Article
Medicine, General & Internal
Yao Lu, Yidan Zhu, Yanjun Ma, Chenglong Li, Rong Hua, Baoliang Zhong, Hongyu Wang, Wuxiang Xie
Summary: There is a positive association between subclinical atherosclerosis and cognitive function. Plaque numbers are significantly associated with global cognitive functioning, memory, and semantic fluency in Montreal Cognitive Assessment (MoCA), while ba-PWV is significantly associated with global cognitive functioning in MoCA and semantic fluency.
Article
Medicine, General & Internal
Gyeongsil Lee, Seulggie Choi, Jooyoung Chang, Daein Choi, Joung Sik Son, Kyuwoong Kim, Sung Min Kim, Seogsong Jeong, Sang Min Park
Summary: A study conducted in South Korea found that the use of alpha-GPC was associated with a higher 10-year stroke risk in a dose-response manner. Alpha-GPC users had a higher risk for both ischemic and hemorrhagic stroke compared to nonusers. Further research is needed to understand the mechanisms behind this potential cerebrovascular risk.
Article
Medicine, General & Internal
Toru Baba, Atsushi Takeda, Aya Murakami, Tadashi Koga, Tatsuya Isomura, Etsuro Mori, D. A. S. H. P. D. Sty Grp
Summary: Administration of donepezil to patients with severe hyposmia in the early stage may be beneficial for cognitive function but has no effect on the incidence of dementia.
Article
Medicine, Research & Experimental
Samuel Booth, Kye Won Park, Chong Sik Lee, Ji Hyun
Summary: A FDG-PET based SVM classifier showed potential in accurately predicting the risk of dementia development in patients with Parkinson's disease with mild cognitive impairment. The model demonstrated high sensitivity and specificity in distinguishing PDD converters from stable MCI patients, and was validated with independent data sets.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Clinical Neurology
Chengsheng Ju, Ian C. K. Wong, Wallis C. Y. Lau, Kenneth K. C. Man, Ruth Brauer, Tian-Tian Ma, Alaa Alsharif, Hassan Alwafi, Kui Kai Lau, Esther W. Chan, Celine S. L. Chui, Xue Li, Li Wei
Summary: Based on sales data from before 2018, there was an increasing trend in the use of symptomatic medications against dementia worldwide, but the usage remained low in low-income countries. Interventions may be needed to support medication use in certain countries.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Orthopedics
Tiev Miller, Michael Ying, Charlotte Sau Lan Tsang, Meizhen Huang, Marco Y. C. Pang
Summary: The study systematically reviewed the psychometric properties of ultrasound elastography techniques for evaluating muscle stiffness in people with neurological conditions. The results showed moderate reliability, good convergent validity with clinical assessments, and the ability to effectively discriminate tissue changes within and between groups.
Article
Clinical Neurology
S. Neumann, J. Taylor, A. Bamford, C. Metcalfe, D. M. Gaunt, A. Whone, D. Steeds, S. R. Emmett, W. Hollingworth, Y. Ben-Shlomo, E. J. Henderson
Summary: This is a multi-center, double-blind, randomized placebo-controlled trial evaluating the effectiveness of a cholinesterase inhibitor on fall rate in people with idiopathic Parkinson's disease. The study aims to determine whether cholinesterase inhibitor therapy is effective in preventing falls in Parkinson's disease, and if cost-effective, it may change current management guidelines by offering a new therapeutic option for this high-risk population.
Article
Medicine, General & Internal
Qiaohong Wang, Yiping Chen, Linbo Li, Chao Li, Li Li, Huili Cao, Hui Yang
Summary: This study aimed to explore the barriers to home exercise for patients with Parkinson's disease (PwPDs) and provide guidelines for healthcare providers. The findings identified five themes including psychosomatic stress and low activity, lack of early rehabilitation authorisation, poor 'flow' state of home exercise, inaccessibility of continued service, and sociocultural impact on family coping. By addressing these challenges through multidisciplinary management, early rehabilitation authorisation, exercise experience, continuous service mode, and family coping strategies, the home exercise behavior of PwPDs can be gradually improved.
Article
Medicine, General & Internal
Sara Marceglia, Costanza Conti, Oleg Svanidze, Guglielmo Foffani, Andres M. Lozano, Elena Moro, Jens Volkmann, Mattia Arlotti, Lorenzo Rossi, Alberto Priori
Summary: This study aims to evaluate the safety and efficacy of the new generation AlphaDBS system for aDBS and cDBS treatment in patients with Parkinson's disease. The study involves multiple international sites and 15 patients, and will include short-term and long-term follow-ups.
Review
Cell Biology
Augoustos Tsamourgelis, Peter Swann, Leonidas Chouliaras, John T. O'Brien
Summary: Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia. Proteomics has revealed protein dysregulation in the brain and peripheral tissues in DLB, which shares common features with other dementias but also has unique protein signatures. Identifying novel protein targets and diagnostic biomarkers could lead to new therapeutics and improved clinical trials for DLB.
AGEING RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Patrick Oeckl, Sarah Anderl-Straub, Christine A. F. Von Arnim, Ines Baldeiras, Janine Diehl-Schmid, Timo Grimmer, Steffen Halbgebauer, Anna M. Kort, Marisa Lima, Taina M. Marques, Marion Ortner, Isabel Santana, Petra Steinacker, Marcel M. Verbeek, Alexander E. Volk, Albert C. Ludolph, Markus Otto
Summary: This study reveals differences in serum levels of GFAP in AD and bvFTD, showing an early increase in MCI-AD and superior diagnostic performance for AD compared to NfL.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Osvaldo P. Almeida, Christopher Etherton-Beer, Frank Sanfilippo, David B. Preen, Amy Page
Summary: The use of antineoplastic medications has been found to be associated with a decreased risk of dementia, which may contribute to the development of novel approaches for dementia prevention.
Article
Clinical Neurology
Anita Nitchingham, Jarett Vanz-Brian Pereira, Eva A. Wegner, Vincent Oxenham, Jacqueline Close, Gideon A. Caplan
Summary: In this study, using FDG-PET, researchers found that patients with delirium showed hypometabolism in the bilateral thalami and certain cortical regions. The hypometabolism was correlated with delirium severity and performance on neuropsychological testing.
ALZHEIMERS & DEMENTIA
(2023)
Article
Cardiac & Cardiovascular Systems
Keenan A. Walker, Noah Silverstein, Yun Zhou, Timothy M. Hughes, Clifford R. Jack, David S. Knopman, A. Richey Sharrett, Dean F. Wong, Thomas H. Mosley, Rebecca F. Gottesman
Summary: White matter hyperintensity volume is modestly positively associated with elevated amyloid in older adults without dementia, with a stronger association observed among Black participants. However, there was no association between white matter microstructure and elevated amyloid. These findings need to be further validated in larger, multiethnic cohorts.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Clinical Neurology
Katrine B. Andersen, Allan K. Hansen, Malene F. Damholdt, Jacob Horsager, Casper Skjaerbaek, Hanne Gottrup, Henriette Klit, Erik H. Danielsen, David J. Brooks, Per Borghammer
Summary: This study evaluated synaptic density in PD and dementia patients using in vivo PET imaging and found widespread cortical reduction in DLB/PDD subjects. The results suggest that synaptic density loss contributes to cognitive impairment in nPD and DLB/PDD.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Jin Ho Jung, Yae Ji Kim, Seok Jong Chung, Han Soo Yoo, Yang Hyun Lee, Kyoungwon Baik, Seong Ho Jeong, Young Gun Lee, Hye Sun Lee, Byoung Seok Ye, Young H. Sohn, Yong Jeong, Phil Hyu Lee
Summary: The study aimed to investigate the role of white matter connectivity networks in the development of levodopa-induced dyskinesia, and comparative analysis between vulnerable and resistant groups revealed lower mean diffusivity in the left frontal region of the vulnerable group. Furthermore, the study found stronger connectivity within subnetwork A and hub-subnetwork centered on the left superior frontal gyrus in the vulnerable group, which were associated with the development of levodopa-induced dyskinesia.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Seok Jong Chung, Yae Ji Kim, Jin Ho Jung, Hye Sun Lee, Byoung Seok Ye, Young H. Sohn, Yong Jeong, Phil Hyu Lee
Summary: This study demonstrates that disrupted white matter connectivity in the frontal and posterior cortical regions is associated with early dementia conversion in patients with newly diagnosed Parkinson's disease with mild cognitive impairment (PD-MCI).
Article
Clinical Neurology
Han Soo Yoo, Seun Jeon, Enrica Cavedo, MinJin Ko, Mijin Yun, Phil Hyu Lee, Young H. Sohn, Michel J. Grothe, Stefan Teipel, Harald Hampel, Alan C. Evans, Byoung Seok Ye
Summary: The relationship between cholinergic degeneration, beta-amyloid, brain atrophy, and cognitive dysfunction in Alzheimer disease (AD) and Lewy body disease (LBD) was comparatively evaluated. The results showed a common mechanism of beta-amyloid-related degeneration with or without the mediation of basal forebrain. However, the association of basal forebrain atrophy with cognitive dysfunction was more profound in LBD, where there was also localized beta-amyloid-cortical atrophy interaction.
Article
Multidisciplinary Sciences
Miriam Vignando, Dominic Ffytche, Simon J. G. Lewis, Phil Hyu Lee, Seok Jong Chung, Rimona S. Weil, Michele T. Hu, Clare E. Mackay, Ludovica Griffanti, Delphine Pins, Kathy Dujardin, Renaud Jardri, John-Paul Taylor, Michael Firbank, Grainne McAlonan, Henry K. F. Mak, Shu Leong Ho, Mitul A. Mehta
Summary: A study using a large-scale analysis of structural imaging data in Parkinson's disease patients with visual hallucinations reveals wider cortical involvement and associations with attentional control networks.
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Young-gun Lee, Seun Jeon, Mincheol Park, Sung Woo Kang, So Hoon Yoon, Kyoungwon Baik, Phil Hyu Lee, Young Ho Sohn, Byoung Seok Ye
Summary: This study aimed to analyze the pattern of FDG-PET related to postmortem Lewy body disease (LBD) pathology. The results showed that AD and LBD pathologies had significant effects on the antemortem brain metabolism, and considering both pathologies could elucidate specific metabolic patterns related to AD and LBD pathologies.
ANNALS OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Sakulrat Mankhong, Sujin Kim, Sohee Moon, Seong-Hye Choi, Hyo-Bum Kwak, Dong-Ho Park, Pratik Shah, Phil Hyu Lee, Seong Wook Yang, Ju-Hee Kang
Summary: This study discovered differentially expressed blood miRNAs in Korean AD patients and investigated their role in amyloidogenesis. However, the diagnostic utility of these miRNAs as biomarkers was limited.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Cell & Tissue Engineering
Jin Young Shin, Dong-Yeol Kim, Jieun Lee, Yu Jin Shin, Yi Seul Kim, Phil Hyu Lee
Summary: Priming MSCs with alpha-syn enhances stemness properties and modulates autophagy-related gene expression profiles, suggesting a potential neuroprotective effect in Parkinsonian models.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Seok Jong Chung, Yae Ji Kim, Yun Joong Kim, Hye Sun Lee, Mijin Yun, Phil Hyu Lee, Yong Jeong, Young H. Sohn
Summary: This study found a link between cognitive function and motor reserve in patients with newly diagnosed Parkinson's disease. The motor reserve estimate was correlated with verbal memory function and white matter integrity in the left fornix.
JOURNAL OF MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Seong Ho Jeong, Chan Wook Park, Hye Sun Lee, Yun Joong Kim, Mijin Yun, Phil Hyu Lee, Young H. Sohn, Seok Jong Chung
Summary: The study investigated whether different patterns of striatal dopamine depletion are associated with motor deficits in Parkinson's disease. A total of 404 drug-naive patients with early-stage PD were enrolled and underwent dopamine transporter imaging. Principal component analysis identified three patterns of dopamine depletion: overall deficiency, selective loss in the sensorimotor striatum, and symmetric loss in the striatum. Linear regression analysis revealed that overall deficiency and selective loss were associated with motor deficits, while symmetric loss was not. Mediation analysis showed that dopamine deficiency in the posterior putamen mediated the association between dopamine depletion patterns and motor deficits. These findings suggest that dopamine deficiency in the posterior putamen plays a crucial role in motor deficits in PD.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Multidisciplinary Sciences
Kyoungwon Baik, Jin Ho Jung, Seong Ho Jeong, Seok Jong Chung, Han Soo Yoo, Phil Hyu Lee, Young H. Sohn, Seung Wan Kang, Byoung Seok Ye
Summary: This study evaluated the patterns of quantitative EEG in patients with Alzheimer's disease, Lewy body disease, and mixed disease. It was found that patients in the LBD and mixed disease groups had higher TBR values, while the presence of AD was not associated with TBR. Among cognitively impaired patients, higher TAR values were associated with language, memory, and visuospatial dysfunction, while higher TBR values were associated with memory and frontal/executive dysfunction.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
Seong Ho Jeong, Namki Hong, Hye Sun Lee, Sookyeong Han, Young-gun Lee, Yoonju Lee, Yumie Rhee, Young H. Sohn, Phil Hyu Lee
Summary: This study found that skull bone density in female PD patients is associated with disease progression and motor impairments, especially in younger patients.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Seong Ho Jeong, Eun-Chong Lee, Seok Jong Chung, Hye Sun Lee, Jin Ho Jung, Young H. Sohn, Joon-Kyung Seong, Phil Hyu Lee
Summary: This study found that in early-stage Parkinson's disease (PD), local striatal volume (LSV) is correlated with individual motor reserve (MR). A larger volume of the anterior and ventro-posterior putamen is associated with initially lower levodopa equivalent dose (LED) requirement and accelerated LED increment thereafter.
NPJ PARKINSONS DISEASE
(2022)
Review
Clinical Neurology
Jin Yong Hong, Phil Hyu Lee
Summary: Subjective cognitive complaints (SCCs), self-perceived cognitive decline, are related to objective cognitive decline. SCCs in cognitively normal individuals serve as a preclinical sign of subsequent cognitive impairment due to Alzheimer's disease. This review highlights the current research on SCCs in cognitively normal patients with Parkinson's disease, emphasizing the need for coherence in defining and assessing SCCs, and the value of SCCs in predicting cognitive decline. It also calls for further biomarker studies to establish the underlying pathological basis for these findings.
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Seong Ho Jeong, Jungho Cha, Jin Ho Jung, Mijin Yun, Young H. Sohn, Seok Jong Chung, Phil Hyu Lee
Summary: This study found that additional occipital amyloid-beta deposition is associated with poor baseline language function and rapid cognitive deterioration in patients with Alzheimer's disease.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Kyoungwon Baik, Seun Jeon, Mincheol Park, Young-gun Lee, Phil Hyu Lee, Young H. Sohn, Byoung Seok Ye
Summary: This study compared the imaging characteristics and cutoff value of 18F-florapronol (FC119S) and 18F-florbetaben (FBB) positron emission tomography (PET) in detecting 3-amyloid positivity and Alzheimer's disease (AD) in patients with cognitive impairment. The findings showed that quantitative FC119S-PET analysis provided reliable information for detecting 3-amyloid deposition and the presence of AD.
JOURNAL OF CLINICAL NEUROLOGY
(2023)