-free survival. Assessment of treatment outcome by interim F-18-FDG-PET may aid in treatment decisions for these patients.
Review
Oncology
Nozipho Nyakale, Luca Filippi, Colleen Aldous, Mike Sathekge
Summary: Several PET targets have been developed for the detection and staging of hepatocellular cancer. Early detection is crucial for hepatocellular carcinomas, which are aggressive and unresponsive to chemotherapy. Various PET radiopharmaceuticals have been experimented with to overcome the limitations of conventional radiological imaging.
Review
Oncology
Kenji Hirata, Nagara Tamaki
Summary: Positron emission tomography (PET) allows quantitative assessment of tumour biology, particularly metabolic activity, treatment monitoring, and predicting prognosis. Biochemical changes assessed by FDG-PET are often more sensitive than morphological changes, with complete metabolic response indicating better prognosis. Recent studies have introduced machine learning techniques and texture analysis for tissue characterization and predicting treatment effect based on FDG-PET imaging.
Review
Engineering, Biomedical
Xiaojie Lin, Ching Ting Tsao, Masayuki Kyomoto, Miqin Zhang
Summary: Osteoarthritis (OA) is a prevalent chronic disease in the elderly population, with current clinical treatments limited to symptom relief. Injectable natural polymer hydrogels are considered highly promising for controlled drug delivery.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Guanyou Lin, Jianxi Huang, Mengyuan Zhang, Shanshan Chen, Miqin Zhang
Summary: This study reports the development of a novel nanoparticle formulation (NP-Chi-xPEI) that can safely and effectively deliver DNA into breast cancer cells for successful transfection. The NP-Chi-xPEI nanoparticle shows high transfection efficiency and low cytotoxicity, making it a potential reliable vehicle for DNA delivery to breast cancer cells.
Article
Materials Science, Multidisciplinary
Peter A. Chiarelli, Richard A. Revia, Zachary R. Stephen, Kui Wang, Forrest M. Kievit, Jordan Sandhu, Meenakshi Upreti, Seokhwan Chung, Richard G. Ellenbogen, Miqin Zhang
Summary: This study introduces a tumor-targeted nanoparticle that enhances the effectiveness of radiation therapy on a selective cellular basis, improving the treatment outcomes for GBM.
Article
Chemistry, Analytical
Zhiyong Wei, Qingxin Mu, Hui Wang, Guanyou Lin, Miqin Zhang
Summary: The assessment of biodegradability of nanomaterials is crucial for understanding interactions with biological systems and determining potential applications. A study on carbon-based biconcave nanodisks (CBBNs) reveals significant degradation in biological systems, making them suitable for biomedical use.
Article
Chemistry, Analytical
Richard A. Revia, Brandon Wagner, Matthew James, Miqin Zhang
Summary: Cells cultured in three-dimensional scaffolds exhibit a phenotype more similar to in vivo cells, and natural polymers are suitable materials for creating such scaffolds for high-throughput drug screening. However, the high viscosity of natural polymer solutions poses a challenge for dispensing. In this study, an automated scaffold dispensing system was developed using pneumatic control and programming software, allowing for the even distribution of high-viscosity polymer solutions.
Article
Nanoscience & Nanotechnology
Seokhwan Chung, Yutaro Sugimoto, Jianxi Huang, Miqin Zhang
Summary: This study demonstrates the use of peptide-functionalized nanoparticles to deliver siRNA to sensitize glioma cells to drugs and achieve efficient gene silencing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
William Hunter, Sergei Dolinsky, Paul Kinahan, Robert Miyaoka
Summary: We evaluated the 3-D spatial, energy, and timing resolution of the BING PET detector. The BING detector consists of stacked slats of LYSO scintillator with silicon-photomultiplier (SiPM) arrays to determine interaction positions and timing. The performance of the BING detector was measured and it showed effective resolution for a small field of view PET system.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Guanyou Lin, Miqin Zhang
Summary: The potential of theranostic nanoparticles in tumor treatment is widely recognized due to their ability to integrate multifaceted functionalities into a single nanosystem. These nanoparticles typically consist of an inorganic core for imaging and therapeutic functions, bioinert coatings for improved biocompatibility, controlled drug-loading-release modules, and targeting ligands for specific cell uptake. The design and assembly of these functionalities require sophisticated molecular design and precise execution. Ligand chemistry plays a decisive role in translating theoretical designs into functionalized theranostic nanoparticles. This Account reviews the properties and utilities of capping ligands, drug-loading ligands, and targeting ligands in theranostic nanoparticles.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yuanzhang Tang, Yang Zhou, Guanyou Lin, Miqin Zhang
Summary: Human-induced pluripotent stem cells (hiPSCs) cultured in 3D matrices can benefit from improved cell penetration and pluripotency maintenance by modifying the scaffold with hiPSCs conditioned medium (CM). This study demonstrates that CM treatment promotes uniform cell adhesion and distribution, enhances pluripotency markers, and upregulates genes associated with pluripotency. The results highlight the importance of CM treated scaffolds in maintaining the primitive and undifferentiated phenotype of hiPSCs in 3D matrices.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Yang Zhou, Gillian Pereira, Yuanzhang Tang, Matthew James, Miqin Zhang
Summary: Natural polymer-based porous scaffolds with tunable pore size have been developed as three-dimensional tumor models for high-throughput screening of cancer therapeutics. The CHA scaffold-based platform showed potential for mimicking the in vivo malignancy and revealed the influence of pore size on cell growth kinetics, tumor spheroid morphology, gene expression and drug response. The CHA scaffold-based HTS platform demonstrated comparable performance with commercial tissue culture plates and may provide an improved alternative for future cancer study and drug discovery.
Article
Pharmacology & Pharmacy
Jianxi Huang, Guanyou Lin, Taylor Juenke, Seokhwan Chung, Nicholas Lai, Tianxin Zhang, Tianyi Zhang, Miqin Zhang
Summary: This study introduces a novel approach using iron oxide nanoparticles for safe and efficient mRNA delivery to hard-to-transfect cancer cells. The developed nanoparticles showed enhanced cellular internalization of mRNA, easy mRNA release, and minimal cytotoxicity, suggesting great promise for mRNA therapy against hard-to-transfect cancers.
Article
Pharmacology & Pharmacy
Yoshiki Ando, Fei-Chien Chang, Matthew James, Yang Zhou, Miqin Zhang
Summary: In this study, three-dimensional chitosan scaffolds are developed as microcarriers for the prolonged expansion of human neural stem cells (hNSCs) in bioreactors. The chitosan scaffolds exhibit desirable microstructural characteristics and mechanical properties, allowing for hNSC expansion in dynamic conditions for up to three weeks. This microcarrier approach has the potential for mass production of hNSCs in a three-dimensional setting.
Article
Radiology, Nuclear Medicine & Medical Imaging
Celia Valladares, John Barrio, Marta Freire, Neus Cucarella, Efthymios Lamprou, Robert S. Miyaoka, William C. J. Hunter, Robert Harrison, Antonio J. Gonzalez
Summary: The HyPET project proposes a hybrid time of flight-positron emission tomography technology for prostate imaging. The experimental results show that the detector with a thickness of 5 mm exhibits the best spatial resolution. Additionally, the time resolution worsens with increasing thickness.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Aria W. Tarudji, Connor C. Gee, Hunter A. Miller, Rylie Steffen, Evan T. Curtis, Aaron M. Priester, Anthony J. Convertine, Forrest M. Kievit
Summary: Following a traumatic brain injury (TBI), excess ROS and LPOx lead to secondary injury. Current treatments have poor target engagement. Nanoparticle-based treatments have shown promise in increasing accumulation in damaged brain. NPC3, containing thiol functional groups, can neutralize ROS and LPOx. Immediate administration of NPC3 reduces ROS levels and improves spatial learning and memory in males. It also prevents necrosis spread in male mice but not in females, possibly explaining the sex-based differences in cognitive improvement. Overall, there are sex-based differences to nanoparticle treatments and an upper threshold of antioxidant activity that benefits injured brain.
ADVANCED THERAPEUTICS
(2023)
Review
Chemistry, Physical
Ariane Erickson, Peter A. Chiarelli, Jianxi Huang, Sheeny Lan Levengood, Miqin Zhang
Summary: Nanofibers synthesized by electrospinning have great clinical potential in cancer research and treatment, serving as a biomimetic tumor microenvironment model, a drug release platform, and a cancer diagnostic tool. This review provides an overview of nanofiber design and fabrication techniques, discussing the impact of nanofiber properties on their functionality, as well as current and foreseeable barriers to their clinical translation in oncology.
NANOSCALE HORIZONS
(2022)