Article
Neurosciences
Yuanyuan Dang, Yong Wang, Xiaoyu Xia, Yi Yang, Yang Bai, Jianning Zhang, Jianghong He
Summary: This study demonstrated the efficacy of deep brain stimulation (DBS) in enhancing recovery from minimally conscious state (MCS) by improving functional connectivity and brain networks.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Anna Estraneo, Alfonso Magliacano, Salvatore Fiorenza, Rita Formisano, Antonello Grippo, Efthymios Angelakis, Helena Cassol, Aurore Thibaut, Olivia Gosseries, Gianfranco Lamberti, Enrique Noe, Sergio Bagnato, Brian L. Edlow, Camille Chatelle, Nicolas Lejeune, Vigneswaran Veeramuthu, Michelangelo Bartolo, Donatella Mattia, Jlenia Toppi, Nathan Zasler, Caroline Schnakers, Luigi Trojano
Summary: This study found that patients with prolonged disorders of consciousness have a high mortality rate within 24 months post-injury, with different predictors of mortality in patients with vegetative state/unresponsive wakefulness syndrome compared to those with minimally conscious state.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Baohu Liu, Xu Zhang, Lijia Wang, Yuanyuan Li, Jun Hou, Guoping Duan, Tongtong Guo, Dongyu Wu
Summary: This study investigated the role of non-linear dynamic analysis of the EEG in predicting patient outcome in UWS and MCS. The results indicated that certain cortical regions may play key roles in modulating disorders of consciousness, and connectivity patterns of affected and unaffected cortical networks were important for improvement in mGOS scores.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Chuan Xu, Hangcheng Li, Jiaxin Gao, Lingling Li, Fangping He, Jie Yu, Yi Ling, Jian Gao, Jingqi Li, Lucia Melloni, Benyan Luo, Nai Ding
Summary: When listening to speech, cortical activity can track constructed linguistic units, and this can predict the outcome for patients with consciousness disorders. Statistical learning can occur in patients with minimal consciousness and may be used to induce neural plasticity.
Article
Geriatrics & Gerontology
Yi Yang, Yangyang Dai, Qiheng He, Shan Wang, Xueling Chen, Xiaoli Geng, Jianghong He, Feng Duan
Summary: The study explores the association between altered network structures and clinical symptoms of disorders of consciousness (DoC) and demonstrates the feasibility of using network metrics to differentiate patients with different subtypes of DoC.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Aurore Thibaut, Rajanikant Panda, Jitka Annen, Leandro R. D. Sanz, Lionel Naccache, Charlotte Martial, Camille Chatelle, Charlene Aubinet, Estelle A. C. Bonin, Alice Barra, Marie-Michele Briand, Benedetta Cecconi, Sarah Wannez, Johan Stender, Steven Laureys, Olivia Gosseries
Summary: A study investigated brain activity in non-responsive brain-injured patients, finding that a significant proportion of them showed partial preservation of brain metabolism, labeled as MCS*. Patients with MCS* had better outcomes, global functional connectivity, and grey matter preservation compared to those with VS/UWS. MCS* patients had lower brain metabolism in posterior brain regions compared to MCS patients.
ANNALS OF NEUROLOGY
(2021)
Article
Neurosciences
Julia Nekrasova, Mikhail Kanarskii, Ilya Borisov, Pranil Pradhan, Denis Shunenkov, Alexey Vorobiev, Maria Smirnova, Vera Pasko, Marina V. Petrova, Elena Luginina, Igor Pryanikov
Summary: This study evaluates the prognostic value of demographical and clinical data in patients with severe acquired brain injury over a period of 12 months. Younger age and higher CRS-R scores predict better survival rates. Etiology plays a role in prognosis, with anoxic brain injury having the worst prognosis and the first three months post injury being crucial for patients with vascular lesions. Gender does not appear to influence outcomes.
Review
Clinical Neurology
Camillo Porcaro, Idan Efim Nemirovsky, Francesco Riganello, Zahra Mansour, Antonio Cerasa, Paolo Tonin, Bobby Stojanoski, Andrea Soddu
Summary: This article reviews the importance and methods of using neuroimaging and electrophysiological techniques to diagnose patients with disorders of consciousness (DOC) and differentiate between Vegetative State/Unresponsive Wakefulness Syndrome (VS/UWS) and Minimally Conscious State (MCS). By analyzing studies conducted within the last 10 years, the article summarizes the promising results achieved in improving diagnostic accuracy with these techniques and emphasizes the need to incorporate them into standard clinical practice, as well as the importance of data sharing.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neuroimaging
Corinde E. Wiers, Jizheng Zhao, Peter Manza, Kristina Murani, Veronica Ramirez, Amna Zehra, Clara Freeman, Kai Yuan, Gene-Jack Wang, Sukru Baris Demiral, Anna Rose Childress, Dardo Tomasi, Nora D. Volkow
Summary: This study used fMRI to assess the brain's responses to food, cocaine, and neutral cues, revealing distinct activation patterns for food and cocaine, as well as significant differences in visual and cognitive responses under different presentation durations. The findings suggest that negative items may be perceived at a faster speed than positive ones, although no diurnal differences in brain activation were observed.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Rehabilitation
Katherine Golden, Kimberly S. Erler, John Wong, Joseph T. Giacino, Yelena G. Bodien
Summary: This study investigates the significance of consistent command-following (CCF) in the diagnostic criteria for emergence from the minimally conscious state (eMCS). The findings show that CCF reemerges around the same time as functional object use (FOU) or functional communication (FC) in patients recovering from disorders of consciousness (DoC). This supports the inclusion of CCF in the existing diagnostic criteria for eMCS.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Rehabilitation
Kristin M. Kostick, Abby Halm, Katherine O'Brien, Sunil Kothari, Jennifer S. Blumenthal-Barby
Summary: Family caregivers and healthcare professionals caring for minimally conscious patients share similar views on consciousness and believe that decisions about rehabilitative care should be based on considerations of suffering and well-being rather than just the level of consciousness. Providers are more likely to view suffering as rationale for discontinuation of care, while family members see suffering as an indicator of and motivator for potential recovery.
DISABILITY AND REHABILITATION
(2021)
Article
Rehabilitation
Manon Carriere, Roberto Llorens, Maria Dolores Navarro, Jose Olaya, Joan Ferri, Enrique Noe
Summary: Accurately describing the behavioral signs indicating transition from unresponsive wakefulness syndrome/vegetative state to minimally conscious state or emergence from minimally conscious state after severe brain injury is crucial for prognosis. This study examined a large sample of patients with chronic disorders of consciousness and identified the behavioral signs that led to a change in diagnosis, as well as the factors influencing this transition. The study found that transition to minimally conscious state was mostly indicated by visual fixation, localization to noxious stimulation, visual pursuit, and object manipulation. Emergence from minimally conscious state was characterized by functional communication and object use. Clinicians should pay attention to the visual and motor subscales to detect behavioral recovery.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Neurosciences
Fabrice Ferre, Lizette Heine, Edouard Naboulsi, Florent Gobert, Maude Beaudoin-Gobert, Frederic Dailler, William Buffieres, Alexandra Corneyllie, Benjamine Sarton, Beatrice Riu, Jacques Luaute, Stein Silva, Fabien Perrin
Summary: Research shows that approximately 30% of patients with acquired disorders of consciousness are able to process self-referential auditory stimuli, which may be related to consciousness recovery.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Teresa Grimm, Martin Gross, Urs M. Nater, Oliver Summ, Gunter Kreutz
Summary: This explorative study investigated the effects of music and language on the physiological and endocrine systems of UWS and MCS patients. The results showed that biographical language interventions can decrease salivary cortisol levels.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Sung Ho Jang, Seong Ho Kim, Jae Woon Kim, Han Do Lee, Min Kyeong Cho
Summary: The study utilized diffusion tensor tractography to investigate differences in the ascending reticular activating system (ARAS) in TBI patients. Results indicated that the prefrontal cortex plays a critical role in distinguishing between VS and MCS.
Article
Neurosciences
Daniela Cortese, Francesco Riganello, Francesco Arcuri, Lucia Lucca, Paolo Tonin, Caroline Schnakers, Steven Laureys
FRONTIERS IN HUMAN NEUROSCIENCE
(2020)
Article
Rehabilitation
Paolo Boldrini, Carlotte Kiekens, Stefano Bargellesi, Rodolfo Brianti, Silvia Galeri, Lucia Lucca, Andrea Montis, Federico Posteraro, Federico Scarponi, Sofia Straudi, Stefano Negrini
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2020)
Article
Biotechnology & Applied Microbiology
Stefania Laratta, Lucia Francesca Lucca, Paolo Tonin, Antonio Cerasa
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Computer Science, Artificial Intelligence
Antonio Candelieri, Riccardo Perego, Ilaria Giordani, Andrea Ponti, Francesco Archetti
Article
Neurosciences
A. Estraneo, O. Masotta, M. Bartolo, F. Pistoia, C. Perin, S. Marino, L. Lucca, V Pingue, E. Casanova, A. Romoli, S. Gentile, R. Formisano, G. P. Salvi, F. Scarponi, A. De Tanti, P. Bongioanni, E. Rossato, A. Santangelo, A. R. Diana, M. Gambarin, D. Intiso, R. Antenucci, S. Premoselli, M. Bertoni, F. De Bellis
Summary: The study assessed the overall clinical complexity of patients with acquired disorders of consciousness (DoC) and found that patients with non-traumatic etiology had higher complexity compared to traumatic etiology patients. Patients with anoxic etiology had higher complexity and greater need for medical devices. Overall clinical complexity was significantly higher in patients with vegetative state/unresponsive wakefulness syndrome (VS/UWS) compared to minimally conscious state (MCS).
Article
Critical Care Medicine
Lucia F. Lucca, Antonio De Tanti, Francesca Cava, Annamaria Romoli, Rita Formisano, Federico Scarponi, Anna Estraneo, Diana Frattini, Paolo Tonin, Chiara Bertolino, Pamela Salucci, Bahia Hakiki, Mariagrazia D'Ippolito, Mauro Zampolini, Orsola Masotta, Silvia Premoselli, Matteo Interlenghi, Christian Salvatore, Annalisa Polidori, Antonio Cerasa
Summary: This multi-center study evaluated the clinical variability associated with paroxysmal sympathetic hyperactivity (PSH) in acquired brain injury (ABI) patients. Machine learning was used to identify predictive models, with PSH-AM scores, neurological diagnosis, CRS-r, and RLAS scores being crucial factors in outcomes. The study demonstrates PSH's predictive value compared to other clinical measures.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Neurosciences
A. Estraneo, A. Pascarella, O. Masotta, M. Bartolo, F. Pistoia, C. Perin, S. Marino, L. Lucca, V Pingue, E. Casanova, A. M. Romoli, S. Gentile, R. Formisano, G. P. Salvi, F. Scarponi, A. De Tanti, P. Bongioanni, E. Rossato, A. Santangelo, A. R. Diana, M. Gambarin, D. Intiso, R. Antenucci, S. Premoselli, M. Bertoni, L. Trojano
Summary: This study aimed to assess the occurrence and clinical correlates of neurogenic heterotopic ossifications (NHO) in patients with prolonged disorder of consciousness. The results showed that NHO is relatively frequent in these patients and independently associated with functional disability, bone fractures, and spasticity.
Article
Neurosciences
Antonino Naro, Loris Pignolo, Lucia Francesca Lucca, Rocco Salvatore Calabro
Summary: This study investigated the influence of motor observation on motor imagery in individuals with prolonged Disorders of Consciousness, finding that some MCS patients showed preservation of both high- and low-level sensorimotor processing, while one UWS patient exhibited similar responses, indicating preservation of cognitively-mediated sensorimotor processing.
RESTORATIVE NEUROLOGY AND NEUROSCIENCE
(2021)
Article
Neurosciences
Francesco Riganello, Martina Vatrano, Simone Carozzo, Miriam Russo, Lucia Francesca Lucca, Maria Ursino, Valentina Ruggiero, Antonio Cerasa, Camillo Porcaro
Summary: This study aimed to observe fluctuations in EEG and HRV parameters, finding higher values of PSDalpha, alpha/theta, etc for HC individuals in the morning, and significant differences between groups in CI, PSDalpha, PSDtheta, etc in the afternoon.
Article
Neurosciences
Elio Leto, Danilo Lofaro, Lucia Francesca Lucca, Maria Ursino, Stefania Rogano, Paolo Scola, Paolo Tonin, Domenico Conforti, Antonio Cerasa
Summary: Through our study, we proposed a new set of clinical variables for a more accurate early prediction of safe decannulation in patients with severe acquired brain injury. These variables, including age, coma recovery scale scores, and length of ICU stay, were validated through logistic regression models to improve prediction accuracy.
Article
Neurosciences
Sergio Bagnato, Maria Enza D'Ippolito, Cristina Boccagni, Antonio De Tanti, Lucia Francesca Lucca, Antonio Nardone, Pamela Salucci, Teresa Fiorilla, Valeria Pingue, Serena Gennaro, Maria Ursino, Valentina Colombo, Teresa Barone, Francesca Rubino, Maria Andriolo
Summary: The study found that patients with prolonged disorder of consciousness exhibit sustained axonal degeneration, which is influenced differently over time by the severity and etiology of brain injury.
Article
Neurosciences
Maria Daniela Cortese, Francesco Arcuri, Idan E. Nemirovsky, Lucia Francesca Lucca, Paolo Tonin, Andrea Soddu, Francesco Riganello
Summary: NCS and NCS-R can be used to assess patients' behavioral responses to pain, with changes in behavioral abilities potentially indicating improvement in CRS-R diagnosis. Evaluating responses to nociceptive stimuli in DOC patients may be effective in assessing their evolving conscious state.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Computer Science, Artificial Intelligence
Antonio Candelieri, Andrea Ponti, Francesco Archetti
Summary: This paper explores the balance between exploration and exploitation in a global optimization task. Experimental analysis suggests that human behavior may deviate from rationality in situations where improvement seems impossible and the budget is running out, leading to a behavior called exasperated exploration. The development of an interpretable machine learning model based on decision tree learning helps to classify between Pareto and non-Pareto decisions, and a synthetic human searcher/optimizer proves to be more effective and efficient in half of the test problems compared to Bayesian optimization.
BIG DATA AND COGNITIVE COMPUTING
(2022)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Antonio Candelieri, Riccardo Perego, Ilaria Giordani, Francesco Archetti
NUMERICAL COMPUTATIONS: THEORY AND ALGORITHMS, PT II
(2020)
Article
Social Sciences, Mathematical Methods
B. G. Galuzzi, I Giordani, A. Candelieri, R. Perego, F. Archetti
COMPUTATIONAL MANAGEMENT SCIENCE
(2020)