Article
Neurosciences
Ajay K. Verma, Ying Yu, Sergio F. Acosta-Lenis, Tyler Havel, David Escobar Sanabria, Gregory F. Molnar, Colum D. MacKinnon, Michael J. Howell, Jerrold L. Vitek, Luke A. Johnson
Summary: Excessive daytime sleepiness is a common problem for Parkinson's disease patients, and current treatment options are limited. This study investigated the possibility of using deep brain stimulation (DBS) to monitor and classify daytime sleep-wake states in nonhuman primates. The results showed that spectral features extracted from DBS lead recordings could reasonably classify sleep and wake states, suggesting the potential for developing closed-loop DBS approaches for automatic detection and disruption of sleep-related neural oscillations in Parkinson's disease.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Xiaoying Zhang, Sheng Zhuang, Jiajing Wu, Lanxiang Wang, Chengjie Mao, Jing Chen, Chun-feng Liu
Summary: Low frequency rTMS over right DLPFC may improve symptoms of excessive daytime sleepiness in Parkinson's disease patients. This study provides new possibilities for the treatment of EDS.
Article
Clinical Neurology
Keitaro Ogaki, Hiroaki Fujita, Narihiro Nozawa, Tomohiko Shiina, Hirotaka Sakuramoto, Keisuke Suzuki
Summary: The study aimed to identify the contributors to sleep disturbances, including insomnia, restless legs syndrome, rapid eye movement sleep behavior disorder (RBD), sleep-disordered breathing, nocturnal akinesia and excessive daytime sleepiness (EDS), in patients with Parkinson's disease (PD). The results showed that autonomic symptoms were associated with sleep disturbances or EDS, and depressive and RBD symptoms in addition to autonomic symptoms were associated with both sleep disturbances and EDS in patients with PD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Yezhou Li, Jing Wang, Lirong Ji, Chaohong Cheng, Tong Su, Shuqing Wu, Fei Han, Daniel J. Cox, Erlei Wang, Rui Chen
Summary: This study aims to investigate the effects of excessive daytime sleepiness on cortical thickness in patients with obstructive sleep apnoea. It was found that the cortical thickness was significantly thinner in the sleepiness group, particularly in the left temporal, frontal, and parietal lobe, and bilateral pre- and postcentral gyri. There was a significant negative correlation between the cortical thickness and the Epworth Sleepiness Scale score.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Anatilde Trindade, Catarina Custodio, Jorge Cabral, Telma Lopes, Vera Martins, Margarida Aguiar, Ines Goncalves, Sofia Furtado
Summary: This study aimed to compare the adherence to positive airway pressure (PAP) therapy between patients with or without excessive daytime sleepiness (EDS) in different severities of obstructive sleep apnea (OSA). The results showed that there were differences in adherence between patients with different severities of OSA but without EDS. However, there was no difference in adherence between patients with or without EDS, regardless of the severity.
Review
Neurosciences
Rachel K. Rowe, Grace S. Griesbach
Summary: Sleep-wake disturbances are common and debilitating symptoms following traumatic brain injury (TBI). Understanding the impact of sleep disturbances on chronic TBI symptoms can help maximize long-term recovery. Current treatments for sleep-wake disturbances are disorder-specific, but identifying the underlying pathology may lead to improved pharmacological and rehabilitative treatments. The immune and endocrine systems play a critical role in sleep regulation and may be potential therapeutic targets for TBI-induced sleep disturbances.
BRAIN RESEARCH BULLETIN
(2022)
Review
Clinical Neurology
Ramona Cordani, Marco Veneruso, Flavia Napoli, Natascia Di Iorgi, Claudia Milanaccio, Alessandro Consales, Nicola Disma, Elisa De Grandis, Mohamad Maghnie, Lino Nobili
Summary: Craniopharyngiomas, a rare type of brain tumor, can cause sleep disorders due to hypothalamic involvement. This systematic review examines the underlying mechanisms and potential treatment strategies for sleep disorders in patients with craniopharyngioma. A high prevalence of excessive daytime sleepiness, narcolepsy, and sleep-disordered breathing was found in these patients. The review also suggests a possible diagnostic algorithm for accurately identifying and treating sleep disorders in this population.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Henrik Holtstrand Hjalm, Erik Thunstrom, Helena Glantz, Martin Karlsson, Yeliz Celik, Yuksel Peker
Summary: There is an independent and dose-response relationship between the severity of obstructive sleep apnea (OSA) and prevalent atrial fibrillation (AF), especially among individuals without excessive daytime sleepiness (EDS).
Article
Clinical Neurology
Gianpaolo Maggi, Carmine Vitale, Francesco Cerciello, Gabriella Santangelo
Summary: Sleep disorders are common in Parkinson's disease and have variable prevalence rates. They are multifactorial in etiology, resulting from degenerative processes, drug interactions, and clinical features. A meta-analytic study found that RBD had a prevalence of 46% and was associated with older age, lower education, longer disease duration, higher medication doses, and more severe symptoms. EDS had a prevalence of 35% and was associated with older age, longer disease duration, more severe symptoms, higher medication doses, and reduced autonomy. Insomnia was reported in 44% of patients and was related to longer disease duration, higher medication doses, and more severe depression. Sleep disorders are associated with a more severe clinical phenotype of Parkinson's disease, and further research is needed to understand their underlying mechanisms and develop targeted therapies.
SLEEP MEDICINE REVIEWS
(2023)
Article
Multidisciplinary Sciences
Changxiu Ma, Ying Zhang, Jiuyu Liu, Gengyun Sun
Summary: The study evaluated the new parameter AHT% for assessing nocturnal hypoxaemia and excessive daytime sleepiness in patients with obstructive sleep apnoea, comparing it with the traditional AHI. Results showed that AHT% was superior to AHI in predicting excessive daytime sleepiness and better reflected the clinical characteristics of patients with obstructive sleep apnoea.
SCIENTIFIC REPORTS
(2021)
Review
Neurosciences
Yu Jin Jung, Han-Joon Kim, Sun Ha Paek, Beomseok Jeon
Summary: DBS has two effects on SWD in PD patients: one is through the direct effect of circuit-mediated effect, and the other is through the indirect effect to improve SWD, such as resolving nocturnal motor complications and reducing dopaminergic medication doses.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Clinical Neurology
Simon J. Schreiner, Esther Werth, Leonie Ballmer, Philipp O. Valko, Kai M. Schubert, Lukas L. Imbach, Christian R. Baumann, Angelina Maric, Heide Baumann-Vogel
Summary: This study found that excessive daytime sleepiness (EDS) in Parkinson disease (PD) is associated with nocturnal sleep disturbance, as indicated by reduced overnight slow-wave activity (SWA) decline and reduced spindle frequency activity.
Article
Medicine, General & Internal
Michael A. Grandner, Jae S. Min, Ragy Saad, Eileen B. Leary, Lev Eldemir, Danielle Hyman
Summary: Approximately 1 billion people worldwide have obstructive sleep apnea (OSA) and experience excessive daytime sleepiness (EDS), which has negative impacts on their health, behavioral choices, and lifestyle. This study reveals that people with OSA and EDS have higher rates of anxiety, depression, insomnia, and impairments in daytime functioning. EDS also prevents physical activity and influences dietary choices.
POSTGRADUATE MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Jiahe Wang, Xiang Li, Siyuan Yang, Tianyi Wang, Zhongmou Xu, Jianguo Xu, Heng Gao, Gang Chen
Summary: Pitolisant demonstrated efficacy and controllable safety in treating excessive daytime sleepiness in patients with narcolepsy and OSA, showing reductions in ESS score, increased sleep latency, and improved quality of life. However, treatment with pitolisant may lead to insomnia as a treatment-emergent adverse event, emphasizing the importance of monitoring and management.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Muhammed Tunc, Pinar Soysal, Ozge Pasin, Lee Smith, Masoud Rahmati, Veliye Yigitalp, Sevnaz Sahin, Moustapha Drame
Summary: The aim of this study was to investigate the relationship between serum magnesium levels and insomnia and excessive daytime sleepiness (EDS) in older adults. It found that hypomagnesemia was associated with a higher prevalence of EDS but not insomnia in older outpatients. Other health conditions such as hypertension and diabetes mellitus were also more common in the hypomagnesemia group. These findings suggest that hypomagnesemia should be considered when evaluating older adults with EDS.
Article
Mathematical & Computational Biology
Yvonne Hoeller, Kevin H. G. Butz, Aljoscha Thomschewski, Elisabeth Schmid, Christoph D. Hofer, Andreas Uhl, Arne C. Bathke, Wolfgang Staffen, Raffaele Nardone, Fabian Schwimmbeck, Markus Leitinger, Giorgi Kuchukhidze, Marlene Derner, Juergen Fell, Eugen Trinka
COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE
(2020)
Article
Clinical Neurology
Nathalie Garner, Aljoscha Thomschewski, Adrian Marcu, Eugen Trinka, Yvonne Hoeller
FRONTIERS IN NEUROLOGY
(2020)
Article
Clinical Neurology
Yvonne Hoeller, Christopher Hoehn, Fabian Schwimmbeck, Gaen Plancher, Eugen Trinka
FRONTIERS IN NEUROLOGY
(2020)
Article
Clinical Neurology
Lawrence J. Hirsch, Michael W. K. Fong, Markus Leitinger, Suzette M. LaRoche, Sandor Beniczky, Nicholas S. Abend, Jong Woo Lee, Courtney J. Wusthoff, Cecil D. Hahn, M. Brandon Westover, Elizabeth E. Gerard, Susan T. Herman, Hiba Arif Haider, Gamaleldin Osman, Andres Rodriguez-Ruiz, Carolina B. Maciel, Emily J. Gilmore, Andres Fernandez, Eric S. Rosenthal, Jan Claassen, Aatif M. Husain, Ji Yeoun Yoo, Elson L. So, Peter W. Kaplan, Marc R. Nuwer, Michel van Putten, Raoul Sutter, Frank W. Drislane, Eugen Trinka, Nicolas Gaspard
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Aljoscha Thomschewski, Eugen Trinka, Julia Jacobs
Summary: In a study on intracranial EEG during a spatial navigation task, it was found that there was no task-related effect on ripple-band coherences between the prefrontal cortex and hippocampus. Subsequent analysis suggested that short periods of synchrony may be more significant than general task-related changes in ripple-band coherence.
Article
Clinical Neurology
Barbara Ladisich, Lukas Machegger, Alexander Romagna, Herbert Krainz, Juergen Steinbacher, Markus Leitinger, Gudrun Kalss, Niklas Thon, Eugen Trinka, Peter A. Winkler, Christoph Schwartz
Summary: This study evaluated the accuracy and treatment-associated morbidity of frameless VarioGuide (R) (VG) neuronavigation-guided depth electrode (DE) implantations in patients with drug-resistant epilepsy. The results showed that VG-SEEG proved to be accurate in identifying EZ with low risk and is a feasible and safe alternative to frame-based or robotic systems.
ACTA NEUROCHIRURGICA
(2021)
Review
Clinical Neurology
Rainer Surges, Stefan Conrad, Hajo M. Hamer, Andreas Schulze-Bonhage, Anke M. Staack, Bernhard J. Steinhoff, Adam Strzelczyk, Eugen Trinka
Summary: SUDEP is the sudden and unexpected death of an epilepsy patient that occurs under benign circumstances without typical causes of death. The risk of SUDEP depends on the characteristics of epilepsy and seizures, with unsupervised TCS patients having the potential to prevent two thirds of cases. Awareness of SUDEP and risk factors can have a positive impact on treatment adherence and behavior for patients and their relatives.
Review
Clinical Neurology
Eugen Trinka, Simona Lattanzi, Kate Carpenter, Tommaso Corradetti, Bruna Nucera, Fabrizio Rinaldi, Rohit Shankar, Francesco Brigo
Summary: The study aimed to explore the potential of perampanel as a broad-spectrum antiseizure medication by analyzing data from patients with different types of epileptic seizures, supporting its effectiveness in multiple types of generalised seizures. However, most available data come from non-randomised, non-controlled studies with a high risk of bias, indicating a need for further research to provide more robust evidence.
Article
Medicine, General & Internal
Johannes A. R. Pfaff, Lukas Machegger, Eugen Trinka, Johannes Sebastian Mutzenbach
Summary: This case report describes a male patient who exhibited clinical and radiological signs consistent with delayed post-hypoxic leukoencephalopathy following acute ischemic stroke. The findings suggest that this condition can occur in patients with large vessel occlusion in the corresponding vascular territories, not just in cases of global hypoxia.
JOURNAL OF MEDICAL CASE REPORTS
(2022)
Article
Clinical Neurology
Kateriine Orav, Pilar Bosque Varela, Tanja Pruewasser, Lukas Machegger, Markus Leitinger, Eugen Trinka, Giorgi Kuchukhidze
Summary: The clinical outcome of patients with possible and definitive post-hypoxic status epilepticus was evaluated in this study. The study also aimed to describe the types of status epilepticus observed in patients with definitive post-hypoxic status epilepticus. The results showed a poor prognosis for patients with possible or definitive status epilepticus due to hypoxic brain injury.
EPILEPTIC DISORDERS
(2023)
Article
Clinical Neurology
Laura Schnetzer, Verena S. Schaetzle, Lisa Kronbichler, Juergen Bergmann, Stefan Leis, Alexander B. Kunz, Julia S. Crone, Eugen Trinka, Martin Kronbichler
Summary: Diagnosing patients with disorders of consciousness can be prone to misdiagnosis. This study aims to determine the proportion of patients who display covert command following and evaluate the prognostic value of improved diagnosis. The researchers used functional MRI and a motor imagery task to identify patients with cognitive motor dissociation. The results showed that some patients exhibited covert command following, while others showed increased brain activation during rest. Additionally, 40% of patients showed significant activations in the whole brain analysis.
ACTA NEUROLOGICA SCANDINAVICA
(2023)
Article
Clinical Neurology
Eugen Trinka, Rodrigo Rocamora, Joao Chaves, Mathias J. Koepp, Stephan Rueegg, Martin Holtkamp, Joana Moreira, Miguel M. Fonseca, Guillermo Castilla-Fernandez, Fabio Ikedo
Summary: In patients with newly diagnosed focal epilepsy, monotherapy with ESL was associated with a lower proportion of increased plasma total cholesterol and LDL cholesterol compared to CBZ-CR. Switching from CBZ-CR to ESL resulted in a significant decrease in the proportion of patients with increased levels of cholesterol.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Clinical Neurology
Julia Feige, Klaus Berek, Michael Seiberl, Patrick Hilpold, Wolfgang Hitzl, Franziska Di Pauli, Harald Hegen, Florian Deisenhammer, Eugen Trinka, Andrea Harrer, Peter Wipfler, Tobias Moser
Summary: Anti-CD20 therapies decrease humoral response to SARS-CoV-2 immunization. Peripheral B cells are required to generate antibodies to neo-antigens but not for a recall response during anti-CD20 therapy.
NEUROLOGY INTERNATIONAL
(2022)
Article
Behavioral Sciences
Sofia Markoula, Andreas Liampas, Guido Rubboli, John Duncan, Demetrios N. Velis, Andreas Schulze-Bonhage, Alla Guekht, Karen Bartholomeyczik, Jane de Tisi, Adrien Gras, Morten Ingvar Lossius, Flavio Villani, Anke Maren Staack, Annette Hospes, Johannes C. Baaijen, Elisabeth C. W. van Straaten, Hanneke E. Ronner, Sara Casciato, Alfredo D'Aniello, Addolorata Mascia, Susana Ferrao Santos, Carla Bentes, Angel Aledo-Serrano, Antonio Gil-Nagel, Petia Dimova, Hrvoje Hecimovic, Cigdem Ozkara, Kristina Malmgren, Savvas Papacostas, Anna Kelemen, Markus Reuber, Eugen Trinka, Philippe Ryvlin
EPILEPSY & BEHAVIOR
(2020)
Article
Behavioral Sciences
Andrea Egger-Rainer, Eugen Trinka, Georg Zimmermann, Stephan Arnold, Christian Bosselmann, Hajo Hamer, Anna Hengsberger, Johannes Lang, Holger Lerche, Soheyl Noachtar, Ekaterina Pataraia, Andreas Schulze-Bonhage, Anke Maren Staack, Iris Unterberger, Stefan Lorenzl
EPILEPSY & BEHAVIOR
(2020)