Article
Immunology
Chenjing Sun, Jinming Han, Ye Lin, Xiaokun Qi, Changqing Li, Jianguo Liu, Feng Qiu
Summary: This study aimed to investigate the differences in clinical and pathological features between primary central nervous system lymphoma (PCNSL) and atypical tumefactive demyelinating lesions (TDLs) and provide early accurate diagnosis. The results showed that TDLs patients had a younger age of onset, while PCNSL patients frequently presented with cognitive impairment. Neuroimaging features on CT scans could provide clues for differential diagnosis. The presence of Creutzfeldt-Peters cells was an important feature in diagnosing TDLs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xinnan Li, Xiuling Miao, Yaming Wang, Junzhao Sun, Haifeng Gao, Jing Han, Yuxin Li, Qingjun Wang, Chenjing Sun, Jianguo Liu
Summary: This study aimed to track the clinical outcomes of patients with tumefactive demyelinating lesions (TDLs), summarize the clinical characteristics of different etiologies, and identify possible risk factors for relapse. The study found that around 46.6% of TDLs had relapses, with the highest recurrence rate in the multiple sclerosis (MS) group. Lesion location, diffuse infiltrative lesions, and multiple lesions were identified as potential independent risk factors for relapse. However, despite extensive diagnostic work and long-term follow-up, the etiology of TDLs in some patients remained unclear. These patients tended to have a monophase course and a low rate of relapse.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Li Jiao, Shougang Guo
Summary: This review summarizes the research progress and prospects of anti-interleukin-6 (IL-6) therapy in the treatment of central nervous system inflammatory demyelinating diseases (IDDs).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Maria Ruby Rose Q. Castaneda, Adrian Espiritu, Marilyn A. Tan
Summary: This study provides a comprehensive summary of the clinical features of children with PADS at a Philippine tertiary hospital, highlighting the importance of using clinical diagnostic criteria to improve case recognition in low- and middle-income countries. The study also emphasizes the need for international registries with wider geographic representation to develop diagnostic and management guidelines suitable for different levels of care.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Merel C. Broers, Carina Bunschoten, Judith Drenthen, Tiago A. O. Beck, Esther Brusse, Hester F. Lingsma, Jeffrey A. Allen, Richard A. Lewis, Pieter A. van Doorn, Bart C. Jacobs
Summary: This study reveals a common occurrence of over- and underdiagnosis of CIDP, with diagnostic pitfalls such as lack of attention to proximal muscle weakness, insufficient recognition of clinical atypical phenotypes, overreliance on CSF protein levels, and failure to exclude other causes of polyneuropathy.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Biology
Akinori Okada, Yuji Nozaki, Shinya Rai, Koji Kinoshita, Masanori Funauchi, Itaru Matsumura
Summary: This case study presents a 35-year-old male patient with both HIV infection and concomitant SLE, highlighting the challenges in choosing treatment strategies for these two conditions that involve conflicting immunological responses. Rheumatologists in Japan should consider the possibility of HIV infection when diagnosing autoimmune diseases, especially given the relatively low prevalence of HIV in the country.
Editorial Material
Neurosciences
Tomoya Shibahara, Kuniyuki Nakamura, Daisuke Abe, Naoki Tagawa, Yoshinobu Wakisaka, Takanari Kitazono, Tetsuro Ago
Summary: We report a case of multiple small-vessel strokes in a patient with HIV/AIDS during the immune reconstitution phase. The patient presented with mild dysarthria and left-sided hemiparesis, and MRI revealed multiple hyperintense lesions in the anterior circulation system. Decreased protein S activity was identified, and treatment with steroids successfully prevented stroke recurrence.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Multidisciplinary Sciences
Xiaohua Dong, Shuchen Sun, Jie Li, Sen Shen, Wanting Chen, Tongqi Li, Xinyuan Li
Summary: This study performed peptidomic analysis of brain tissue from a mouse model of multiple sclerosis (MS), revealing 217 peptides expressed at different levels compared to control mice. GO and KEGG analysis showed that the precursor proteins of these differentially expressed peptides were associated with myelin sheath and oxidative phosphorylation. These findings provide new insights into the pathogenesis and complexity of MS.
Article
Cell Biology
Nhungoc Luong, Julie K. Olson
Summary: During TMEV infection, microglia secrete exosomes containing viral RNA, which can activate uninfected bystander CNS cells to promote an inflammatory immune response, contributing to viral persistence and neuroinflammation in the development of demyelinating disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Wasey Ali Yadullahi Mir, Dhan B. Shrestha, Francesco Fiumara, Sunita Mohapatra, Thomas Sullivan, Anurag Adhikari, Larissa Verda
Summary: HIV encephalopathy is a severe manifestation of HIV-associated neurological disorders, requiring diagnosis through cerebrospinal fluid analysis and neuroimaging. In this case, a patient presented with symptoms resembling acute multiple sclerosis flares, but showed significant improvement after treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Ya Liu, Qiuyu Fan, Chao Jia, Qibin Wan, Huiqin Yang
Summary: This study aimed to assess the effects of belimumab on demyelinating syndromes in SLE patients. The results showed that belimumab could be an effective and safe option for the treatment of SLE demyelination. In addition, PBX1 might be a potential biomarker for the clinical diagnosis of lupus in patients with demyelinating syndrome.
Article
Microbiology
Ana Borrajo, Valentina Svicher, Romina Salpini, Michele Pellegrino, Stefano Aquaro
Summary: Chronic infection of HIV-1 leads to serious CD4+ T cell immunodeficiency and neurocognitive disorders in the central nervous system, contributing to increasing morbidity and mortality globally. Despite advancements in treatment, there is still incomplete understanding of the pathogenesis and role of inflammation in neurodegenerative difficulties.
Article
Neurosciences
Francesco Di Virgilio, Valentina Vultaggio-Poma, Simonetta Falzoni, Anna Lisa Giuliani
Summary: Nucleotides, especially extracellular ATP (eATP), play a crucial role in inter-species extracellular signaling. Different organisms have evolved sensors with varying affinity and selectivity for eATP, resulting in a highly flexible signaling system. In mammalian evolution, the control of intracellular ATP and eATP homeostasis is closely linked to that of Ca2+. Specific plasma membrane receptors, known as P2 receptors (P2Rs), sense eATP with various degrees of affinity and selectivity, adding to the plasticity of the system. The central nervous system (CNS) is a privileged site for purinergic signaling, with all brain cell types expressing P2Rs. Evidence suggests that eATP not only participates in synaptic transmission but also plays a crucial homeostatic role in brain cell responses. Modulating eATP concentration in the CNS may hold promise for the treatment of neuroinflammation.
Article
Medicine, General & Internal
Hye Lim Lee, Jin-Woo Park, Jin Myoung Seok, Mi Young Jeon, Hojin Kim, Young-Min Lim, Ha Young Shin, Sa-Yoon Kang, Oh-Hyun Kwon, Sang-Soo Lee, Hung Youl Seok, Ju-Hong Min, Sung-Hyun Lee, Byung-Jo Kim, Byoung Joon Kim
Summary: The study investigated IgG autoantibody responses to various peptides in patients with CNS inflammatory demyelinating disorders, finding that IgG responses to CMV-related peptides were relatively higher in patients with multiple sclerosis and NMOSD.
Letter
Clinical Neurology
Mena Farag, Naomi Sibtain, James Burge, Vinay Chaudhry, Eli Silber
Summary: The patient presented with peripheral demyelination in the form of CIDP and central demyelination following a relapsing-remitting course. Despite poor response to steroids and regular IVIg, aggressive immunomodulatory therapy resulted in clinical improvement. The overlap of central and peripheral demyelination is rare, with autoimmune mechanisms postulated in the pathogenesis.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Immunology
David Delman, Xianming Peng, Daniel C. Zedek, Valerie Jewells, Nizar Chahin, Silva Markovic-Plese
JOURNAL OF NEUROIMMUNOLOGY
(2015)
Article
Clinical Neurology
Hae W. Shin, Valerie Jewells, Arif Sheikh, Jingwen Zhang, Hongtu Zhu, Hongyu An, Wei Gao, Dinggang Shen, Eldad Hadar, Weili Lin
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2015)
Article
Environmental Sciences
Lilian Calderon-Garciduenas, Valerie Jewells, Carolina Galaz-Montoya, Brigitte van Zundert, Angel Perez-Calatayud, Eric Ascencio-Ferrel, Gildardo Valencia-Salazar, Marcela Sandoval-Cano, Esperanza Carlos, Edelmira Solorio, Hilda Acuna-Ayala, Ricardo Torres-Jardon, Amedeo D'Angiulli
ENVIRONMENTAL RESEARCH
(2016)
Article
Computer Science, Artificial Intelligence
Zhengwang Wu, Yaozong Gao, Feng Shi, Guangkai Ma, Valerie Jewells, Dinggang Shen
MEDICAL IMAGE ANALYSIS
(2018)
Article
Immunology
Xin Zhang, Nazanin Kiapour, Sahil Kapoor, Joseph R. Merrill, Yongjuan Xia, Woomi Ban, Stephanie M. Cohen, Bentley R. Midkiff, Valerie Jewells, Yen-Yu I. Shih, Silva Markovic-Plese
CLINICAL IMMUNOLOGY
(2018)
Article
Otorhinolaryngology
Raphael E. Alford, David V. Fried, Benjamin Y. Huang, Mark Weissler, Carol Shores, William Shockley, Trevor Hackman, Adam Zanation, Neil Hayes, Jared Weiss, Juneko Grilley-Olson, Valerie Jewells, Katherine Birchard, Bhishamjit S. Chera
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2014)
Article
Neurosciences
Yang Li, Valerie Jewells, Minjeong Kim, Yasheng Chen, Andrew Moon, Diane Armao, Luigi Troiani, Silva Markovic-Plese, Weili Lin, Dinggang Shen
HUMAN BRAIN MAPPING
(2013)
Article
Immunology
Yazhong Tao, Xin Zhang, Manisha Chopra, Ming-Jeong Kim, Kinnari R. Buch, Dehan Kong, Jianping Jin, Yunan Tang, Hongtu Zhu, Valerie Jewells, Silva Markovic-Plese
JOURNAL OF IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Lucile Bompard, Shun Xu, Martin Styner, Beatriz Paniagua, Mihye Ahn, Ying Yuan, Valerie Jewells, Wei Gao, Dinggang Shen, Hongtu Zhu, Weili Lin
Article
Clinical Neurology
Jorge Daniel Oldan, Hae Won Shin, Amir Hossein Khandani, Carlos Zamora, Thad Benefield, Valerie Jewells
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2018)
Article
Pharmacology & Pharmacy
Lilian Calderon-Garciduenas, Antonieta Mora-Tiscareno, Maricela Franco-Lira, Janet V. Cross, Randall Engle, Mariana Aragon-Flores, Gilberto Gomez-Garza, Valerie Jewells, Lin Weili, Humberto Medina-Cortina, Edelmira Solorio, Chih-kai Chao, Hongtu Zhu, Partha S. Mukherjee, Lara Ferreira-Azevedo, Ricardo Torres-Jardon, Amedeo D'Angiulli
FRONTIERS IN PHARMACOLOGY
(2013)
Review
Clinical Neurology
J. D. Oldan, V. L. Jewells, B. Pieper, T. Z. Wong
Summary: This article familiarizes neuroradiologists with the pathophysiology, clinical findings, MR imaging, PET imaging, and emerging techniques of multiple forms of dementia. Cases from multiple institutions are compiled to improve diagnostic accuracy, patient care, and provide information on upcoming biomarkers. Dementia topics addressed include Alzheimer's disease, frontotemporal dementia, cerebral amyloid angiopathy, Lewy body dementia, Parkinson's disease, amyotrophic lateral sclerosis, multisystem atrophy, Huntington's disease, vascular dementia, and Creutzfeldt-Jakob disease.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Review
Medicine, General & Internal
Jessica D. Rich, Stephen M. Clark, Yuri Fedoriw, Valerie Jewells, William Wood, Christopher Dittus
CLINICAL CASE REPORTS
(2019)
Proceedings Paper
Computer Science, Artificial Intelligence
Zhengwang Wu, Yaozong Gao, Feng Shi, Valerie Jewells, Dinggang Shen
MACHINE LEARNING IN MEDICAL IMAGING, MLMI 2016
(2016)
Article
Clinical Neurology
Fumin Tong, Valerie Jewells, Dimitri G. Trembath, Eldad Hadar, Hae Won Shin
EPILEPSY & BEHAVIOR CASE REPORTS
(2015)