Article
Radiology, Nuclear Medicine & Medical Imaging
Grayson Wass, Kari Clifford, Rathan M. Subramaniam
Summary: This study evaluated the diagnostic performance of fibroblast-activation protein (FAP) PET/CT compared to 18F-FDG PET/CT in cancer. The results showed that FAP PET/CT had higher sensitivity in detecting primary lesions, nodal metastases, and distant metastases. Further studies are needed to assess its utility and indication in specific cancer types and clinical settings.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Katharina Sprute, Vasko Kramer, Stefan A. Koerber, Manuel Meneses, Rene Fernandez, Cristian Soza-Ried, Mathias Eiber, Wolfgang A. Weber, Isabel Rauscher, Kambiz Rahbar, Michael Schaefers, Tadashi Watabe, Motohide Uemura, Sadahiro Naka, Norio Nonomura, Jun Hatazawa, Constantin Schwab, Viktoria Schuetz, Markus Hohenfellner, Tim Holland-Letz, Juergen Debus, Clemens Kratochwil, Horacio Amaral, Pete L. Choyke, Uwe Haberkorn, Camilo Sandoval, Frederik L. Giesel
Summary: F-18-PSMA-1007 PET/CT reliably detects malignant lymph nodes in prostate cancer patients with exceptional specificity of more than 99% for nodal metastases.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Otorhinolaryngology
Sinisa Stevanovic, Tomislav Greguric, Leo Pazanin, Boris Ivkic, Antonela Geber, Ayla Hadzavdic, Andro Kosec
Summary: This study evaluated the diagnostic accuracy of preoperative CT and intraoperative endoscopic tumor staging for histopathologic staging in patients with early laryngeal cancer. The results showed that CT provides little valuable information for differentiating small superficial lesions in the glottis and tends to overstage cases of early laryngeal cancer. Endoscopy should be the preferred diagnostic method for T1a and T1b glottic tumors.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rathan M. Subramaniam, Fenghai M. Duan, Justin Romanoff, Jian Qin Yu, Twyla Bartel, Farrokh Dehdashti, Charles M. Intenzo, Lilja Solnes, JoRean Sicks, Brendan C. Stack, Val J. Lowe
Summary: This study is the first multicenter clinical trial to report inter-observer agreement of 18F-FDG PET/CT scans for staging of clinical N0 neck in head and neck cancer, with high negative predictive value.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Yang Yu, Le Zhang, Bilkis Sultana, Bo Wang, Hongzan Sun
Summary: This study investigated the diagnostic value of integrated positron emission tomography/magnetic resonance imaging (PET/MRI) for the staging of endometrial carcinoma. The results showed that PET/MRI had higher accuracy compared to PET/CT, especially for stage I tumors. PET/MRI quantitative parameters were associated with tumor stage and other clinicopathological characteristics.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Ryul Shim, Seong-Jang Kim
Summary: This study evaluated the diagnostic accuracies of F-18-FDG PET or PET/CT for Merkel cell carcinoma (MCC) through a systematic review and meta-analysis. The results showed that F-18-FDG PET/CT had excellent performance in diagnosing MCC and could be useful for exclusion and confirmation of the disease. Further large multicenter studies are needed to validate its diagnostic accuracy.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xin Zhou, Shuailiang Wang, Xiaoxia Xu, Xiangxi Meng, Huiyuan Zhang, Annan Zhang, Yufei Song, Hua Zhu, Zhi Yang, Nan Li
Summary: This study compared the clinical staging performance of [(68) Ga]Ga-DOTA-FAPI-04 PET/CT and 2-[F-18]FDG PET/CT in non-small cell lung cancer (NSCLC) patients. The results showed that [(68) Ga]Ga-DOTA-FAPI-04 PET/CT had better staging performance in NSCLC patients, especially in localized disease.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oncology
Vijay Mistry, Justin R. R. Scott, Tzu-Yang Wang, Peter Mollee, Kenneth A. A. Miles, W. Phillip Law, Greg Hapgood
Summary: This study compared the diagnostic performance of FDG PET/MRI and FDG PET/CT in adult patients with newly diagnosed Hodgkin and Non-Hodgkin lymphoma. The results showed high concordance in disease site identification, staging, and response assessment between PET/MRI and PET/CT. PET/MR has the potential to be an alternative to PET/CT in lymphoma, minimizing radiation exposure.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sang Woo Lee, Seong-Jang Kim
Summary: The systematic review and meta-analysis showed that F-18-FDG PET/CT has good diagnostic performance in detecting lymph node metastasis in penile cancer patients, with similar accuracy in detecting inguinal and pelvic lymph node metastasis.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Clemens Mingels, Karl Peter Bohn, Axel Rominger, Ali Afshar-Oromieh, Ian Alberts
Summary: This study investigated the diagnostic accuracy of [F-18]PSMA-1007 PET/CT in biochemically recurrent prostate cancer. The results showed good performance in terms of regional sensitivity and negative predictive value, but limited positive predictive value, especially for bone lesions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lara Marchetti, Luca Perrucci, Fabio Pellegrino, Luca Baroni, Annalisa Merlo, Massimo Tilli, Ilaria Rambaldi, Elisa Maietti, Aldo Carnevale, Mirco Bartolomei, Melchiore Giganti
Summary: The study aimed to evaluate the diagnostic value of contrast-enhanced CT (CECT) compared to unenhanced CT (UECT) in PET/CT staging and treatment response assessment of F-18-FDG-avid lymphomas. Results showed that CECT did not provide significant additional diagnostic value compared to UECT, suggesting that CECT examination may be unnecessary for these purposes.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Si Tang, Yingying Hu, Jiling Zeng, Zhijian Li, Yongluo Jiang, Yinghe Li, Jingyi Wang, Hongyan Sun, Xiao Wu, Yun Zhou, Xu Zhang, Yumo Zhao
Summary: This study compared the diagnostic and staging efficacy of PET/DxCT and PET/LDCT in pediatric lymphoma patients. It found that PET/LDCT allowed for a significant reduction in CT effective dose without compromising diagnostic and staging efficacy.
EUROPEAN RADIOLOGY
(2023)
Review
Medicine, General & Internal
Salam Awenat, Arnoldo Piccardo, Patricia Carvoeiras, Giovanni Signore, Luca Giovanella, John O. Prior, Giorgio Treglia
Summary: F-18-PSMA-1007 PET/CT demonstrates good diagnostic accuracy for PCa staging, showing similar results compared to other PSMA-targeted radiopharmaceuticals. This method has the potential to replace traditional imaging techniques for PCa staging. Prospective multicentric studies are needed to confirm these findings.
Article
Oncology
Andrea G. Rockall, Tara D. Barwick, William Wilson, Naveena Singh, Nishat Bharwani, Aslam Sohaib, Marielle Nobbenhuis, Victoria Warbey, Marc Miquel, Dow-Mu Koh, Katja N. De Paepe, Pierre Martin-Hirsch, Sadaf Ghaem-Maghami, Christina Fotopoulou, Helen Stringfellow, Sudha Sundar, Ranjit Manchanda, Anju Sahdev, Allan Hackshaw, Gary J. Cook
Summary: The study compared FEC-PET/CT, FDG-PET/CT, and DW-MRI with conventional MRI for nodal staging accuracy in cervical and endometrial cancer patients. All imaging techniques had low sensitivity for detecting nodal metastases and cannot replace surgical nodal staging. FDG-PET/CT showed higher sensitivity in detecting nodal metastases compared to nodal size.
CLINICAL CANCER RESEARCH
(2021)
Article
Hematology
M. Picardi, C. Cavaliere, R. Della Pepa, E. Nicolai, A. Soricelli, C. Giordano, N. Pugliese, M. G. Rascato, I. Cappuccio, G. Campagna, C. Cerchione, E. Vigliar, G. Troncone, M. Mascolo, M. Franzese, R. Castaldo, M. Salvatore, F. Pane
Summary: The study compared the performance of FDG-PET/unenhanced MRI and FDG-PET/diagnostic CT in detecting infiltration in patients with newly diagnosed HL. The findings showed equivalence between PET/MRI and PET/CT in defining the staging system, with a significant difference observed in bony infiltration detection rates. Overall, PET/MRI was identified as a promising safe alternative to PET/CT in the care of HL patients.
ANNALS OF HEMATOLOGY
(2021)
Article
Physiology
Reza Piri, Yaran Hamakan, Ask Vang, Lars Edenbrandt, Mans Larsson, Olof Enqvist, Oke Gerke, Poul Flemming Hoilund-Carlsen
Summary: This study compared a convolutional neural network (CNN) approach with manual segmentation of the common carotids. The results showed that the CNN-based segmentation method was much faster and provided results virtually identical to manual segmentation.
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
M. W. Kusk, J. Stowe, S. Hess, O. Gerke, S. Foley
Summary: A study was conducted to evaluate the automatic measurement method using a 3D-printed heart phantom. The results showed that the phantom closely mimicked the real scans and the automatic algorithm reliably measured left ventricular volume.
Review
Urology & Nephrology
Robert Seifert, Louise Emmett, Steven P. Rowe, Ken Herrmann, Boris Hadaschik, Jeremie Calais, Frederik L. Giesel, Robert Reiter, Tobias Maurer, Matthias Heck, Andrei Gafita, Michael J. Morris, Stefano Fanti, Wolfgang A. Weber, Thomas A. Hope, Michael S. Hofman, Wolfgang Peter Fendler, Matthias Eiber
Summary: This study proposes the PROMISE V2 framework for standardized interpretation and reporting of PSMA-PET findings, aiming to improve communication between imaging experts and uro-oncologists. The framework integrates an updated miTNM system, improved assessment of local disease, and a slightly modified PSMA-expression score for clinical routine and research.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sys Vestergaard, Oke Gerke, Mette Bay, Anders Rorbaek Madsen, Lis Stilgren, Charlotte Ejersted, Kate Isabella Rewers, Nick Jakobsen, Jon Thor Asmussen, Poul-Erik Braad, Henrik Petersen, Anders Thomassen, Soren Schifter
Summary: This study compared the efficacy of Tc-99m-sestamibi SPECT/CT and C-11-L-methionine PET/CT in identifying hyperfunctioning parathyroid glands in patients with hyperparathyroidism. The results showed that both imaging methods had similar sensitivity and positive predictive value.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Marianne Vogsen, Mohammad Naghavi-Behzad, Frederik Graae Harbo, Nick Moldrup Jakobsen, Oke Gerke, Jon Thor Asmussen, Henriette Juel Nissen, Sara Elisabeth Dahlsgaard-Wallenius, Poul-Erik Braad, Jeanette Dupont Jensen, Marianne Ewertz, Malene Grubbe Hildebrandt
Summary: This study compares CE-CT and 2-[F-18]FDG-PET/CT for monitoring treatment response in metastatic breast cancer patients. The results show that 2-[F-18]FDG-PET/CT is a better predictor of progression-free and disease-specific survival compared to CE-CT, and there is low concordance between the two modalities in response categorization.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Lytfi Krasniqi, Axel Brandes, Poul Erik Mortensen, Jordi Sanchez Dahl, Oke Gerke, Mulham Ali, Lars Peter Schodt Riber
Summary: This study aims to investigate whether prophylactic administration of atorvastatin reduces postoperative atrial fibrillation (POAF) in patients undergoing surgical aortic valve replacement (SAVR). The study is a randomized, double-blind, placebo-controlled trial involving 266 patients without a history of AF or statin use. The primary endpoint is the occurrence of POAF, documented by rhythm strip or 12-lead ECG.
Article
Otorhinolaryngology
Sanne Hoxbroe Michaelsen, Mette Bay, Oke Gerke, Sys Vestergaard, Ole Graumann, Viveque Egsgaard Nielsen, Anders Rorbaek Madsen, Steen Joop Bonnema, Christian Godballe
Summary: This study investigated whether surgeon-performed ultrasonography is as effective as scintigraphy in localizing pathological parathyroid glands in patients with primary hyperparathyroidism. The results showed that conventional ultrasonography by an experienced parathyroid surgeon-sonographer was noninferior to scintigraphy and may be considered as a valid first-line imaging modality.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Borjana Bogdanovic, Esteban L. Solari, Alberto Villagran Asiares, Sandra van Marwick, Sylvia Schachoff, Matthias Eiber, Wolfgang A. Weber, Stephan G. Nekolla
Summary: This study aimed to determine the effects of different PSMA PET timing on signal kinetics and its correlation with patients' PSA and Gleason scores. The results showed that the detection of tumors remained unchanged in static and dynamic scans. The activity concentration trend of lesions in pelvic lymph nodes and bones was mostly negative, while lesions in the prostate and prostatic fossa showed a positive trend. The correlation between dynamic parameters and PSA varied depending on the radiotracer used.
EUROPEAN JOURNAL OF HYBRID IMAGING
(2023)
Article
Medicine, General & Internal
Selma Hasific, Kristian A. Ovrehus, Susanne Hosbond, Jess Lambrechtsen, Preman Kumarathurai, Anna Mejldal, Emil Johannes Ravn, Lars Melholt Rasmussen, Oke Gerke, Hans Mickley, Axel Diederichsen
Summary: This study aims to investigate the effects of vitamin K2 and D3 supplementation on severe coronary artery calcification. The findings suggest that supplementation with these vitamins can slow down the calcification process and have a protective role in predicting acute myocardial infarction and cardiovascular mortality.
Review
Mathematics, Applied
Oke Gerke, Soeren Moeller
Summary: Bland-Altman limits of agreement are commonly used in method comparison studies for quantitative outcomes. However, certain assumptions need to be met for a straightforward application of Bland-Altman analysis. If these assumptions are violated, variance-stabilizing transformations or fractional polynomial regression can be used. This review revisits an inter-rater agreement analysis on coronary calcification and demonstrates the inappropriate use of a straightforward Bland-Altman analysis, as well as the application of nonparametric limits of agreement and fractional polynomials.
Article
Imaging Science & Photographic Technology
Rosa Gram-Nielsen, Ivar Yannick Christensen, Mohammad Naghavi-Behzad, Sara Elisabeth Dahlsgaard-Wallenius, Nick Moldrup Jakobsen, Oke Gerke, Jeanette Dupont Jensen, Marianne Ewertz, Malene Grubbe Hildebrandt, Marianne Vogsen
Summary: The study compared the metastatic pattern of breast cancer and the agreement between [F-18]FDG-PET/CT and CE-CT. The results showed that [F-18]FDG-PET/CT reported bone and distant lymph node metastases more frequently, while CE-CT reported liver and lung metastases more frequently.
JOURNAL OF IMAGING
(2023)
Article
Multidisciplinary Sciences
Werner Vach, Oke Gerke
Summary: Gwet's AC1 is proposed as an alternative to Cohen's kappa for evaluating agreement between binary ratings. This paper investigates the properties of Gwet's AC1 and compares it to Cohen's kappa, particularly in terms of the impact of prevalence of positive ratings and behavior in cases of no association or maximal disagreement. The two approaches have fundamental differences in how they are calculated and interpreted, making Gwet's AC1 not a substitute for Cohen's kappa.
Article
Radiology, Nuclear Medicine & Medical Imaging
Johanne Kuhl, Mohammad Talal Elhakim, Sarah Wordenskjold Stougaard, Benjamin Schnack Brandt Rasmussen, Mads Nielsen, Oke Gerke, Lisbet Bronsro Larsen, Ole Graumann
Summary: The objective of this study was to validate the accuracy of a standalone AI system for breast cancer detection on an entire screening population, compared to first-reading breast radiologists.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Christoffer Bing Madsen, Max Rohde, Oke Gerke, Christian Godballe, Jens Ahm Sorensen
Summary: This study investigated the diagnostic accuracy of up-front 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and MRI for detecting cervical lymph node metastases in patients with T1-T2 oral squamous cell carcinoma. The results showed that PET/CT had higher sensitivity but lower specificity compared to neck MRI, and the overall accuracy of both imaging modalities was comparable. Therefore, a combination of PET/CT and MRI should be used for diagnosing cervical lymph node metastases in T1-T2 oral cavity cancer.
Article
Multidisciplinary Sciences
Mohammad Naghavi-Behzad, Oke Gerke, Annette Raskov Kodahl, Marianne Vogsen, Jon Thor Asmussen, Wolfgang Weber, Malene Grubbe Hildebrandt, Kristian Kidholm
Summary: This study evaluated the cost-effectiveness of 2-[F-18]FDG-PET/CT compared to CE-CT for response monitoring in metastatic breast cancer patients. The findings suggest that 2-[F-18]FDG-PET/CT is a cost-effective modality, particularly in patients with favorable prognostic factors, while CE-CT may be more cost-effective for poor prognosis patients.
SCIENTIFIC REPORTS
(2023)