Article
Neuroimaging
David F. Tate, Emily L. Dennis, John T. Adams, Maheen M. Adamson, Heather G. Belanger, Erin D. Bigler, Heather C. Bouchard, Alexandra L. Clark, Lisa M. Delano-Wood, Seth G. Disner, Blessen C. Eapen, Carol E. Franz, Elbert Geuze, Naomi J. Goodrich-Hunsaker, Kihwan Han, Jasmeet P. Hayes, Sidney R. Hinds, Cooper B. Hodges, Elizabeth S. Hovenden, Andrei Irimia, Kimbra Kenney, Inga K. Koerte, William S. Kremen, Harvey S. Levin, Hannah M. Lindsey, Rajendra A. Morey, Mary R. Newsome, John Ollinger, Mary Jo Pugh, Randall S. Scheibel, Martha E. Shenton, Danielle R. Sullivan, Brian A. Taylor, Maya Troyanskaya, Carmen Velez, Benjamin S. C. Wade, Xin Wang, Ashley L. Ware, Ross Zafonte, Paul M. Thompson, Elisabeth A. Wilde
Summary: Traumatic brain injury (TBI) is common in military and civilian populations, leading to a range of clinical, cognitive, behavioral, mood, and neuroimaging changes. The inconsistent presentation of TBI poses challenges in establishing biological and imaging markers, although big data approaches offer opportunities to better understand its impact in military populations.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Biotechnology & Applied Microbiology
Xiancheng Yu, Thuy-Tien Nguyen, Tianchi Wu, Mazdak Ghajari
Summary: This study investigated the difference in cerebrospinal fluid (CSF) cavitation between blasts and impacts, and proposed a mechanism explaining the lower negative pressure produced by blasts in the contrecoup CSF region. Experimental results and computational modeling validated this mechanism. These findings have significant implications for the prevention and diagnosis of blast-induced traumatic brain injury.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Michael E. Hanna, Bryan J. Pfister
Summary: Annually, millions of people globally suffer from traumatic brain injury (TBI). Studies have replicated different mechanical loading types associated with head trauma in animal and in vitro cell culture systems to investigate the link between TBI and neurological deficits. In vitro models have provided insights into injury mechanisms and identified potential targets for protection and treatment. This review focuses on recent developments in culture systems and identifies future directions for research.
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2023)
Article
Neurosciences
Carmen Munoz-Ballester, Dzenis Mahmutovic, Yusuf Rafiqzad, Alia Korot, Stefanie Robel
Summary: This study using a mouse model of mTBI found that exposure of neurons to blood-borne factors causes a rapid and sustained loss of neuronal proteins and changes in spine morphology, without neurodegeneration, which may be relevant to many neuropathologies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Ariel Walker, Ben Chapin, Jose Abisambra, Steven T. DeKosky
Summary: This literature review investigated whether a single moderate to severe head injury leads to long-term development of tauopathy. The results of most human and animal studies suggest that a single moderate to severe head injury is associated with greater chronic development of tauopathy, but caution is needed due to limitations in the studies.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Neurosciences
Emily L. Dennis, Brian A. Taylor, Mary R. Newsome, Maya Troyanskaya, Tracy J. Abildskov, Aaron M. Betts, Erin D. Bigler, James Cole, Nicholas Davenport, Timothy Duncan, Jessica Gill, Vivian Guedes, Sidney R. Hinds, Elizabeth S. Hovenden, Kimbra Kenney, Mary Jo Pugh, Randall S. Scheibel, Pashtun-Poh Shahim, Robert Shih, William C. Walker, J. Kent Werner, Gerald E. York, David X. Cifu, David F. Tate, Elisabeth A. Wilde
Summary: This study investigates the association between history of mild traumatic brain injury (mTBI) and accelerated brain aging among United States military Service Members and Veterans. The results showed that males with a history of deployment-related mTBI had advanced brain age compared to those without, while this association was not significant in females. Additionally, severity of posttraumatic stress disorder (PTSD), depression symptoms, and alcohol misuse were also associated with advanced brain aging in male participants.
Article
Biochemistry & Molecular Biology
Hao Cheng, Pengfei Wang, Ning Wang, Wenwen Dong, Ziyuan Chen, Mingzhe Wu, Ziwei Wang, Ziqi Yu, Dawei Guan, Linlin Wang, Rui Zhao
Summary: Ferroptosis and iron-related redox imbalance worsen outcomes of traumatic brain injury (TBI). NRF2, the main transcription factor regulating oxidative stress and neuroinflammation in TBI, has an unclear role in iron-induced post-TBI damage. This study investigated ferroptotic neuronal damage in the injured cortex and observed amelioration with the iron chelator deferoxamine (DFO) in wild-type mice. In Nrf2-knockout (Nrf2(-/-)) mice, more severe ferroptosis and neurological deficits were found. Activation of NRF2 with dimethyl fumarate (DMF) alleviated neural dysfunction in TBI mice, partly due to ferroptosis mitigation induced by TBI. Protein levels of FTH-FTL and FSP1, related to iron metabolism and ferroptotic redox balance, were highly dependent on NRF2 after TBI. Therefore, NRF2 has a neuroprotective effect against TBI-induced ferroptosis through regulation of iron levels and redox status, suggesting its potential use in TBI treatment.
Review
Chemistry, Analytical
Maria Roldan, Panayiotis A. Kyriacou
Summary: Traumatic brain injury (TBI) occurs when sudden trauma causes damage to the brain, with secondary injuries potentially affecting cerebral oxygenation and autoregulation. Near-infrared spectroscopy (NIRS) is a potential noninvasive monitoring technique for assessing TBI early, based on chromophore absorption of infrared light.
Article
Biochemistry & Molecular Biology
Pei-Wen Cheng, Yi-Chung Wu, Tzyy-Yue Wong, Gwo-Ching Sun, Ching-Jiunn Tseng
Summary: Traumatic brain injury is a significant public health burden and a major environmental risk factor for dementia. This study aimed to investigate the impact of stretching on neuroblastoma cells. Stretching led to oxidative DNA damage, decreased levels of brain-derived neurotrophic factors, and increased amyloid-beta, indicating neuronal stress.
Article
Biochemistry & Molecular Biology
Samuel S. Shin, Vanessa M. Mazandi, Andrea L. C. Schneider, Sarah Morton, Jonathan P. Starr, M. Katie Weeks, Nicholas J. Widmann, David H. Jang, Shih-Han Kao, Michael K. Ahlijanian, Todd J. Kilbaugh
Summary: Traumatic brain injury (TBI) leads to the production of tau protein. Targeting hyperphosphorylated tau (p-tau) could potentially provide new therapy for TBI. In a study involving pigs, treatment with PNT001, a monoclonal antibody for p-tau, showed significant improvement in white matter injury and neural injury biomarkers compared to placebo treatment.
Article
Psychology, Multidisciplinary
Ashley N. Clausen, Heather C. Bouchard, Kathleen A. Welsh-Bohmer, Rajendra A. Morey
Summary: This study compared the chronic effects of combat-related blast mTBI and subconcussive blast exposure on neuropsychological performance in Veterans. Results showed that Veterans with combat-related blast mTBI exhibited significantly slower processing speed compared to controls, even after controlling for PTSD and depressive symptoms. However, there were no significant differences in cognition between subconcussive and control groups, or between subconcussive and combat-related blast mTBI groups, suggesting that neurocognitive assessment may not be sensitive enough to detect the long-term effects of subconcussive blast exposure.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Neurosciences
Yuanda Zhang, Jin Lan, Dongxu Zhao, Cijie Ruan, Jue Zhou, Haoyuan Tan, Yinghui Bao
Summary: The study found that NTN1 levels increased after TBI, and it had a neuroprotective effect by inhibiting ferroptosis through activation of the UNC5B/Nrf2 pathway. These findings may provide new strategies for the treatment of TBI.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Anuvab Dey, Subhrojyoti Ghosh, Tiyasa Bhuniya, Madhurima Koley, Aishi Bera, Sudeepta Guha, Kashmira Chakraborty, Sathish Muthu, Sukhamoy Gorai, Rany Vorn, Chithravel Vadivalagan, Krishnan Anand
Summary: Traumatic brain injury (TBI) is a common cause of disability and fatality worldwide. Accurate early diagnosis can strongly impact the patient's discomfort, prognosis, therapeutic approach, survival rates, and recurrence. Brain-derived extracellular vesicles (EVs) have a specific screening role in TBI research, and their therapeutic impact shows promise for aiding in TBI healing. This review highlights the relationships between EVs and TBI theranostics, EVs and TBI-related clinical trials, and the challenges and solutions in the research domain.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Oncology
Chung-Che Lu, Tee-Tau Eric Nyam, Chung-Han Ho, Jinn-Rung Kuo, Chung-Ching Chio, Jhi-Joung Wang, Che-Chuan Wang
Summary: This study found that moderate/severe TBI patients had a higher mortality rate and shorter time interval from TBI to death compared to mild TBI patients. There were no significant differences in cancer incidence and risk factors for mortality between mild and moderate/severe TBI patients. However, patients aged between 46 and 55 years, female patients, and patients with pre-existing renal disease had a significantly higher cancer incidence risk in moderate/severe TBI compared with mild TBI patients.
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Neuroimaging
Katherine A. Koenig, Lynn M. Bekris, Stephen Ruedrich, Grace E. Weber, Maria Khrestian, Se-Hong Oh, Sanghoon Kim, Z. Irene Wang, James B. Leverenz
Summary: The study found that individuals with Down syndrome show alterations in functional connectivity within the default mode network, similar to changes seen in preclinical Alzheimer's disease, indicating a potential measure of dementia risk that warrants further investigation.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Clinical Neurology
Michael W. Parsons, Melissa M. Gardner, Janet C. Sherman, Kathryn Pasquariello, Julie A. Grieco, Christina D. Kay, Lauren E. Pollak, Amy K. Morgan, Britt Carlson-Emerton, Karen Seligsohn, Sigurros Davidsdottir, Margaret B. Pulsifer, Giuliana Zarrella, Sarah M. Burstein, Sarah M. Mancuso
Summary: This study examined the feasibility and acceptance of neuropsychological assessment via video conferencing. The findings indicate that conducting assessments through video conferencing during the COVID-19 pandemic was found to be feasible and satisfactory by both patients and clinicians, but there are also limitations. Further research is needed to establish the reliability and validity of this method.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2022)
Review
Psychology, Clinical
Hannah M. Lindsey, Cooper B. Hodges, Kaitlyn M. Greer, Elisabeth A. Wilde, Tricia L. Merkley
Summary: There is evidence that diffusion-weighted imaging (DWI) is able to detect tissue alterations following mild traumatic brain injury (mTBI), but findings are inconsistent. This systematic review assesses patterns of differences in DWI metrics between those with and without a history of mTBI, and identifies specific brain regions where alterations are commonly reported. However, heterogeneity in sample characteristics and study methods limit the consistency of findings. Future research can benefit from larger samples, improved data analysis methods, and standardized reporting.
NEUROPSYCHOLOGY REVIEW
(2023)
Article
Clinical Neurology
Emily L. Dennis, Karen Caeyenberghs, Kristen R. Hoskinson, Tricia L. Merkley, Stacy J. Suskauer, Robert F. Asarnow, Talin Babikian, Brenda Bartnik-Olson, Kevin Bickart, Erin D. Bigler, Linda Ewing-Cobbs, Anthony Figaji, Christopher C. Giza, Naomi J. Goodrich-Hunsaker, Cooper B. Hodges, Elizabeth S. Hovenden, Andrei Irimia, Marsh Konigs, Harvey S. Levin, Hannah M. Lindsey, Jeffrey E. Max, Mary R. Newsome, Alexander Olsen, Nicholas P. Ryan, Adam T. Schmidt, Matthew S. Spruiell, Benjamin S. C. Wade, Ashley L. Ware, Christopher G. Watson, Anne L. Wheeler, Keith Owen Yeates, Brandon A. Zielinski, Peter Kochunov, Neda Jahanshad, Paul M. Thompson, David F. Tate, Elisabeth A. Wilde
Summary: The study explored the association between moderate-severe traumatic brain injury (TBI) in pediatric patients and widespread white matter disruption, as well as the impact of demographic and clinical variables on this disruption. Results revealed altered white matter diffusion metrics and indicated that injury severity and time post-injury significantly influenced these changes. A sex-by-group interaction was also observed with female TBI patients showing lower fractional anisotropy in specific WM tracts and experiencing more reported behavioral problems. Future work will focus on harmonizing neurocognitive data to identify clinically meaningful patient subtypes.
Article
Multidisciplinary Sciences
Katherine A. Koenig, Erik B. Beall, Ken E. Sakaie, Daniel Ontaneda, Lael Stone, Stephen M. Rao, Kunio Nakamura, Stephen E. Jones, Mark J. Lowe
Summary: This study proposes the Structural and Functional Connectivity Index (SFCI) as a metric for quantifying cognitive decline in Multiple Sclerosis (MS) patients, showing significant differences between MS patients and healthy controls, as well as significant correlations with processing speed, verbal fluency, and the Multiple Sclerosis Functional Composite. The SFCI changes over time performed better in predicting cognitive decline in MS compared to traditional measures like brain parenchymal fraction and lesion volume.
Article
Oncology
Deborah Y. Park, Martin C. Tom, Wei Wei, Surabhi Tewari, Manmeet S. Ahluwalia, Jennifer S. Yu, Samuel T. Chao, John H. Suh, David Peereboom, Glen H. J. Stevens, Gene H. Barnett, Lilyana Angelov, Alireza M. Mohammadi, Thomas Hogan, Courtney Kissel, Brittany Lapin, Isabel Schuermeyer, Michael W. Parsons, Richard Naugle, Erin S. Murphy
Summary: This study evaluated the impact of concurrent temozolomide-based chemoradiation (RT + TMZ) or observation on quality of life (QOL) in patients with low-grade glioma. The results showed that there was no significant decline in patient QOL or depression scores, and no difference between RT + TMZ and observation groups.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Immunology
Grace E. Weber, Maria Khrestian, Elizabeth D. Tuason, Yvonne Shao, Jagan Pillai, Stephen Rao, Hao Feng, Yadi Zhou, Feixiong Cheng, Tara M. DeSilva, Shaun Stauffer, James B. Leverenz, Lynn M. Bekris
Summary: This study explores the relationship between human plasma sTREM2 and inflammatory activity in AD. The results suggest that there are different patterns of inflammatory activity across AD stages, indicating early-stage alterations in peripheral sTREM2-related inflammatory activity in AD. Three inflammatory factors exhibit lower levels in AD and a change in the relationship with sTREM2.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Oncology
Deborah Y. Park, Martin C. Tom, Yanwen Chen, Surabhi Tewari, Manmeet S. Ahluwalia, Jennifer S. Yu, Samuel T. Chao, John H. Suh, David M. Peereboom, Glen H. J. Stevens, Gene H. Barnett, Lilyana Angelov, Alireza Mohammadi, Thomas Hogan, Courtney Kissel, Brittany Lapin, Isabel Schuermeyer, Michael W. Parsons, Richard Naugle, Erin S. Murphy
Summary: This study evaluated the effects of concurrent temozolomide-based chemoradiation therapy on neurocognitive function in low-grade glioma patients. Patients aged over 40 and with education over 16 years demonstrated superior baseline verbal memory. Overall, neurocognitive function remained stable following the treatment.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Psychology, Clinical
Tricia L. Merkley, Carrie Esopenko, Vanessa S. Zizak, Robert M. Bilder, Adriana M. Strutt, David F. Tate, Andrei Irimia
Summary: This article emphasizes the importance of considering cultural and linguistic variables in neuropsychological test performance. It highlights the impact of cultural and language differences on test outcomes, and raises concerns about the misinterpretation of results if norms are applied universally.
Article
Oncology
Deborah A. Forst, Alyx F. Podgurski, Kit M. Quain, Sophia L. Landay, Maya Anand, Emilia Kaslow-Zieve, Michelle M. Mesa, Jamie M. Jacobs, Jorg Dietrich, Michael W. Parsons, Nora Horick, Joseph A. Greer, Tracy T. Batchelor, Vicki A. Jackson, Areej El-Jawahri, Jennifer S. Temel
Summary: Male gender, higher caregiver burden, greater patient depression symptoms, and younger patient age are associated with increased distress among caregivers of patients with malignant gliomas.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Neurosciences
Wanyong Shin, Katherine A. Koenig, Mark J. Lowe
Summary: This study investigates the cardiac and respiratory hemodynamic phase functions reflected in rs-fMRI data using retrospective correction of physiological motion and proposes an update to an existing software package. The updated method shows improved efficacy in estimating physiological signals.
Meeting Abstract
Oncology
Giuliana Zarrella, Michael Parsons, Janet Sherman, Jorg Dietrich, Helen Shih
Meeting Abstract
Oncology
Melissa Gardner, Giuliana Zarrella, Jorg Dietrich, Michael Parsons
Meeting Abstract
Oncology
D. Y. Park, M. C. Tom, Y. Chen, W. Wei, S. Tewari, M. Ahluwalia, J. S. Yu, S. T. Chao, J. H. Suh, D. Peereboom, G. Stevens, G. H. Barnett, L. Angelov, A. M. Mohammadi, I. Katzan, T. Hogan, C. Kissel, B. Lapin, I. Schuermeyer, M. W. Parsons, R. Naugle, E. S. Murphy
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Clinical Neurology
Katherine A. Koenig, Se-Hong Oh, Melissa R. Stasko, Elizabeth C. Roth, H. Gerry Taylor, Stephen Ruedrich, Z. Irene Wang, James B. Leverenz, Alberto C. S. Costa
Summary: Down syndrome is the phenotypic consequence of trisomy 21, involving both neurodevelopmental and neurodegenerative components. Individuals with Down syndrome exhibit cognitive deficits, particularly in hippocampal-mediated processes, which may be related to Alzheimer's disease-type pathology. High-field MRI has been shown to detect subtle differences in hippocampal structure and function in individuals with Down syndrome, suggesting potential for development of MRI-derived measures as surrogate markers for drug efficacy in cognitive enhancement studies.
BRAIN COMMUNICATIONS
(2021)