Article
Radiology, Nuclear Medicine & Medical Imaging
F. B. Achterberg, M. M. Deken, R. P. J. Meijer, J. S. D. Mieog, J. Burggraaf, C. J. H. van de Velde, R. J. Swijnenburg, A. L. Vahrmeijer
Summary: Transitioning tumor-specific fluorescence-guided surgery from phase I-II studying imaging agent efficacy to phase III proving patient benefit can be challenging. It is vital to establish a trial team overseeing the translational process and providing participating clinicians with well-defined protocols to gather reliable trial data. Successful clinical translation of imaging agents for image-guided cancer surgery requires collaboration with all stakeholders involved in the process.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Biotechnology & Applied Microbiology
Zhongquan Cheng, Yushen Jin, Jiaqian Li, Guangyuan Shi, Leyi Yu, Bing Shao, Jie Tian, Yang Du, Zhu Yuan
Summary: A smart fibronectin-targeting and metalloproteinase-activatable imaging probe CREKA-GK8-QC is developed to detect breast cancer and lung micro-metastatic lesions, improving surgery prognosis.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Caiting Deng, Meichen Zheng, Shupeng Han, Yuanjie Wang, Jingqi Xin, Omer Aras, Liang Cheng, Feifei An
Summary: Sonodynamic therapy (SDT) is a promising cancer therapy that uses ultrasound to trigger a sonosensitizer to generate reactive oxygen species (ROS) with excellent tissue penetration depth. However, the spread of the sonosensitizer to healthy tissue beyond the tumor can cause undesired side effects. In this study, a GSH-activatable sonosensitizer prodrug is designed by attaching a quencher to tetraphydroxy porphyrin, which shows high tumor selectivity and activation in the presence of overexpressed GSH. The prodrug demonstrates effective tumor growth inhibition under ultrasound irradiation, highlighting its potential as a highly effective cancer treatment.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Surgery
Trevor M. Yeung
Summary: Fluorescence imaging is a potentially useful tool for colorectal surgery, with applications in assessing tissue perfusion, tumor evaluation, lymphatic drainage, and urinary tract identification. While nonspecific fluorescent dyes like indocyanine green and methylene blue are commonly used, the development of specific fluorescently labeled molecular markers holds great promise for enhancing the utility of fluorescence imaging during surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Medicine, General & Internal
Luise Knospe, Ines Gockel, Boris Jansen-Winkeln, Rene Thieme, Stefan Niebisch, Yusef Moulla, Sigmar Stelzner, Orestis Lyros, Michele Diana, Jacques Marescaux, Claire Chalopin, Hannes Koehler, Annekatrin Pfahl, Marianne Maktabi, Ji-Hyeon Park, Han-Kwang Yang
Summary: Innovations and advancements in intraoperative real-time imaging, such as ICG-FI and HSI, have become increasingly important in gastric cancer surgery. These methods allow for accurate visualization of tissue characteristics, improving surgical outcomes and reducing complications.
Article
Biochemical Research Methods
Mebin B. George, Benjamin Lew, Steven Blair, Zhongmin Zhu, Zuodong Liang, Indrajit Srivastava, Austin Chang, Hyungsoo Choi, Kyekyoon Kim, Shuming Nie, Sunil Singhal, Viktor Gruev
Summary: We developed a bioinspired endoscopic system that can image multiple tumor-targeted probes, quantify volumetric ratios, and detect tumors. Our optimized endoscope achieves a 60% improvement in NIR spatial resolution compared to a leading FDA-approved endoscope. The system can help assess multiple tumor-targeted probe concepts during surgical procedures.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
Article
Biotechnology & Applied Microbiology
Honghui Li, Mao Huang, Zixuan Wei, Jiawen He, Yunong Ma, Cuixia Lu, Albert Jin, Zhixiong Wang, Liewei Wen
Summary: This study reports a novel development of metal-organic frameworks (MOFs) that can respond to the high content of hydrogen sulfide (H2S) in the tumor microenvironment of colorectal cancer (CRC). The MOFs, synthesized through a facile one-pot process, can serve as an H2S activatable nano-photosensitizer for real-time fluorescence imaging-guided and targeted photodynamic therapy (PDT) of CRC.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qiurong Zhu, Fang Sun, Tianliang Li, Mengxue Zhou, Jiayi Ye, Aiyan Ji, Hui Wang, Chunyong Ding, Hao Chen, Zhiai Xu, Haijun Yu
Summary: A versatile prodrug nanoparticle for second near-infrared (NIR-II) fluorescence imaging-guided combinatory immunotherapy of colorectal cancer has been reported. The nanoparticles show high intratumoral accumulation and trigger immunogenic cell death of the tumor cells, elicit antitumor immune response in a spatiotemporally controllable manner. The combination of the nanoparticle-based photothermal therapy/chemotherapy with programmed death ligand 1 blockade significantly promotes intratumoral infiltration of cytotoxic T lymphocytes and eradicates CRC tumors.
Review
Medicine, General & Internal
Zoe Garoufalia, Steven D. D. Wexner
Summary: ICG imaging is increasingly used in colorectal surgery for perfusion assessment, ureteral and urethral assessment, lymphatic mapping, and assessment of hepatic and peritoneal metastases. Although evidence level is low, promising results have been observed, especially in reducing anastomotic leaks. ICG imaging is a safe and relatively cheap imaging modality in colorectal surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Barbara Bortot, Alessandro Mangogna, Giovanni Di Lorenzo, Guglielmo Stabile, Giuseppe Ricci, Stefania Biffi
Summary: Surgical resection is the main treatment for solid tumors, but accurate and safe intraoperative assessment of tumor margins is clinically necessary. Positive surgical margins have negative effects on treatment outcomes and survival. Image-guided surgery using nanoparticles as contrast agents shows promise in reducing positive surgical margins and improving resection accuracy. However, more research is needed to fully utilize nanotechnology in surgical imaging.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Feifei Wang, Liangqiong Qu, Fuqiang Ren, Ani Baghdasaryan, Yingying Jiang, RuSiou Hsu, Peng Liang, Jiachen Li, Guanzhou Zhu, Zhuoran Ma, Hongjie Dai
Summary: This study developed a compact imager capable of simultaneous visible photographic and near-infrared II (NIR-II) fluorescence imaging for preclinical image-guided surgery. Using molecular imaging of angiogenesis markers in a murine breast tumor model, high-resolution noninvasive tumor imaging was achieved with NIR-IIb imaging, enabling clear identification of tumor margin and residual cancer cells during surgery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nutrition & Dietetics
Hailun Xie, Lishuang Wei, Guanghui Yuan, Mingxiang Liu, Yanren Liang, Shunhui Gao, Qiwen Wang, Xin Lin, Shuangyi Tang, Jialiang Gan
Summary: The combination of Geriatric Nutritional Risk Index (GNRI) and carcinoembryonic antigen (CEA) can effectively stratify the prognosis of colorectal cancer (CRC) patients, providing personalized reference for prognosis assessment and clinical decision-making.
FRONTIERS IN NUTRITION
(2022)
Letter
Gastroenterology & Hepatology
Sung Uk Bae
Summary: Near infrared fluorescence using indocyanine green is useful for reducing the risk of iatrogenic ureteral lesions in colorectal surgery. It allows visual assessment of blood vessels, blood flow, and tissue perfusion, as well as sentinel lymph node biopsy and lymph node road mapping.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Rui-Qin Yang, Pei-Yuan Wang, Kang-Liang Lou, Yong-Ying Dang, Hai-Na Tian, Yang Li, Yi-Yang Gao, Wen-He Huang, Yong-Qu Zhang, Xiao-Long Liu, Guo-Jun Zhang
Summary: A biodegradable cyclic RGD pentapeptide/hollow virus-like gadolinium-based indocyanine green nanoprobe is developed for fluorescence image-guided surgery and radiotherapy in breast cancer, showing improved efficacy and diagnostic accuracy, and providing a basis for developing precision treatment strategies.
Review
Oncology
Imke Boekestijn, Matthias N. van Oosterom, Paolo Dell'Oglio, Floris H. P. van Velden, Martin Pool, Tobias Maurer, Daphne D. D. Rietbergen, Tessa Buckle, Fijs W. B. van Leeuwen
Summary: Molecular imaging technologies are increasingly important in the diagnosis, monitoring, and treatment of cancer. The relevance and accessibility of surgical targets, as well as the selection of the correct combination of imaging agents for visualizing disease sites with high affinity and specificity are crucial. Developments within engineering/imaging physics continue to drive image-guided surgery, enhancing sensitivity and spatial resolution to ensure cancer sites are not overlooked during surgery.
Review
Oncology
Valentina Ambrosini, Jolanta Kunikowska, Eric Baudin, Lisa Bodei, Catherine Bouvier, Jaume Capdevila, Marta Cremonesi, Wouter W. de Herder, Clarisse Dromain, Massimo Falconi, Melpomeni Fani, Stefano Fanti, Rodney J. Hicks, Levent Kabasakal, Gregory Kaltsas, Val Lewington, Silvia Minozzi, Michela Cinquini, Kjell Oberg, Wim J. G. Oyen, Dermot O'Toole, Marianne Pavel, Philippe Ruszniewski, Aldo Scarpa, Jonathan Strosberg, Anders Sundin, David Taieb, Irene Virgolini, Damian Wild, Ken Herrmann, James Yao
Summary: Nuclear medicine plays a crucial role in managing neuroendocrine neoplasms, using techniques such as peptide receptor radionuclide therapy and positron emission tomography. Recommendations from the European Association of Nuclear Medicine provide valuable guidance for the diagnosis and treatment of NETs.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth J. de Koster, Wyanne A. Noortman, Jacob M. Mostert, Jan Booij, Catherine B. Brouwer, Bart de Keizer, John M. H. de Klerk, Wim J. G. Oyen, Floris H. P. van Velden, Lioe-Fee De Geus-Oei, Dennis Vriens
Summary: The study aimed to evaluate whether quantitative [F-18]FDG-PET/CT assessment and radiomic analysis of [F-18]FDG-positive thyroid nodules could improve the preoperative differentiation of indeterminate thyroid nodules. The results showed that applying distinct SUV cut-offs for non-Hurthle cell and Hurthle cell nodules can optimize the ability to rule out malignancy, while radiomic analysis did not provide additional differentiation for [F-18]FDG-positive nodules.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth J. de Koster, Lioe-Fee de Geus-Oei, Adrienne H. Brouwers, Eveline W. C. M. van Dam, Lioe-Ting Dijkhorst-Oei, Adriana C. H. van Engen-van Grunsven, Wilbert B. van den Hout, Tamira K. Klooker, Romana T. Netea-Maier, Marieke Snel, Wim J. G. Oyen, Dennis Vriens
Summary: The study aimed to assess the impact of an [F-18]FDG-PET/CT-driven diagnostic workup on patients with indeterminate thyroid nodules. The results showed that this workup accurately reduced futile surgeries by 40% and should be limited to non-Hurthle cell nodules.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Rheumatology
Chantal A. M. Bouman, Noortje van Herwaarden, Annelies B. Blanken, Conny J. Van der Laken, Martin Gotthardt, Wim J. G. Oyen, Alfons A. den Broeder, Aatke van der Maas, Cornelia H. van den Ende
Summary: FDG-PET arthritis scoring in RA patients with low disease activity is reliable and has some construct validity, but no predictive values were found for FDG-PET parameters for successful tapering and/or discontinuation of TNFi.
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth J. de Koster, Dennis Vriens, Maarten O. van Aken, Lioe-Ting Dijkhorst-Oei, Wim J. G. Oyen, Robin P. Peeters, Abbey Schepers, Lioe-Fee De Geus-Oei, Wilbert B. van den Hout
Summary: This study evaluates the cost-effectiveness of an [F-18]FDG-PET/CT-driven diagnostic workup compared to diagnostic surgery for thyroid nodules with Bethesda III/IV cytology. The results show that [F-18]FDG-PET/CT avoids unnecessary diagnostic surgeries and reduces costs while maintaining quality of life.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fijs W. B. van Leeuwen, Margret Schottelius, Felix M. Mottaghy, Fabien Hyafil, Mark Lubberink, Gabriela Kramer-Marek, Wim J. G. Oyen
Article
Oncology
Maarten J. van der Doelen, Irma M. Oving, Dirk N. J. Wyndaele, Jean-Paul van Basten, Frederiek Terheggen, Addy C. M. van de Luijtgaarden, Wim J. G. Oyen, W. Dick van Schelven, Franchette van den Berkmortel, Niven Mehra, Marcel J. R. Janssen, Judith B. Prins, Winald R. Gerritsen, Jose A. E. Custers, Inge M. van Oort
Summary: This study evaluated the health-related quality of life, psychological distress, and fatigue in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with radium-223. The study found that patients who discontinued radium-223 therapy had worse HR-QoL, psychological distress, and fatigue at baseline and more frequent deterioration over time compared to patients who completed therapy.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Endocrinology & Metabolism
Elizabeth J. de Koster, Olga Husson, Eveline W. C. M. van Dam, G. Sophie Mijnhout, Romana T. Netea-Maier, Wim J. G. Oyen, Marieke Snel, Lioe-Fee de Geus-Oei, Dennis Vriens
Summary: The study examined HRQoL in patients undergoing FDG-PET/CT for an indeterminate thyroid nodule, finding that active surveillance following a negative FDG result resulted in stable HRQoL scores over a year. Patients with benign histopathology who underwent diagnostic surgery had more cognitive impairment and physical problems, but improved goitre symptoms and anxiety. Anxiety also decreased in patients with malignant histopathology.
ENDOCRINE CONNECTIONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth J. de Koster, Adriana C. H. van Engen-van Grunsven, Johan Bussink, Cathelijne Frielink, Lioe-Fee de Geus-Oei, Benno Kusters, Hans Peters, Wim J. G. Oyen, Dennis Vriens
Summary: This study explored the association between [F-18]FDG uptake and the quantitative expression of immunohistochemical markers related to glucose metabolism, hypoxia, and cell proliferation in benign and malignant thyroid nodules of indeterminate cytology. The results showed that the expression of GLUT1, HK2, and MCT4 increased in [F-18]FDG-positive benign nodules and thyroid carcinomas as compared to [F-18]FDG-negative benign nodules, and VEGF expression was higher in thyroid carcinomas.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Dennis Vriens, Elizabeth J. de Koster, Lioe-Fee de Geus-Oei, Wim J. G. Oyen, EfFECTS trial consortium
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Medicine, General & Internal
Lidija Antunovic, Alessia Artesani, Michael Coniglio, Wim J. G. Oyen, Michele Ciccarelli, Carlo Selmi, Arturo Chiti, Martina Sollini
Summary: This study evaluated the diagnostic accuracy of [F-18]-fluorodeoxyglucose ([F-18]FDG) PET/CT in large vessel vasculitis (LVV) and found that an experienced reader had higher accuracy compared to a less experienced one. The expert reader performed better in patients with normal BMI, normal glycemia, younger age, and no ongoing therapy. The use of semi-quantitative parameters did not improve the diagnostic performance of the readers.
Article
Radiology, Nuclear Medicine & Medical Imaging
H. Adams, E. M. W. van de Garde, D. J. Vugts, J. C. Grutters, Wim. J. G. Oyen, R. G. Keijsers
Summary: This study investigates the use of imaging CD20-positive cells in predicting the response to anti-CD20 treatment for immune-mediated interstitial lung disease. PET/CT imaging was performed on 21 patients, and it was found that the uptake of [89Zr]-rituximab in the lungs correlated with changes in pulmonary function test results and treatment outcomes. Patients with a higher uptake of [89Zr]-rituximab had better response to treatment. Therefore, [89Zr]-rituximab PET imaging may serve as a potential predictive biomarker for anti-CD20 therapy.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Elizabeth J. de Koster, Willem E. Corver, Lioe-Fee de Geus-Oei, Wim J. G. Oyen, Dina Ruano, Abbey Schepers, Marieke Snel, Tom van Wezel, Dennis Vriens, Hans Morreau
Summary: This study described the patterns of copy number alterations (CNA) in benign and malignant oncocytic cell thyroid neoplasms (OCN) using a next-generation sequencing (NGS) panel. The study found that the CNA patterns differed between benign and malignant cases, and suggested the application of CNA-LOH analysis using the NGS panel in the molecular diagnostics of OCN.
ENDOCRINE-RELATED CANCER
(2023)
Article
Oncology
Stefano Fanti, Alberto Briganti, Louise Emmett, Karim Fizazi, Silke Gillessen, Karolien Goffin, Boris A. Hadaschik, Ken Herrmann, Jolanta Kunikowska, Tobias Maurer, Steven MacLennan, Nicolas Mottet, Declan G. Murphy, Daniela E. Oprea-Lager, Joe M. O'Sullivan, Wim J. G. Oyen, Olivier Rouviere, Oliver Sartor, Arnulf Stenzl, Hendrik Van Poppel, Jochen Walz, Wim Witjes, Anders Bjartell
Summary: The use and potential of PSMA PET/CT in prostate cancer treatment and management were assessed and achieved consensus among a panel of experts, particularly in utilizing PSMA PET/CT for patient selection and guiding [177Lu]Lu-PSMA therapy.
EUROPEAN UROLOGY ONCOLOGY
(2022)
Review
Oncology
Miriam N. Mikhail Lette, Diana Paez, Lawrence N. Shulman, Mathias Guckenberger, Jean-Yves Douillard, Wim J. G. Oyen, Francesco Giammarile, Venkatesh Rangarajan, Michelle Ginsberg, Olivier Pellet, Zhongxing Liao, May Abdel Wahab
Summary: This paper emphasizes the importance of improving medical imaging and nuclear medicine infrastructure globally to achieve better outcomes for lung cancer patients. It highlights the significant role of imaging findings in treatment selection and patient outcomes, and discusses the current gaps in diagnostics and therapies. The paper also emphasizes the high burden of lung cancer in low- and middle-income countries and the need for strategic planning to improve population-based outcomes.
JCO GLOBAL ONCOLOGY
(2022)
