Article
Oncology
Lara Cavinato, Martina Sollini, Alessandra Ragni, Francesco Bartoli, Roberta Zanca, Francesco Pasqualetti, Andrea Marciano, Francesca Ieva, Paola Anna Erba
Summary: Advanced image analysis, specifically radiomics, was used to characterize the intra-tumor heterogeneity of metastatic prostate cancer. The study found that metastatic prostate cancer patients had lesions with different radiomic profiles, indicating intra-tumor radiomic heterogeneity. The presence of multiple radiomic profiles within the same patient impacted the treatment outcome.
Review
Endocrinology & Metabolism
Jie Jiang, Xiaoxia Tang, Yongzhu Pu, Yong Yang, Conghui Yang, Fake Yang, Yadong Tian, Jindan Li, Hua Sun, Sheng Zhao, Long Chen
Summary: This article reviews the progress of PET/CT research in biochemical recurrence of prostate cancer, aiming to introduce new technologies and provide more direction for future research.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Sankarsh Jetty, James Ryan Loftus, Abhinav Patel, Akshya Gupta, Savita Puri, Vikram Dogra
Summary: The imaging of prostate cancer has advanced with the use of molecular imaging, particularly Positron Emission Tomography (PET), replacing traditional CT and MRI for detecting prostate cancer recurrence. PET imaging provides better localization and characterization of disease recurrence, and also plays a role in assessing treatment response and determining patient prognosis and survival. This article reviews the commonly used molecular imaging agents for prostate cancer, focusing on Fluorine-18 fluciclovine (Axumin) and PSMA-ligand agents, including their imaging protocols, interpretation, and potential pitfalls.
Article
Oncology
Jonathan Chou, Emily A. Egusa, Sinan Wang, Michelle L. Badura, Fei Lee, Anil P. Bidkar, Jun Zhu, Tanushree Shenoy, Kai Trepka, Troy M. Robinson, Veronica Steri, Jiaoti Huang, Yuzhuo Wang, Eric J. Small, Emily Chan, Bradley A. Stohr, Alan Ashworth, Brant Delafontaine, Sylvie Rottey, Keegan S. Cooke, Nooshin Hashemi Sadraei, Brian Yu, Mark Salvati, Julie M. Bailis, Felix Y. Feng, Robert R. Flavell, Rahul Aggarwal
Summary: The expression of DLL3 in de novo and treatment-emergent small-cell/neuroendocrine (t-SCNC) prostate cancer is associated with reduced survival. A PET agent, [89Zr]-DFO-DLL3-scFv, has been developed to detect DLL3 levels in mouse SCNC models. The DLL3-targeted bispecific T-cell engager (BiTE) immunotherapy, AMG 757 (tarlatamab), exhibits potent and durable antitumor activity in patient-derived xenograft models.
Article
Biotechnology & Applied Microbiology
Jiaying Zhang, Zefang Lin, Xiaojun Zhang, Rong Lin, Mengchao Cui, Weibing Miao, Shaobo Yao
Summary: The injection of Ga-68-DOTA-DiPSMA is safe and associated with low absorbed and effective doses. Ga-68-DOTA-DiPSMA demonstrates favorable kinetics and imaging characteristics, showing potential as an alternative for gallium-68-labeled PSMA clinical PET.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Surgery
Conrad Leitsmann, Marianne Schmid, Carsten-Oliver Sahlmann, Lutz Trojan, Arne Strauss
Summary: This study found that MLN metastases detected by Ga-68-PSMA-PET/CT may serve as an important localization of tumor manifestation in recurrent PCa, guiding treatment decisions. Individualized therapies, such as salvage lymphadenectomy or radiation therapy with a defined field, could be options for patients with sole MLN metastases.
FRONTIERS IN SURGERY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yazan Z. Alabed
Summary: This case demonstrates the significance of F-18-PSMA PET/CT for staging and follow-up of patients with ductal variant prostate cancer, particularly those with normal PSA levels. It highlights the diagnostic and monitoring value of this imaging modality in such patients.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Felix Dietlein, Carsten Kobe, Sergio Munoz Vazquez, Thomas Fischer, Heike Endepols, Melanie Hohberg, Manuel Reifegerst, Bernd Neumaier, Klaus Schomaecker, Alexander E. Drzezga, Markus Dietlein
Summary: The study found that Zr-89-PSMA-DFO can detect low-expressed PSMA prostate cancer lesions more sensitively and reliably than existing tracers in PET/CT scans. This research is of great significance in helping patients with undetectable lesions.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Beatrice Detti, Maria Grazia Carnevale, Sara Lucidi, Luca Burchini, Saverio Caini, Carolina Orsatti, Niccolo Bertini, Manuele Roghi, Vanessa di Cataldo, Simona Fondelli, Gianluca Ingrosso, Giulio Francolini, Daniele Scartoni, Angela Sardaro, Antonio Pisani, Silvia Scoccianti, Cynthia Aristei, Lorenzo Livi
Summary: Biochemical recurrence (BR) occurs in up to 40% of patients with prostate cancer (PCa) treated with primary radical prostatectomy (RP). Choline PET/CT may show the site of tumor recurrence earlier than traditional imaging methods, particularly at low prostate-specific antigen (PSA) levels, thus influencing subsequent treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Ioannis Tsechelidis, Alexis Vrachimis
Summary: PSMA PET, the latest nuclear medicine development, is regarded as the most promising tool for the diagnosis and treatment of prostate malignancy. However, there is still debate and ongoing research regarding its utility and position in guidelines, requiring further studies and trials for clarification.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Keith L. Spinali, David J. Papke, Hina J. Shah
Summary: F-18-DCFPyl is used to detect recurrent or metastatic prostate cancer and can target nonprostatic disease entities that mimic prostate cancer. The interpreting physician needs to consider serum prostate-specific antigen levels and uptake distribution to avoid misdiagnosis of metastatic prostate cancer. We describe the association of F-18-DCFPyl uptake with a previously undescribed hepatic small vessel neoplasm.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Oncology
P. A. Glemser, L. T. Rotkopf, C. H. Ziener, B. Beuthien-Baumann, V Weru, A. Kopp-Schneider, H. P. Schlemmer, A. Dimitrakopoulou-Strauss, C. Sachpekidis
Summary: [Ga-68]PSMA-11 PET-CT and PET-MRI provide equally good detection rates for prostate cancer recurrence, both outperforming stand-alone MRI. PET-MRI is particularly efficient in detecting local recurrences in the prostate bed, while there were no significant differences in lesion detection rate between PET-CT and PET-MRI. The probability of a positive scan significantly increased with increasing PSA levels for all imaging modalities.
Review
Radiology, Nuclear Medicine & Medical Imaging
Feng-Yuan Liu, Ting-Wen Sheng, Jing-Ren Tseng, Kai-Jie Yu, Ke-Hong Tsui, Se-Tong Pang, Li-Jen Wang, Gigin Lin
Summary: This study compared the use of PET-CT and PET-MRI in patients with prostate cancer through a systematic literature search. The results showed that PET-MRI has better performance in the detection and staging of local tumors, as well as in the detection of recurrences, while PET-CT is more effective in detecting distant metastases.
BRITISH JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ingrid L. Bakker, Alida C. Froberg, Martijn B. Busstra, J. Fred Verzijlbergen, Mark Konijnenberg, Geert J. L. H. van Leenders, Ivo G. Schoots, Erik de Blois, Wytske M. van Weerden, Simone U. Dalm, Theodosia Maina, Berthold A. Nock, Marion de Jong
Summary: The study demonstrated that the GRPr receptor overexpressed in prostate cancer cells is effective for early prostate cancer imaging, with 68Ga-SB3 PET/CT imaging showing tumor lesions and a significant correlation between GRPr expression and tracer uptake.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wolfgang P. Fendler, Matthias Eiber, Mohsen Beheshti, Jamshed Bomanji, Jeremie Calais, Francesco Ceci, Steve Y. Cho, Stefano Fanti, Frederik L. Giesel, Karolien Goffin, Uwe Haberkorn, Heather Jacene, Phillip J. Koo, Klaus Kopka, Bernd J. Krause, Liza Lindenberg, Charles Marcus, Felix M. Mottaghy, Daniela E. Oprea-Lager, Joseph R. Osborne, Morand Piert, Steven P. Rowe, Heiko Schoeder, Simon Wan, Hans-Jurgen Wester, Thomas A. Hope, Ken Herrmann
Summary: This article aims to provide updated guidance and standards for the use of PSMA PET/CT in imaging prostate cancer. It discusses procedures and characteristics of various PSMA small radioligands and different clinical scenarios for their use. The document is intended to support clinicians and technicians in implementing PSMA PET/CT imaging in both research and routine practice.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Orthopedics
Yaniv Pines, Dan Gordon, Matthew Alben, Young W. Kwon, Joseph D. Zuckerman, Mandeep S. Virk
Summary: This prospective longitudinal study reports the responsiveness of PROMIS UE CAT in patients undergoing shoulder arthroplasty and its correlation with legacy instruments. The study found that PROMIS UE CAT showed positive responsiveness and strong correlation with other assessment tools at various postoperative time points.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Editorial Material
Orthopedics
Mandeep Singh Virk
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Orthopedics
Christopher A. Colasanti, Charles C. Lin, Ryan W. Simovitch, Mandeep S. Virk, Joseph D. Zuckerman
Summary: This study evaluates the impact of a history of cervical spine arthrodesis on the outcomes of total shoulder arthroplasty (TSA). The results show that patients with a history of cervical arthrodesis have lower postoperative functional outcomes, satisfaction, and higher rates of adverse events compared to those without a history of arthrodesis. Furthermore, a time interval of at least 16 months between cervical arthrodesis and shoulder arthroplasty optimizes the chances of achieving satisfactory functional scores.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Rheumatology
Matthew G. G. Alben, Neil Gambhir, Dhruv Shankar, Dan Gordon, Joseph D. D. Zuckerman, Mandeep S. S. Virk
Summary: This study aims to calculate the minimal clinically important difference (MCID), substantial clinical benefit (SCB), and patient acceptable symptom state (PASS) of Patient-Reported Outcomes Measurement Information System (PROMIS) in patients with nonoperative treatment for idiopathic adhesive capsulitis (IAC) using anchor-based and distribution-based methods.
CLINICAL RHEUMATOLOGY
(2023)
Article
Orthopedics
Christopher A. Colasanti, Charles C. Lin, Utkarsh Anil, Ryan W. Simovitch, Mandeep S. Virk, Joseph D. Zuckerman
Summary: This study examines the correlation between preoperative diagnosis of anxiety and depression and postoperative outcomes after total shoulder arthroplasty (TSA). It found that patients with anxiety and/or depression had inferior postoperative outcomes and higher rates of adverse events (AEs). Treatment with medication did not significantly improve postoperative outcomes or satisfaction rate. Additionally, lower Patient-Reported Outcomes Measurement Information System Mental Health (PROMIS-MH) scores were associated with worse postoperative outcomes.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Orthopedics
Gabriel Larose, Alexander T. Greene, Amaury Jung, Sandrine V. Polakovic, Noah Z. Davis, Joseph D. Zuckerman, Mandeep S. Virk
Summary: This study reviewed the efficacy and complications of computer-assisted navigation (CAN) surgery for glenoid deformity in total shoulder arthroplasty (TSA). The results showed high accuracy and good utilization of CAN in glenoid positioning during surgery. However, further research should focus on assessing the impact of CAN on the longevity and survival of glenoid components and improving the cost-effectiveness of this technology.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Orthopedics
Christopher A. Colasanti, Charles C. Lin, Keir A. Ross, Tyler Luthringer, Josie A. Elwell, Christopher P. Roche, Mandeep S. Virk, Ryan W. Simovitch, Howard D. Routman, Joseph D. Zuckerman
Summary: This study aimed to compare the outcomes of primary reverse total shoulder arthroplasty using glenoid bone grafting and augmented glenoid baseplates with a minimum 2-year follow-up. Results showed that patients in the augmented glenoid baseplate group had significant improvements in patient-reported outcome measures and range of motion compared to the bone grafting group. Moreover, the use of augmented baseplates also reduced operative time, intraoperative blood loss, scapular notching, and adverse events requiring revision. Therefore, the use of augmented glenoid baseplates is superior to glenoid bone grafting.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Orthopedics
David Adekanye, Aidan G. Papalia, Paul V. Romeo, Matthew T. Kingery, Erel Ben-Ari, Sebastian Bustamante, Joseph D. Zuckerman, Mandeep S. Virk
Summary: This study aimed to determine the severity of symptoms during the freezing phase of primary idiopathic adhesive capsulitis (AC) and identify factors associated with patient selection of corticosteroid injection (CSI) for treatment. The results showed that AC patients in the freezing phase exhibit varying degrees of pain and limitations in shoulder range of motion (ROM), with those experiencing higher pain severity and greater ROM limitations more likely to choose CSI for treatment.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Orthopedics
Christopher A. Colasanti, Charles C. Lin, Ryan W. Simovitch, Mandeep S. Virk, Joseph D. Zuckerman
Summary: This study aimed to determine the consensus among a group of experts on factors influencing surgical decision-making and treatment modalities for glenohumeral arthritis in patients under 50 years old. The study found 50 factors associated with the decision to proceed with surgery, with 10 strongly supporting surgery. Additionally, there is controversy regarding the optimal treatment for glenohumeral arthritis in patients < 50 years old, indicating the need for further research and discussion.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Orthopedics
Matthew G. Alben, Dan Gordon, Neil Gambhir, Matthew T. Kim, Paul V. Romeo, Andrew S. Rokito, Joseph D. Zuckerman, Mandeep S. Virk
Summary: The purpose of this study was to calculate and determine the factors associated with achieving the Minimal Clinically Important Difference (MCID) and the Substantial Clinical Benefit (SCB) of Patient-Reported Outcomes Measurement Information System (PROMIS) in patients undergoing arthroscopic rotator cuff repair (aRCR). Using a variety of analyses, the study found that lower preoperative P-Intensity scores and concomitant biceps tenodesis were associated with higher odds of achieving the SCB for PROMIS UE. The study highlights the importance of understanding the MCID and SCB values for PROMIS instruments in determining the clinical significance of improvements after aRCR.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Orthopedics
Aidan G. Papalia, Matthew T. Kingery, Paul V. Romeo, Trevor Simcox, Charles C. Lin, Utkarsh Anil, Joseph D. Zuckerman, Mandeep S. Virk
Summary: This study compared the rates of complications, revisions, and inpatient charges in shoulder arthroplasty procedures between patients with Parkinson's disease (PD) and those without PD. The results showed that PD patients had higher rates of complications and revisions, longer length of stay, and higher inpatient charges.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Orthopedics
Paul V. Romeo, Aidan G. Papalia, Matthew G. Alben, Joshua Halpern, Sehar Resad Ferati, Gabriel Larose, Hartej Singh, Mandeep S. Virk
Summary: The aim of this study was to evaluate the outcomes and complications of radial head arthroplasty for Mason Type III and IV radial head fractures within 90 days postoperatively. The study found a low complication rate of 8.1%, including heterotopic ossification, superficial wound dehiscence, and posterior interosseous nerve palsy. Factors such as diabetes, ASA class, trauma energy level, and concomitant injury were not significantly associated with higher complication rates.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)
Review
Surgery
Erik S. Contreras, Matthew T. Kingery, Joseph D. Zuckerman, Mandeep S. Virk
Summary: The treatment of glenoid bone loss is a challenge in total shoulder arthroplasty. Augmented glenoid components provide predictable and easy correction of glenoid wear while preserving bone stock and improving biomechanics. They have advantages over glenoid bone grafting, but there is currently no evidence for the superiority of one design over others.
Article
Orthopedics
Neil Gambhir, Matthew G. Alben, Gabriel Larose, Mandeep S. Virk
Summary: Open surgical repair of anterior glenoid fractures utilizing subscapularis split leads to good functional outcomes and low risk of recurrence.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)
Article
Orthopedics
Neil Gambhir, Matthew G. Alben, Dhruv Shankar, Gabriel Larose, Young W. Kwon, Mandeep S. Virk
Summary: This study compares the 90-day complication rates of total elbow arthroplasty (TEA) performed for arthritis and distal humerus fractures. The results show that patients with arthritis have higher complication rates, possibly due to chronic inflammation and treatment side effects. However, patients with humerus fractures have lower complication rates.
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2023)
