Article
Physiology
Milad Ghasemi, Robert D. Johnston, Caitriona Lally
Summary: This study introduces a novel algorithm to investigate the mechanical response of arterial tissue to the remodelling of collagen fibres, predicting the optimal fibre distribution at the carotid bifurcation in healthy and diseased cases. It explores the impact of different fibre configurations on plaque stability, providing critical insights into the collagen fibre patterns necessary for maintaining plaque stability in carotid arteries.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Engineering, Biomedical
X. Xu, L. Huang, R. Wu, W. Zhang, G. Ding, L. Liu, M. Chi, J. Xie
Summary: This paper proposes a multi-feature fusion method to accurately identify high-risk plaque by combining global features, echo features of regions of interests (ROI), and expert knowledge from ultrasound reports. The proposed method creates a more complete feature set and improves the classification performance on limited datasets.
Article
Chemistry, Multidisciplinary
Doina Butcovan, Veronica Mocanu, Mihai Enache, Beatrice Gabriela Ioan, Grigore Tinica
Summary: Atherosclerosis is a common condition that can lead to ischemic syndromes. This study proposed a score of ten parameters for assessing high-risk plaques by quantifying risk factors for acute cardiovascular events. Using carotid endarterectomy samples, the study found more macrophages and neovessels in unstable plaques compared to stable plaques.
APPLIED SCIENCES-BASEL
(2022)
Article
Surgery
Brajesh K. Lal, Amir A. Khan, Vikram S. Kashyap, Matthew T. Chrencik, Ajay Gupta, Alexander H. King, Jigar B. Patel, Janice Martinez-Delcid, Domingo Uceda, Sarasi Desikan, Siddhartha Sikdar, John D. Sorkin, Andrew Buckler
Summary: A predictive model incorporating plaque morphology, patient demographics, and clinical information was developed and validated for predicting major adverse neurologic events (MANE) in patients with carotid atherosclerosis. The model performed better than traditional methods relying solely on the degree of stenosis, highlighting the importance of including multiple factors in risk assessment and patient selection for targeted treatment.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Clinical Neurology
Nicola Giannotti, Jonathan McNulty, Shane Foley, John McCabe, Marey Barry, Morgan Crowe, Eamon Dolan, Joseph Harbison, Gillian Horgan, Eoin Kavanagh, Martin O'Connell, Michael Marnane, Sean Murphy, Ciaran Mc Donnell, Martin O'Donohoe, David Williams, Peter J. Kelly
Summary: This study identified novel correlations between non-invasive imaging biomarkers of inflammation-related plaque metabolism and morphological MRI markers of plaque instability. If replicated, these findings may support the use of combined MRI and PET to detect vulnerable plaque in future clinical practice and randomized trials.
FRONTIERS IN NEUROLOGY
(2021)
Article
Peripheral Vascular Disease
Ruijing Xin, Dandan Yang, Huimin Xu, Hualu Han, Jin Li, Yingyu Miao, Ziwei Du, Qian Ding, Shasha Deng, Zihan Ning, Rui Shen, Rui Li, Cheng Li, Chun Yuan, Xihai Zhao
Summary: For patients with bilateral carotid vulnerable plaques, symptomatic plaques exhibited greater plaque burden, higher presence of juxtaluminal IPH and/or thrombus, and FCR compared to asymptomatic plaques. Differences in juxtaluminal IPH and/or thrombus and FCR between bilateral sides were independent of plaque burden.
Article
Cardiac & Cardiovascular Systems
Luna Gargani, Matteo Baldini, Raffaella Berchiolli, Ida Rebecca Bort, Giancarlo Casolo, Dante Chiappino, Mirco Cosottini, Gennaro D'Angelo, Mariella De Santis, Paola Erba, Iacopo Fabiani, Plinio Fabiani, Ilaria Gabbriellini, Gian Giacomo Galeotti, Irene Ghicopulos, Isabel Goncalves, Simone Lapi, Gabriele Masini, Carmela Morizzo, Vinicio Napoli, Jan Nilsson, Giovanni Orlandi, Carlo Palombo, Francesco Pieraccini, Stefano Ricci, Gabriele Siciliano, Riemer H. J. A. Slart, Raffaele De Caterina
Summary: The CAMP study aims to identify the best predictors of silent and overt ischemic stroke and vascular dementia in patients with asymptomatic subcritical carotid artery disease. It also aims to assess whether low-cost diagnostic methods can provide the same level of information as more expensive techniques.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
Lin Tao, Yi-Han Wang, Zi-Yang Shang, Ben-Qiang Yang, Hui-Sheng Chen
Summary: This study provides the first evidence supporting a potential etiological role of vulnerable petrous plaque in embolic stroke of undetermined source (ESUS).
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Shi-Ting Weng, Qi-Lun Lai, Meng-Ting Cai, Jun-Jun Wang, Li-Ying Zhuang, Lin Cheng, Ye-Jia Mo, Lu Liu, Yin-Xi Zhang, Song Qiao
Summary: This study compares different clinical imaging methods and discusses the advantages and limitations of different imaging techniques for identifying vulnerable carotid plaque, providing effective methods for preventing and treating cerebrovascular diseases.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dongye Li, Huiyu Qiao, Xieqing Yang, Jin Li, Wei Dai, Xiaoyi Chen, Jun Shen, Xihai Zhao
Summary: Co-existing hypertension and hyperhomocysteinemia (H-Hcy) are associated with carotid vulnerable plaque features, and the combination of the two has a stronger predictive value for subsequent vascular events than each measurement alone.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Rui Shen, Xinyu Tong, Dongye Li, Zihan Ning, Hualu Han, Yongjun Han, Dandan Yang, Chenlin Du, Tao Wang, Jingli Cao, Yilan Xu, Ran Huo, Huiyu Qiao, Xihai Zhao
Summary: This study investigated the association between slice-based and time-specific hemodynamic measurements and carotid vulnerable plaque using magnetic resonance (MR) vessel wall imaging and histology. The results showed that hemodynamic measurements were significantly associated with carotid intra-plaque hemorrhage (IPH). Combining hemodynamic measurements with carotid plaque burden may be a stronger indicator for carotid vulnerable plaque features than individual measurements alone.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yilin Wang, Tao Wang, Yumin Luo, Liqun Jiao
Summary: Vulnerable plaques are a hot topic in the field of stroke and carotid atherosclerosis. Risk stratification and intervention for carotid plaques are currently guided by the degree of luminal stenosis. However, it has been recognized that the vulnerability of plaques may contribute to the risk of stroke. This review summarizes the identification of vulnerable plaques at both macroscopic and microscopic levels.
Article
Clinical Neurology
John C. Benson, Adnan Shahid, Anthony Larson, Waleed Brinjikji, Deena Nasr, Luca Saba, Giuseppe Lanzino, Luis E. Savastano
Summary: This study aimed to evaluate the associations between various types of arterial tortuosity and vulnerable plaque components on magnetic resonance angiography (MRA). The results showed that the left carotid plaque was more likely to have intraplaque hemorrhage (IPH), and the left internal carotid artery (ICA) was more likely to have a retrojugular course. On the right, there was an association between the presence of a lipid-rich necrotic core (LRNC) and retropharyngeal and/or retrojugular arterial pathway. On the left, there was an association between the presence of any abnormal arterial curvature and IPH volume.
CLINICAL NEURORADIOLOGY
(2023)
Review
Medicine, General & Internal
Vassiliki I. Kigka, Vassiliki Potsika, Michalis Mantzaris, Vassilis Tsakanikas, Igor Koncar, Dimitrios I. Fotiadis
Summary: Carotid artery disease is a major cause of strokes, and circulating biomarkers, including inflammatory and lipid profile markers, as well as more specialized types like endothelial and cell adhesion markers, can assist in diagnosis and prognosis. Robust clinical evidence is still needed to establish their use as a standard of care.
Article
Clinical Neurology
Hediyeh Baradaran, Tyrel Foster, Paul Harrie, J. Scott McNally, Matthew Alexander, Ankur Pandya, Yoshimi Anzai, Ajay Gupta
Summary: This study evaluated the reporting of carotid plaque features on neck CTAs at an academic institution, finding that while nearly all reports mentioned the degree of luminal stenosis, only a minority mentioned specific plaque features. There is a lack of comprehensive reporting on plaque features despite their importance in stroke risk assessment.
Review
Radiology, Nuclear Medicine & Medical Imaging
Alfred O. Ankrah, Ismaheel O. Lawal, Rudi A. J. O. Dierckx, Mike M. Sathekge, Andor W. J. M. Glaudemans
Summary: The population at risk for invasive fungal disease has increased due to medical therapy advances and diseases compromising the immune system. Non-invasive and indirect evidence, such as serology and imaging, has been used for early diagnosis of fungal infection. Imaging serves as a non-invasive biomarker for early diagnosis and monitoring of infection during treatment.
SEMINARS IN NUCLEAR MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Nick D. van Rijsewijk, Frank F. A. IJpma, Marjan Wouthuyzen-Bakker, Andor W. J. M. Glaudemans
Summary: F-18-FDG PET/CT has good diagnostic accuracy and value in the diagnosis of fever of unknown origin, providing reliable results in various patient groups. Compared to 67Ga-citrate and WBC scintigraphy, F-18-FDG PET/CT has been more extensively researched and is preferred due to its advantages and shorter procedural duration.
SEMINARS IN NUCLEAR MEDICINE
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
N. D. van Rijsewijk, B. van Leer, O. V. Ivashchenko, E. H. Scholvinck, F. van den Heuvel, J. H. van Snick, R. H. J. A. Slart, W. Noordzij, A. W. J. M. Glaudemans
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Infectious Diseases
Marjan Wouthuyzen-Bakker, Marleen van Oosten, Wouter Bierman, Rik Winter, Andor Glaudemans, Riemer Slart, Marlous Toren-Wielema, Ignace Tielliu, Clark J. Zeebregts, Niek H. J. Prakken, Jean Paul de Vries, Ben R. Saleem
Summary: Vascular graft or endograft infection (VGEI) is a serious complication of vascular surgery, which has high morbidity and mortality rates. To diagnose and treat VGEI effectively, a multidisciplinary team of vascular surgeons, infectious disease specialists, medical microbiologists, radiologists, nuclear medicine specialists, and hospital pharmacists is required. A structured diagnostic, antibiotic, and surgical treatment algorithm can help guide clinical decision-making and improve the clinical outcome of patients with VGEI.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Derk ten Hove, Ali R. Wahadat, Riemer H. J. A. Slart, Marjan Wouthuyzen-Bakker, Gianclaudio Mecozzi, Kevin Damman, Hester Witteveen, Kadir Caliskan, Olivier C. Manintveld, Bhanu Sinha, Ricardo P. J. Budde, Andor W. J. M. Glaudemans
Summary: This study evaluated the diagnostic capability of [F-18]FDG PET/CT for device-related infections (DRIs) in heart failure patients and investigated the factors affecting its accuracy. The results showed that [F-18]FDG PET/CT reliably predicts the presence of DRI in LVAD recipients, and semi-quantitative analysis can increase the specificity of [F-18]FDG PET/CT for the analysis of central device component infection.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Kornelis S. M. van der Geest, Berend G. C. Slijkhuis, Alessandro Tomelleri, Olivier Gheysens, William F. Jiemy, Costanza Piccolo, Pieter Nienhuis, Maria Sandovici, Elisabeth Brouwer, Andor W. J. M. Glaudemans, Douwe J. Mulder, Riemer H. J. A. Slart
Summary: FDG-PET/CT is a valuable diagnostic tool for identifying inflammation in large and medium-sized blood vessels in patients with systemic vasculitides. It can complement other vascular imaging techniques such as ultrasound, CTA, and MRA. In addition, FDG-PET/CT plays an important role in monitoring the treatment of vasculitis patients. The introduction of new immune-cell targeted radiotracers may enable direct visualization of inflammatory cell infiltrates in the vasculature of vasculitis patients.
CARDIOLOGY CLINICS
(2023)
Article
Microbiology
Lisanne M. Braams, Jurgen W. A. Sijbesma, Hendrikus H. Boersma, Jan Maarten van Dijl, Philip H. Elsinga, Andor W. J. M. Glaudemans, Riemer H. J. A. Slart, Marleen van Oosten
Summary: Fluorine-18-fluorodeoxyglucose ([18F]FDG) positron emission tomography (18F-FDG-PET) is widely used for the detection of inflammatory and infectious diseases. However, there is a need for bacteria-specific tracers for PET imaging. In this study, the potential of 2-[18F]-fluorodeoxysorbitol ([18F]FDS) as a tracer for detection of Enterobacterales infections was explored. Sorbitol-based PET showed promise in detecting a broad range of bacterial isolates, including Enterobacterales, Pseudomonas aeruginosa, and Corynebacterium jeikeium.
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Bram van Leer, Nick D. van Rijsewijk, Maarten W. N. Nijsten, Riemer H. J. A. Start, Janesh Pillay, Andor W. J. M. Glaudemans
Summary: The use of F-18-FDG-PET/CT in ICU patients is limited but feasible and safe. It has been shown to be effective in studying the pathophysiology of conditions such as acute respiratory distress syndrome and traumatic brain injury, and has the potential to improve outcomes in cases of infection with unknown origin.
SEMINARS IN NUCLEAR MEDICINE
(2023)
Article
Medicine, General & Internal
Andor W. J. M. Glaudemans, Olivier Gheysens
Summary: Nuclear medicine imaging techniques have gained widespread acceptance in diagnosing and monitoring infectious and inflammatory diseases. PET imaging has been incorporated into diagnostic flowcharts in recent clinical guidelines. This perspective paper discusses current guidelines, limitations, and future research goals for achieving the differentiation between infection, inflammation, and malignancy in nuclear medicine.
FRONTIERS IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pascalle Mossel, Wejdan M. Arif, Giordana Salvi De Souza, Lara Garcia Varela, Chris W. J. van der Weijden, Hendrikus H. Boersma, Antoon T. M. Willemsen, Ronald Boellaard, Philip H. Elsinga, Ronald J. H. Borra, Rudi A. J. O. Dierckx, Adriaan A. Lammertsma, Anna L. Bartels, Gert Luurtsema
Summary: The aim of this study was to determine the best pharmacokinetic model to describe [F-18]MC225 kinetics in the human brain and assess test-retest variability. The reversible two tissue compartment model corrected for plasma metabolites with an estimated blood volume (VB) showed the highest AIC weight score. The preferred parameter to describe P-gp function in the human BBB using this model was [F-18]MC225 VT, which had an average test-retest variability of 28%.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Medicine, Legal
Robin-Alissa Emaus, Lennaert Christiaan Pieter Borra, Rogier van der Hulst, Dick-Paul Kloos, Dingeman Johannes Rijken, Philip Hein Elsinga, Hendrikus Hessel Boersma, Ingrid Jolanda Bosman, Daniel Johannes Touw
Summary: A challenge in forensic toxicology is the correct interpretation of quantitative analyses in postmortem cases. The ratio of cardiac blood concentration/peripheral blood concentration (C/P) is often used as a marker of postmortem redistribution (PMR). This study investigated the relationship between different variables and the C/P ratios of cocaine and its metabolites, aiming to provide guidelines for interpreting postmortem quantitative results and differentiating between PMR and degradation.
FORENSIC SCIENCE INTERNATIONAL
(2023)
Review
Oncology
Mostafa Roya, Samaneh Mostafapour, Philipp Mohr, Laura Providencia, Zekai Li, Johannes H. van Snick, Adrienne H. Brouwers, Walter Noordzij, Antoon T. M. Willemsen, Rudi A. J. O. Dierckx, Adriaan A. Lammertsma, Andor W. J. M. Glaudemans, Charalampos Tsoumpas, Riemer H. J. A. Slart, Joyce van Sluis
Summary: Recently, a new type of PET scanner with long axial field-of-view (LAFOV) has been introduced in clinical practice. Compared to conventional PET scanners, LAFOV scanners have a larger coverage and higher sensitivity, providing new opportunities for clinical applications, such as reducing scan time, decreasing the amount of radiotracer used, and using dynamic or parametric imaging. Emerging technologies like artificial intelligence and imaging with multiple radiotracers can further enhance the clinical application of LAFOV PET.
Article
Biochemistry & Molecular Biology
Chiara Lauri, Giuseppe Campagna, Andor W. J. M. Glaudemans, Riemer H. J. A. Slart, Bram van Leer, Janesh Pillay, Marzia Colandrea, Chiara Maria Grana, Antonio Stigliano, Alberto Signore
Summary: This study aimed to evaluate the metabolic activity of the thyroid and adrenal glands in COVID-19 patients using F-18-FDG PET/CT. The results showed persistent low adrenal uptake in COVID-19 patients, suggesting chronic hypofunction. However, the thyroid uptake in COVID-19 patients was comparable to normal subjects at disease onset, but some patients showed increased metabolism after recovery, potentially indicating the onset of inflammatory thyroiditis.
Review
Oncology
Jasper J. L. van Geel, Erik F. J. de Vries, Michel van Kruchten, Geke A. P. Hospers, Andor W. J. M. Glaudemans, Carolina P. Schroder
Summary: Molecular imaging, such as PET, is being used more frequently as a biomarker to predict and assess treatment response in breast cancer. Specific tracers are used to measure metabolic activity, estrogen receptor expression, and human epidermal growth factor receptor 2 expression. These biomarkers have potential in predicting treatment response and outcome, but more studies are needed before implementation in clinical practice.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bram van Leer, Johannes H. van Snick, Mark Londema, Maarten W. N. Nijsten, Oemer Kasalak, Riemer H. J. A. Slart, Andor W. J. M. Glaudemans, Janesh Pillay
Summary: We report the findings of four critically ill patients with persistent inflammation during late phase of COVID-19 who underwent [F-18]FDG-PET/CT imaging. PET/CT findings showed that bilateral lung anomalies could explain the increased CRP and leukocytes in all patients. Based on PET/CT results, secondary infection/inflammatory focus was suspected in two patients (pancreatitis and gastritis). Lymphadenopathy was present in patients with detectable SARS-CoV-2 viral load. Muscle uptake around the hips or shoulders was observed in all patients, possibly due to the process of heterotopic ossification.
CLINICAL AND TRANSLATIONAL IMAGING
(2023)
