Article
Biophysics
Jing-yan Tian, Chang-liang Chi, Ge Bian, Dong Xing, Feng-jun Guo, Xiao-qing Wang
Summary: The development of genistein and plumbagin co-encapsulating liposomes with PSMA specific antibodies showed selective targeting of prostate cancer cells, resulting in over 90% decrease in cell proliferation. This strategy may potentially be applied to encapsulate other drugs for inhibiting the growth of different types of cancers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Pharmacology & Pharmacy
Carla M. A. van Alem, Josbert M. Metselaar, Cees van Kooten, Joris I. Rotmans
Summary: Liposomes are considered ideal carriers for anti-inflammatory drugs due to their ability to target sites of inflammation and increase local efficacy. However, clinical translation of liposomal nanomedicines in the field of inflammatory diseases still poses challenges. Recent research has focused on innovations and cutting-edge developments in liposomal treatment.
Article
Chemistry, Multidisciplinary
Zili Gu, Yang Hao, Timo Schomann, Ferry Ossendorp, Peter ten Dijke, Luis J. Cruz
Summary: The cGAS-STING pathway acts as a bridge between innate and adaptive immunity, making it a promising approach for anti-cancer immunotherapy. Chemotherapy-induced DNA damage can directly induce dendritic cell maturation and recruitment, which synergizes with STING activation to enhance anti-tumor effects. In this study, liposomes encapsulating oxaliplatin were developed and combined with a STING agonist to treat colorectal cancer, resulting in complete remission of tumors. Mechanistic studies showed that this treatment resulted in the recruitment of infiltrating CD8 and CD4 T cells, reduction of suppressive Treg cells, and a shift in the phenotype of tumor-associated suppressive macrophages, leading to an immune-stimulating environment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mike Sathekge, Frank Bruchertseifer, Mariza Vorster, Ismaheel O. Lawal, Kgomotso Mokoala, Janet Reed, Letjie Maseremule, Honest Ndlovu, Khanyi Hlongwa, Alex Maes, Alfred Morgenstern, Christophe Van de Wiele
Summary: In this retrospective study, we evaluated the treatment outcome of Ac-225-PSMA-617 radioligand therapy in patients with de novo metastatic hormone-sensitive prostate carcinoma (mHSPC). The results showed that this treatment option had a good anti-tumor effect, with a significant decline in PSA levels in the majority of patients and minimal side effects.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Urology & Nephrology
Benedikt Feuerecker, Robert Tauber, Karina Knorr, Matthias Heck, Ali Beheshti, Christof Seidl, Frank Bruchertseifer, Anja Pickhard, Andrei Gafita, Clemens Kratochwil, Margitta Retz, Jurgen E. Gschwend, Wolfgang A. Weber, Calogero D'Alessandria, Alfred Morgenstern, Matthias Eiber
Summary: Ac-225-PSMA-617 demonstrated measurable antitumor effect in late-stage mCRPC after Lu-177-PSMA failure. Grade 3/4 hematological side effects were observed in up to one-third of patients, and xerostomia led to treatment halt in a relevant number of patients.
Article
Medicine, Research & Experimental
Falco Reissig, Kristof Zarschler, Zbynek Novy, Milos Petrik, Katerina Bendova, Daniela Kurfurstova, Jan Bouchal, Marie-Charlotte Ludik, Florian Brandt, Klaus Kopka, Marta Khoylou, Hans-Juergen Pietzsch, Marian Hajduch, Constantin Mamat
Summary: The modification of PSMA-based 225Ac-radioconjugates with albumin-binding entities resulted in improved radiopharmacological behavior, leading to enhanced tumor accumulation and low uptake in non-targeted organs with high excretion through the kidneys. The novel derivatives showed enhanced binding to serum components and serum albumin, indicating their potential for targeted alpha therapy of metastatic prostate cancer. Biodistribution studies in LNCaP tumor xenografts demonstrated prolonged blood circulation times and substantially increased tumor uptake.
Article
Pharmacology & Pharmacy
Puneet Kaur, Jin Gao, Zhenjia Wang
Summary: Dietary omega 3 polyunsaturated fatty acids (PUFAs), including DHA and EPA, have beneficial effects on cardiovascular diseases and cancer due to their anti-inflammatory properties. This study introduces a novel liposomal formulation of EPA (EPA-liposomes) that shows significant reduction in inflammation-related molecules, providing potential therapeutic applications.
Article
Pharmacology & Pharmacy
Ronja Bjornstad, Ingeborg Nerbo Reiten, Kaja Skalnes Knudsen, Jan Schjott, Lars Herfindal
Summary: Co-encapsulation of simvastatin and doxorubicin in liposomes can effectively reduce the risk of doxorubicin-induced cardiotoxicity while retaining or even potentiating the anticancer effect of doxorubicin.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Food Science & Technology
Guodong Zheng, Kanghui Wang, Baizhong Chen, Mengshi Liu, Wanling Yang, Jinrong Ning, Yi Cai, Minyan Wei
Summary: Citrus peel polymethoxyflavonoids (PMFs) were enriched from citrus peel by reflux extraction, and liposomes loaded with PMFs extract (PLS) were prepared by thin film hydration-high pressure homogenization method. PLS showed improved solubility and stronger anti-lipase effect, making it a potential anti-obesity agent.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Biophysics
Simona Sennato, Angelo Sarra, Carlo Panella La Capria, Cecilia Bombelli, Enrica Donati, Paolo Postorino, Federico Bordi
Summary: Laser Transmission Spectroscopy (LTS) is a technique that can determine the particle concentration and size of colloidal suspensions by measuring the transmittance of a laser beam through the suspension as a function of wavelength. This study demonstrates the application of LTS in investigating liposome suspensions, where accurate quantification of particle concentration is crucial for defining the colloidal properties. LTS is validated by comparing results with High-Performance Liquid Chromatography, and then applied to state-of-art liposomal nanocarrier suspensions. The study also explores data analysis methods and potential future applications of LTS in characterizing nanocarriers and other nanoparticles.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Analytical
Basseem Radwan, Amrutha Prabhakaran, Stefano Rocchetti, Ewelina Matuszyk, Tia E. Keyes, Malgorzata Baranska
Summary: The cellular uptake and bioavailability of anti-inflammatory antioxidant astaxanthin (AXT) can be improved via liposomal encapsulation. Endothelial cells (EC), which line blood vessels, play important roles in maintaining cardiovascular homeostasis. Dysfunction of EC is associated with various diseases and is closely related to oxidative stress and inflammation. Liposomal encapsulation of AXT showed enhanced uptake and anti-inflammatory effects, especially in reducing lipid unsaturation, lipid droplets, and intercellular adhesion molecule 1 (ICAM-1) overexpression in EC.
Article
Chemistry, Inorganic & Nuclear
Amanda Morgenstern, Laura M. Lilley, Benjamin W. Stein, Stosh A. Kozimor, Enrique R. Batista, Ping Yang
Summary: This study focuses on the interaction between actinium and macrocyclic chelators, exploring key factors and proposing a new design strategy. The findings highlight the importance of maximizing ionic bonding interactions and minimizing electronic repulsion to improve actinium chelation chemistry for future development of multifunctional chelators.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xiaotong Li, Jiayi Gu, Qingqing Xiao, Ying Liu, Ping Zhou, Lifang Fan, Xiulian Zhang, Xiang Lu, Jun Wu, Zhengxia Liu, Wei He
Summary: In this study, a pH-sensitive liposome co-loaded with an anti-inflammatory agent and a plaque-collagen protector was developed for the treatment of atherosclerosis. The co-loaded system showed improved pharmacokinetics and effective accumulation in plaque, leading to efficient anti-atherosclerosis activities. The findings provide a potential guideline for clinical practice.
CHINESE CHEMICAL LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Khaled S. Allemailem, Ahmad Almatroudi, Faris Alrumaihi, Aseel Aljaghwani, Abdullah M. Alnuqaydan, Habibullah Khalilullah, Hina Younus, Asmaa M. El-Kady, Fahad M. Aldakheel, Amjad Ali Khan, Arif Khan, Masood Alam Khan
Summary: The study demonstrated that Lip-TQ showed excellent efficacy in treating Acinetobacter baumannii infection in immunocompromised mice, significantly improving the survival rate and reducing bacterial burden. Additionally, Lip-TQ effectively alleviated inflammatory responses, oxidative stress, and histological changes in lung tissues.
Article
Oncology
Falco Reissig, David Bauer, Kristof Zarschler, Zbynek Novy, Katerina Bendova, Marie-Charlotte Ludik, Klaus Kopka, Hans-Juergen Pietzsch, Milos Petrik, Constantin Mamat
Summary: This study focused on finding a universal chelator for the radiolabeling of Ac-225 and developed an aza-macrocycle-derived mcp chelator with functional groups for universal connection of biomolecules using click chemistry. The resulting Ac-225-radioconjugates showed high receptor affinity on tumor cells and high tumor accumulation in tumor-bearing mice. The synthesized chelators have the potential to improve the treatment of addressable tumor targets by overcoming stability obstacles and better labeling needs for Ac-225 complexation.