Article
Neurosciences
Tomoo Inubushi, Masanori Ito, Yutaro Mori, Masami Futatsubashi, Kengo Sato, Shigeru Ito, Masamichi Yokokura, Tomomi Shinke, Yosuke Kameno, Akihiro Kakimoto, Toshihiko Kanno, Hiroyuki Okada, Yasuomi Ouchi, Etsuji Yoshikawa
Summary: The study compared changes in brain activity, cerebral blood flow, and dopamine release during PET scans under restrained and unrestrained conditions, as well as psychological stress responses related to head restraint. The results indicated that head restraint could cause undesired responses in brain physiology and emotional states.
Article
Chemistry, Analytical
Siyang Liu, Ye Liu, Zhe Zhang, Xiaodong Wang, Yicheng Yang, Kai Sun, Jiangbo Yu, Daniel T. Chiu, Changfeng Wu
Summary: This study developed a near-infrared optical transducer to monitor glucose variations in cerebrospinal fluid, and observed abnormal glucose uptake in transgenic mice with brain tumors.
ANALYTICAL CHEMISTRY
(2022)
Article
Neurosciences
Oskari Kantonen, Lauri Laaksonen, Michael Alkire, Annalotta Scheinin, Jaakko Langsjo, Roosa E. Kallionpaa, Kaike Kaisti, Linda Radek, Jarkko Johansson, Timo Laitio, Anu Maksimow, Joonas Scheinin, Mikko Nyman, Mika Scheinin, Olof Solin, Tero Vahlberg, Antti Revonsuo, Katja Valli, Harry Scheinin
Summary: We investigated the differences in brain activity between connectedness and disconnectedness during anesthesia by administering various anesthetics to subjects. Using PET, it was found that the level of thalamic activity differed between these states. Compared to the placebo group, widespread cortical metabolic suppression was observed in both connected and disconnected subjects, suggesting that these findings may represent necessary but alone insufficient mechanisms for the change in the state of consciousness.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan P. M. Souza, Fernanda C. Frasson, Maria Emilia S. Takahashi, Gislaine B. O. Duarte, Vania P. Castro, Fernando V. Pericole, Licio A. Velloso, Carmino A. De Souza, Irene Lorand-Metze, Allan O. Santos, Celso D. Ramos
Summary: The aim of this study was to compare [F-18]FDG and [Ga-68]Ga-PSMA-11 PET/CT image findings in patients with multiple myeloma (MM). The study found that both methods can detect most lesions, but half of the lesions can only be identified by one tracer, suggesting their possible complementary role in MM.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Neurosciences
Alexander Cuculiza Henriksen, Markus Nowak Lonsdale, Dan Fuglo, Daniel Kondziella, Vardan Nersesjan, Lisbeth Marner
Summary: This study aimed to evaluate the quantification of cerebral glucose metabolic rate (CMRglc) using a Gjedde-Patlak plot and non-invasive image-derived input functions (IDIF) from the aorta, compared to the reference standard based on sampling the arterial input function (AIF). The results showed excellent agreement between the two methods.
Article
Neurosciences
Annalotta Scheinin, Oskari Kantonen, Michael Alkire, Jaakko Langsjo, Roosa E. Kallionpaa, Kaike Kaisti, Linda Radek, Jarkko Johansson, Nils Sandman, Mikko Nyman, Mika Scheinin, Tero Vahlberg, Antti Revonsuo, Katja Valli, Harry Scheinin
Summary: The experiments indicate that losing consciousness does not necessarily mean losing unconsciousness, as most subjects had internally generated experiences during unresponsive states. Unresponsive anesthetic states and verified sleep stages indicated a disconnected state, distinct from a connected state. Activity of the thalamus, cingulate cortices, and angular gyri was found to be fundamental for human consciousness.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Anita Nitchingham, Jarett Vanz-Brian Pereira, Eva A. Wegner, Vincent Oxenham, Jacqueline Close, Gideon A. Caplan
Summary: In this study, using FDG-PET, researchers found that patients with delirium showed hypometabolism in the bilateral thalami and certain cortical regions. The hypometabolism was correlated with delirium severity and performance on neuropsychological testing.
ALZHEIMERS & DEMENTIA
(2023)
Review
Biochemistry & Molecular Biology
Miikka-Juhani Honka, Eleni Rebelos, Simona Malaspina, Pirjo Nuutila
Summary: This review explores the use of PET in evaluating hepatic metabolism, haemodynamics, and cancer. F-18-FDG is the most commonly used tracer for assessing glucose uptake and endogenous glucose production. Other tracers such as F-18-FTHA, C-11-Palmitate, and C-11-Acetate have been applied for measuring fatty acid uptake rates, blood flow, and oxidation in the liver. O-15 labelled water is used for quantifying hepatic perfusion. The challenges and modelling approaches in utilizing PET for assessing hepatic metabolism are also discussed.
Article
Neurosciences
Maximilian Grosch, Leonie Beyer, Magdalena Lindner, Lena Kaiser, Seyed-Ahmad Ahmadi, Anna Stockbauer, Peter Bartenstein, Marianne Dieterich, Matthias Brendel, Andreas Zwergal, Sibylle Ziegler
Summary: Metabolic connectivity patterns based on [F-18]-FDG PET were used to classify rats after unilateral labyrinthectomy, achieving high accuracy compared to random and machine learning classification. This novel statistical method shows potential for supporting PET-based diagnostic decisions in neurological disorders.
Article
Dermatology
Yunyi Liu, Yingna Xu, Zhe Guo, Xiaoyan Wang, Yang Xu, Lijun Tang
Summary: This study found specific neural functional changes in patients with rosacea using F-18-FDG PET/CT scans, which may explain the pathogenesis of rosacea.
SKIN RESEARCH AND TECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Saeka Shimochi, Jukka Ihalainen, Vilhelmiina Parikka, Nobuyuki Kudomi, Tuula Tolvanen, Ari Hietanen, Esa Kokkomaeki, Stefan Johansson, Masahiro Tsuji, Shigehiko Kanaya, Emrah Yatkin, Tove J. Groenroos, Hidehiro Iida
Summary: This study evaluated the feasibility of PET methodology without intravenous or tracheal cannulation to assess temporal changes in CBF and CMRO2 in a neonatal HIE rat model. The results showed that CBF and CMRO2 in the injured hemispheres of HIE pups decreased and gradually recovered over time, similar to the healthy controls. The magnitude of tissue loss correlated with the decreases in CBF and CMRO2, indicating its potential for monitoring damage progression in neonatal HIE.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Eleni Rebelos, Andrea Mari, Miikka-Juhani Honka, Laura Pekkarinen, Aino Latva-Rasku, Sanna Laurila, Johan Rajander, Paulina Salminen, Hidehiro Iida, Ele Ferrannini, Pirjo Nuutila
Summary: This study confirms differences in renal cortical glucose uptake rates between people with obesity and healthy non-obese controls. Moreover, the negative correlations between renal cortical glucose uptake and free fatty acids, ketone bodies, and citrate suggest substrate competition in the renal cortex.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Oncology
Yao Yao, Rui Zhou, Rui Bai, Jing Wang, Mengjiao Tu, Jingjing Shi, Xiao He, Jinyun Zhou, Liu Feng, Yuanxue Gao, Fahuan Song, Feng Lan, Xingguo Liu, Mei Tian, Hong Zhang
Summary: This study demonstrated that resveratrol, an herbal compound, can enhance mitochondrial metabolism of hypoxia-conditioned neuronal progenitor cells (hcNPCs), promoting neuronal differentiation and improving neurological and metabolic recovery in stroke rats.
FRONTIERS OF MEDICINE
(2021)
Article
Biochemical Research Methods
Palak Wadhwa, Kris Thielemans, Nikos Efthimiou, Kristen Wangerin, Nicholas Keat, Elise Emond, Timothy Deller, Ottavia Bertolli, Daniel Deidda, Gaspar Delso, Michel Tohme, Floris Jansen, Roger N. Gunn, William Hallett, Charalampos Tsoumpas
Summary: This research demonstrates successful computational and physical modelling of the PET-MR system for image acquisition, generating images comparable to those from the manufacturer; the new software developments will be integrated into STIR, providing researchers worldwide with opportunities to establish and expand their image reconstruction methods; by modelling all effects within the system matrix, PET images showing the metabolic uptake of administered radiopharmaceuticals were reconstructed accurately.
Article
Neurosciences
Arianna Sala, Aldana Lizarraga, Isabelle Ripp, Paul Cumming, Igor Yakushev
Summary: This article discusses a number of fundamental issues raised by the study conducted by Jamadar et al., including terminology choice, interpretation of cross-modal findings, group-to-single subject level inferences, and the significance of metabolic connectivity as a biomarker. The authors argue that both sPET and fPET can provide valuable information about brain connectivity.
Article
Clinical Neurology
E. Noe, J. Olaya, C. Colomer, B. Moliner, P. Ugart, C. Rodriguez, R. Llorens, J. Ferri
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Alessandra Repetto, Carolina Igua, Pablo Sopena, Pilar Bello
CLINICAL NUCLEAR MEDICINE
(2018)
Article
Geriatrics & Gerontology
Fermin Segovia, Raquel Sanchez-Vano, Juan M. Gorriz, Javier Ramirez, Pablo Sopena-Novales, Nathalie Testart Dardel, Antonio Rodriguez-Fernandez, Manuel Gomez-Rio
FRONTIERS IN AGING NEUROSCIENCE
(2018)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
R. Sanchez-Vano, S. Prado-Wohlwend, P. Sopena-Novales, E. Uruburu-Garcia, M. D. Monedero-Picazo, C. Martinez-Carsi
REVISTA ESPANOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULAR
(2018)
Article
Neurosciences
Fermin Segovia, Manuel Gomez-Rio, Raquel Sanchez-Vano, Juan Manuel Gorriz, Javier Ramirez, Eva Trivino-Ibanez, Cristobal Carnero-Pardo, Maria Dolores Martinez-Lozano, Pablo Sopena-Novales
JOURNAL OF ALZHEIMERS DISEASE
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
V. Camacho, A. Gomez-Grande, P. Sopena, D. Garcia-Solis, M. Gomez Rio, C. Lorenzo, S. Rubi, J. Arbizu
REVISTA ESPANOLA DE MEDICINA NUCLEAR E IMAGEN MOLECULAR
(2018)
Article
Medicine, General & Internal
Eva Maria Trivino-Ibanez, Raquel Sanchez-Vano, Pablo Sopena-Novales, Juan Carlos Romero-Fabrega, Antonio Rodriguez-Fernandez, Cristobal Carnero Pardo, Maria Dolores Martinez Lozano, Manuel Gomez-Rio
Letter
Clinical Neurology
Enrique Noe, Joan Ferri, Carolina Colomer, Belen Moliner, Myrtha O'Valle, Patricia Ugart, Clara Rodriguez, Roberto Llorens
Article
Neurosciences
Enrique Noe, Joan Ferri, Jose Olaya, Maria Dolores Navarro, Myrtha O'Valle, Carolina Colomer, Belen Moliner, Camilla Ippoliti, Anny Maza, Roberto Llorens
Summary: The study investigated the neurobehavioral progress of 100 patients with unresponsive wakefulness syndrome, revealing that 34% were able to progress to a minimally conscious state, 12% could emerge from MCS, and 10% died during the analyzed period. Transition to MCS was mainly denoted by visual signs and predicted by etiology and a specific scale score, while emergence from MCS was characterized by functional communication and object use. Predictive models for emergence from MCS and mortality were not valid in this study.
Article
Neurosciences
Jose Olaya, Enrique Noe, Maria Dolores Navarro, Myrtha O'Valle, Carolina Colomer, Belen Moliner, Camilla Ippoliti, Joan Ferri, Anny Maza, Roberto Llorens
Article
Radiology, Nuclear Medicine & Medical Imaging
A. Manas-Garcia, I. Gonzalez-Valverde, E. Camacho-Ramos, A. Alberich-Bayarri, J. A. Maldonado, M. Marcos, M. Robles
Summary: Structured reporting in radiology has known benefits but also limitations. This study presents a web-based system that addresses these limitations, including support for multiple languages and automated calculations.
JOURNAL OF DIGITAL IMAGING
(2022)
Article
Multidisciplinary Sciences
Tamara Escriva-Martinez, Ma Dolores Vara, Nadia Czeraniuk, Matias Denis, Francisco J. Nunez-Benjumea, Luis Fernandez-Luque, Alba Jimenez-Diaz, Vicente Traver, Juan Jose Llull, Antonio Martinez-Millana, Jorge Garces-Ferrer, Marta Miragall, Rocio Herrero, Analia Enriquez, Verena Schaefer, Sergio Cervera-Torres, Cecilia Villasanti, Carmen V. Cabral, Irene Fernandez, Rosa Ma Banos
Summary: This study aims to test the efficacy of the Adhera (R) MejoraCare digital program in improving the quality of life of patients with chronic diseases during the COVID-19 outbreak in Paraguay. A randomized controlled trial will be conducted, and outcomes such as quality of life, anxiety, and health empowerment will be evaluated.
Article
Neurosciences
Alfonso Magliacano, Piergiuseppe Liuzzi, Rita Formisano, Antonello Grippo, Efthymios Angelakis, Aurore Thibaut, Olivia Gosseries, Gianfranco Lamberti, Enrique Noe, Sergio Bagnato, Brian L. Edlow, Nicolas Lejeune, Vigneswaran Veeramuthu, Luigi Trojano, Nathan Zasler, Caroline Schnakers, Michelangelo Bartolo, Andrea Mannini, Anna Estraneo
Summary: This study compared the prognostic accuracy of Clinical Diagnosis and Coma Recovery Scale-Revised (CRS-R) total score with that of a novel Consciousness Domain Index (CDI) for recovery of full consciousness in patients with prolonged Disorders of Consciousness (pDoC). The CDI, obtained by combining the CRS-R subscales using unsupervised machine learning, showed the highest prediction accuracy and sensitivity.
Proceedings Paper
Computer Science, Artificial Intelligence
Juan Jose Lull, Adrian Cid-Menendez, Gema Ibanez-Sanchez, Pedro Luis Sanchez, Jose Luis Bayo-Monton, Vicente Traver, Carlos Fernandez-Llatas
Summary: This study deployed a one-stop cardiology clinic in a hospital in Spain, and through the iterative implementation of Interactive Process Indicators (IPIs), it helped clinicians and managers gain a better understanding of outpatient processes and provided a high-quality source of information to improve daily medical care.
PROCESS MINING WORKSHOPS, ICPM 2021
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
P. Olivan-Sasot, P. Sopena-Novales, B. Martinez-Sanchis, I. Torres-Espallardo, A. Yepes-Agudelo, M. Agudelo-Cifuentes, J. Bernal Vergara, P. Bello-Arques
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2018)