Journal
JOURNAL OF NEUROTRAUMA
Volume 31, Issue 14, Pages 1268-1276Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2013.3250
Keywords
cognitive memory deficits; hemorrhage; Src family kinases (SFKs); thrombin; traumatic brain injury (TBI)
Funding
- AHA [12BGIA12060381]
- NIH [NS054652]
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Traumatic brain injury (TBI) is often associated with intracerebral and intraventricular hemorrhage. Thrombin is a neurotoxin generated at bleeding sites fater TBI and can lead to cell death and subsequent cognitive dysfunction via activation of Src family kinases (SFKs). We hypothesize that inhibiting SFKs can protect hippocampal neurons and improve cognitive memory function after TBI. To test these hypotheses, we show that moderate lateral fluid percussion (LFP) TBI in adult rats produces bleeding into the cerebrospinal fluid (CSF) in both lateral ventricles, which elevates oxyhemoglobin and thrombin levels in the CSF, activates the SFK family member Fyn, and increases Rho-kinase 1(ROCK1) expression. Systemic administration of the SFK inhibitor, PP2, immediately after moderate TBI blocks ROCK1 expression, protects hippocampal CA2/3 neurons, and improves spatial memory function. These data suggest the possibility that inhibiting SFKs after TBI might improve clinical outcomes.
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