Journal
JOURNAL OF NEUROVIROLOGY
Volume 18, Issue 3, Pages 151-156Publisher
SPRINGER
DOI: 10.1007/s13365-012-0090-5
Keywords
Clade C virus; HIV infection; South Africa; Neuroimaging
Categories
Funding
- National Institute of Health [MH065857]
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Previous studies have reported cognitive deficits among HIV-positive individuals infected with clade C virus. However, no study has examined whether individuals predominately infected with clade C virus exhibit brain atrophy relative to healthy controls. This study examined volumetric differences between 28 HIV+ individuals and 23 HIV- controls from South Africa. Volumetric measures were obtained from six regions of interest - caudate, thalamus, corpus callosum, total cortex, total gray matter, and total white matter. HIV+ participants had significantly lower volumes in the total white matter (p < 0.01), thalamus (p < 0.01) and total gray matter (inclusive of cortical and subcortical regions, p < 0.01). This study is the first to provide evidence of brain atrophy among HIV+ individuals in South Africa, where HIV clade C predominates. Additional research that integrates neuroimaging, comprehensive neuropsychological testing, genetic variance in clade-specific proteins, and the impact of treatment with Antiretrovirals (ARV) are necessary to understand the development of HIV-related neurocognitive disorders in South Africa.
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