Article
Radiology, Nuclear Medicine & Medical Imaging
Diana Paez, Mike M. Sathekge, Hassan Douis, Francesco Giammarile, Shazia Fatima, Anil Dhal, Sunil K. Puri, Paola A. Erba, Elena Lazzeri, Rodolfo Ferrando, Paulo Almeida Filho, Vincent Peter Magboo, Olga Morozova, Rodolfo Nunez, Olivier Pellet, Giuliano Mariani
Summary: This study aimed to assess the diagnostic performance of MRI, [F-18]FDG PET/CT, and SPECT/CT in patients with suspected postoperative spine infection. The results showed that MRI and [F-18]FDG PET/CT had similarly satisfactory diagnostic performance, with the best performance achieved by combining the results of both modalities. SPECT/CT with Tc-99m-UBI 29-41 performed suboptimally in this clinical setting.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Biochemistry & Molecular Biology
Jyotsna Bhatt Mitra, Saurav Chatterjee, Anuj Kumar, Anupam Bandyopadhyay, Archana Mukherjee
Summary: Developing potent and novel bacterial imaging agents remains a challenge due to bacterial resistance. This study investigates the use of covalent probes and non-covalent interactions to improve bacterial infection imaging. Tc-99m-UBI (29-41)-2-APBA demonstrates enhanced uptake and higher target-to-non-target ratio in a mouse model.
RSC MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
V. D. Zavadovskaya, M. S. Larkina, E. S. Stasyuk, M. A. Zorkaltsev, V. D. Udodov, V. V. Ivanov, N. M. Shevtsova, A. S. Rogov, A. Ya Lushchyk, A. Yantsevich, M. Belousov, A. N. Baikov, V. S. Skuridin, A. G. Pershina
Summary: The radiolabeled complexes Tc-99m-DPAH-UBI29-41 and Tc-99m-DPAH-UBI18-35, derived from antimicrobial peptides UBI29-41 and UBI18-35, showed high labeling yield and purity. Accumulation of these complexes in bacterial inflammation sites and absence in aseptic inflammation sites were confirmed in a rat model of traumatic osteomyelitis using single-photon emission computed tomography.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Physical
Priya Singh, Neelam Kumari, Ankur Kaul, Abhishek Srivastava, Vijay Kumar Singh, Krishna Srivastava, Anjani Kumar Tiwari
Summary: In this study, a new molecule DOTA-MBP was designed and its binding affinity towards translocator protein (TSPO) was evaluated through in-silico studies. The stability of DOTA-MBP as a magnetic resonance contrast agent was assessed. In vivo studies using a mouse model showed that DOTA-MBP could locate lung inflammation and monitor the severity of the disease through radioactivity imaging techniques.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Pharmacology & Pharmacy
Mahdi Ghadi, Seyed Jalal Hosseinimehr, Fereshteh Talebpour Amiri, Alireza Mardanshahi, Zohreh Noaparast
Summary: P-glycoprotein (P-gp) serves as a vital efflux pump in chemotherapy resistance in human colon cancer. The study demonstrates the synergistic anti-tumor activity of itraconazole and paclitaxel, showing enhanced cytotoxicity and tumor growth suppression. Additionally, Tc-99m-MIBI is identified as an effective radiotracer for monitoring response to treatment in MDR tumors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jinzhi Chen, Xi Zhang, Qian Li, Meng Liu, Zhanli Fu
Summary: A 62-year-old man presented with progressive myasthenia, myalgia, and skin changes for 5 years. Lab tests revealed elevated serum creatine kinase and lactate dehydrogenase, as well as monoclonal immunoglobulin G. Imaging studies showed generalized muscular uptake of Tc-99m-MDP on bone scan, while F-18-FDG PET/CT showed mild hypermetabolism of the muscles. Muscle biopsy indicated myofibrillary vacuolar degeneration, and a skin biopsy confirmed scleromyxedema. The patient was diagnosed with scleromyxedema-associated myopathy.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Endocrinology & Metabolism
Fabio Bioletto, Marco Barale, Mirko Parasiliti-Caprino, Nunzia Prencipe, Alessandro Maria Berton, Massimo Procopio, Desiree Deandreis, Ezio Ghigo
Summary: This study compared the diagnostic accuracy of C-11-Methionine and F-18-Fluorocholine PET for parathyroid localization in primary hyperparathyroidism patients for the first time. The findings suggested that F-18-Fluorocholine had superior sensitivity compared to C-11-Methionine, while both tracers had similar positive predictive value.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vincent Boudousq, Nicolas Guignard, Olivier Gilly, Benjamin Chambert, Adel Mamou, Olivier Moranne, Mathilde Zemmour, Haitham Sharara, Benjamin Lallemant
Summary: This study compared the use of F-18-fluorocholine PET/CT, cervical ultrasonography (CU), and conventional scintigraphic imaging modalities (MIBI scintigraphy) for preoperative localization of hyperfunctional parathyroids in patients with primary hyperparathyroidism (PHPT). The results showed that F-18-fluorocholine PET/CT had higher accuracy and sensitivity compared to CU and MIBI scintigraphy, making it the preferred method for PHPT diagnosis.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Zhenghao Tong, Qi Shen, Hongwei Sun, Jianhua Zhang, Yan Fan
Summary: A 26-year-old woman was incidentally found to have bilatera renal tumors, and the biopsy confirmed eosinophilic solid and cystic renal cell carcinoma. Tc-99m-MIBI SPECT/CT has the potential to differentiate renal tumors with eosinophilic features from other histologies.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Suzanne C. van Es, Ton Velleman, Sjoerd G. Elias, Frederike Bensch, Adrienne H. Brouwers, Andor W. J. M. Glaudemans, Thomas C. Kwee, Marleen Woltman-van Iersel, John H. Maduro, Sjoukje F. Oosting, Elisabeth G. E. de Vries, Carolina P. Schroder
Summary: Assessment of bone lesions in metastatic breast cancer patients with F-18-FDG PET and BS led to clinically relevant management differences in 16% of patients, with BS providing insufficient information in over one fourth of cases that required additional F-18-FDG PET scans. Based on this data, F-18-FDG PET should be considered the primary imaging modality for assessing bone lesions in newly diagnosed MBC.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Instruments & Instrumentation
Erik V. Johnstone, Natalia Mayordomo, Edward J. Mausolf
Summary: New methods of producing Tc-99m and Tc-101 using a compact accelerator neutron source were investigated in this study. Neutrons generated from a 16.5 MeV cyclotron were utilized for irradiation, and natural molybdenum targets were used for the (n, gamma) reactions to produce Tc isotopes. The production and potential applications of Tc-99m and Tc-101 under these conditions were discussed.
EPJ TECHNIQUES AND INSTRUMENTATION
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Emi Yamaga, Tomoyuki Fujioka, Takahiro Asakage, Keiko Miura, Ukihide Tateishi
Summary: Brown tumor is a rare osteolytic lesion associated with hyperparathyroidism. This case report describes a patient with a maxillary brown tumor and the use of imaging techniques to accurately diagnose and treat the condition.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Oncology
Q. Wu, L. Zhong, X. Xie
Summary: This study evaluated the diagnostic accuracy of dynamic CT, dynamic MRI, F-18-FDG PET, and Tc-99m depreotide SPECT for SPNs, showing that these non-invasive approaches are effective in distinguishing malignant SPNs from benign ones. Among the methods, dynamic MRI was recommended for SPNs due to its cost-effectiveness and avoidance of radiation.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liming Xiao, Shupeng Yu, Weina Xu, Yishan Sun, Jun Xin
Summary: Tc-99m-3PRGD(2) SPECT/CT imaging performs well in diagnosing lymph node metastasis of primary malignant lung tumors and can indirectly predict the presence of lymph node metastasis through uptake in the primary lesions.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Review
Medicine, General & Internal
Miriam Conte, Maria Silvia De Feo, Viviana Frantellizzi, Miriam Tomaciello, Francesco Marampon, Laura Evangelista, Luca Filippi, Giuseppe De Vincentis
Summary: Radio-guided surgery is a reliable approach for localizing lung nodules, ground-glass opacities, and metastatic lymph nodes. Using different tracers, it has been demonstrated to be a low-cost and low-morbidity alternative to existing approaches with low radiation exposure.
Article
Neurosciences
Ravichandran Rajkumar, Ezequiel Farrher, Joerg Mauler, Praveen Sripad, Claudia Regio Brambilla, Elena Rota Kops, Juergen Scheins, Juergen Dammers, Christoph Lerche, Karl-Josef Langen, Hans Herzog, Bharat Biswal, N. Jon Shah, Irene Neuner
Summary: This study utilized trimodal PET/MRI/EEG data to explore brain functional states. The results showed a significant positive correlation between microstate C and the DC metric, indicating a functional relationship between different brain regions.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Ann Kristin Schmitz, Ruediger Sorg, Gabriele Stoffels, Oliver M. Grauer, Norbert Galldiks, Hans-Jakob Steiger, Marcel A. Kamp, Karl-Josef Langen, Michael Sabel, Marion Rapp
Summary: This study analyzed the impact of additional F-18-FET PET imaging following dendritic cell vaccination therapy for glioblastoma patients, showing that F-18-FET PET may have an additional impact on monitoring treatment outcome, especially in cases where it indicated treatment related changes that were not detected by MRI.
BRITISH JOURNAL OF NEUROSURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Norbert Galldiks, Diana S. Y. Abdulla, Matthias Scheffler, Fabian Wolpert, Jan-Michael Werner, Martin Huellner, Gabriele Stoffels, Viola Schweinsberg, Max Schlaak, Nicole Kreuzberg, Jennifer Landsberg, Philipp Lohmann, Garry Ceccon, Christian Baues, Maike Trommer, Eren Celik, Maximilian Ruge, Martin Kocher, Simone Marnitz, Gereon R. Fink, Joerg-Christian Tonn, Michael Weller, Karl-Josef Langen, Juergen Wolf, Cornelia Mauch
Summary: The study showed that F-18-FET PET is valuable for treatment monitoring in patients with brain metastasis undergoing ICI or TT, assisting in distinguishing between metastasis relapse and treatment-related changes, and providing valuable information in assessing metabolic responses to ICI or TT.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eike Steidl, Karl-Josef Langen, Sarah Abu Hmeidan, Nenad Polomac, Christian P. Filss, Norbert Galldiks, Philipp Lohmann, Fee Keil, Katharina Filipski, Felix M. Mottaghy, Nadim Jon Shah, Joachim P. Steinbach, Elke Hattingen, Gabriele D. Maurer
Summary: The retrospective analysis evaluated the diagnostic value of consecutive PWI and [F-18]FET PET, showing that the combination of both methods can improve overall accuracy. Under specific conditions, PWI outperformed [F-18]FET PET for certain tumors. These results emphasize the importance of sequential use of PWI and [F-18]FET PET in clinical diagnosis.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Neurosciences
Anna Weller, Gerard N. Bischof, Philipp Schlueter, Nils Richter, Julian Dronse, Oezguer Onur, Bernd Neumaier, Juraj Kukolja, Karl-Josef Langen, Gereon Fink, Angela Kunoth, Yaping Shao, Thilo van Eimeren, Alexander Drzezga
Summary: The study revealed a reorganization of functional connectome communities in Alzheimer's disease patients, resulting in lower overall efficiency and higher tau pathology burden in nodes tending to leave communities. This suggests a correlation between local tau pathology in AD and fundamental changes in basic organizational principles of the human connectome.
BRAIN CONNECTIVITY
(2021)
Article
Biochemistry & Molecular Biology
Julia Post, Vanessa Kogel, Anja Schaffrath, Philipp Lohmann, N. Jon Shah, Karl-Josef Langen, Dieter Willbold, Antje Willuweit, Janine Kutzsche
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with neuroinflammation playing a key role in its pathogenesis. A treatment study using RD2RD2 in a transgenic mouse model of ALS showed reduction of astrocytes and microglia activation, rescue of neurons, and slowed disease progression, making RD2RD2 a potential therapeutic candidate against ALS.
Article
Geriatrics & Gerontology
Nils Nellessen, Oezguer A. Onur, Nils Richter, Heidi I. L. Jacobs, Kim N. H. Dillen, Boris von Reutern, Karl J. Langen, Gereon R. Fink, Juraj Kukolja
Summary: In individuals with subjective cognitive decline (SCD), memory complaints are associated with sub-clinical depression and executive functions rather than memory performance. Additionally, memory complaints in SCD are correlated with higher gray matter density in specific brain regions. The study did not find evidence of early neurodegeneration in SCD, but identified sub-clinical depression as a potential underlying factor for subjective cognitive complaints.
NEUROBIOLOGY OF AGING
(2021)
Article
Oncology
Martin Kocher, Christiane Jockwitz, Philipp Lohmann, Gabriele Stoffels, Christian Filss, Felix M. Mottaghy, Maximilian I. Ruge, Carolin Weiss Lucas, Roland Goldbrunner, Nadim J. Shah, Gereon R. Fink, Norbert Galldiks, Karl-Josef Langen, Svenja Caspers
Summary: This study used structural MRI and amino acid PET in conjunction with brain atlases and elastic registration techniques to investigate the impact of treatment-related brain damage on cognitive functioning in well-functioning WHO Grade III/IV glioma patients. The results showed that T2/FLAIR hyperintensities caused by radiation therapy significantly impaired cognitive performance, especially affecting the left hemisphere functional nodes and fiber tracts, which were highly correlated with verbal episodic memory dysfunction.
Article
Biochemistry & Molecular Biology
Julia Post, Anja Schaffrath, Ian Gering, Sonja Hartwig, Stefan Lehr, N. Jon Shah, Karl-Josef Langen, Dieter Willbold, Janine Kutzsche, Antje Willuweit
Summary: The study demonstrates that RD2RD2 has therapeutic potential in SOD1(G93A) mice, significantly improving performance in behavioral and motor coordination tests and slowing the progression of neurodegenerative phenotype. Additionally, treatment of SOD1(G93A) mice leads to a significant reduction in glial cell activation and rescue of neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Clinical Neurology
Francesco Cicone, Karl-Josef Langen, Giuseppe Minniti
WORLD NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Luana Cristina Camargo, Dominik Honold, Robert Bauer, N. Jon Shah, Karl-Josef Langen, Dieter Willbold, Janine Kutzsche, Antje Willuweit, Sarah Schemmert
Summary: Research on the Tau-P301L mouse model revealed that male mice exhibit olfactory and motor deficits, increased Tau pathology, while female mice did not show these changes. Both male and female Tau-P301L mice showed phenotypic alterations, as well as cognitive deficits in behavioral tests.
Article
Biochemistry & Molecular Biology
Katharina Wintz, Julia Post, Karl-Josef Langen, Dieter Willbold, Antje Willuweit, Janine Kutzsche
Summary: Amyotrophic lateral sclerosis (ALS) is a deadly disease with no cure, causing complete muscle loss and respiratory arrest. Only three symptomatic drugs have been approved by the FDA so far. RD2RD2, a new drug candidate, has shown the ability to delay symptom onset in mouse models of ALS.
Review
Oncology
Karl-Josef Langen, Norbert Galldiks, Joerg Mauler, Martin Kocher, Christian Peter Filss, Gabriele Stoffels, Claudia Regio Brambilla, Carina Stegmayr, Antje Willuweit, Wieland Alexander Worthoff, Nadim Jon Shah, Christoph Lerche, Felix Manuel Mottaghy, Philipp Lohmann
Summary: Advanced MRI methods and PET using radiolabelled amino acids provide valuable additional information for brain tumour diagnostics. While the hybrid PET/MRI has allowed for the convergence of these methods, simultaneous imaging has limited relevance in clinical neuro-oncology. A multimodal approach that combines PET and MRI shows promising improvement in the diagnosis of cerebral gliomas.
Article
Radiology, Nuclear Medicine & Medical Imaging
Garry Ceccon, Philipp Lohmann, Jan-Michael Werner, Caroline Tscherpel, Veronika Dunkl, Gabriele Stoffels, Jurij Rosen, Marion Rapp, Michael Sabel, Ulrich Herrlinger, Niklas Schaefer, Nadim J. Shah, Gereon R. Fink, Karl-Josef Langen, Norbert Galldiks
Summary: Changes in F-18-FET PET parameters were found to be helpful for early identification of responders to adjuvant TMZ therapy, predicting prolonged progression-free survival (PFS) and overall survival (OS). These changes were independent of other strong prognostic factors, suggesting their potential clinical utility in glioma patients.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Computer Science, Interdisciplinary Applications
Christoph W. Lerche, Timon Radomski, Philipp Lohmann, Liliana Caldeira, Claudia Regio Brambilla, Lutz Tellmann, Juergen Scheins, Elena Rota Kops, Norbert Galldiks, Karl-Josef Langen, Hans Herzog, N. Jon Shah
Summary: A linearized model for dynamic PET scans of F-18-FET TACs was derived and validated in this study, showing high agreement with measured TACs and small parameter uncertainties. The model demonstrated good diagnostic performance in discriminating between IDH wildtype and IDH mutant gliomas in adult patients. Voxel-wise fitting within a short computation time and comparable classification accuracy to linear fits based on average TAC values were achievable.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
