Article
Oncology
Lin-Lin Liu, Lei-Lei Zhu, Zhen-Guo Lu, Jun-Die Sun, Jun Zhao, Hai-Feng Wang, Zuo-Lin Xiang
Summary: This study aimed to assess the impact of PSMA Ligand PET/MRI on target delineation in whole pelvis radiotherapy for high-risk prostate cancer compared to conventional imaging. The results showed that there were little differences in CTV delineation based on PET/MRI and MRI, while PET/MRI accurately encompassed metastatic pelvic lymph nodes and avoided covering non-metastatic lymph nodes. This emphasizes the utility of PET/MRI fusion images in GTVn delineation for more individual and precise radiotherapy for PCa.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zahra Falahatpour, Parham Geramifar, Seyed Rabie Mahdavi, Hamid Abdollahi, Yazdan Salimi, Alireza Nikoofar, Mohammad Reza Ay
Summary: This study investigated the potential benefits of FDG PET radiomic feature maps (RFMs) for target delineation in non-small cell lung cancer (NSCLC) radiotherapy. Thirty-two NSCLC patients were included and nine grey-level co-occurrence matrix (GLCM) RFMs were generated for each patient. The results showed that RFMs, specifically entropy, contrast, and Haralick correlation, were useful for tumor segmentation. Linear regression analysis demonstrated positive correlations between the gold standard and RFM-derived target volumes. These findings suggest that FDG PET-based radiomics features have promising potential for decision support in radiotherapy for NSCLC, aiding in accurate tumor delineation and segmentation of heterogeneous tumor regions.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Oncology
Stephanie E. Combs, Brigitta G. Baumert, Martin Bendszus, Alessandro Bozzao, Michael Brada, Laura Fariselli, Alba Fiorentino, Ute Ganswindt, Anca L. Grosu, Frank L. Lagerwaard, Maximilian Niyazi, Tufve Nyholm, Ian Paddick, Damien Charles Weber, Claus Belka, Giuseppe Minniti
Summary: This study established a joint guideline for target volume definition of skull base tumors, emphasizing the use of high-precision and tissue-contrast MRI images to improve target delineation accuracy. Experts agreed that radiation techniques, imaging techniques, and technical aspects specific to different tumor types are crucial factors affecting target delineation.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Ouying Yan, Hui Wang, Yaqian Han, Shengnan Fu, Yanzhu Chen, Feng Liu
Summary: In locoregionally advanced nasopharyngeal carcinoma, utilizing the 50% SUVmax threshold regimen for GTV delineation with dose-painting appeared to be superior to visual criteria or SUV2.5 threshold, without increased toxicity.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Nicolas Martz, Julia Salleron, Frederic Dhermain, Guillaume Vogin, Jean-Francois Daisne, Raphaelle Mouttet-Audouard, Ronan Tanguy, Georges Noel, Matthieu Peyre, Isabelle Lecouillard, Julian Jacob, Justine Attal, Marie Charissoux, Ovidiu Veresezan, Chantal Hanzen, Aymeri Huchet, Igor Latorzeff, Alexandre Coutte, Jerome Doyen, Dinu Stefan, Loic Feuvret, Gabriel C. T. E. Garcia, Philippe Royer
Summary: This study aims to develop delineation guidelines for radiotherapy in meningiomas. It is based on a consensus endorsed by a multidisciplinary group of brain tumor experts. The recommendations are expected to improve the uniformity in target volume definition.
RADIATION ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Kyung Su Kim, Kwang-Ho Cheong, Kyubo Kim, Taeryool Koo, Hyeon Kang Koh, Ji Hyun Chang, Ah Ram Chang, Hae Jin Park
Summary: The study evaluated the inter-physician variability in target contouring for radiotherapy of ASCC. The results showed high agreement for pelvic CTV but lower agreement for inguinal CTV, indicating the need for further studies to establish clearer delineation guidelines.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Shupeng Chen, An Qin, Di Yan
Summary: This study investigated the dynamic characteristics and predictive capability of tumor voxel dose-response matrix (DRM) using feedback from serial FDG-PET/CT imaging during radiotherapy. The results showed that DRM constructed using a single FDG-PET/CT feedback image after the 2nd treatment week has good predictive capability, and the predictive capability improves continuously using a later feedback image and slightly improves when two feedback images are applied.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xianghua Ye, Dazhou Guo, Chen-Kan Tseng, Jia Ge, Tsung-Min Hung, Ping-Ching Pai, Yanping Ren, Lu Zheng, Xinli Zhu, Ling Peng, Ying Chen, Xiaohua Chen, Chen-Yu Chou, Danni Chen, Jiaze Yu, Yuzhen Chen, Feiran Jiao, Yi Xin, Lingyun Huang, Guotong Xie, Jing Xiao, Le Lu, Senxiang Yan, Dakai Jin, Tsung-Ying Ho
Summary: This study validated the clinical applicability of a deep learning multimodality esophageal GTV contouring model, which was developed at one institution and tested at multiple institutions. The model, utilizing a two-streamed deep learning approach, demonstrated flexibility in segmenting GTV using pCT alone or pCT+PET/CT combined. The performance of the model was compared against human experts and radiation oncologists, showing promising results in contouring accuracy and efficiency.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cedric Draulans, Robin De Roover, Uulke A. van der Heide, Linda Kerkmeijer, Robert J. Smeenk, Floris Pos, Wouter V. Vogel, James Nagarajah, Marcel Janssen, Sofie Isebaert, Frederik Maes, Cindy Mai, Raymond Oyen, Steven Joniau, Martina Kunze-Busch, Karolien Goffin, Karin Haustermans
Summary: Threshold-based contouring using SOSTs trained with GTV(majority) achieved accuracy comparable to manual contours in delineating GTV(histo). Median SOSTs were found to be 41 SUV% for 68Ga-PSMA-11 PET and 44 SUV% for 18F-PSMA-1007 PET, forming a basis for tracer-specific window leveling.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Johannes Kraft, Paul Lutyj, Felix Grabenbauer, Serge-Peer Stroehle, Joerg Tamihardja, Gary Razinskas, Stefan Weick, Anne Richter, Henner Huflage, Andrea Wittig, Michael Flentje, Dominik Lisowski
Summary: This study evaluates the image quality of brain metastases on dual-energy computed tomography (DECT) virtual monoenergetic imaging (VMI) and its impact on target volume delineation. The results show that VMI provides superior image contrast, lesion demarcation, and target volume delineation compared to conventional CT. This has significant implications for stereotactic radiotherapy planning.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Engineering, Biomedical
R. Nigam, M. Field, G. Harris, M. Barton, M. Carolan, P. Metcalfe, L. Holloway
Summary: Non-small cell lung cancer (NSCLC) patients with bone metastases can benefit from stereotactic ablative body radiotherapy and FDG-PET/CT imaging for improved staging and treatment response. A software tool has been developed for automatic detection and quantification of bone metastases using FDG-PET/CT images, which showed strong concordance with manual contouring. The tool has various applications in radiotherapy and scientific studies.
PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE
(2023)
Article
Oncology
Florit Marcuse, Stephanie Peeters, Kato Herman, Femke Vaassen, Wouter van Elmpt, Alexander P. W. M. Maat, John Praag, Charlotte Billiet, Paul Van Schil, Maarten Lambrecht, Dirk Van Raemdonck, Kim Cao, Madalina Grigoroiu, Nicolas Girard, Monique Hochstenbag, Jos Maessen, Dirk De Ruysscher
Summary: This study is the first to investigate CTV definition in thymoma, revealing significant variability between radiation oncologists and surgeons. Collaborative delineation resulted in significantly smaller CTV volumes, favoring surgeons' judgement. A multidisciplinary approach is recommended for PORT treatment of thymomas in clinical practice.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Fang-Fang Kong, Guang-Sen Pan, Rui-Ping Zhai, Cheng-Run Du, Xia-Yun He, Chun-Ying Shen, Xue-Guan Lu, Tuan-Qi Sun, Yu Wang, Qing-Hai Ji, Chao-Su Hu, Hong-Mei Ying
Summary: Based on our long-term clinical experience, distant metastasis is the major failure pattern for CASTLE patients after surgery and IMRT. For patients without lateral neck node metastasis, omitting irradiation for the lateral neck nodal regions does not affect patient survival.
Article
Oncology
Yan-Nan Zhang, Zhen-Guo Lu, Shuai-Dong Wang, Xin Lu, Lei-Lei Zhu, Xu Yang, Li-Ping Fu, Jun Zhao, Hai-Feng Wang, Zuo-Lin Xiang
Summary: This study assessed the clinical value of PSMA PET/MRI in the gross tumor volume (GTV) delineation of radiotherapy for prostate cancer (PCa). The results showed that PET/MRI imaging can visually delineate GTV in PCa radiotherapy, and PET/MRI fusion images are useful in GTV delineation.
Review
Radiology, Nuclear Medicine & Medical Imaging
Farkhad Manapov, Chukwuka Eze, Adrien Holzgreve, Lukas Kaesmann, Alexander Nieto, Julian Taugner, Marcus Unterrainer
Summary: In the clinical routine of lung cancer patients, radiotherapy is an important treatment method. Conventional imaging techniques like CT and MR are commonly used for staging and radiotherapy planning, but advanced imaging techniques like PET have overcome their limitations and have relevance in radiotherapy planning.
SEMINARS IN NUCLEAR MEDICINE
(2022)
Article
Allergy
Maria Elena Laino, Angela Ammirabile, Francesca Motta, Maria De Santis, Victor Savevski, Marco Francone, Arturo Chiti, Lorenzo Mannelli, Carlo Selmi, Lorenzo Monti
Summary: The cardiovascular system is frequently affected by COVID-19, particularly in hospitalized cases, leading to complications such as myocarditis and pulmonary embolism. Early detection through imaging techniques such as CT scan and MRI is important for prompt disease recognition and evaluation. The immune system's abnormal response is responsible for severe COVID-19 and organ-specific injury, with molecular mimicry possibly being the immunological mechanism for myocarditis in COVID-19.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Martina Sollini, Fabrizia Gelardi, Matteo Biroli, Arturo Chiti
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Margarita Kirienko, Paola A. Erba, Arturo Chiti, Martina Sollini
Summary: PET/MRI technology shows promise in the diagnosis and evaluation of infection and inflammation, providing accurate diagnoses and insights into disease biology in various conditions.
SEMINARS IN NUCLEAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Paola Tiberio, Lidija Antunovic, Mariangela Gaudio, Alessandro Vigano, Manuela Pastore, Chiara Miggiano, Flavia Jacobs, Chiara Benvenuti, Elisabetta Farina, Arturo Chiti, Armando Santoro, Rita De Sanctis
Summary: The impact of patients' eating habits on breast cancer management and inflammation has been investigated. The study found positive correlations between bowel [18]F-FDG uptake and pro-inflammatory drinks and foods, as well as a negative correlation between rectum SUVmean and anti-inflammatory foods. In addition, colon SUVmean was significantly lower in patients with pCR. This suggests that PET scan could be used to identify patients with unhealthy behaviors.
Review
Oncology
Gaia Ninatti, Cristiano Pini, Fabrizia Gelardi, Martina Sollini, Arturo Chiti
Summary: This study aimed to review the use of PET imaging in adult-type diffuse gliomas and assess its capability in distinguishing radiation necrosis from tumor recurrence. The study found that PET imaging has some value in differentiating between these two conditions, but there is high heterogeneity among existing studies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Martina Sollini, Margarita Kirienko, Luca di Tommaso, Cristiano Pini, Fabrizia Gelardi, Salvatore Ariano, Andrea Gerardo Lania, Gherardo Mazziotti, Giuseppe Mercante, Arturo Chiti
Summary: This study investigated the potential role of Prostate Specific Membrane Antigen (PSMA) in thyroid carcinoma (TC) and found that PSMA expression and 2-[F-18]fluoro-2-deoxy-D-glucose ([F-18]FDG) uptake on PET/CT can serve as complementary biomarkers for TC outcome prediction.
Article
Oncology
Damiano Dei, Nicola Lambri, Sara Stefanini, Veronica Vernier, Ricardo Coimbra Brioso, Leonardo Crespi, Elena Clerici, Luisa Bellu, Chiara De Philippis, Daniele Loiacono, Pierina Navarria, Giacomo Reggiori, Stefania Bramanti, Marcello Rodari, Stefano Tomatis, Arturo Chiti, Carmelo Carlo-Stella, Marta Scorsetti, Pietro Mancosu
Summary: The contouring of lymph node clinical target volume (CTV_LN) in total marrow and lymph node irradiation (TMLI) is complex and time-consuming. The introduction of internal guidelines reduced inter- and intraobserver variability in CTV_LN delineation. The guidelines improved the consistency of contouring in TMLI treatments.
Article
Radiology, Nuclear Medicine & Medical Imaging
Gaia Ninatti, Cristiano Pini, Fabrizia Gelardi, Samuele Ghezzo, Paola Mapelli, Maria Picchio, Lidija Antunovic, Alberto Briganti, Francesco Montorsi, Claudio Landoni, Martina Sollini, Arturo Chiti
Summary: In this study, we investigated the potential association between osteoporosis and unspecific bone uptake in PET imaging using [F-18]PSMA-1007. We found that blood count parameters showed a significant correlation with unspecific bone uptake, suggesting a possible link between [F-18]PSMA-1007 uptake and osteoporosis. Further research with larger populations and specific osteoporosis markers is needed to explore this hypothesis.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Gaia Ninatti, Cristiano Pini, Beatrice Claudia Bono, Fabrizia Gelardi, Lidija Antunovic, Bethania Fernandes, Martina Sollini, Claudio Landoni, Arturo Chiti, Federico Pessina
Summary: This study aimed to assess the prognostic value of MET PET in newly diagnosed, treatment naive IDH-wt gliomas with histological features of LGGs. The results showed that positive MET PET was significantly associated with shorter PFS and OS time. Incomplete surgical resection and higher TBRmean values were independent predictors of shorter PFS, while higher tumor grade and incomplete surgical resection were independent predictors of OS.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Paola Mapelli, Samuele Ghezzo, Alessandro Spataro, Carolina Bezzi, Ana Maria Samanes Gajate, Arturo Chiti, Maria Picchio
MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA
(2023)
Review
Biology
Francesco Vito Mandarino, Sabrina Gloria Giulia Testoni, Alberto Barchi, Francesco Azzolini, Emanuele Sinagra, Gino Pepe, Arturo Chiti, Silvio Danese
Summary: Gastroparesis is a chronic disease characterized by upper gastrointestinal symptoms and delayed gastric emptying. The gold standard for diagnosis is gastric emptying scintigraphy, although its correlation with symptoms is weak. Recent research focuses on developing treatments that target the underlying pathophysiology, such as Gastric Peroral Endoscopic Myotomy. New diagnostic tools, including wireless motility capsule and the Endoluminal Functional Lumen Imaging Probe, have the potential to characterize the pathophysiology of gastroparesis and identify patients who may benefit from targeted therapies.
Article
Biotechnology & Applied Microbiology
Samuele Ghezzo, Ilaria Neri, Paola Mapelli, Annarita Savi, Ana Maria Samanes Gajate, Giorgio Brembilla, Carolina Bezzi, Beatrice Maghini, Tommaso Villa, Alberto Briganti, Francesco Montorsi, Francesco De Cobelli, Massimo Freschi, Arturo Chiti, Maria Picchio, Paola Scifo
Summary: This study proposes a new workflow for accurate co-registration of prostate PET images with histopathological images using a dual-tracer PET/MRI study. The method allows a deeper understanding of PET tracer distribution and enables advanced analyses. The co-registration workflow involves five steps and the precision was evaluated using target registration error (TRE) and DICE score.
BIOENGINEERING-BASEL
(2023)
Article
Oncology
Gaia Ninatti, Cristiano Pini, Beatrice Claudia Bono, Fabrizia Gelardi, Lidija Antunovic, Bethania Fernandes, Martina Sollini, Claudio Landoni, Arturo Chiti, Federico Pessina
Summary: MET PET is important for prognostic stratification of IDH-wt gliomas with histological LGGs features. Combined with molecular analysis, it can improve prognostic accuracy and influence therapeutic choices.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Review
Health Care Sciences & Services
Maria Elena Laino, Angela Ammirabile, Ludovica Lofino, Lorenzo Mannelli, Francesco Fiz, Marco Francone, Arturo Chiti, Luca Saba, Matteo Agostino Orlandi, Victor Savevski
Summary: The combined use of different imaging modalities is usually required for the diagnosis, evaluation, and treatment planning of pancreatic pathologies. Artificial intelligence (AI) has shown great potential in transforming medical imaging and has been applied to various radiological techniques. Computer-aided diagnosis (CAD) and radiomics have proven to be useful in pancreatic imaging for both non-oncological and oncological purposes.
Review
Radiology, Nuclear Medicine & Medical Imaging
Margarita Kirienko, Matteo Biroli, Cristiano Pini, Fabrizia Gelardi, Martina Sollini, Arturo Chiti
Summary: PET/CT scans can identify COVID-19 vaccine-related deltoid [F-18]FDG uptake and axillary hypermetabolic lymph nodes, with variable frequency depending on the tracer used. Awareness of vaccination timing, patient characteristics, and concurrent therapies is necessary for interpreting vaccine-related findings.
CLINICAL AND TRANSLATIONAL IMAGING
(2022)
