Article
Oncology
Emilio Bertani, Francesco Collamati, Marzia Colandrea, Riccardo Faccini, Nicola Fazio, Mahila E. Ferrari, Marta Fischetti, Uberto Fumagalli Romario, Luigi Funicelli, Micol De Simoni, Carlo Mancini-Terracciano, Riccardo Mirabelli, Silvio Morganti, Stefano Papi, Eleonora Pisa, Elena Solfaroli-Camillocci, Francesca Spada, Marta Cremonesi, Chiara M. Grana
Summary: The study focused on validating a new probe for radioguided surgery (RGS) in small intestine neuroendocrine tumor (SI-NET) patients, showing that the probe can effectively discriminate between tumor and healthy tissues, leading to more precise surgery.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2021)
Article
Engineering, Biomedical
Stephen F. Mee, Daniel F. Polan, Yuni K. Dewaraja, Kyle C. Cuneo, Joseph J. Gemmete, Joseph R. Evans, Theodore S. Lawrence, Janell S. Dow, Justin K. Mikell
Summary: This study introduces a method for treating underdosed hepatocellular carcinoma lesions using stereotactic body radiation therapy (SBRT) following post-selective internal radiation therapy (SIRT) dosimetry. It demonstrated that selectively targeting these lesions with SBRT could reduce normal tissue toxicity and improve treatment outcomes.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Bin Jiang, Zhangkai Yang, Hangyu Shi, Abduladheem Turki Jalil, Marwan Mahmood Saleh, Weiyang Mi
Summary: Localized drug delivery vehicles based on implantable electrospun nanofibrous scaffolds have attracted interest in cancer cell eradication and tissue regeneration. In this study, zeolite Y nanoparticles were used to load Curcumin as an anticancer agent. The synthesized Curc@nZY was then integrated into a hybrid of PCL-gelatin electrospun nanofibers. The results showed successful loading of Curc@nZY into the nanofibers and a steady drug release over a long period.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nasser K. Yaghi, Mark R. Gilbert
Summary: This review examines the challenges faced by immunotherapies in treating glioblastoma, explores current treatment options, and proposes future directions for GBM immunotherapy.
Article
Biology
Srinivas Cheenu Kappadath, Benjamin P. Lopez
Summary: In this study, an ablative dosimetry model was developed to calculate the dose distribution for tumors and at-risk margins, based on numerical mm-scale dose modeling and clinical evidence. The necessary dose metrics needed to achieve complete pathologic necrosis (CPN) following Y-90 radioembolization were calculated for a range of tumor sizes and tumor-to-normal-liver uptake ratios.
Article
Oncology
Gordon Winter, Carmen Hamp-Goldstein, Gabriel Fischer, Peter Kletting, Gerhard Glatting, Christoph Solbach, Hendrik Herrmann, Elisa Sala, Michaela Feuring, Hartmut Doehner, Ambros J. Beer, Donald Bunjes, Vikas Prasad
Summary: Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative treatment for high-risk patients with diseases of the hematopoietic cells. High-dose chemotherapy and external beam radiotherapy (EBRT) are commonly used in preparation, but they can have toxic effects, leading to treatment failure or even death. High-dose radioimmunotherapy offers a less stressful treatment option for the bone marrow. This study aims to improve radiolabeling and reduce non-specific accumulation using a chelator variant.
Article
Medicine, General & Internal
Matthew D. Walker, Jonathan I. Gear, Allison J. Craig, Daniel R. McGowan
Summary: Respiratory motion can degrade the quantification accuracy of PET imaging, particularly in dosimetric measures. However, using device-driven quiescent period respiratory motion correction can improve accuracy.
Review
Biochemistry & Molecular Biology
Longfei Deng, Xuan Zhai, Ping Liang, Hongjuan Cui
Summary: TRAIL holds therapeutic potential in cancer treatment, but many cancers, including GBM, exhibit resistance. Recent studies have identified new mechanisms in regulating TRAIL-induced apoptosis in GBM and effective combinatorial strategies. The TRAIL/TRAIL death receptor axis may have future clinical applications for GBM treatment.
Article
Engineering, Electrical & Electronic
K. P. Shabeeb Ahamed, Kavitha Arunachalam
Summary: This study reports on the use of a ferrite sleeve for electrically short choke in coaxial antennas used for intracavitary microwave hyperthermia treatment. The optimized ferrite sleeve in intracavitary applicators showed stable resonance and targeted power deposition at 700, 915, and 2450 MHz, regardless of insertion depth. Thermal simulations revealed that the applicators with the ferrite sleeve had a spherical heating volume. Prototype intracavitary applicators with the optimized ferrite choke exhibited return loss of more than 22, 27, and 22 dB at 700, 915, and 2450 MHz, respectively, for various insertion depths, consistent with the simulations. Local electric field measurements indicated a reduction of 51% and 58% in the 25% field contour along the antenna axis for the lambda/4 monopole with a 0.24 lambda ferrite sleeve and the 3 lambda/8 monopole with a 0.12 lambda ferrite sleeve, respectively.
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATION
(2022)
Review
Health Care Sciences & Services
Diogo Roque, Nuno Cruz, Hugo Alexandre Ferreira, Catarina Pinto Reis, Nuno Matela, Manuel Herculano-Carvalho, Rita Cascao, Claudia C. Faria
Summary: Glioblastoma is a malignant brain tumor with limited treatment options. Nanoparticles provide a promising approach for the treatment of glioblastoma by overcoming the blood-brain barrier and reducing systemic side effects.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Multidisciplinary Sciences
Gefei Chen, Zhonglin Lu, Han Jiang, Ko-Han Lin, Greta S. P. Mok
Summary: In this study, a new VSV method is proposed and compared with PM, MC and other VSV methods for Y-90 RE treatment planning. The results show that LiCKLuKD method has the smallest deviation in the liver and tumors, while LiLuKD and LiCKLuKD perform the best in the lungs.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Oncology
Fernando Aranda, Inaki Eguren-Santamaria, Angela Bella, Pedro Berraondo, Ignacio Melero
Summary: Ovarian cancer often spreads within the peritoneal cavity as peritoneal carcinomatosis, allowing for targeted delivery of combination immunotherapy agents to maximize effectiveness and minimize systemic exposure and side effects.
CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, General & Internal
Pia M. Linder, Wenhong Lan, Nils F. Trautwein, Julia Brosch-Lenz, Sebastian von Beschwitz, Juergen Kupferschlaeger, Gerald Reischl, Gerd Groezinger, Helmut Dittmann, Christian la Fougere, Fabian P. Schmidt
Summary: Optimized imaging protocol allows high image quality and quantification accuracy for post-treatment dosimetry of Y-90 radioembolization.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anne-Claire Dupont, Fanny Borrelly, Thierry Lecomte, Serge Maia, Maria-Joao Santiago Ribeiro
Summary: In this case, Ga-68-DOTATOC PET/CT imaging revealed abnormal biodistribution of the tracer with vascular binding and very low fixation on known lesions, possibly due to a high intake of turmeric inhibiting hepatic uptake process.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Alessandro Di Federico, Alessandro Rizzo, Riccardo Carloni, Andrea De Giglio, Riccardo Bruno, Dalia Ricci, Giovanni Brandi
Summary: This article discusses the main evidence regarding the use of Y-90-TARE in HCC, the recent progress of immunotherapy in this tumor, and the preclinical rationale of combining VEGF blockade with the other two treatment strategies. HCC has an extremely heterogeneous tumor immune microenvironment. Combining an immune-checkpoint inhibitor with VEGF blockade and Y-90-TARE might overcome primary resistances observed when each of these treatments is administered alone.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dominik Summer, Christine Rangger, Maximilian Klingler, Peter Laverman, Gerben M. Franssen, Beatrix E. Lechner, Thomas Orasch, Hubertus Haas, Elisabeth von Guggenberg, Clemens Decristoforo
CONTRAST MEDIA & MOLECULAR IMAGING
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christian Uprimny, Anna Svirydenka, Josef Fritz, Alexander Stephan Kroiss, Bernhard Nilica, Clemens Decristoforo, Roland Haubner, Elisabeth von Guggenberg, Sabine Buxbaum, Wolfgang Horninger, Irene Johanna Virgolini
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2018)
Article
Multidisciplinary Sciences
Dominik Summer, Andrea Kroess, Rudolf Woerndle, Christine Rangger, Maximilian Klingler, Hubertus Haas, Leopold Kremser, Herbert H. Lindner, Elisabeth von Guggenberg, Clemens Decristoforo
Article
Radiology, Nuclear Medicine & Medical Imaging
Maximilian Klingler, Dominik Summer, Christine Rangger, Roland Haubner, Julie Foster, Jane Sosabowski, Clemens Decristoforo, Irene Virgolini, Elisabeth von Guggenberg
JOURNAL OF NUCLEAR MEDICINE
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Johanna Maffey-Steffan, Lorenza Scarpa, Anna Svirydenka, Nilica Bernhard, Christian Mair, Sabine Buxbaum, Jasmin Bektic, Elisabeth von Guggenberg, Christian Uprimny, Wolfgang Horninger, Irene Virgolini
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Article
Pharmacology & Pharmacy
Katja Fresacher, Anna Helbok, Martin Reiser, Sandra Blass, Christine Rangger, Christian Mair, Elisabeth von Guggenberg, Clemens Decristoforo, Fritz Andreae, Andreas Zimmer
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Johanna Maffey-Steffan, Lorenza Scarpa, Anna Svirydenka, Bernhard Nilica, Christian Mair, Sabine Buxbaum, Jasmin Bektic, Elisabeth von Guggenberg, Christian Uprimny, Wolfgang Horninger, Irene Virgolini
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Correction
Biochemistry & Molecular Biology
Nathalie M. Grob, Martin Behe, Elisabeth von Guggenberg, Roger Schibli, Thomas L. Mindt
JOURNAL OF PEPTIDE SCIENCE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christian Uprimny, Steffen Bayerschmidt, Alexander Stephan Kroiss, Josef Fritz, Bernhard Nilica, Anna Svirydenka, Clemens Decristoforo, Gianpaolo di Santo, Elisabeth von Guggenberg, Wolfgang Horninger, Irene Johanna Virgolini
Summary: This study aimed to assess the impact of intravenous hydration and furosemide diuresis at different dosages on tracer accumulation and halo artefact in urinary system. Results showed that 20mg furosemide and 500ml sodium chloride significantly reduced bladder halo artefacts and tracer accumulation intensity in [Ga-68]Ga-PSMA-11-PET/CT scans.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Biochemistry & Molecular Biology
Maximilian Klingler, Anton Amadeus Hormann, Elisabeth Von Guggenberg
CURRENT MEDICINAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Anton Amadeus Hoermann, Maximilian Klingler, Maliheh Rezaeianpour, Nikolas Hoermann, Ronald Gust, Soraya Shahhosseini, Elisabeth von Guggenberg
Article
Medicine, General & Internal
Steffen Bayerschmidt, Christian Uprimny, Alexander Stephan Kroiss, Josef Fritz, Bernhard Nilica, Hanna Svirydenka, Clemens Decristoforo, Elisabeth von Guggenberg, Wolfgang Horninger, Irene Johanna Virgolini
Summary: The study evaluated the diagnostic performance of early static imaging in comparison to 68Ga-PSMA-11 PET imaging conducted 60 min post-injection in prostate cancer patients with biochemical recurrence. The results showed no statistically significant differences between the combination of early and 60 min post-injection imaging, suggesting that additional early static imaging may not be routinely recommended for assessing biochemical recurrence in prostate cancer patients following a protocol with forced diuresis.
Review
Oncology
Elisabeth von Guggenberg, Petra Kolenc, Christof Rottenburger, Renata Mikolajczak, Alicja Hubalewska-Dydejczyk
Summary: Peptide analogs derived from gastrin show promise in improving tumor imaging and treatment by specifically binding to the cholecystokinin-2 receptor expressed on tumor cells. Recent developments include modifications to safely deliver radiation to tumor sites, leading to the introduction of new radiolabeled peptide analogs for cancer imaging and therapy. Ongoing clinical trials suggest a reasonable clinical applicability for CCK2R-targeted radiopharmaceuticals, especially in advanced medullary thyroid cancer.
Article
Chemistry, Medicinal
Taraneh Sadat Zavvar, Anton Amadeus Hormann, Maximilian Klingler, Dominik Summer, Christine Rangger, Laurence Desrues, Helene Castel, Pierrick Gandolfo, Elisabeth von Guggenberg
Summary: Different modifications were explored for the minigastrin analog DOTA-MGS5, and five new derivatives were synthesized for radiolabeling. The new derivatives showed high receptor affinity and resistance against enzymatic degradation. Among them, [In-111]In-DOTA-[(N-Me)1Nal(8)]MGS5 exhibited the most promising targeting properties.
Article
Chemistry, Medicinal
Maximilian Klingler, Christine Rangger, Dominik Summer, Piriya Kaeopookum, Clemens Decristoforo, Elisabeth von Guggenberg