Article
Engineering, Biomedical
Xueqi Chen, Sulei Zhang, Jianhua Zhang, Lixin Chen, Rongfu Wang, Yun Zhou
Summary: The study evaluates an optimization approach based on Patlak plot with reduced blood samples for noninvasive quantification of dynamic F-18-FDG PET imaging. The results show that the method is reliable and can potentially be extended to further translational human studies.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Chemistry, Medicinal
Hiroki Matsumoto, Tadashi Watabe, Chika Igarashi, Tomoko Tachibana, Fukiko Hihara, Atsuo Waki, Ming-Rong Zhang, Hideaki Tashima, Taiga Yamaya, Kazuhiro Ooe, Eku Shimosegawa, Jun Hatazawa, Sei Yoshida, Kenichiro Naito, Hiroaki Kurihara, Makoto Ueno, Kimiteru Ito, Tatsuya Higashi, Yukie Yoshii
Summary: To improve the prognosis of pancreatic cancer, a new PET imaging method was developed to detect tumor lesions smaller than 1 cm, showing promising results in mouse and monkey experiments.
Article
Biochemistry & Molecular Biology
Sarita Garg, Tarun K. Garg, Stephen Y. Wise, Oluseyi O. Fatanmi, Isabelle R. Miousse, Alena V. Savenka, Alexei G. Basnakian, Vijay K. Singh, Martin Hauer-Jensen
Summary: This study evaluated the effects of the vitamin E analog gamma-tocotrienol (GT3) on GI recovery in nonhuman primates (NHPs) after total-body irradiation. The results showed that GT3 promoted the survival and proliferation of intestinal stem cells, reduced cell apoptosis, and had a radioprotective function. Therefore, GT3 has the potential to be used as a prophylactic medical countermeasure for radiation-induced GI injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Samantha Rossano, Takuya Toyonaga, Eric Berg, Isabella Lorence, Krista Fowles, Nabeel Nabulsi, Jim Ropchan, Songye Li, Yunpeng Ye, Zachary Felchner, David Kukis, Yiyun Huang, Helene Benveniste, Alice F. Tarantal, Stephanie Groman, Richard E. Carson
Summary: This study assessed synaptic density changes in the developing fetal brain using positron emission tomography (PET) radioligands. The results showed an increase in SV2A concentration during the third trimester, with lower levels in cortical regions. Furthermore, the post-mortem quantification of SV2A density correlated significantly with the PET measurements.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yali Long, Chang Yi, Renbo Wu, Yuying Zhang, Bing Zhang, Xinchong Shi, Xiangsong Zhang, Zhihao Zha
Summary: In this study, the distribution, tumor detecting ability, and radiation dosimetry of [F-18]DFA in humans were evaluated using PET imaging. [F-18]DFA showed high uptake and retention in tumors, and exhibited a similar distribution pattern as AA. This suggests that [F-18]DFA may be a promising radiopharmaceutical for identifying tumors with high affinity for SVCT2 and monitoring AA distribution in both normal tissues and tumors.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Neurosciences
Yanxiao Li, Yee Ling Ng, Manish D. Paranjpe, Qi Ge, Fengyun Gu, Panlong Li, Shaozhen Yan, Jie Lu, Xiuying Wang, Yun Zhou
Summary: This study aimed to improve the statistical power in detecting changes in brain glucose metabolism, amyloid, and tau deposition in Alzheimer's disease studies by using a reference tissue-based quantification approach. The results showed that the tracer-specific reference tissue improved the detection of PET SUVR changes, which is beneficial for early diagnosis, disease progression monitoring, and therapeutic response in Alzheimer's disease.
HUMAN BRAIN MAPPING
(2022)
Article
Chemistry, Medicinal
Xiaojun Zhang, Yitian Wu, Qi Zeng, Tianxin Xie, Shulin Yao, Jinming Zhang, Mengchao Cui
Summary: The study designed, synthesized, and evaluated three more lipophilic F-18-labeled PSMA tracers, investigating the effect of lipophilicity on their distribution and excretion in different species. Higher lipophilicity led to increased radioactivity accumulation in the liver of primates and humans, as well as reduced excretion to the bladder through urine. The screened tracer [F-18]8c showed low bladder retention and good imaging properties in patients with prostate cancer.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Y. Alashban, N. Shubayr, M. Almalki, S. Albeshan, A. M. Aldosari
Summary: The study investigated occupational radiation exposure in cyclotron workers in Saudi Arabia and found that workers' doses did not exceed the dose limits set by the International Commission of Radiological Protection. It recommended that workers wear ring dosimeters for accurate measurement and use advanced absorbers to discriminate between different types of radiation.
RADIATION PHYSICS AND CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Bhuvanachandra Bhoopal, Krishna Kumar Gollapelli, Naresh Damuka, Mack Miller, Ivan Krizan, Avinash Bansode, Thomas Register, Brett M. Frye, Jeongchul Kim, Akiva Mintz, Miranda Orr, Suzanne Craft, Christopher Whitlow, Samuel N. Lockhart, Carol Shively, Kiran Kumar Solingapuram Sai
Summary: This study developed a new brain-penetrant PET ligand and found that its uptake was positively correlated with the instability of microtubules (MT) and inversely related to CSF A beta(42) levels and age in an AD model. In vitro autoradiography studies further confirmed the reliability of PET imaging results. These findings provide important evidence for a better understanding of the onset and development of AD and related dementias.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Katarina Varnas, Sangram Nag, Christer Halldin, Lars Farde
Summary: In this study, a novel reversible radioligand[F-18]GEH200449 for MAO-B was evaluated as a PET imaging marker in non-human primates. The PET studies demonstrated that [F-18]GEH200449 had suitable brain exposure and regional distribution consistent with the known localization of MAO-B. The binding of [F-18]GEH200449 to MAO-B was reversible and could be displaced by the administration of selective MAO-B ligands.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Sarita Garg, Tarun K. Garg, Isabelle R. Miousse, Stephen Y. Wise, Oluseyi O. Fatanmi, Alena Savenka, Alexei G. Basnakian, Vijay K. Singh, Martin Hauer-Jensen
Summary: Exposure to high doses of radiation can cause gastrointestinal injury, and there are currently no effective therapies available for mitigating this damage. Gamma-tocotrienol (GT3) is being investigated as a potential radioprotector, but its effectiveness in accelerating gastrointestinal recovery has not been well-studied. This study examined the effects of GT3 in nonhuman primates exposed to partial-body irradiation and found that it had some protective effects in reducing intestinal injury and promoting cell proliferation, although its impact on citrulline levels was minimal.
Article
Biochemistry & Molecular Biology
Se-Ran Jun, Marjan Boerma, Zulema Udaondo, Sasha Richardson, Karla D. Thrall, Isabelle R. Miousse, John Seng, Rupak Pathak, Martin Hauer-Jensen
Summary: The study found different discovery times in metabolomics pattern after radiation-induced GI injury between male and female adult Rhesus monkeys, leading to restricted detailed analyses only in males. Radiation resulted in increased fatty acid oxidation and circulating levels of corticosteroids, as well as changes in amino acid metabolism, with the most significant changes observed at days 9 and 10 post-irradiation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Leonie Beyer, Astrid Gosewisch, Simon Lindner, Friederike Voelter, Lena M. Mittlmeier, Reinhold Tiling, Matthias Brendel, Clemens C. Cyran, Marcus Unterrainer, Johannes Ruebenthaler, Christoph J. Auernhammer, Christine Spitzweg, Guido Boening, F. J. Gildehaus, Klaus Jurkschat, Carmen Wangler, Bjoern Wangler, Ralf Schirrmacher, Vera Wenter, Andrei Todica, Peter Bartenstein, Harun Ilhan
Summary: This study demonstrated the high tumor-to-background ratios and comparable effective dose of [F-18]SiTATE-PET/CT in NET patients from 60 to 180 minutes after injection, with the best compromise between image quality and tumor-to-background contrast reached at 120 minutes followed by 60 minutes.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph Therriault, Andrea L. Benedet, Tharick A. Pascoal, Melissa Savard, Nicholas J. Ashton, Mira Chamoun, Cecile Tissot, Firoza Lussier, Min Su Kang, Gleb Bezgin, Tina Wang, Jaime Fernandes-Arias, Gassan Massarweh, Paolo Vitali, Henrik Zetterberg, Kaj Blennow, Paramita Saha-Chaudhuri, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Neto
Summary: This study assessed multiple methods for determining an optimal cutoff for F-18-AZD4694 PET positivity, with good convergence among different approaches. The findings suggest that a threshold of 1.55 SUVR may have reliable discriminative accuracy for amyloid-beta positivity on PET imaging.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jin Qi, Elizabeth Kurian, Orhan K. oez
Summary: Hibernomas are rare benign tumors originating from fetal brown adipose tissue. They can occur in various parts of the body, with thigh, shoulder, back, and neck being the most common locations, and are rarely found in the abdominal cavity, retroperitoneum, breast, bones, scrotum, and perirectum. We present a case of a 58-year-old woman with a mediastinal mass, who was incidentally found to have an FDG-avid fat-containing lesion in the omentum abutting the stomach.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Swatabdi R. Kamal, Shreya Potukutchi, David J. Gelovani, Robin E. Bonomi, Srinivasu Kallakuri, John M. Cavanaugh, Thomas Mangner, Alana Conti, Ren-Shyan Liu, Renata Pasqualini, Wadih Arap, Richard L. Sidman, Shane A. Perrine, Juri G. Gelovani
Summary: The role of epigenetic regulatory mechanisms in neuroplasticity and adaptive responses to traumatic brain injury is gaining recognition. This study used PET/CT imaging to examine the expression-activity of HDACs class IIa in adult rats with mTBI and found that HDAC4 and HDAC5 were downregulated in certain brain regions post-TBI, supporting the development of therapeutic strategies to upregulate their expression.
MOLECULAR PSYCHIATRY
(2022)
Review
Engineering, Biomedical
Tanyaluck Thientunyakit, Shuichi Shiratori, Kazunari Ishii, Juri George Gelovani
Summary: This review focuses on the recent advances in molecular PET imaging of the brain and its clinical applications in AD. PET imaging studies can provide diagnostic and prognostic biomarkers of AD, as well as for selection and monitoring of novel therapies. Multimodal studies are required to better understand the relationships between different biomarkers and incorporate new diagnostic criteria for the various stages in the continuum of AD.
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Asma Wasfi, Falah Awwad, Juri George Gelovani, Naser Qamhieh, Ahmad I. Ayesh
Summary: This study designs a novel SiNW-FET sensor and investigates its electronic transport properties for accurate detection of the COVID-19 spike protein, demonstrating high sensitivity and selectivity.
Article
Chemistry, Medicinal
Mari Nakaie, Fumihiro Katayama, Takehiro Nakagaki, Sakura Yoshida, Masao Kawasaki, Kodai Nishi, Kazuma Ogawa, Akira Toriba, Noriyuki Nishida, Morio Nakayama, Takeshi Fuchigami
Summary: The researchers designed and synthesized a novel single-photon emission computed tomography probe for the detection of cerebral PrPSc deposits. The probe showed high binding affinity to PrPSc and remarkable selectivity against other aggregates. In vivo and in vitro experiments demonstrated its potential imaging applications.
ACS INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Yauhen Statsenko, Tetiana Habuza, Tatsiana Talako, Mikalai Pazniak, Elena Likhorad, Aleh Pazniak, Pavel Beliakouski, Juri G. Gelovani, Klaus Neidl-Van Gorkom, Taleb M. Almansoori, Fatmah Al Zahmi, Dana Sharif Qandil, Nazar Zaki, Sanaa Elyassami, Anna Ponomareva, Tom Loney, Nerissa Naidoo, Guido Hein Huib Mannaerts, Jamal Al Koteesh, Milos R. Ljubisavljevic, Karuna M. Das
Summary: The study developed an automatic assessment method for lung impairment in COVID-19 associated pneumonia using machine learning algorithms. The models based on multi-plane 2D images showed slightly better performance than single-projection images, and the models trained on 3D images were more accurate than those on 2D, although the differences were not statistically significant.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemical Research Methods
Iori Nozaki, Natsumi Ishikawa, Yusuke Miyanari, Kazuma Ogawa, Ayako Tagawa, Sakura Yoshida, Masayuki Munekane, Kenji Mishiro, Akira Toriba, Morio Nakayama, Takeshi Fuchigami
Summary: In this study, Bor peptides were designed and synthesized as survivin-targeting agents for the diagnosis and treatment of cancers. These peptides showed high binding affinity for survivin and were able to inhibit cancer cell growth and induce apoptosis. In mouse experiments, Bor peptides significantly suppressed tumor growth. Therefore, Bor peptides hold promise for the development of cancer imaging and anticancer agents targeting survivin.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Asma Wasfi, Falah Awwad, Naser Qamhieh, Badria Al Murshidi, Abdul Rasheed Palakkott, Juri George Gelovani
Summary: The rapid spread of the COVID-19 virus and the lack of specific treatment emphasize the need for accurate and early diagnosis. A graphene oxide-based field-effect transistor (GO-FET) biosensor has been developed for real-time detection of the COVID-19 spike protein antigen. The biosensor shows high specificity and sensitivity to COVID-19 spike protein, and the limit of detection is 1 fg/mL. This promising biosensor could greatly contribute to COVID-19 diagnosis.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Kenji Mishiro, Sayaka Imai, Yuki Ematsu, Katsumi Hirose, Takeshi Fuchigami, Masayuki Munekane, Seigo Kinuya, Kazuma Ogawa
Summary: A probe with potential application in cancer therapy was synthesized and evaluated in this study. The probe contains boron clusters, a compound for nuclear medicine imaging, and a peptide for tumor targeting. Biodistribution experiments showed high uptake of the probe in the tumor.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Kenji Mishiro, Takahiro Ueno, Hiroshi Wakabayashi, Masato Fukui, Seigo Kinuya, Kazuma Ogawa
Summary: Guanidine is a common functional group found in natural products and drugs, with high basicity and effective as a cationic hydrogen bond donor. Finding a suitable bioisostere of guanidinium is challenging due to its high basicity and unique trigonal planar shape. In this study, deltic guanidinium was explored as a potential bioisostere for guanidinium, and it was found that peptides containing deltic guanidinium exhibited similar biological properties and improved in vivo stability compared to the parent peptides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mohamed Elsaid Nasr Elghobary, Masayuki Munekane, Kenji Mishiro, Takeshi Fuchigami, Kazuma Ogawa
Summary: Thermosensitive liposomes (TSLs) encapsulating I-125-labeled doxorubicin (DOX) were developed for Auger electron therapy, targeting cancer cell DNA. The radioiodinated DOX derivative [I-125]5 accumulated in the nuclei of cancer cells and showed potent cytotoxicity against Colon 26 cancer cells by Auger electrons. TSLs encapsulating [I-125]5 demonstrated efficient release at 42 degrees C and high uptake in the nuclei, suggesting their potential as an effective cancer therapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hiroaki Echigo, Kenji Mishiro, Masayuki Munekane, Takeshi Fuchigami, Kohshin Washiyama, Kazuhiro Takahashi, Yoji Kitamura, Hiroshi Wakabayashi, Seigo Kinuya, Kazuma Ogawa
Summary: We developed probes for multiradionuclides radiotheranostics using RGD peptide and an albumin binding moiety. The use of 4-(4-astatophenyl)-butyric acid as the albumin binding moiety improved the therapeutic effects of targeted alpha therapy. [At-211]5 showed higher tumor accumulation and retention compared to other probes.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Multidisciplinary Sciences
Daniela I. Staquicini, Marina Cardo-Vila, Jimmy A. Rotolo, Fernanda I. Staquicini, Fenny H. F. Tang, Tracey L. Smith, Aditya Ganju, Carmine Schiavone, Prashant Dogra, Zhihui Wang, Vittorio Cristini, Ricardo J. Giordano, Michael G. Ozawa, Wouter H. P. Driessen, Bettina Proneth, Glauco R. Souza, Lina M. Brinker, Achraf Noureddine, Ashley J. Snider, Daniel Canals, Juri G. Gelovani, Irina Petrache, Rubin M. Tuder, Lina M. Obeid, Yusuf A. Hannun, Richard N. Kolesnick, C. Jeffrey Brinker, Renata Pasqualini, Wadih Arap
Summary: The vascular endothelium in individual organs has specialized functions and unique molecular targets. This study identifies a lipid-based receptor system in the lung vascular endothelium, where CGSPGWVRC peptide interacts with C16-ceramide to trigger ceramide-rich platform formation and activate ceramide production. This peptide shows lung selectivity dependent on ceramide production and has potential applications in pulmonary imaging and lung immunization against COVID-19.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Yauhen Statsenko, Tetiana Habuza, Darya Smetanina, Gillian Lylian Simiyu, Sarah Meribout, Fransina Christina King, Juri G. Gelovani, Karuna M. Das, Klaus N. -V. Gorkom, Kornelia Zareba, Taleb M. Almansoori, Miklos Szolics, Fatima Ismail, Milos Ljubisavljevic
Summary: The high occurrence of neurodegenerative diseases and neurodevelopmental disorders necessitates clear diagnostic criteria for these pathologies based on brain imaging findings. Currently, there are no easily applicable quantitative markers for abnormal brain development and aging. Our aim is to identify the characteristic features of non-pathological development and degeneration in different brain structures and develop a precise descriptive model of brain morphometry in different age groups.
Proceedings Paper
Acoustics
Aryaz Baradarani, Kiyanoosh Shapoori, Eugene V. Malyarenko, Jeff Sadler, Juri G. Gelovani, Roman Gr. Maev
Summary: TRUBI is a 3D transcranial ultrasound brain imaging device that overcomes the limitations caused by the human skull in conventional imaging. This paper presents a signal processing algorithm used in the prototype version of TRUBI for detecting ICH.
2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS)
(2022)
Article
Computer Science, Information Systems
Yauhen Statsenko, Tetiana Habuza, Tatsiana Talako, Tetiana Kurbatova, Gillian Lylian Simiyu, Darya Smetanina, Juana Sido, Dana Sharif Qandil, Sarah Meribout, Juri G. Gelovani, Klaus Neidl-Van Gorkom, Taleb M. Almansoori, Fatmah Al Zahmi, Tom Loney, Anthony Bedson, Nerissa Naidoo, Alireza Dehdashtian, Milos Ljubisavljevic, Jamal Al Koteesh, Karuna M. Das
Summary: This study examines the effectiveness of machine learning in eliminating data redundancy of radiomics and reflecting pathophysiologic changes in patients with COVID-19 pneumonia. The results show that radiomic findings are a reliable source of information for assessing the functional status of COVID-19 patients. Machine learning models can predict the oxygenation level, respiratory and cardiovascular functioning based on radiomics and demographic data.
