Article
Radiology, Nuclear Medicine & Medical Imaging
Hee Jin Park, Sung Hae Chang, Jeong Won Lee, Sang Mi Lee
Summary: The study investigated the clinical implication of F-18 sodium fluoride PET/CT in assessing disease activity of rheumatoid arthritis. Results showed strong positive correlation between joint uptake on F-18 NaF PET/CT and DAS28ESR, with accurate predictions of high disease activity. F-18 NaF PET/CT parameters could be used as imaging biomarkers for disease activity in rheumatoid arthritis.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Review
Oncology
Kenji Hirata, Nagara Tamaki
Summary: Positron emission tomography (PET) allows quantitative assessment of tumour biology, particularly metabolic activity, treatment monitoring, and predicting prognosis. Biochemical changes assessed by FDG-PET are often more sensitive than morphological changes, with complete metabolic response indicating better prognosis. Recent studies have introduced machine learning techniques and texture analysis for tissue characterization and predicting treatment effect based on FDG-PET imaging.
Article
Chemistry, Medicinal
Chunmei Lu, Xiuting Wang, Qiqi Wang, Lixia Zhang, Jianguo Lin, Ling Qiu
Summary: Legumain is overexpressed in several cancers and serves as an important biomarker for cancer diagnosis. In this study, a novel radioactive tracer [F-18]SF-AAN was designed and synthesized for positron emission tomography (PET) imaging, targeting legumain. The tracer showed specificity in detecting legumain activity in vitro and in vivo, making it a promising tool for the diagnosis of legumain-related diseases.
Article
Medicine, General & Internal
Kalevi Kairemo, S. Cheenu Kappadath, Timo Joensuu, Homer A. Macapinlac
Summary: In this study, the quantitative differences between Fluorocholine-18 (FCH) and sodium fluoride-18 (NaF) in assessing skeletal disease in prostate cancer patients were characterized. The results suggest that a combination of NaF and FCH provides complementary information about the activity of skeletal disease, improving diagnosis and disease staging in PCa.
Review
Multidisciplinary Sciences
Zhi-Ming Liu, Min Zhang, Yuan Zong, Ding Zhang, Zhu-Bin Shen, Xiao-Qing Guan, Fei Yin
Summary: This study aimed to compare the efficacy of alendronate and teriparatide in the treatment of glucocorticoid-induced osteoporosis. The study found that compared to alendronate, teriparatide could reduce the rate of new vertebral fractures and increase the bone mineral density of the lumbar spine, femoral neck, and total hip. There was no significant difference in the incidence of non-vertebral fractures and adverse events between the two groups.
Article
Oncology
Xiufang Qiu, Haixia Wu, Ting Xu, Shihan Xie, Ziqing You, Yixin Hu, Yinghong Zheng, Zewei Liang, Chaoxiong Huang, Li Yi, Li Li, Jing Liu, Zhaodong Fei, Chuanben Chen
Summary: This study aimed to reassess the clinical significance of standardized uptake values (SUVs) in nasopharyngeal carcinoma (NPC) on F-18-fluorodeoxyglucose (F-18-FDG) positron-emission tomography (PET). The results showed that high SUVs were associated with cancer recurrence, and the SUVmax-NTR ratio was identified as a potential prognostic factor.
Article
Biochemical Research Methods
Yingqing Lu, Yingfang He, Roger Schibli, Linjing Mu, R. Michael van Dam
Summary: Copper-mediated radiofluorination has great potential in the synthesis of PET radioligands. We demonstrated the feasibility of Cu-mediated radiosynthesis on a high-throughput microdroplet platform and optimized the reaction conditions. By utilizing microscale conditions, we achieved higher radiochemical yield and excellent radiochemical purity and molar activity. We also successfully translated these optimized conditions to a vial-based method, expanding the applicability of the synthesis approach.
Article
Biochemistry & Molecular Biology
Hishar Hassan, Muhamad Faiz Othman, Hairil Rashmizal Abdul Razak, Zainul Amiruddin Zakaria, Fathinul Fikri Ahmad Saad, Mohd Azuraidi Osman, Loh Hui Yi, Zarif Ashhar, Jaleezah Idris, Mohd Hamdi Noor Abdul Hamid, Zaitulhusna M. Safee
Summary: In this study, [F-18]AlF-NOTA-pamidronic acid was prepared and radiolabeled. The preliminary in vitro results showed its potential application in cancer-specific bone imaging.
Article
Multidisciplinary Sciences
Satoshi Nozaki, Yuka Nakatani, Aya Mawatari, Nina Shibata, William E. Hume, Emi Hayashinaka, Yasuhiro Wada, Hisashi Doi, Yasuyoshi Watanabe
Summary: The aim of this study was to determine if [F-18]FIMP can be used for the early-phase evaluation of radiotherapy accompanied by inflammation, and compare its effectiveness with [C-11]MET and [F-18]FDG. The results showed that tumor uptake of [F-18]FIMP decreased after irradiation, while [F-18]FDG initially decreased, then transiently elevated, and decreased again, and [C-11]MET decreased at day 10. The findings suggest that [F-18]FIMP may be a PET probe involved in the early detection and prediction of radiotherapy efficacy, but further clarification is needed.
SCIENTIFIC REPORTS
(2023)
Review
Psychology, Clinical
Leigh Townsend, Toby Pillinger, Pierluigi Selvaggi, Mattia Veronese, Federico Turkheimer, Oliver Howes
Summary: This study investigates brain metabolism in patients with schizophrenia and finds evidence of lower glucose metabolism in the frontal cortex, supporting the hypothesis of hypofrontality in schizophrenia. However, there were no consistent alterations in other brain regions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Oncology
Suk-Hyun Lee, Jee-Soo Park, Hyunjeong Kim, Dongwoo Kim, Seung-Hwan Lee, Won-Sik Ham, Woong-Kyu Han, Young-Deuk Choi, Mijin Yun
Summary: The heterogeneous uptake of both F-18 FDG and C-11 methionine on PET/CT in renal cell carcinomas is associated with higher grades of cancer. The metabolic tumour volume on F-18 FDG PET/CT but not C-11 methionine PET/CT is significant in predicting advanced-stage renal cell carcinoma. These metabolic features derived from PET/CT imaging may aid in the development of new drugs targeting glucose and amino acid metabolic pathways.
Article
Clinical Neurology
Anita Nitchingham, Jarett Vanz-Brian Pereira, Eva A. Wegner, Vincent Oxenham, Jacqueline Close, Gideon A. Caplan
Summary: In this study, using FDG-PET, researchers found that patients with delirium showed hypometabolism in the bilateral thalami and certain cortical regions. The hypometabolism was correlated with delirium severity and performance on neuropsychological testing.
ALZHEIMERS & DEMENTIA
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
R. Gallicchio, A. Nardelli, G. Calice, A. Guarini, G. Guglielmi, G. Storto
Summary: This study evaluated the prognostic significance of combined use of FDG and FLT PET/CT in MM patients, showing that PET/CT can predict patient prognosis and that FDG+; FLT- patients have better EFS compared to other groups.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Patimat Murtazalieva, Darya Ryzhkova, Eduard Malev, Ekaterina Zhiduleva, Olga Moiseeva
Summary: The study aimed to assess the prognostic value of valvular inflammation and calcification measured by F-18-FDG and F-18-NaF PET/CT in patients with TAV and BAV. The results suggest that F-18-NaF PET/CT may be a valuable predictor for hemodynamic progression of calcific AS in TAV patients, while F-18-FDG PET/CT does not play a significant role in predicting AS progression.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Amanda Nguyen, Felipe Martinez, Ba D. Nguyen
Summary: This case report presents chest wall keloids detected on F-18-piflufolastat PET/CT during the evaluation of prostate cancer recurrence.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shizuka Yamada, Hideaki Tsuyoshi, Makoto Yamamoto, Tetsuya Tsujikawa, Yasushi Kiyono, Hidehiko Okazawa, Yoshio Yoshida
Summary: This study evaluated the potential of F-18-FES PET in predicting prognosis in endometrial cancer patients. The results showed that low F-18-FES SUV was associated with poor prognostic factors such as LVSI and lymph node metastasis, and was an independent prognostic factor for PFS in EC patients. These findings suggest that F-18-FES PET may be useful in guiding treatment decisions for EC patients.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tetsuya Tsujikawa, Yukihiro Umeda, Harumi Itoh, Toyohiko Sakai, Hiromichi Iwasaki, Hidehiko Okazawa, Tamotsu Ishizuka, Hirohiko Kimura
Summary: This pictorial essay examines the early features and potential progressive behavior of COVID-19 on HRCT of the lung, providing important clues for understanding the disease.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2021)
Article
Clinical Neurology
Hiroshi Matsuda, Kengo Ito, Kazunari Ishii, Eku Shimosegawa, Hidehiko Okazawa, Masahiro Mishina, Sunao Mizumura, Kenji Ishii, Kyoji Okita, Yoko Shigemoto, Takashi Kato, Akinori Takenaka, Hayato Kaida, Kohei Hanaoka, Keiko Matsunaga, Jun Hatazawa, Masamichi Ikawa, Tetsuya Tsujikawa, Miyako Morooka, Kenji Ishibashi, Masashi Kameyama, Tensho Yamao, Kenta Miwa, Masayo Ogawa, Noriko Sato
Summary: This study aimed to establish cutoffs for positivity in quantitative analysis of F-18-flutemetamol PET scans and evaluate the clinical efficacy of amyloid PET in diagnosing Alzheimer's disease. The results showed high agreement between quantitative assessments and visual interpretation of PET scans, with amyloid PET significantly impacting the diagnosis of AD by altering disease likelihood categories.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Hideaki Tsuyoshi, Tetsuya Tsujikawa, Shizuka Yamada, Hidehiko Okazawa, Yoshio Yoshida
Summary: F-18-FDG PET/MRI demonstrates superior diagnostic performance in cervical cancer compared to CT and MRI, particularly for evaluating lymph node and distant metastases.
Article
Radiology, Nuclear Medicine & Medical Imaging
Akinobu Kita, Hidehiko Okazawa, Katsuya Sugimoto, Ryoto Kaido, Nobuyuki Kosaka, Takayuki Shibutani, Masahisa Onoguchi, Eiji Kidoya, Hirohiko Kimura
Summary: The study indicates that SBR values decrease with reduced acquisition counts, but there is a strong correlation between halfSBR and fullSBR values. Even with half the acquisition counts, the accuracy of diagnosis remains unaffected. It is suggested that fullSBR can be estimated from halfSBR using a calibration formula when scan times are reduced.
ANNALS OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tetsuya Tsujikawa, Mizuho Takahashi, Hiroyuki Maeda, Tetsuya Mori, Akira Makino, Yasushi Kiyono, Yoshiaki Imamura, Takanori Goi, Hidehiko Okazawa
Summary: Metastatic invasive lobular breast cancer (ILC) to the colon is rare and often ER-positive. This study reports a case of ER-negative metastatic ILC presenting as linitis plastica of the colon, with evaluation of ER phenotypic transformation using [F-18]FES PET/MRI.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Daichi Shiotsu, Minyoung Jung, Kaie Habata, Taku Kamiya, Ichiro M. Omori, Hidehiko Okazawa, Hirotaka Kosaka
Summary: This study investigated the association between the Adolescent/Adult Sensory Profile (AASP) and neural connectivity in white matter tracts using diffusion tensor imaging (DTI). The results indicated a positive relationship between AASP scores and DTI parameters in the cingulum-cingulate gyrus bundle (CCG) and uncinate fasciculus (UNC), suggesting the critical role of CCG and UNC in determining sensory processing levels in young adults.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Masayuki Sato, Yukihiro Umeda, Tetsuya Tsujikawa, Tetsuya Mori, Miwa Morikawa, Masaki Anzai, Yuko Waseda, Maiko Kadowaki, Yasushi Kiyono, Hidehiko Okazawa, Tamotsu Ishizuka
Summary: Changes in F-18-FLT PET parameters may serve as an early predictive biomarker for the response to anti-PD-1 therapy in NSCLC patients, but pseudoprogression should be noted in imaging at 2 weeks after treatment initiation.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Hidehiko Okazawa
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Shun Seto, Tetsuya Tsujikawa, Katsuji Sawai, Hidetaka Kurebayashi, Mitsuhiro Morikawa, Hidehiko Okazawa, Takanori Goi
Summary: This study aimed to evaluate the diagnostic accuracy of [F-18]FDG PET/MRI for preoperative staging and the usefulness of EMVI detection for predicting metastasis in rectal cancer. The results showed that [F-18]FDG PET/MRI had high sensitivity and specificity in T and N staging, and pmrEMVI positivity was a significant predictor for metastasis.
Article
Biochemistry & Molecular Biology
Hidehiko Okazawa, Masamichi Ikawa, Tetsuya Tsujikawa, Tetsuya Mori, Akira Makino, Yasushi Kiyono, Yasunari Nakamoto, Hirotaka Kosaka, Makoto Yoneda
Summary: This study applied oxidative stress imaging using Cu-ATSM PET/MRI to evaluate patients with early Alzheimer's disease. The results showed that oxidative stress was particularly evident in the cingulate cortex and hippocampus of the patients. This study is important for understanding the pathogenesis and diagnosis of Alzheimer's disease.
Article
Medicine, General & Internal
Makoto Kitade, Hideaki Nakajima, Tetsuya Tsujikawa, Sakon Noriki, Tetsuya Mori, Yasushi Kiyono, Hidehiko Okazawa, Akihiko Matsumine
Summary: Activated microglia play a role in secondary injury after acute spinal cord injury (SCI) and the development of spinal cord-related neuropathic pain (NeP). This study assessed the expression of translocator protein 18 kDa (TSPO) as an indicator of microglial activation and visualized the dynamics of activated microglia in the injured spinal cord using PET imaging with (R)-[C-11]PK11195. Results showed that TSPO was mainly expressed in activated microglia in SCI chimeric animal models.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kai Nakagawa, Yongjeon Cheong, Seonkyoung Lee, Kaie Habata, Taku Kamiya, Daichi Shiotsu, Ichiro M. Omori, Hidehiko Okazawa, Hirotaka Kosaka, Minyoung Jung
Summary: The caudate nucleus, traditionally associated with motor control, may also play a role in attachment behavior, cognition, emotion, and mental functions. This study explores the relationship between white matter structure in the caudate nucleus and sensory processing using diffusion tensor imaging (DTI). The results suggest that diffusion parameters in the caudate nucleus are correlated with the Adolescent/Adult Sensory Profile (AASP) scores, specifically in relation to tactile sensation and avoidance.
Article
Medicine, General & Internal
Kenji Takata, Hirohiko Kimura, Shota Ishida, Makoto Isozaki, Yoshifumi Higashino, Ken-Ichiro Kikuta, Hidehiko Okazawa, Tetsuya Tsujikawa
Summary: The relationship between MRI-arterial spin labeling (ASL) parameters and PET-cerebral blood flow (CBF)/cerebrovascular reactivity (CVR) was investigated in Moyamoya disease. The results showed significant correlations between ASL parameters and PET-CBF/PET-CVR. Furthermore, ASL-ATT in the MCA territories was found to be related to CVR.
Article
Medicine, General & Internal
Akinobu Kita, Hidehiko Okazawa, Katsuya Sugimoto, Nobuyuki Kosaka, Eiji Kidoya, Tetsuya Tsujikawa
Summary: This study developed a new CNN method to estimate the specific binding ratio (SBR) using only frontal projection images in single-photon emission-computed tomography. Different datasets were created to train two CNNs, and the accuracy of SBR estimation was evaluated. The new CNN method showed feasibility and small error rate in estimating SBR from frontal projection images.