Article
Chemistry, Multidisciplinary
Jasper W. Dittmar, Michelle H. Teplensky, Michael Evangelopoulos, Lei Qin, Bin Zhang, Chad A. Mirkin
Summary: The stability of the liposome core is crucial for the effectiveness of liposome-based drugs. This study explores the impact of anchor chemistry on immunotherapeutic function and demonstrates that a stable anchor can enhance immune stimulation and improve therapeutic efficacy.
Article
Chemistry, Multidisciplinary
Yuanyuan Chen, Peng Gao, Wei Pan, Mingwan Shi, Shujie Liu, Na Li, Bo Tang
Summary: The research developed an X-ray-induced phenotypic transformation strategy through macrophage engineering for safe and efficient tumor immunotherapy. The engineered macrophages demonstrated high tumor recognition and X-ray-induced polarization effects, significantly inhibiting tumor growth in mice even with a reduced radiation dose compared to natural macrophages. The X-PT strategy opens a new avenue for clinical immune cell-based therapy.
Article
Chemistry, Multidisciplinary
Yujie Song, Xiao Xie, Yang Liu, Zhen Zhu, Litao Sun
Summary: Metal ions, especially Cu2+, play vital roles in various biochemical reactions in the human body and are essential for maintaining good health. This study investigates the interaction between Cu2+ and DNA using transmission electron microscopy (TEM) and in situ liquid-cell TEM. Results demonstrate that the binding of Cu2+ to DNA results in the bending of the DNA strand and provides a site for the nucleation and growth of copper crystals. The arrangement of the copper crystals along the curved DNA strand correlates with the guanine arrangement on the DNA sequence. This research provides a direct observation of the DNA-Cu2+ complex at the nanometer scale and contributes to further understanding the interaction mechanism, benefiting biomedical research.
Article
Chemistry, Multidisciplinary
Yang Fang, Xueguang Lu, Dali Wang, Jiansong Cai, Yuyan Wang, Peiru Chen, Mengqi Ren, Hao Lu, Jennifer Union, Lei Zhang, Yehui Sun, Fei Jia, Xi Kang, Xuyu Tan, Ke Zhang
Summary: A self-assembled, skin-depigmenting SNA structure was reported in this study, showing a reduction in melanin content in melanoma cells and a potent antimelanogenic effect in an ultraviolet B-induced hyperpigmentation mouse model.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Krishna S. Paranandi, Andrew Lee, Nikola Stanic, Chad A. Mirkin
Summary: Liposomal spherical nucleic acids (LSNAs) are effective structures for cell modulation through oligonucleotides. This study investigates the export fate of LSNA and finds that the components of LSNA are differentially exported by cells. The output materials are degraded into lysophospholipids, and these findings suggest avenues for leveraging pharmacologic effects from exported LSNA components.
Article
Chemistry, Multidisciplinary
Tianyu Du, Zewen Shi, Zhaojian Qin, Yiwei Hu, Yabin Zhu, Hui Jiang, Xuemei Wang
Summary: This study proposes an in situ targeted therapy strategy using a photothermally triggered nanoplatform. The nanoplatform, consisting of spherical nucleic acids, black phosphorus nanosheets, and zinc porphyrin metal-organic framework nanosheets, can disassemble during photothermal therapy, allowing for photothermally triggered photodynamic therapy. The enhanced singlet oxygen generation decreases heat shock proteins and improves the therapeutic effect. The superstructure shows potential as a synergistic platform for advanced cancer theranostics.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yan Hao, Yanjuan Li, Lei Song, Zhaoxiang Deng
Summary: By using a rapid dehydration method, the synthesis of spherical nucleic acids with record-high DNA density is achieved in seconds, resulting in a 3-time increase in DNA density compared to traditional methods. This ultra-high density DNA grafting facilitates the formation of core-satellite assemblies, making the synthesis of spherical nucleic acids easier and enabling future explorations of the physical, chemical, and biological effects of high-density DNA spherical nucleic acids.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Analytical
Kaifei Jin, Xiyue Xie, Jing Zhu, Zhenqiang Wang, Yuxin Xing, Lu Wang, Kaiyong Cai, Jixi Zhang
Summary: A homogeneous and label-free miRNA sensing system was developed using magnetically separable spherical nucleic acids (SNA) and signal amplification in PEC detection. The system achieved highly repeatable and anti-interference analysis of miR-21 in complex physiological samples, with a low limit of detection. It was successfully applied for sensitive profiling of miR-21 in tumor cells and tumor-bearing mice plasma.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Materials Science, Multidisciplinary
Xuehui Xu, Yingxu Shang, Fengsong Liu, Qiao Jiang, Baoquan Ding
Summary: Nucleic acid logic devices are highly flexible and responsive, able to perform logic operations in complex biological environments. They can respond to various stimuli, such as DNA/RNA strands, metal ions, and small molecules.
Article
Chemistry, Multidisciplinary
Miao Sun, Zijing Wu, Jialu Zhang, Mingying Chen, Yao Lu, Chaoyong Yang, Yanling Song
Summary: The Omicron variant of SARS-CoV-2 has been spreading rapidly worldwide. It has been found to evade the human immune response. In this study, a new approach was used to block the interaction between the Omicron variant and host cells, effectively inhibiting its infection.
Article
Chemistry, Multidisciplinary
Andrew J. Sinegra, Michael Evangelopoulos, Jungsoo Park, Ziyin Huang, Chad A. Mirkin
Summary: Lipid nanoparticle SNAs show enhanced activity with G-rich sequences and increased cholesterol content in the LNP core, leading to reduced siRNA concentration required for silencing mRNA. Optimized LNP-SNA candidates also exhibit altered biodistribution and efficacy profiles in mice, suggesting their potential for targeted tissue delivery.
Review
Chemistry, Analytical
Jingjing Li, Yuanyuan Li, Limeng Pan, Wei Pan, Na Li, Bo Tang
Summary: This study summarizes the recent advances and applications of spherical nucleic acid (SNAs)-based biosensors for tracking and imaging cancer-related biomarkers, and discusses the future challenges and opportunities of SNAs for cancer diagnosis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Michelle H. Teplensky, Max E. Distler, Caroline D. Kusmierz, Michael Evangelopoulos, Haley Gula, Derek Elli, Anastasia Tomatsidou, Vlad Nicolaescu, Ian Gelarden, Anjana Yeldandi, Daniel Batlle, Dominique Missiakas, Chad A. Mirkin
Summary: This study explores how the presentation of vaccine components in spherical nucleic acids (SNAs) can induce and maximize antiviral response. The SNA vaccine, encapsulating the receptor-binding domain (RBD) subunit and decorated with Toll-like receptor 9 agonist oligonucleotides, shows promising results in inducing immune responses in human cells and mice, outperforming traditional vaccines.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Ya-Ling Tan, A-Qian Huang, Li-Juan Tang, Jian-Hui Jiang
Summary: The development of multiplexed droplet loop-mediated isothermal amplification (multiplexed dLAMP) technique, which allows simultaneous quantification of multiple targets, provides a highly sensitive digital nucleic acid method for rapid and effective detection of viruses and other pathogens. The technology not only has been successfully demonstrated in the laboratory, but also holds promise for digital detection of HCV and HIV RNA in clinical applications. With high precision and low detection limits, it offers a new approach for the prevention and control of infectious diseases.
Article
Chemistry, Multidisciplinary
Yuanyuan Guo, Jingcan Qin, Qianqian Zhao, Jiapei Yang, Xiaoer Wei, Yu Huang, Miao Xie, Chuan Zhang, Yuehua Li
Summary: In this study, a rapamycin spherical nucleic acid structure specifically targeted at plaques was constructed for synergistic treatment of atherosclerosis. This structure not only induced autophagy and reduced apoptosis of pathological macrophages, but also inhibited the formation of damageable foam cells, achieving a synergistic therapeutic effect.
Article
Chemistry, Multidisciplinary
Hye In Cho, Seungjoo Yi, Ji-Seong Hwang, Ji-Hun Seo, Jae-Seung Lee
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2020)
Article
Chemistry, Physical
Han-Jung Ryu, Ha-Lin Kim, Jang Ho Joo, Jae-Seung Lee
Review
Chemistry, Physical
Yan Li, Jae-Seung Lee
Article
Chemistry, Physical
Bo-In Park, Miri Shin, Jaeho Park, Jae-Seung Lee, Seung Yong Lee, Seunggun Yu
Summary: In this study, high crystallinity Bi0.5Sb1.5Te3.0 (BST) nanoparticles (NPs) were successfully synthesized via a mechanochemical process, and their sizes were further reduced and uniformly distributed through a wet-milling process. The BST nanocomposites fabricated from BST NPs with smaller grain sizes and finer distributions exhibited significantly reduced thermal conductivities. Wet-milled BST NPs showed ultralow thermal conductivity values at approximately 398 K, demonstrating their potential for thermoelectric applications.
Article
Chemistry, Physical
Won Kyu Lee, Kihun Kwon, Yeonho Choi, Jae-Seung Lee
Summary: This study explored the dynamic metallization of spherically condensed DNA nanoparticles, leading to the formation of various Au nanostructures with unprecedented morphologies through controlled conformational transitions. The condensed DNA nanoparticles served as templates for synthesis, reservoirs of Au3+ for growth, and stabilizers of the surface, resulting in stable Au nanostructures with catalytic activities and excellent SERS properties. This research offers new synthetic routes for bioinorganic nanomaterials.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Multidisciplinary Sciences
Nu-Ri Im, Taeseok Daniel Yang, Kwanjun Park, Jang-Hoon Lee, Jonghwan Lee, Yoon Hyuck Kim, Jae-Seung Lee, Byoungjae Kim, Kwang-Yoon Jung, Youngwoon Choi, Seung-Kuk Baek
Summary: Activated M1 macrophages demonstrated higher uptake capacity and active infiltration towards NPs compared to non-activated M Phi macrophages. Using M1 as live vector led to a more rapid reduction in tumor size, indicating higher efficacy of PTT with NPs-loaded M1.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Chemistry, Analytical
Han-Jung Ryu, Won Kyu Lee, Yoon Hyuck Kim, Jae-Seung Lee
Summary: This review focuses on recent developments in the design of SERS probes over the last 4 years, emphasizing their conjugation chemistry for functionalization. Raman dyes tend to have a strong preference for covalent bonding, while antibodies are bonded to nanostructures depending on their activity in the SERS probes.
Article
Chemistry, Physical
Han-Jung Ryu, Won Kyu Lee, Jong Yun Choi, Jae-Seung Lee
Summary: This study investigates the catalytic properties of Ag-M bimetallic nanoparticles and the impact of precursor-induced silver halide byproducts, finding that the catalytic properties are significantly enhanced by removing AgCl with ascorbic acid. The study provides guidance for the controlled synthesis of high purity bimetallic nanoparticles and their efficient applications in various fields.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)
Article
Chemistry, Multidisciplinary
Yoon Hyuck Kim, Ju-Hwan Oh, Jae-Seung Lee
Summary: The gram-scale synthesis of gold nanoparticles (AuNPs) using a polymerizable deep eutectic solvent (DES) has been developed, leading to high productivity and scalability. The chemical and physical properties of AuNPs have been thoroughly investigated.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Heehyeon Lee, Jongwon Oh, Jin Young Koo, Hiroyoshi Ohtsu, Hyeong Min Jin, Soyoung Kim, Jae-Seung Lee, Hyunchul Kim, Hee Cheul Choi, Youngtak Oh, Seok Min Yoon
Summary: A hierarchical metal-organic aerogel (HMOA) with well-defined micropores has been designed for CO2 adsorption, exhibiting high adsorption capacity and selectivity, as well as vacuum-induced surface regeneration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Han-Jung Ryu, Mingyeong Shin, Myeongkee Park, Jae-Seung Lee
Summary: This study introduces an in situ ligand engineering method to stabilize organic-inorganic hybrid perovskite nanoparticles (OIHP NPs) and control their optical properties. By adjusting the concentration and molecular structure of tetraalkylammonium (TAA) halides, the stability of the nanoparticles is significantly improved. In certain conditions, approximately 90% of the initial photoluminescence intensity is preserved.
Article
Chemistry, Multidisciplinary
Yoon Hyuck Kim, Jae-Seung Lee
Summary: Noble metal nanoparticles have unique properties that make them suitable for various applications. This study presents a method for gram-scale synthesis of gold nanoparticles using acrylamide as a solvent. The viscosity of the solvent can be chemically tuned to stabilize high concentrations of synthesized nanoparticles. The synthesized nanoparticles exhibit stability and catalytic activity under high ionic strength conditions.
Article
Biochemical Research Methods
Seung Yeon Seo, Won Kyu Lee, Jae-Seung Lee
Summary: Recently, DNA-assembly nanoparticles based on DNA-metalion interactions have been developed for drug delivery and metal nanostructure synthesis. In this study, a new chemical strategy was developed to functionalize DNA-assembly nanoparticles with thiolated probe DNA, leading to the successful detection of multiple DNA targets.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Won Kyu Lee, Joonbum Lee, Jae-Seung Lee
Summary: In this study, highly stable DNA-poly-L-lysine (PLL) polyplexes were synthesized and used as cores to synthesize uniform gold nanoshells for photothermal therapy. By introducing gold nanoparticles (AuNPs) to the polyplex surface, the chemical and physical stability of the polyplexes were significantly enhanced, while maintaining their enzymatic biodegradability. The resulting poly@AuNSs exhibit excellent photothermal properties, high photothermal stability, and outstanding targeting ability towards cancer cells.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Han-Jung Ryu, Kyung Tae Kim, Won Kyu Lee, Jae-Seung Lee
Summary: This study investigates the pivotal role of precursor ligands in the photochemical synthesis of metallic cubic mesh nanostructures on the AgCl templates. The study discovers the partial destruction of AgCl and the formation of undesirable byproducts caused by the presence of highly oxidizing and Cl-containing AuCl4(-). Additionally, a synthetic route for producing highly pure and stable metallic nanostructures using a halogen-free Au precursor or Pt-priming is proposed.
Article
Chemistry, Physical
Sergey Yu. Ketkov, Sheng-Yuan Tzeng, Elena A. Rychagova, Anton N. Lukoyanov, Wen-Bih Tzeng
Summary: Metallocenes, including methylcobaltocene, play important roles in various fields of chemistry. The ionization energy and vibrational structure of (Cp ')(Cp)Co can be influenced by introducing methyl substituents. The mass-analyzed threshold ionization spectrum and DFT calculations provide accurate information about the properties and transformations of (Cp ')(Cp)Co.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Review
Chemistry, Physical
Qifeng Mu, Jian Hu
Summary: Polymer mechanochemistry has experienced a renaissance due to the rapid development of mechanophores and principles governing mechanochemical transduction or material strengthening. It has not only provided fundamental guidelines for converting mechanical energy into chemical output, but also found applications in engineering and smart devices.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Da Hye Yang, Francesco Ricci, Fredrik L. Nordstrom, Na Li
Summary: Through systematic evaluation of the oiling-out behavior of procaine, we identified both stable and metastable liquid-liquid phase separation, and established phase diagrams to assist in rational selection of crystallization strategies.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Vikki Anand Varma, Simmie Jaglan, Mohd Yasir Khan, Sujin B. Babu
Summary: Designing engineering structures like nanocages, shells, and containers through self-assembly of colloids is a challenging problem. This work proposes a simple model for the subunit, which leads to the formation of monodispersed spherical cages or containers. The model with only one control parameter can be used to design cages with the desired radius.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Hainan Jiang, Yaolong He, Xiaolin Li, Zhiyao Jin, Huijie Yu, Dawei Li
Summary: The cycling lifespan and coulombic efficiency of lithium-ion batteries are crucial for high C-rate applications. The Li-ion concentration plays a crucial role in determining the mechanical integrity and structural stability of electrodes. This study focuses on graphite as the working electrode and establishes an experimental system to investigate the mechanical properties of composite graphite electrode at different C-rates. Considering the effect of Li-ion concentration in stress analysis is found to be significant.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Zhiye Wang, Yunchuan Li, Mingjun Sun
Summary: This study investigates the influence of intramolecular pi-pi interactions on the electronic transport capabilities of molecules. By designing and analyzing three pi-conjugated molecules, the researchers observe that different pi-conjugated structures have varying effects on electron transport. The findings provide a theoretical foundation for designing single-molecule electronic devices with multiple electron channels based on intramolecular pi-pi interactions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Yuandong Xu, Haoyang Feng, Chaoyang Dong, Yuqing Yang, Meng Zhou, Yajun Wei, Hui Guo, Yaqing Wei, Jishan Su, Yingying Ben, Xia Zhang
Summary: Hollow MoS2 cubes and spheres were successfully synthesized using a one-step hydrothermal method with the hard template method. The hollow MoS2 cubes exhibited higher specific capacitance and energy density compared to the hollow MoS2 spheres. The symmetrical supercapacitors assembled with these hollow structures showed good performance and high capacity retention after multiple cycles. These findings suggest that controlling the pore structure and surface characteristics of MoS2 is crucial for enhancing its electrochemical properties.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Ainhoa Oliden-Sanchez, Rebeca Sola-Llano, Joaquin Perez-Pariente, Luis Gomez-Hortiguela, Virginia Martinez-Martinez
Summary: The combination of photoactive molecules and inorganic structures is important for the development of advanced materials in optics. In this study, bulky dyes were successfully encapsulated in a zeolitic framework, resulting in emission throughout the visible spectrum.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Miaomiao Zhang, Cunyuan Pei, Qiqi Xiang, Lintao Liu, Zhongxu Dai, Huijuan Ma, Shibing Ni
Summary: The design of a solid electrolyte interphase (SEI) plays a crucial role in improving the electrochemical performance of anode materials. In this study, lithium difluoro(oxalate)borate (LiDFOB) is used as an electrolyte additive to form a protective SEI film on Li3VO4 (LVO) anodes. The addition of LiDFOB results in a dense, uniform, stable, and LiF-richer SEI, which enhances the Li-ion storage kinetics. The generated SEI also prevents further decomposition of the electrolyte and maintains the morphology of LVO anodes during charge/discharge processes. This work demonstrates the effectiveness of LiDFOB as a multi-functional additive for LiPF6 electrolytes and provides insights into SEI construction for high-performance LVO anodes.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
B. V. Andryushechkin, T. V. Pavlova, V. M. Shevlyuga
Summary: The atomic structure of the Ag(111)-p(4 x 4)-O phase was reexamined and two phases with the same periodicity were discovered. It was demonstrated that the accepted Ag6 model is incompatible with high-resolution oxygen-sensitive STM images.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
S. L. Romo-Avila, D. Marquez-Ruiz, R. A. Guirado-Lopez
Summary: In this study, we used density functional theory (DFT) calculations to investigate the interaction between model graphene oxide (GO) nanostructures and chlorine monoxide ClO. We aimed to understand the role of this highly oxidizing species in breaking C-C bonds and forming significant holes on GO sheets. Our results showed that C-C bonds in a single graphene oxide sheet can be broken through a simple mechanism involving the dissociation of two chemically attached ClO molecules. The formation of carbonyl groups and holes on the GO surface was also observed. This study provides important insights into the degradation of carbon nanotubes and the stability of GO during the myeloperoxidase (MPO) catalytic cycle.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Alberto Garcia-Fernandez, Birgit Kammlander, Stefania Riva, Hakan Rensmo, Ute B. Cappel
Summary: In this study, the X-ray stability of five different lead halide perovskite compositions (MAPbI3, MAPbCl3, MAPbBr3, FAPbBr3, CsPbBr3) was investigated using photoelectron spectroscopy. Different degradation mechanisms and resistance to X-ray were observed depending on the crystal composition. Overall, perovskite compositions based on the MA+ cation were found to be less stable than those based on FA+ or Cs+. Metallic lead formation was most easily observed in the chloride perovskite, followed by bromide, and very little in MAPbI3. Multiple degradation processes were identified for the bromide compositions, including ion migration, formation of volatile and solid products, as well as metallic lead. CsBr was formed as a solid degradation product on the surface of CsPbBr3.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Timofei Rostilov, Vadim Ziborov, Alexander Dolgoborodov, Mikhail Kuskov
Summary: The shock-loading behavior of nanomaterials is investigated in this study. It is found that shock compaction waves exhibit a distinct two-step structure, with the formation of faster precursor waves that travel ahead of the main compaction waves. The complexity of the shock Hugoniot curve of the tested nanomaterial is described, and the effect of initial porosity on the compressed states is demonstrated.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Sergey S. Nikitin, Alexander D. Koryakov, Elizaveta A. Antipinskaya, Alexey A. Markov, Mikhail V. Patrakeev
Summary: The stability of La1/3Sr2/3Fe1-xMnxO3-delta, a perovskite-type oxide, under reducing conditions is dependent on the manganese content. Increasing the manganese content leads to a decrease in stability. The behavior of iron and manganese in the oxide shows distinct differences, which can be attributed to the difference in the enthalpy of oxidation reactions. Additionally, the change in the La/Sr ratio affects the concentration of iron and manganese ions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
Article
Chemistry, Physical
Mosayeb Naseri, Shirin Amirian, Mehrdad Faraji, Mohammad Abdur Rashid, Maicon Pierre Lourenco, Venkataraman Thangadurai, D. R. Salahub
Summary: Inspired by the successful transfer of freestanding ultrathin films of SrTiO3 and BiFeO3, this study assessed the structural stability and investigated the electronic, optical, and thermoelectric properties of a group of two-dimensional perovskite-type materials called perovskenes. The findings revealed that these materials are wide bandgap semiconductors with potential application in UV shielding. Moreover, they exhibit better electrical and thermal conductivity at high temperatures, enabling efficient power generation in thermoelectric devices.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2024)
