Review
Pharmacology & Pharmacy
David A. Eagles, Chun Yuen Chow, Glenn F. King
Summary: This review examines the role of Na(V)1.7 channels in nociception, their history as a therapeutic target, and the challenges in developing potent inhibitors. Despite significant progress in drug development, effective analgesia remains elusive in clinical trials.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mansour Haddad, Federica Cherchi, Mohammad Alsalem, Yousef M. Al-saraireh, Saba Madae'en
Summary: This review presents new findings on the role of adenosine and its receptors in neuropathic and inflammatory pain. Adenosine receptor ligands have shown promising efficacy and safety in clinical research and could be used as therapeutic targets for various pain disorders. The review also discusses the latest studies on adenosine receptor ligands in different pain models and the potential of newly synthesized allosteric adenosine receptor modulators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Maria M. Cobo, Caroline Hartley, Deniz Gursul, Foteini Andritsou, Marianne van der Vaart, Gabriela Schmidt Mellado, Luke Baxter, Eugene P. Duff, Miranda Buckle, Ria Evans Fry, Gabrielle Green, Amy Hoskin, Richard Rogers, Eleri Adams, Fiona Moultrie, Rebeccah Slater
Summary: Despite the high burden of pain in hospitalised neonates, few analgesics have proven efficacy. Testing analgesics in neonates comes with challenges, both experimentally and ethically; however, EEG-derived measures of noxious-evoked brain activity can help assess efficacy. A new experimental paradigm accounting for individual differences in noxious-evoked baseline sensitivity was developed and tested across four studies, providing evidence of the efficacy of gentle brushing and paracetamol in neonates. This work represents an important step towards safe and cost-effective clinical trials of analgesics in neonates.
Article
Biology
Sydney Trask, Jeffrey S. Mogil, Fred J. Helmstetter, Cheryl L. Stucky, Katelyn E. Sadler
Summary: The mechanisms underlying the transition from acute to chronic pain are still unclear, but it may involve the persistence or strengthening of pain memories acquired through associative learning. Recent studies have shown that contextual cues play a critical role in regulating pain memory. Animals and humans exhibit increased pain sensitivity in environments associated with painful experiences. This study suggests that pain perception and activation of endogenous opioid systems can be modified through psychological association with environmental cues.
Article
Anesthesiology
Vaskar Das, Michael B. Basovich, Jeffrey S. Kroin, Asokumar Buvanendran, Robert J. McCarthy
Summary: The study demonstrates that the peripheral AMPKa activator O304 reduces allodynia in a dose-dependent manner and modulates protein expression in the dorsal root ganglion (DRG).
ANESTHESIA AND ANALGESIA
(2022)
Article
Multidisciplinary Sciences
Charles Havnar, Kathy Hotzel, Carmina Espiritu, Amy Lo, Joshua D. Webster
Summary: Positive and negative controls with known protein expression are crucial in developing immunohistochemistry assays. Tissue controls are suitable for well-characterized proteins, while cell pellets, including cancer cell lines with defined protein or transcript expression levels, can serve as valuable controls for novel or poorly characterized proteins. Processed and embedded in a way that mimics tissue processing, these formalin-fixed, paraffin-embedded cell pellet controls are useful for the development of IHC methods.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Biochemistry & Molecular Biology
Jan-Luca Stampf, Cosmin I. Ciotu, Stefan Heber, Stefan Boehm, Michael J. M. Fischer, Isabella Salzer
Summary: The mechanism of acetaminophen (APAP) analgesia is not fully understood. In this study, it was found that the APAP metabolite N-acetyl-p-benzoquinone imine (NAPQI) activates Kv7 channels in neurons, leading to a decrease in neuronal firing. The Kv7 channel blocker XE991 was shown to reduce the analgesic effect of APAP on mechanical pain in vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lamees Alhassen, Travis Dabbous, Allyssa Ha, Leon Hoang Lam Dang, Olivier Civelli
Summary: Corydalis yanhusuo extract contains over 160 compounds, with alkaloids being the most important for analgesic effects, as over 80 have been isolated and identified. This review aims to comprehensively discuss the phytochemical and pharmacological effects of these alkaloids in relation to pain relief.
Article
Chemistry, Multidisciplinary
Jovana Juloski, Dina Vasovic, Ljiljana Vucic, Tina Pajevic, Nevena Gligoric, Mladen Mirkovic, Branislav Glisic
Summary: This study analyzed the correlation between orthodontic pain and analgesic consumption and identified age, pain intensity, and headache as predictors of analgesic consumption. Understanding these factors can help clinicians identify orthodontic patients who may self-administer analgesics.
APPLIED SCIENCES-BASEL
(2022)
Article
Pharmacology & Pharmacy
Ya Wang, Di Qin, Zhihua Guo, Fuqiang Shi, Nazzareno Cannella, Roberto Ciccocioppo, Hongwu Li
Summary: Pain is a common symptom in many clinical conditions and causes distress to patients. The development of new, safe, and non-addictive opioid analgesics is currently a focus of pain research. BU08028, a potential novel analgesic, has shown promising effects with fewer adverse effects, targeting multiple receptors and potentially offering a safer alternative for pain management and addiction treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Engineering, Environmental
Fahad Ahmed, Benjamin Tscharke, Jake W. O'Brien, Wayne D. Hall, Peter J. Cabot, P. Marcin Sowa, Saer Samanipour, Kevin V. Thomas
Summary: A wastewater-based epidemiology method was used to estimate analgesic consumption and assess pain burden in Australian communities. The concentration of analgesics in wastewater samples from 60 communities was analyzed, and the amount of drug consumed per day per 1000 inhabitants was estimated. The burden of pain treatment was categorized as mild to moderate or strong to severe pain, and a higher burden was observed in regional and remote areas. The correlation analysis showed that pain affects populations across socioeconomic groups. Australians spent approximately US $3.5 per day on analgesics. The study suggests that wastewater-based epidemiology can be an effective tool to estimate analgesic consumption and assess pain burden in communities.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Yang Jiao, Xinglei Wang, Ji-hua Chen
Summary: Gold nanoparticles were successfully synthesized using coriander leaf extract, which showed antioxidant and analgesic properties through various analyses; the results indicated that the combined use of AuNPs and coriander leaf extract is more effective in pain relief and antioxidant activity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Lukas Barsch, Robert Werdehausen, Andreas Leffler, Volker Eulenburg
Summary: The study revealed that the metabolite DEG from propacetamol influences both glycine transporter and receptor function, potentially facilitating glycinergic neurotransmission through multiple pathways.
Article
Multidisciplinary Sciences
Jae Chan Choi, Hae-Jeong Park, Jeong A. Park, Dae Ryong Kang, Young-Seok Choi, SoHyun Choi, Hong Gyu Lee, Jun-Ho Choi, In-Ho Choi, Min Woo Yoon, Jong-Min Lee, Jinhee Kim
Summary: Prior experiences of successful and failed treatments can influence the efficacy of a new treatment. This study found that a history of failed treatment with placebo analgesic cream can affect the therapeutic outcomes of cold-pack treatment, and these effects are associated with brain activity.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Malvindar K. Singh-Bains, Nasim F. Mehrabi, Adelie Y. S. Tan, Richard L. M. Faull, Mike Dragunow
Summary: Using HBTMA technology can improve the efficiency of discovering and validating drug targets for neurodegenerative disorders by reducing tissue and reagent usage. It allows for simultaneous detection of protein and mRNA locations in a large number of samples.